Gene Gene information from NCBI Gene database.
Entrez ID 10933
Gene name Mortality factor 4 like 1
Gene symbol MORF4L1
Synonyms (NCBI Gene)
Eaf3FWP006HsT17725MEAF3MORFRG15MRG15S863-6
Chromosome 15
Chromosome location 15q25.1
miRNA miRNA information provided by mirtarbase database.
738
miRTarBase ID miRNA Experiments Reference
MIRT019410 hsa-miR-148b-3p Microarray 17612493
MIRT020406 hsa-miR-29c-3p Sequencing 20371350
MIRT021448 hsa-miR-9-5p Microarray 17612493
MIRT021617 hsa-miR-142-3p Microarray 17612493
MIRT032039 hsa-miR-16-5p Proteomics 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0000724 Process Double-strand break repair via homologous recombination IDA 20332121
GO:0000786 Component Nucleosome IDA 27153538
GO:0000786 Component Nucleosome IEA
GO:0003682 Function Chromatin binding IEA
GO:0005515 Function Protein binding IPI 12963728, 14506250, 15647280, 16189514, 16230350, 16407074, 17577209, 20332121, 21516116, 22244764, 24981860, 25416956, 25960410, 26496610, 27107012, 28514442, 31515488, 32296183, 33961781, 36217029
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607303 16989 ENSG00000185787
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UBU8
Protein name Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (MRG15) (Protein MSL3-1) (Transcription factor-like protein MRG15)
Protein function Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA intera
PDB 2AQL , 2EFI , 2F5J , 2F5K , 2LKM , 2N1D , 6AGO , 6INE , 7S4A , 8BPA , 8C60
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11717 Tudor-knot 11 53 RNA binding activity-knot of a chromodomain Family
PF05712 MRG 174 352 MRG Family
Sequence
Sequence length 362
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  ATP-dependent chromatin remodeling  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
16
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARCINOMA, ADENOID CYSTIC CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ATHEROSCLEROSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of lung (disorder) Lung adenocarcinoma GWASDB_DG 19836008
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma GWASCAT_DG 28604730
★☆☆☆☆
Found in Text Mining only
Adenoid Cystic Carcinoma Adenocarcinoma CTD_human_DG 23685749
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 31460868 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 20844547, 21466675
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma GWASCAT_DG 28604730
★☆☆☆☆
Found in Text Mining only
Carotid Stenosis Carotid artery stenosis Pubtator 31651847 Associate
★☆☆☆☆
Found in Text Mining only
Cerebral Infarction Ischemic stroke Pubtator 31460868 Associate
★☆☆☆☆
Found in Text Mining only
Coronary Artery Disease Coronary artery disease GWASDB_DG 23202125, 24262325
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease Coronary artery disease GWASCAT_DG 26343387, 28714975, 29212778, 30104761
★★☆☆☆
Found in Text Mining + Unknown/Other Associations