Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	11015
Gene name	KDEL endoplasmic reticulum protein retention receptor 3
Gene symbol	KDELR3
Synonyms (NCBI Gene)	ERD23ERD2L3
Chromosome	22
Chromosome location	22q13.1
Summary	This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval f

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miRTarBase ID	miRNA	Experiments
MIRT1083931	hsa-miR-1302	CLIP-seq
MIRT1083932	hsa-miR-154	CLIP-seq
MIRT1083933	hsa-miR-181a	CLIP-seq
MIRT1083934	hsa-miR-181b	CLIP-seq
MIRT1083935	hsa-miR-181c	CLIP-seq
MIRT1083936	hsa-miR-181d	CLIP-seq
MIRT1083937	hsa-miR-1827	CLIP-seq
MIRT1083938	hsa-miR-300	CLIP-seq
MIRT1083939	hsa-miR-3122	CLIP-seq
MIRT1083940	hsa-miR-3148	CLIP-seq
MIRT1083941	hsa-miR-3663-5p	CLIP-seq
MIRT1083942	hsa-miR-3673	CLIP-seq
MIRT1083943	hsa-miR-3714	CLIP-seq
MIRT1083944	hsa-miR-374c	CLIP-seq
MIRT1083945	hsa-miR-381	CLIP-seq
MIRT1083946	hsa-miR-382	CLIP-seq
MIRT1083947	hsa-miR-3913-5p	CLIP-seq
MIRT1083948	hsa-miR-3925-5p	CLIP-seq
MIRT1083949	hsa-miR-4259	CLIP-seq
MIRT1083950	hsa-miR-4262	CLIP-seq
MIRT1083951	hsa-miR-4263	CLIP-seq
MIRT1083952	hsa-miR-4298	CLIP-seq
MIRT1083953	hsa-miR-4311	CLIP-seq
MIRT1083954	hsa-miR-4316	CLIP-seq
MIRT1083955	hsa-miR-4425	CLIP-seq
MIRT1083956	hsa-miR-4477a	CLIP-seq
MIRT1083957	hsa-miR-4684-3p	CLIP-seq
MIRT1083958	hsa-miR-4690-5p	CLIP-seq
MIRT1083959	hsa-miR-4698	CLIP-seq
MIRT1083960	hsa-miR-4715-5p	CLIP-seq
MIRT1083961	hsa-miR-4736	CLIP-seq
MIRT1083962	hsa-miR-4766-5p	CLIP-seq
MIRT1083963	hsa-miR-488	CLIP-seq
MIRT1083964	hsa-miR-543	CLIP-seq
MIRT1083965	hsa-miR-548a-3p	CLIP-seq
MIRT1083966	hsa-miR-548ae	CLIP-seq
MIRT1083967	hsa-miR-548ag	CLIP-seq
MIRT1083968	hsa-miR-548ai	CLIP-seq
MIRT1083969	hsa-miR-548aj	CLIP-seq
MIRT1083970	hsa-miR-548am	CLIP-seq
MIRT1083971	hsa-miR-548e	CLIP-seq
MIRT1083972	hsa-miR-548f	CLIP-seq
MIRT1083973	hsa-miR-548x	CLIP-seq
MIRT1083974	hsa-miR-570	CLIP-seq
MIRT1083975	hsa-miR-624	CLIP-seq
MIRT1083976	hsa-miR-655	CLIP-seq
MIRT1083977	hsa-miR-767-5p	CLIP-seq
MIRT1083978	hsa-miR-940	CLIP-seq
MIRT2021223	hsa-miR-1261	CLIP-seq
MIRT2021224	hsa-miR-133a	CLIP-seq
MIRT2021225	hsa-miR-133b	CLIP-seq
MIRT1083933	hsa-miR-181a	CLIP-seq
MIRT1083934	hsa-miR-181b	CLIP-seq
MIRT1083935	hsa-miR-181c	CLIP-seq
MIRT1083936	hsa-miR-181d	CLIP-seq
MIRT2021226	hsa-miR-205	CLIP-seq
MIRT2021227	hsa-miR-2053	CLIP-seq
MIRT2021228	hsa-miR-218	CLIP-seq
MIRT2021229	hsa-miR-3607-5p	CLIP-seq
MIRT1083946	hsa-miR-382	CLIP-seq
MIRT1083948	hsa-miR-3925-5p	CLIP-seq
MIRT2021230	hsa-miR-3978	CLIP-seq
MIRT1083950	hsa-miR-4262	CLIP-seq
MIRT1083953	hsa-miR-4311	CLIP-seq
MIRT2021231	hsa-miR-4457	CLIP-seq
MIRT2021232	hsa-miR-4796-3p	CLIP-seq
MIRT2021233	hsa-miR-513a-3p	CLIP-seq
MIRT2021234	hsa-miR-513b	CLIP-seq
MIRT2021235	hsa-miR-524-3p	CLIP-seq
MIRT2021236	hsa-miR-525-3p	CLIP-seq
MIRT1083964	hsa-miR-543	CLIP-seq
MIRT2021237	hsa-miR-619	CLIP-seq
MIRT2021238	hsa-miR-636	CLIP-seq
MIRT2021239	hsa-miR-875-3p	CLIP-seq
MIRT2021224	hsa-miR-133a	CLIP-seq
MIRT2021225	hsa-miR-133b	CLIP-seq
MIRT1083937	hsa-miR-1827	CLIP-seq
MIRT2252785	hsa-miR-3143	CLIP-seq
MIRT2252786	hsa-miR-383	CLIP-seq
MIRT2021230	hsa-miR-3978	CLIP-seq
MIRT1083954	hsa-miR-4316	CLIP-seq
MIRT2252787	hsa-miR-4661-5p	CLIP-seq
MIRT1083957	hsa-miR-4684-3p	CLIP-seq
MIRT2252788	hsa-miR-4733-5p	CLIP-seq
MIRT2252789	hsa-miR-4772-5p	CLIP-seq
MIRT2021232	hsa-miR-4796-3p	CLIP-seq
MIRT2021233	hsa-miR-513a-3p	CLIP-seq
MIRT1083964	hsa-miR-543	CLIP-seq
MIRT1083965	hsa-miR-548a-3p	CLIP-seq
MIRT1083971	hsa-miR-548e	CLIP-seq
MIRT1083972	hsa-miR-548f	CLIP-seq
MIRT2021237	hsa-miR-619	CLIP-seq
MIRT2252790	hsa-miR-628-5p	CLIP-seq
MIRT2252791	hsa-miR-640	CLIP-seq
MIRT1083977	hsa-miR-767-5p	CLIP-seq
MIRT2021239	hsa-miR-875-3p	CLIP-seq
MIRT2021224	hsa-miR-133a	CLIP-seq
MIRT2021225	hsa-miR-133b	CLIP-seq
MIRT2021230	hsa-miR-3978	CLIP-seq
