Gene Gene information from NCBI Gene database.
Entrez ID 10971
Gene name Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Gene symbol YWHAQ
Synonyms (NCBI Gene)
14-3-31C5HS1
Chromosome 2
Chromosome location 2p25.1
Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to th
miRNA miRNA information provided by mirtarbase database.
791
miRTarBase ID miRNA Experiments Reference
MIRT001321 hsa-miR-1-3p pSILAC 18668040
MIRT001321 hsa-miR-1-3p Proteomics;Other 18668040
MIRT024964 hsa-miR-214-3p Microarray;Other 19859982
MIRT051526 hsa-let-7e-5p CLASH 23622248
MIRT051373 hsa-let-7f-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
ESR1 Unknown 22329840
PGR Unknown 22329840
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 7760835, 8663231, 9092538, 10954706, 11697890, 11984006, 14743216, 15094368, 15196694, 15657067, 15660133, 16367866, 16775625, 16868027, 16912074, 17085597, 17620599, 18045992, 18458160, 19172738, 19289404, 19371722, 19559006, 19640509, 19860830, 20029029, 20600589, 20642453, 209367
GO:0005634 Component Nucleus IDA 31906564
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA 15163635, 31906564
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609009 12854 ENSG00000134308
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P27348
Protein name 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Protein function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally resu
PDB 2BTP , 5IQP , 6BCR , 6BD2 , 6BQT , 6KZG , 6KZH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00244 14-03-2003 9 229 14-3-3 protein Domain
Tissue specificity TISSUE SPECIFICITY: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest
Sequence
Sequence length 245
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell cycle
Oocyte meiosis
PI3K-Akt signaling pathway
Hippo signaling pathway
Hepatitis C
Hepatitis B
Viral carcinogenesis
  Activation of BAD and translocation to mitochondria
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
RECTUM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 33254518, 37468915 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 11080204
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis Pubtator 11080204, 30283000 Associate
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma Pubtator 23020756, 33469081 Associate
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorder Autism Pubtator 28522826 Associate
★☆☆☆☆
Found in Text Mining only
Brain Diseases Brain disease Pubtator 21332526 Associate
★☆☆☆☆
Found in Text Mining only
Brain Ischemia Brain ischemia Pubtator 22558368 Associate
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain neoplasms Pubtator 33469081 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 23292247 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 21755566, 21935479, 23785426 Associate
★☆☆☆☆
Found in Text Mining only