COPS8 (COP9 signalosome subunit 8)

Gene

• Entrez ID: 10920
• Gene name: COP9 signalosome subunit 8
• Gene symbol: COPS8
• Synonyms (NCBI Gene): COP9, CSN8, SGN8
• Chromosome: 2
• Chromosome location: 2q37.3
• Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to tha

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024114	hsa-let-7i-5p	Western blot	21530537
MIRT032086	hsa-let-7f-5p	Western blot	21530537
MIRT032094	hsa-let-7e-3p	Western blot	21530537
MIRT032190	hsa-let-7c-5p	Western blot	21530537
MIRT053496	hsa-miR-146a-5p	In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	22992343
MIRT053496	hsa-miR-146a-5p	In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	22992343
MIRT717902	hsa-miR-3123	HITS-CLIP	19536157
MIRT717901	hsa-miR-3919	HITS-CLIP	19536157
MIRT717900	hsa-miR-4756-3p	HITS-CLIP	19536157
MIRT717899	hsa-miR-1250-3p	HITS-CLIP	19536157
MIRT717898	hsa-miR-153-5p	HITS-CLIP	19536157
MIRT717897	hsa-miR-7703	HITS-CLIP	19536157
MIRT717896	hsa-miR-3942-3p	HITS-CLIP	19536157
MIRT717895	hsa-miR-30a-3p	HITS-CLIP	19536157
MIRT717894	hsa-miR-30d-3p	HITS-CLIP	19536157
MIRT717893	hsa-miR-30e-3p	HITS-CLIP	19536157
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT504347	hsa-miR-4643	HITS-CLIP	21572407
MIRT516896	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT504346	hsa-miR-466	HITS-CLIP	21572407
MIRT504345	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT516894	hsa-miR-448	HITS-CLIP	21572407
MIRT516893	hsa-miR-202-5p	HITS-CLIP	21572407
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT504347	hsa-miR-4643	HITS-CLIP	21572407
MIRT504348	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT504346	hsa-miR-466	HITS-CLIP	21572407
MIRT504345	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT504344	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT504347	hsa-miR-4643	HITS-CLIP	23313552
MIRT504346	hsa-miR-466	HITS-CLIP	23313552
MIRT504345	hsa-miR-4789-5p	HITS-CLIP	23313552
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT504347	hsa-miR-4643	HITS-CLIP	23313552
MIRT504346	hsa-miR-466	HITS-CLIP	23313552
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT646704	hsa-miR-556-3p	HITS-CLIP	23824327
MIRT646703	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT646702	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT504347	hsa-miR-4643	PAR-CLIP	21572407
MIRT516897	hsa-miR-3163	PAR-CLIP	21572407
MIRT516896	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT504346	hsa-miR-466	PAR-CLIP	21572407
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT516893	hsa-miR-202-5p	PAR-CLIP	21572407
MIRT516898	hsa-miR-4282	PAR-CLIP	23446348
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504347	hsa-miR-4643	PAR-CLIP	23446348
MIRT516897	hsa-miR-3163	PAR-CLIP	23446348