MIRT2021232	hsa-miR-4796-3p	CLIP-seq
MIRT2021233	hsa-miR-513a-3p	CLIP-seq
MIRT2021237	hsa-miR-619	CLIP-seq
MIRT2021239	hsa-miR-875-3p	CLIP-seq
MIRT2021224	hsa-miR-133a	CLIP-seq
MIRT2021225	hsa-miR-133b	CLIP-seq
MIRT2021230	hsa-miR-3978	CLIP-seq
MIRT2021231	hsa-miR-4457	CLIP-seq
MIRT2021232	hsa-miR-4796-3p	CLIP-seq
MIRT2021233	hsa-miR-513a-3p	CLIP-seq
MIRT2021234	hsa-miR-513b	CLIP-seq
MIRT2021237	hsa-miR-619	CLIP-seq
MIRT2021239	hsa-miR-875-3p	CLIP-seq
MIRT2021223	hsa-miR-1261	CLIP-seq
MIRT1083931	hsa-miR-1302	CLIP-seq
MIRT2021224	hsa-miR-133a	CLIP-seq
MIRT2021225	hsa-miR-133b	CLIP-seq
MIRT2555864	hsa-miR-19a	CLIP-seq
MIRT2555865	hsa-miR-19b	CLIP-seq
MIRT2555866	hsa-miR-219-5p	CLIP-seq
MIRT1083938	hsa-miR-300	CLIP-seq
MIRT1083939	hsa-miR-3122	CLIP-seq
MIRT2555867	hsa-miR-3126-5p	CLIP-seq
MIRT1083940	hsa-miR-3148	CLIP-seq
MIRT2555868	hsa-miR-3201	CLIP-seq
MIRT2555869	hsa-miR-325	CLIP-seq
MIRT1083941	hsa-miR-3663-5p	CLIP-seq
MIRT1083942	hsa-miR-3673	CLIP-seq
MIRT1083944	hsa-miR-374c	CLIP-seq
MIRT1083945	hsa-miR-381	CLIP-seq
MIRT1083947	hsa-miR-3913-5p	CLIP-seq
MIRT2021230	hsa-miR-3978	CLIP-seq
MIRT1083949	hsa-miR-4259	CLIP-seq
MIRT1083951	hsa-miR-4263	CLIP-seq
MIRT1083952	hsa-miR-4298	CLIP-seq
MIRT1083955	hsa-miR-4425	CLIP-seq
MIRT2555870	hsa-miR-4445	CLIP-seq
MIRT2021231	hsa-miR-4457	CLIP-seq
MIRT2555871	hsa-miR-4686	CLIP-seq
MIRT1083958	hsa-miR-4690-5p	CLIP-seq
MIRT1083960	hsa-miR-4715-5p	CLIP-seq
MIRT2555872	hsa-miR-4742-3p	CLIP-seq
MIRT2555873	hsa-miR-4779	CLIP-seq
MIRT2555874	hsa-miR-4782-3p	CLIP-seq
MIRT2555875	hsa-miR-4791	CLIP-seq
MIRT2021232	hsa-miR-4796-3p	CLIP-seq
MIRT1083963	hsa-miR-488	CLIP-seq
MIRT2555876	hsa-miR-508-3p	CLIP-seq
MIRT2021233	hsa-miR-513a-3p	CLIP-seq
MIRT2021234	hsa-miR-513b	CLIP-seq
MIRT2555877	hsa-miR-522	CLIP-seq
MIRT1083966	hsa-miR-548ae	CLIP-seq
MIRT1083969	hsa-miR-548aj	CLIP-seq
MIRT1083970	hsa-miR-548am	CLIP-seq
MIRT1083973	hsa-miR-548x	CLIP-seq
MIRT1083974	hsa-miR-570	CLIP-seq
MIRT2555878	hsa-miR-582-3p	CLIP-seq
MIRT2021237	hsa-miR-619	CLIP-seq
MIRT1083976	hsa-miR-655	CLIP-seq
MIRT2555879	hsa-miR-767-3p	CLIP-seq
MIRT2021239	hsa-miR-875-3p	CLIP-seq
MIRT2021224	hsa-miR-133a	CLIP-seq
MIRT2021225	hsa-miR-133b	CLIP-seq
MIRT1083938	hsa-miR-300	CLIP-seq
MIRT1083940	hsa-miR-3148	CLIP-seq
MIRT2555869	hsa-miR-325	CLIP-seq
MIRT1083942	hsa-miR-3673	CLIP-seq
MIRT1083944	hsa-miR-374c	CLIP-seq
MIRT1083945	hsa-miR-381	CLIP-seq
MIRT2021230	hsa-miR-3978	CLIP-seq
MIRT2021231	hsa-miR-4457	CLIP-seq
MIRT1083958	hsa-miR-4690-5p	CLIP-seq
MIRT2021232	hsa-miR-4796-3p	CLIP-seq
MIRT1083963	hsa-miR-488	CLIP-seq
MIRT2021233	hsa-miR-513a-3p	CLIP-seq
MIRT2021234	hsa-miR-513b	CLIP-seq
MIRT1083966	hsa-miR-548ae	CLIP-seq
MIRT1083969	hsa-miR-548aj	CLIP-seq
MIRT1083970	hsa-miR-548am	CLIP-seq
MIRT1083973	hsa-miR-548x	CLIP-seq
MIRT1083974	hsa-miR-570	CLIP-seq
MIRT2555878	hsa-miR-582-3p	CLIP-seq
MIRT2021237	hsa-miR-619	CLIP-seq
MIRT1083976	hsa-miR-655	CLIP-seq
MIRT2021239	hsa-miR-875-3p	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	18086916
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005046	Function	KDEL sequence binding	IDA	18086916
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	18086916
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0005801	Component	Cis-Golgi network	IBA
GO:0006621	Process	Protein retention in ER lumen	IBA
GO:0006621	Process	Protein retention in ER lumen	IEA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IDA	18086916
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0030133	Component	Transport vesicle	TAS
GO:0030663	Component	COPI-coated vesicle membrane	IDA	18086916
GO:0030663	Component	COPI-coated vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0046923	Function	ER retention sequence binding	IBA
GO:0046923	Function	ER retention sequence binding	IEA

