Gene Gene information from NCBI Gene database.
Entrez ID 10950
Gene name BTG anti-proliferation factor 3
Gene symbol BTG3
Synonyms (NCBI Gene)
ANAANA/BTG3APRO4TOB5TOB55TOFA
Chromosome 21
Chromosome location 21q21.1
Summary The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two t
miRNA miRNA information provided by mirtarbase database.
441
miRTarBase ID miRNA Experiments Reference
MIRT019633 hsa-miR-340-5p Sequencing 20371350
MIRT020163 hsa-miR-130b-3p Sequencing 20371350
MIRT020477 hsa-miR-106b-5p Microarray 17242205
MIRT002592 hsa-miR-124-3p Microarray 18668037
MIRT002592 hsa-miR-124-3p Microarray 15685193
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
TP53 Unknown 18590053
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
7
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 17690688
GO:0005634 Component Nucleus IBA
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA 9632145
GO:0008285 Process Negative regulation of cell population proliferation IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605674 1132 ENSG00000154640
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14201
Protein name Protein BTG3 (Abundant in neuroepithelium area protein) (BTG family member 3) (Protein Tob5)
Protein function Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07742 BTG 1 115 BTG family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. High expression in the ventricular zone of the developing central nervous system. High in ovary, testis, prostate, thymus and lung. {ECO:0000269|PubMed:9067576}.
Sequence
MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTLILQEKYKNHWYPEKPSKGQAYRCI
RVNKFQRVDPDVLKACENSCILYSDLGLPKELTLWVDPCEVCCRYGEKNNAFIVA
SFENK
DENKDEISRKVTRALDKVTSDYHSGSSSSDEETSKEMEVKPSSVTAAASPVYQISELIFP
PLPMWHPLPRKKPGMYRGNGHQNHYPPPVPFGYPNQGRKNKPYRPIPVTWVPPPGMHCDR
NHWINPHMLAPH
Sequence length 252
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  RNA degradation  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ARTHRITIS, JUVENILE CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, RENAL CELL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHOLESTASIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETIC KETOACIDOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 25701359
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 10232601
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 26614346, 31297057
★☆☆☆☆
Found in Text Mining only
Adult type dermatomyositis Dermatomyositis BEFREE 30807792
★☆☆☆☆
Found in Text Mining only
Alexander Disease Alexander Disease BEFREE 30942895
★☆☆☆☆
Found in Text Mining only
Amnesia Amnesia BEFREE 31250384
★☆☆☆☆
Found in Text Mining only
Anaplasia Anaplasia BEFREE 23657964, 25904053
★☆☆☆☆
Found in Text Mining only
Anemia Anemia BEFREE 29854827
★☆☆☆☆
Found in Text Mining only
Anemia, Hemolytic Anemia BEFREE 30807792
★☆☆☆☆
Found in Text Mining only
Anterior uveitis Uveitis BEFREE 15703957
★☆☆☆☆
Found in Text Mining only