Gene Gene information from NCBI Gene database.
Entrez ID 10981
Gene name RAB32, member RAS oncogene family
Gene symbol RAB32
Synonyms (NCBI Gene)
PARK26
Chromosome 6
Chromosome location 6q24.3
Summary The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this g
miRNA miRNA information provided by mirtarbase database.
331
miRTarBase ID miRNA Experiments Reference
MIRT022613 hsa-miR-124-3p Microarray 18668037
MIRT029421 hsa-miR-26b-5p Microarray 19088304
MIRT516466 hsa-miR-6512-5p PAR-CLIP 20371350
MIRT516465 hsa-miR-8083 PAR-CLIP 20371350
MIRT516464 hsa-miR-506-5p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
54
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IDA 11784320, 21808068
GO:0003924 Function GTPase activity IEA
GO:0005515 Function Protein binding IPI 21808068, 22511774, 25360523, 31552791, 32296183, 38858457
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612906 9772 ENSG00000118508
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13637
Protein name Ras-related protein Rab-32 (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:11784320, PubMed:21808068). Rabs cycle between an inactive GDP-bound form and an acti
PDB 4CYM , 4CZ2 , 5OEC , 5OED , 6FF8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 27 194 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung. {ECO:0000269|PubMed:11784320, ECO:0000269|PubMed:12186851}.
Sequence
Sequence length 225
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DERMATITIS, ALLERGIC CONTACT CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIFFERENTIATED THYROID CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LEPROSY CTD, Disgenet, GWAS catalog
CTD, Disgenet, GWAS catalog
CTD, Disgenet, GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 16557577
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 16557577
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 18827820 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Pancreatic ductal carcinoma Pubtator 32759795 Associate
★☆☆☆☆
Found in Text Mining only
Colitis Colitis BEFREE 30338217
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 36539702 Associate
★☆☆☆☆
Found in Text Mining only
Dermatitis, Allergic Contact Dermatitis CTD_human_DG 17374397
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Encephalitis Encephalitis BEFREE 28115010
★☆☆☆☆
Found in Text Mining only
Endometrial Carcinoma Endometrial carcinoma BEFREE 16557577
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma Pubtator 36922509 Stimulate
★☆☆☆☆
Found in Text Mining only