MIM	HGNC	e!Ensembl
619900	6306	ENSG00000100196

O43731

Protein name

ER lumen protein-retaining receptor 3 (KDEL endoplasmic reticulum protein retention receptor 3) (KDEL receptor 3)

Protein function

Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00810	ER_lumen_recept	28 → 169	ER lumen protein retaining receptor	Family

Sequence

MNVFRILGDLSHLLAMILLLGKIWRSKCCKGISGKSQILFALVFTTRYLDLFTNFISIYN
TVMKVVFLLCAYVTVYMIYGKFRKTFDSENDTFRLEFLLVPVIGLSFLENYSFTLLEILW
TFSIYLESVAILPQLFMISKTGEAETITTHYLFFLGLYRALYLANWIRRYQTENFYDQIA
VVSGVVQTIFYCDFFYLYVTKVLKGKKLSLPMPI

Sequence length

214

Interactions

View interactions

	KEGG		Reactome
	Vibrio cholerae infection		XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHOLELITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GALLSTONES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Atherosclerosis	Atherosclerosis	Pubtator	31043156	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36362375	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	36362375	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Metabolic syndrome	Pubtator	37138862	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	37138862	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	34930465	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	36046379, 40550052	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

KDELR3 (KDEL endoplasmic reticulum protein retention receptor 3)