SERINC3 (serine incorporator 3)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 10955 |
| Gene name | Serine incorporator 3 |
| Gene symbol | SERINC3 |
| Synonyms (NCBI Gene) |
AIGP1DIFF33SBBI99TDETDE1TMS-1
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| Chromosome | 20 |
| Chromosome location | 20q13.12 |
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miRNA
miRNA information provided by mirtarbase database.
776
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q13530 | ||||||||||
| Protein name | Serine incorporator 3 (Tumor differentially expressed protein 1) | ||||||||||
| Protein function | Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP | ||||||||||
| PDB | 7RU6 , 7RUG | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues. {ECO:0000269|PubMed:10559794}. | ||||||||||
| Sequence |
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| Sequence length | 473 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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