MIRT516896	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT516895	hsa-miR-586	PAR-CLIP	23446348
MIRT504346	hsa-miR-466	PAR-CLIP	23446348
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT516894	hsa-miR-448	PAR-CLIP	23446348
MIRT516893	hsa-miR-202-5p	PAR-CLIP	23446348
MIRT509361	hsa-miR-3646	PAR-CLIP	23446348
MIRT509360	hsa-miR-1252-3p	PAR-CLIP	23446348
MIRT509359	hsa-miR-7-1-3p	PAR-CLIP	23446348
MIRT509358	hsa-miR-7-2-3p	PAR-CLIP	23446348
MIRT509357	hsa-miR-105-5p	PAR-CLIP	23446348
MIRT509356	hsa-miR-7853-5p	PAR-CLIP	23446348
MIRT509355	hsa-miR-2467-3p	PAR-CLIP	23446348
MIRT509354	hsa-miR-7158-3p	PAR-CLIP	23446348
MIRT509353	hsa-miR-3678-3p	PAR-CLIP	23446348
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504347	hsa-miR-4643	PAR-CLIP	23446348
MIRT504348	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504346	hsa-miR-466	PAR-CLIP	23446348
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT504344	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504347	hsa-miR-4643	PAR-CLIP	23446348
MIRT504348	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504346	hsa-miR-466	PAR-CLIP	23446348
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT504344	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT717902	hsa-miR-3123	HITS-CLIP	19536157
MIRT717901	hsa-miR-3919	HITS-CLIP	19536157
MIRT717900	hsa-miR-4756-3p	HITS-CLIP	19536157
MIRT717899	hsa-miR-1250-3p	HITS-CLIP	19536157
MIRT717898	hsa-miR-153-5p	HITS-CLIP	19536157
MIRT717897	hsa-miR-7703	HITS-CLIP	19536157
MIRT717896	hsa-miR-3942-3p	HITS-CLIP	19536157
MIRT717895	hsa-miR-30a-3p	HITS-CLIP	19536157
MIRT717894	hsa-miR-30d-3p	HITS-CLIP	19536157
MIRT717893	hsa-miR-30e-3p	HITS-CLIP	19536157
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT504347	hsa-miR-4643	HITS-CLIP	21572407
MIRT516896	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT504346	hsa-miR-466	HITS-CLIP	21572407
MIRT504345	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT516894	hsa-miR-448	HITS-CLIP	21572407
MIRT516893	hsa-miR-202-5p	HITS-CLIP	21572407
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT504347	hsa-miR-4643	HITS-CLIP	21572407
MIRT504348	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT504346	hsa-miR-466	HITS-CLIP	21572407
MIRT504345	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT504344	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT504347	hsa-miR-4643	HITS-CLIP	23313552
MIRT504346	hsa-miR-466	HITS-CLIP	23313552
MIRT504345	hsa-miR-4789-5p	HITS-CLIP	23313552
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT504347	hsa-miR-4643	HITS-CLIP	23313552
MIRT504346	hsa-miR-466	HITS-CLIP	23313552
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT646704	hsa-miR-556-3p	HITS-CLIP	23824327
