Gene Gene information from NCBI Gene database.
Entrez ID 10969
Gene name EBNA1 binding protein 2
Gene symbol EBNA1BP2
Synonyms (NCBI Gene)
EBP2NOBPP40
Chromosome 1
Chromosome location 1p34.2
miRNA miRNA information provided by mirtarbase database.
551
miRTarBase ID miRNA Experiments Reference
MIRT006186 ebv-miR-BHRF1-1 ImmunoprecipitaionqRT-PCRWestern blot 21379335
MIRT006186 ebv-miR-BHRF1-1 ImmunoprecipitaionqRT-PCRWestern blot 21379335
MIRT006186 ebv-miR-BHRF1-1 ImmunoprecipitaionqRT-PCRWestern blot 21379335
MIRT029841 hsa-miR-26b-5p Microarray 19088304
MIRT041523 hsa-miR-193b-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
MYC Activation 22169551
RB1 Activation 22169551
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005515 Function Protein binding IPI 28514442, 32296183, 33961781, 35271311
GO:0005634 Component Nucleus IEA
GO:0005694 Component Chromosome IDA
GO:0005730 Component Nucleolus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614443 15531 ENSG00000117395
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q99848
Protein name Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40)
Protein function Required for the processing of the 27S pre-rRNA.
PDB 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05890 Ebp2 18 298 Eukaryotic rRNA processing protein EBP2 Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11327720}.
Sequence
Sequence length 306
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Major pathway of rRNA processing in the nucleolus and cytosol
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
25
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 22071786, 24194854, 25189640, 26317919, 28298147, 28394798, 28498881, 30718697, 31653135, 31786484
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 26469326
★☆☆☆☆
Found in Text Mining only
Adenoid Cystic Carcinoma Adenocarcinoma BEFREE 31653135
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 25015728
★☆☆☆☆
Found in Text Mining only
Ameloblastoma Ameloblastoma BEFREE 30285997
★☆☆☆☆
Found in Text Mining only
Ankylosing spondylitis Ankylosing Spondylitis BEFREE 29880011
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm, Abdominal Aortic Aneurysm BEFREE 31320700
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 15988104
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 16482511
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 15007350
★☆☆☆☆
Found in Text Mining only