Gene Gene information from NCBI Gene database.
Entrez ID 10955
Gene name Serine incorporator 3
Gene symbol SERINC3
Synonyms (NCBI Gene)
AIGP1DIFF33SBBI99TDETDE1TMS-1
Chromosome 20
Chromosome location 20q13.12
miRNA miRNA information provided by mirtarbase database.
776
miRTarBase ID miRNA Experiments Reference
MIRT005842 hsa-miR-204-5p Luciferase reporter assayMicroarrayqRT-PCR 21282569
MIRT020296 hsa-miR-130b-3p Sequencing 20371350
MIRT024221 hsa-miR-218-5p Sequencing 20371350
MIRT031259 hsa-miR-19b-3p Sequencing 20371350
MIRT039739 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0002376 Process Immune system process IEA
GO:0005515 Function Protein binding IPI 32814053
GO:0005737 Component Cytoplasm IEA
GO:0005794 Component Golgi apparatus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607165 11699 ENSG00000132824
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13530
Protein name Serine incorporator 3 (Tumor differentially expressed protein 1)
Protein function Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP
PDB 7RU6 , 7RUG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03348 Serinc 16 471 Serine incorporator (Serinc) Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues. {ECO:0000269|PubMed:10559794}.
Sequence
Sequence length 473
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Viral life cycle - HIV-1   Serine biosynthesis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
PROSTATIC NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Colitis Ulcerative Ulcerative colitis Pubtator 37345922 Associate
★☆☆☆☆
Found in Text Mining only
Inflammatory Bowel Diseases Inflammatory bowel disease Pubtator 37345922 Associate
★☆☆☆☆
Found in Text Mining only
Keratoconus Keratoconus BEFREE 10951465
★☆☆☆☆
Found in Text Mining only
leukemia Leukemia BEFREE 31186327
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer CTD_human_DG 17013881
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 24424505
★☆☆☆☆
Found in Text Mining only
Ovarian Neoplasms Ovarian neoplasm Pubtator 16928264 Associate
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Prostatic Neoplasms CTD_human_DG 17013881
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Testicular Neoplasms Testicular Neoplasms BEFREE 12949800
★☆☆☆☆
Found in Text Mining only
Vesicular Stomatitis Vesicular Stomatitis BEFREE 30566072
★☆☆☆☆
Found in Text Mining only