Gene Gene information from NCBI Gene database.
Entrez ID 10972
Gene name Transmembrane p24 trafficking protein 10
Gene symbol TMED10
Synonyms (NCBI Gene)
P24(DELTA)S31I125S31III125TMP21Tmp-21-Ip23p24d1
Chromosome 14
Chromosome location 14q24.3
Summary This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a memb
miRNA miRNA information provided by mirtarbase database.
1562
miRTarBase ID miRNA Experiments Reference
MIRT005139 hsa-miR-30a-5p pSILAC 18668040
MIRT022632 hsa-miR-124-3p Microarray 18668037
MIRT024306 hsa-miR-215-5p Microarray 19074876
MIRT025755 hsa-miR-7-5p Microarray 19073608
MIRT026497 hsa-miR-192-5p Microarray 19074876
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
63
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0005515 Function Protein binding IPI 10359607, 12237308, 16595549, 16641999, 18287528, 19837036, 20427317, 23434013, 25959826, 31455601, 32272059, 32814053, 33961781, 35271311
GO:0005783 Component Endoplasmic reticulum IBA
GO:0005783 Component Endoplasmic reticulum IDA 12237308
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605406 16998 ENSG00000170348
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P49755
Protein name Transmembrane emp24 domain-containing protein 10 (Protein TMED10) (21 kDa transmembrane-trafficking protein) (S31I125) (S31III125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta)
Protein function Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi (PubMed:10052452, PubMed:11726511, PubMed:16641999, PubMed:17288597, PubMed:19296914, PubMed:20427317, PubMed:21219331, PubM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01105 EMP24_GP25L 31 213 emp24/gp25L/p24 family/GOLD Domain
Sequence
Sequence length 219
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Pathogenic Escherichia coli infection   COPII-mediated vesicle transport
Cargo concentration in the ER
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 27880046
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 30821607 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Aortic Valve Insufficiency Aortic Valve Insufficiency BEFREE 25241147
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 20847343, 22074947, 22677230, 24106833
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 14621192
★☆☆☆☆
Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia Lymphoblastic Leukemia BEFREE 22677230
★☆☆☆☆
Found in Text Mining only
Cholestasis of pregnancy Cholestasis of pregnancy BEFREE 11444477
★☆☆☆☆
Found in Text Mining only
Developmental reading disorder Developmental dyslexia BEFREE 19277710
★☆☆☆☆
Found in Text Mining only
Esophageal Neoplasms Esophagus Neoplasm BEFREE 12377406
★☆☆☆☆
Found in Text Mining only
Familial Alzheimer Disease (FAD) Alzheimer disease BEFREE 14621192
★☆☆☆☆
Found in Text Mining only