Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10960
Gene name	Lectin, mannose binding 2
Gene symbol	LMAN2
Synonyms (NCBI Gene)	C5orf8GP36BVIP36
Chromosome	5
Chromosome location	5q35.3
Summary	This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quali

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019729	hsa-miR-375	Microarray	20215506
MIRT052347	hsa-let-7b-5p	CLASH	23622248
MIRT048640	hsa-miR-99a-5p	CLASH	23622248
MIRT566924	hsa-miR-23b-3p	PAR-CLIP	20371350
MIRT566923	hsa-miR-130a-5p	PAR-CLIP	20371350
MIRT566922	hsa-miR-23c	PAR-CLIP	20371350
MIRT566921	hsa-miR-23a-3p	PAR-CLIP	20371350
MIRT566920	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT574653	hsa-miR-2116-5p	PAR-CLIP	20371350
MIRT574652	hsa-miR-22-5p	PAR-CLIP	20371350
MIRT566919	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT566918	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT574651	hsa-miR-4273	PAR-CLIP	20371350
MIRT574650	hsa-miR-7156-5p	PAR-CLIP	20371350
MIRT574649	hsa-miR-4677-5p	PAR-CLIP	20371350
MIRT574648	hsa-miR-6739-3p	PAR-CLIP	20371350
MIRT566916	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT566924	hsa-miR-23b-3p	PAR-CLIP	20371350
MIRT566923	hsa-miR-130a-5p	PAR-CLIP	20371350
MIRT566922	hsa-miR-23c	PAR-CLIP	20371350
MIRT566921	hsa-miR-23a-3p	PAR-CLIP	20371350
MIRT566920	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT566919	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT566918	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT566916	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT566924	hsa-miR-23b-3p	PAR-CLIP	20371350
MIRT566923	hsa-miR-130a-5p	PAR-CLIP	20371350
MIRT566922	hsa-miR-23c	PAR-CLIP	20371350
MIRT566921	hsa-miR-23a-3p	PAR-CLIP	20371350
MIRT566920	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT566919	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT566918	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT566916	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT566924	hsa-miR-23b-3p	PAR-CLIP	20371350
MIRT566923	hsa-miR-130a-5p	PAR-CLIP	20371350
MIRT566922	hsa-miR-23c	PAR-CLIP	20371350
MIRT566921	hsa-miR-23a-3p	PAR-CLIP	20371350
MIRT566920	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT574653	hsa-miR-2116-5p	PAR-CLIP	20371350
MIRT574652	hsa-miR-22-5p	PAR-CLIP	20371350
MIRT566919	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT566918	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT574651	hsa-miR-4273	PAR-CLIP	20371350
MIRT574650	hsa-miR-7156-5p	PAR-CLIP	20371350
MIRT574649	hsa-miR-4677-5p	PAR-CLIP	20371350
MIRT574648	hsa-miR-6739-3p	PAR-CLIP	20371350
MIRT566916	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT566924	hsa-miR-23b-3p	PAR-CLIP	20371350
MIRT566923	hsa-miR-130a-5p	PAR-CLIP	20371350
MIRT566922	hsa-miR-23c	PAR-CLIP	20371350
MIRT566921	hsa-miR-23a-3p	PAR-CLIP	20371350
MIRT566920	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT566919	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT566918	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT566916	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT566924	hsa-miR-23b-3p	PAR-CLIP	20371350
MIRT566923	hsa-miR-130a-5p	PAR-CLIP	20371350
MIRT566922	hsa-miR-23c	PAR-CLIP	20371350
MIRT566921	hsa-miR-23a-3p	PAR-CLIP	20371350
MIRT566920	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT566919	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT566918	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT566916	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT1111097	hsa-miR-1225-5p	CLIP-seq
MIRT1111098	hsa-miR-1266	CLIP-seq
MIRT1111099	hsa-miR-1285	CLIP-seq
MIRT1111100	hsa-miR-2116	CLIP-seq
MIRT1111101	hsa-miR-31	CLIP-seq
MIRT1111102	hsa-miR-3120-5p	CLIP-seq
MIRT1111103	hsa-miR-3187-5p	CLIP-seq
MIRT1111104	hsa-miR-3614-5p	CLIP-seq
MIRT1111105	hsa-miR-3653	CLIP-seq
MIRT1111106	hsa-miR-3658	CLIP-seq
MIRT1111107	hsa-miR-3664-3p	CLIP-seq
MIRT1111108	hsa-miR-370	CLIP-seq
MIRT1111109	hsa-miR-3974	CLIP-seq
MIRT1111110	hsa-miR-4476	CLIP-seq
MIRT1111111	hsa-miR-4493	CLIP-seq
MIRT1111112	hsa-miR-4518	CLIP-seq
MIRT1111113	hsa-miR-4660	CLIP-seq
MIRT1111114	hsa-miR-4715-3p	CLIP-seq
MIRT1111115	hsa-miR-4731-5p	CLIP-seq
MIRT1111116	hsa-miR-4766-3p	CLIP-seq
MIRT1111117	hsa-miR-494	CLIP-seq
MIRT1111118	hsa-miR-548p	CLIP-seq
MIRT1111119	hsa-miR-553	CLIP-seq
MIRT1111120	hsa-miR-612	CLIP-seq
MIRT1111121	hsa-miR-629	CLIP-seq
MIRT1111122	hsa-miR-646	CLIP-seq
MIRT1111123	hsa-miR-661	CLIP-seq
MIRT1111124	hsa-miR-873	CLIP-seq
MIRT2031038	hsa-miR-1227	CLIP-seq
MIRT2031039	hsa-miR-199a-5p	CLIP-seq
MIRT2031040	hsa-miR-199b-5p	CLIP-seq
MIRT1111100	hsa-miR-2116	CLIP-seq
MIRT2031041	hsa-miR-3064-3p	CLIP-seq
MIRT2031042	hsa-miR-329	CLIP-seq
MIRT2031043	hsa-miR-362-3p	CLIP-seq
MIRT1111105	hsa-miR-3653	CLIP-seq
MIRT1111106	hsa-miR-3658	CLIP-seq
MIRT1111109	hsa-miR-3974	CLIP-seq
MIRT1111116	hsa-miR-4766-3p	CLIP-seq
MIRT1111117	hsa-miR-494	CLIP-seq
MIRT1111118	hsa-miR-548p	CLIP-seq
MIRT1111119	hsa-miR-553	CLIP-seq
MIRT2261803	hsa-miR-1205	CLIP-seq
MIRT2261804	hsa-miR-1909	CLIP-seq
MIRT2261805	hsa-miR-22	CLIP-seq
MIRT2261806	hsa-miR-4763-5p	CLIP-seq
MIRT1111116	hsa-miR-4766-3p	CLIP-seq
MIRT1111118	hsa-miR-548p	CLIP-seq
MIRT1111119	hsa-miR-553	CLIP-seq
MIRT2390194	hsa-miR-3925-3p	CLIP-seq
MIRT2390195	hsa-miR-766	CLIP-seq
MIRT1111118	hsa-miR-548p	CLIP-seq
MIRT1111099	hsa-miR-1285	CLIP-seq
MIRT1111100	hsa-miR-2116	CLIP-seq
MIRT1111101	hsa-miR-31	CLIP-seq
MIRT1111103	hsa-miR-3187-5p	CLIP-seq
MIRT2561712	hsa-miR-3647-3p	CLIP-seq
MIRT1111105	hsa-miR-3653	CLIP-seq
MIRT1111106	hsa-miR-3658	CLIP-seq
MIRT1111108	hsa-miR-370	CLIP-seq
MIRT1111109	hsa-miR-3974	CLIP-seq
MIRT2561713	hsa-miR-4698	CLIP-seq
MIRT1111114	hsa-miR-4715-3p	CLIP-seq
MIRT2561714	hsa-miR-4729	CLIP-seq
MIRT1111115	hsa-miR-4731-5p	CLIP-seq
MIRT1111117	hsa-miR-494	CLIP-seq
MIRT1111118	hsa-miR-548p	CLIP-seq
MIRT1111120	hsa-miR-612	CLIP-seq
MIRT1111099	hsa-miR-1285	CLIP-seq
MIRT2031039	hsa-miR-199a-5p	CLIP-seq
MIRT2031040	hsa-miR-199b-5p	CLIP-seq
MIRT1111101	hsa-miR-31	CLIP-seq
MIRT1111103	hsa-miR-3187-5p	CLIP-seq
MIRT2561712	hsa-miR-3647-3p	CLIP-seq
MIRT1111108	hsa-miR-370	CLIP-seq
MIRT2561713	hsa-miR-4698	CLIP-seq
MIRT1111114	hsa-miR-4715-3p	CLIP-seq
MIRT1111115	hsa-miR-4731-5p	CLIP-seq
MIRT1111118	hsa-miR-548p	CLIP-seq
MIRT1111120	hsa-miR-612	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	20477988
GO:0005537	Function	D-mannose binding	IBA
GO:0005537	Function	D-mannose binding	IMP	20477988
GO:0005615	Component	Extracellular space	IDA	22016386
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IBA
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IDA	15308636, 20477988
GO:0005794	Component	Golgi apparatus	IDA	20477988
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IDA	22016386
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP	20477988
GO:0009986	Component	Cell surface	IDA	22016386
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0030134	Component	COPII-coated ER to Golgi transport vesicle	IBA
GO:0030246	Function	Carbohydrate binding	IDA	23701871
GO:0030246	Function	Carbohydrate binding	IEA
GO:0031072	Function	Heat shock protein binding	IPI	20477988
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050766	Process	Positive regulation of phagocytosis	IEA
GO:0050766	Process	Positive regulation of phagocytosis	IMP	22016386
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