MIRT646703	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT646702	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT504347	hsa-miR-4643	PAR-CLIP	21572407
MIRT516897	hsa-miR-3163	PAR-CLIP	21572407
MIRT516896	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT504346	hsa-miR-466	PAR-CLIP	21572407
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT516893	hsa-miR-202-5p	PAR-CLIP	21572407
MIRT516898	hsa-miR-4282	PAR-CLIP	23446348
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504347	hsa-miR-4643	PAR-CLIP	23446348
MIRT516897	hsa-miR-3163	PAR-CLIP	23446348
MIRT516896	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT516895	hsa-miR-586	PAR-CLIP	23446348
MIRT504346	hsa-miR-466	PAR-CLIP	23446348
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT516894	hsa-miR-448	PAR-CLIP	23446348
MIRT516893	hsa-miR-202-5p	PAR-CLIP	23446348
MIRT509361	hsa-miR-3646	PAR-CLIP	23446348
MIRT509360	hsa-miR-1252-3p	PAR-CLIP	23446348
MIRT509359	hsa-miR-7-1-3p	PAR-CLIP	23446348
MIRT509358	hsa-miR-7-2-3p	PAR-CLIP	23446348
MIRT509357	hsa-miR-105-5p	PAR-CLIP	23446348
MIRT509356	hsa-miR-7853-5p	PAR-CLIP	23446348
MIRT509355	hsa-miR-2467-3p	PAR-CLIP	23446348
MIRT509354	hsa-miR-7158-3p	PAR-CLIP	23446348
MIRT509353	hsa-miR-3678-3p	PAR-CLIP	23446348
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504347	hsa-miR-4643	PAR-CLIP	23446348
MIRT504348	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504346	hsa-miR-466	PAR-CLIP	23446348
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT504344	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504347	hsa-miR-4643	PAR-CLIP	23446348
MIRT504348	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504346	hsa-miR-466	PAR-CLIP	23446348
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT504344	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT904221	hsa-miR-1283	CLIP-seq
MIRT904222	hsa-miR-1305	CLIP-seq
MIRT904223	hsa-miR-146a	CLIP-seq
MIRT904224	hsa-miR-146b-5p	CLIP-seq
MIRT904225	hsa-miR-200b	CLIP-seq
MIRT904226	hsa-miR-200c	CLIP-seq
MIRT904227	hsa-miR-2054	CLIP-seq
MIRT904228	hsa-miR-2117	CLIP-seq
MIRT904229	hsa-miR-2355-5p	CLIP-seq
MIRT904230	hsa-miR-3065-5p	CLIP-seq
MIRT904231	hsa-miR-3155	CLIP-seq
MIRT904232	hsa-miR-3155b	CLIP-seq
MIRT904233	hsa-miR-3201	CLIP-seq
MIRT904234	hsa-miR-342-3p	CLIP-seq
MIRT904235	hsa-miR-3660	CLIP-seq
MIRT904236	hsa-miR-3662	CLIP-seq
MIRT904237	hsa-miR-3680	CLIP-seq
MIRT904238	hsa-miR-3908	CLIP-seq
MIRT904239	hsa-miR-421	CLIP-seq
MIRT904240	hsa-miR-4273	CLIP-seq
MIRT904241	hsa-miR-429	CLIP-seq
MIRT904242	hsa-miR-4311	CLIP-seq
MIRT904243	hsa-miR-4438	CLIP-seq
MIRT904244	hsa-miR-4477a	CLIP-seq
MIRT904245	hsa-miR-452	CLIP-seq
MIRT904246	hsa-miR-4526	CLIP-seq
MIRT904247	hsa-miR-4637	CLIP-seq
MIRT904248	hsa-miR-4676-3p	CLIP-seq