MIM	HGNC	e!Ensembl
609551	16986	ENSG00000169223

Q12907

Protein name

Vesicular integral-membrane protein VIP36 (Glycoprotein GP36b) (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36)

Protein function

Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03388	Lectin_leg-like	52 → 278	Legume-like lectin family	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MAAEGWIWRWGWGRRCLGRPGLLGPGPGPTTPLFLLLLLGSVTADITDGNSEHLKREHSL
IKPYQGVGSSSMPLWDFQGSTMLTSQYVRLTPDERSKEGSIWNHQPCFLKDWEMHVHFKV
HGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVM
VNNGSLSYDHSKDGRWTELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCI
DITGVRLPTGYYFGASAGTGDLSDNHDIISMKLFQLMVEHTPDEESIDWTKIEPSVNFLK
SPKDNVDDPTGNFRSGPLTGWRVFLLLLCALLGIVVCAVVGAVVFQKRQERNKRFY

Sequence length

356

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum		COPII-mediated vesicle transport Cargo concentration in the ER

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESPIRATORY SYSTEM DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMALL VESSEL STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	35766008	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	35707004	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	29693274		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	36759259	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple System Atrophy	Multiple system atrophy	Pubtator	31535203	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	30154245		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	29693274		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	23161554	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

LMAN2 (lectin, mannose binding 2)