MIRT904249	hsa-miR-4698	CLIP-seq
MIRT904250	hsa-miR-4791	CLIP-seq
MIRT904251	hsa-miR-4798-3p	CLIP-seq
MIRT904252	hsa-miR-484	CLIP-seq
MIRT904253	hsa-miR-494	CLIP-seq
MIRT904254	hsa-miR-515-5p	CLIP-seq
MIRT904255	hsa-miR-583	CLIP-seq
MIRT904256	hsa-miR-589	CLIP-seq
MIRT904257	hsa-miR-105	CLIP-seq
MIRT904221	hsa-miR-1283	CLIP-seq
MIRT904222	hsa-miR-1305	CLIP-seq
MIRT904223	hsa-miR-146a	CLIP-seq
MIRT904224	hsa-miR-146b-5p	CLIP-seq
MIRT904230	hsa-miR-3065-5p	CLIP-seq
MIRT904236	hsa-miR-3662	CLIP-seq
MIRT904239	hsa-miR-421	CLIP-seq
MIRT904258	hsa-miR-4291	CLIP-seq
MIRT904259	hsa-miR-4310	CLIP-seq
MIRT904245	hsa-miR-452	CLIP-seq
MIRT904248	hsa-miR-4676-3p	CLIP-seq
MIRT904249	hsa-miR-4698	CLIP-seq
MIRT904256	hsa-miR-589	CLIP-seq
MIRT1968108	hsa-miR-1178	CLIP-seq
MIRT1968109	hsa-miR-1266	CLIP-seq
MIRT904222	hsa-miR-1305	CLIP-seq
MIRT904223	hsa-miR-146a	CLIP-seq
MIRT904224	hsa-miR-146b-5p	CLIP-seq
MIRT1968110	hsa-miR-2681	CLIP-seq
MIRT904230	hsa-miR-3065-5p	CLIP-seq
MIRT904231	hsa-miR-3155	CLIP-seq
MIRT904232	hsa-miR-3155b	CLIP-seq
MIRT1968111	hsa-miR-323-3p	CLIP-seq
MIRT1968112	hsa-miR-3613-5p	CLIP-seq
MIRT904235	hsa-miR-3660	CLIP-seq
MIRT904236	hsa-miR-3662	CLIP-seq
MIRT1968113	hsa-miR-3664-3p	CLIP-seq
MIRT1968114	hsa-miR-3677-5p	CLIP-seq
MIRT1968115	hsa-miR-3686	CLIP-seq
MIRT1968116	hsa-miR-3689d	CLIP-seq
MIRT1968117	hsa-miR-377	CLIP-seq
MIRT904239	hsa-miR-421	CLIP-seq
MIRT1968118	hsa-miR-4307	CLIP-seq
MIRT904242	hsa-miR-4311	CLIP-seq
MIRT1968119	hsa-miR-4318	CLIP-seq
MIRT1968120	hsa-miR-4433	CLIP-seq
MIRT904243	hsa-miR-4438	CLIP-seq
MIRT1968121	hsa-miR-4447	CLIP-seq
MIRT1968122	hsa-miR-4459	CLIP-seq
MIRT1968123	hsa-miR-4460	CLIP-seq
MIRT1968124	hsa-miR-4472	CLIP-seq
MIRT1968125	hsa-miR-4518	CLIP-seq
MIRT904245	hsa-miR-452	CLIP-seq
MIRT904246	hsa-miR-4526	CLIP-seq
MIRT1968126	hsa-miR-4652-3p	CLIP-seq
MIRT1968127	hsa-miR-4675	CLIP-seq
MIRT904248	hsa-miR-4676-3p	CLIP-seq
MIRT1968128	hsa-miR-4693-5p	CLIP-seq
MIRT904249	hsa-miR-4698	CLIP-seq
MIRT1968129	hsa-miR-4727-3p	CLIP-seq
MIRT1968130	hsa-miR-4741	CLIP-seq
MIRT1968131	hsa-miR-4742-3p	CLIP-seq
MIRT1968132	hsa-miR-4768-3p	CLIP-seq
MIRT1968133	hsa-miR-4797-3p	CLIP-seq
MIRT904252	hsa-miR-484	CLIP-seq
MIRT1968134	hsa-miR-520d-5p	CLIP-seq
MIRT1968135	hsa-miR-520g	CLIP-seq
MIRT1968136	hsa-miR-520h	CLIP-seq
MIRT1968137	hsa-miR-524-5p	CLIP-seq
MIRT1968138	hsa-miR-548u	CLIP-seq
MIRT904256	hsa-miR-589	CLIP-seq
MIRT1968139	hsa-miR-600	CLIP-seq
MIRT1968140	hsa-miR-760	CLIP-seq
MIRT1968141	hsa-miR-892a	CLIP-seq
MIRT1968108	hsa-miR-1178	CLIP-seq
MIRT904230	hsa-miR-3065-5p	CLIP-seq
MIRT2204005	hsa-miR-374a	CLIP-seq
MIRT2204006	hsa-miR-374b	CLIP-seq
MIRT1968117	hsa-miR-377	CLIP-seq
MIRT2204007	hsa-miR-4446-3p	CLIP-seq
MIRT2204008	hsa-miR-4528	CLIP-seq
MIRT1968127	hsa-miR-4675	CLIP-seq
MIRT2204009	hsa-miR-4721	CLIP-seq
MIRT1968130	hsa-miR-4741	CLIP-seq
MIRT1968133	hsa-miR-4797-3p	CLIP-seq
MIRT1968138	hsa-miR-548u	CLIP-seq
MIRT2204010	hsa-miR-944	CLIP-seq
MIRT2507200	hsa-miR-103b	CLIP-seq
MIRT1968108	hsa-miR-1178	CLIP-seq
MIRT2507201	hsa-miR-1205	CLIP-seq
MIRT1968109	hsa-miR-1266	CLIP-seq
MIRT904221	hsa-miR-1283	CLIP-seq
MIRT2507202	hsa-miR-1286	CLIP-seq
MIRT904222	hsa-miR-1305	CLIP-seq
MIRT904223	hsa-miR-146a	CLIP-seq
MIRT904224	hsa-miR-146b-5p	CLIP-seq
MIRT2507203	hsa-miR-1587	CLIP-seq
MIRT904225	hsa-miR-200b	CLIP-seq
MIRT904226	hsa-miR-200c	CLIP-seq
MIRT904227	hsa-miR-2054	CLIP-seq
MIRT904228	hsa-miR-2117	CLIP-seq
MIRT1968110	hsa-miR-2681	CLIP-seq
MIRT2507204	hsa-miR-299-5p	CLIP-seq
MIRT904230	hsa-miR-3065-5p	CLIP-seq
MIRT2507205	hsa-miR-3148	CLIP-seq
MIRT904231	hsa-miR-3155	CLIP-seq
MIRT904232	hsa-miR-3155b	CLIP-seq
MIRT1968111	hsa-miR-323-3p	CLIP-seq
MIRT2507206	hsa-miR-323b-3p	CLIP-seq
MIRT1968112	hsa-miR-3613-5p	CLIP-seq
MIRT2507207	hsa-miR-3647-3p	CLIP-seq
MIRT904235	hsa-miR-3660	CLIP-seq
MIRT904236	hsa-miR-3662	CLIP-seq
MIRT1968113	hsa-miR-3664-3p	CLIP-seq
MIRT1968114	hsa-miR-3677-5p	CLIP-seq
MIRT1968115	hsa-miR-3686	CLIP-seq
MIRT2507208	hsa-miR-3688-3p	CLIP-seq
MIRT1968116	hsa-miR-3689d	CLIP-seq
MIRT2507209	hsa-miR-375	CLIP-seq
MIRT2507210	hsa-miR-376a	CLIP-seq
MIRT2507211	hsa-miR-376b	CLIP-seq
MIRT1968117	hsa-miR-377	CLIP-seq
MIRT2507212	hsa-miR-3924	CLIP-seq
MIRT2507213	hsa-miR-3978	CLIP-seq
MIRT904239	hsa-miR-421	CLIP-seq
MIRT904240	hsa-miR-4273	CLIP-seq
MIRT904241	hsa-miR-429	CLIP-seq
MIRT904258	hsa-miR-4291	CLIP-seq
MIRT1968118	hsa-miR-4307	CLIP-seq
MIRT904259	hsa-miR-4310	CLIP-seq
MIRT904242	hsa-miR-4311	CLIP-seq
MIRT2507214	hsa-miR-4326	CLIP-seq
MIRT1968120	hsa-miR-4433	CLIP-seq
MIRT2507215	hsa-miR-4436b-3p	CLIP-seq
MIRT904243	hsa-miR-4438	CLIP-seq
MIRT1968121	hsa-miR-4447	CLIP-seq
MIRT1968122	hsa-miR-4459	CLIP-seq
MIRT1968123	hsa-miR-4460	CLIP-seq
MIRT1968124	hsa-miR-4472	CLIP-seq
MIRT904244	hsa-miR-4477a	CLIP-seq
MIRT2507216	hsa-miR-4492	CLIP-seq
MIRT2507217	hsa-miR-4498	CLIP-seq
MIRT2507218	hsa-miR-4509	CLIP-seq
MIRT1968125	hsa-miR-4518	CLIP-seq
MIRT904245	hsa-miR-452	CLIP-seq
MIRT904246	hsa-miR-4526	CLIP-seq
MIRT904247	hsa-miR-4637	CLIP-seq
MIRT2507219	hsa-miR-4641	CLIP-seq
MIRT1968126	hsa-miR-4652-3p	CLIP-seq
MIRT2507220	hsa-miR-4656	CLIP-seq
MIRT2507221	hsa-miR-4663	CLIP-seq
MIRT1968127	hsa-miR-4675	CLIP-seq
MIRT904248	hsa-miR-4676-3p	CLIP-seq
MIRT904249	hsa-miR-4698	CLIP-seq
MIRT2507222	hsa-miR-4720-3p	CLIP-seq
MIRT2507223	hsa-miR-4722-5p	CLIP-seq
MIRT1968129	hsa-miR-4727-3p	CLIP-seq
MIRT2507224	hsa-miR-4728-3p	CLIP-seq
MIRT1968130	hsa-miR-4741	CLIP-seq
MIRT1968131	hsa-miR-4742-3p	CLIP-seq
MIRT2507225	hsa-miR-4744	CLIP-seq
MIRT1968132	hsa-miR-4768-3p	CLIP-seq
MIRT1968133	hsa-miR-4797-3p	CLIP-seq
MIRT2507226	hsa-miR-4804-3p	CLIP-seq
MIRT904252	hsa-miR-484	CLIP-seq
MIRT904253	hsa-miR-494	CLIP-seq
MIRT2507227	hsa-miR-495	CLIP-seq
MIRT904254	hsa-miR-515-5p	CLIP-seq
MIRT1968134	hsa-miR-520d-5p	CLIP-seq
MIRT1968135	hsa-miR-520g	CLIP-seq
MIRT1968136	hsa-miR-520h	CLIP-seq
MIRT2507228	hsa-miR-522	CLIP-seq
MIRT1968137	hsa-miR-524-5p	CLIP-seq
MIRT2507229	hsa-miR-548c-3p	CLIP-seq
MIRT1968138	hsa-miR-548u	CLIP-seq
MIRT2507230	hsa-miR-561	CLIP-seq
MIRT2507231	hsa-miR-582-3p	CLIP-seq
MIRT904255	hsa-miR-583	CLIP-seq
MIRT904256	hsa-miR-589	CLIP-seq
MIRT1968139	hsa-miR-600	CLIP-seq
MIRT2507232	hsa-miR-601	CLIP-seq
MIRT1968140	hsa-miR-760	CLIP-seq
MIRT2507233	hsa-miR-762	CLIP-seq
MIRT2507200	hsa-miR-103b	CLIP-seq
MIRT1968108	hsa-miR-1178	CLIP-seq
MIRT2678463	hsa-miR-1202	CLIP-seq
MIRT2507201	hsa-miR-1205	CLIP-seq
MIRT1968109	hsa-miR-1266	CLIP-seq
MIRT904221	hsa-miR-1283	CLIP-seq
MIRT2507202	hsa-miR-1286	CLIP-seq
MIRT904222	hsa-miR-1305	CLIP-seq
MIRT904223	hsa-miR-146a	CLIP-seq
MIRT904224	hsa-miR-146b-5p	CLIP-seq
MIRT2507203	hsa-miR-1587	CLIP-seq
MIRT904225	hsa-miR-200b	CLIP-seq
MIRT904226	hsa-miR-200c	CLIP-seq
MIRT904227	hsa-miR-2054	CLIP-seq
MIRT904228	hsa-miR-2117	CLIP-seq
MIRT1968110	hsa-miR-2681	CLIP-seq
MIRT2507204	hsa-miR-299-5p	CLIP-seq
MIRT904230	hsa-miR-3065-5p	CLIP-seq
MIRT2507205	hsa-miR-3148	CLIP-seq
MIRT904231	hsa-miR-3155	CLIP-seq
MIRT904232	hsa-miR-3155b	CLIP-seq
MIRT2678464	hsa-miR-3194-5p	CLIP-seq
MIRT904233	hsa-miR-3201	CLIP-seq
MIRT1968111	hsa-miR-323-3p	CLIP-seq
MIRT904234	hsa-miR-342-3p	CLIP-seq
MIRT1968112	hsa-miR-3613-5p	CLIP-seq
MIRT904235	hsa-miR-3660	CLIP-seq
MIRT904236	hsa-miR-3662	CLIP-seq
MIRT1968113	hsa-miR-3664-3p	CLIP-seq
MIRT1968114	hsa-miR-3677-5p	CLIP-seq
MIRT904237	hsa-miR-3680	CLIP-seq
MIRT1968115	hsa-miR-3686	CLIP-seq
MIRT2507208	hsa-miR-3688-3p	CLIP-seq
MIRT1968116	hsa-miR-3689d	CLIP-seq
MIRT2507209	hsa-miR-375	CLIP-seq
MIRT2507210	hsa-miR-376a	CLIP-seq
MIRT2507211	hsa-miR-376b	CLIP-seq
MIRT1968117	hsa-miR-377	CLIP-seq
MIRT904238	hsa-miR-3908	CLIP-seq
MIRT2507212	hsa-miR-3924	CLIP-seq
MIRT2678465	hsa-miR-3972	CLIP-seq
MIRT2507213	hsa-miR-3978	CLIP-seq
MIRT904239	hsa-miR-421	CLIP-seq
MIRT904240	hsa-miR-4273	CLIP-seq
MIRT904241	hsa-miR-429	CLIP-seq
MIRT904258	hsa-miR-4291	CLIP-seq
MIRT2678466	hsa-miR-4304	CLIP-seq
MIRT1968118	hsa-miR-4307	CLIP-seq
MIRT904259	hsa-miR-4310	CLIP-seq
MIRT904242	hsa-miR-4311	CLIP-seq
MIRT2507214	hsa-miR-4326	CLIP-seq
MIRT1968120	hsa-miR-4433	CLIP-seq
MIRT2507215	hsa-miR-4436b-3p	CLIP-seq
MIRT904243	hsa-miR-4438	CLIP-seq
MIRT1968121	hsa-miR-4447	CLIP-seq
MIRT1968122	hsa-miR-4459	CLIP-seq
MIRT1968123	hsa-miR-4460	CLIP-seq
MIRT1968124	hsa-miR-4472	CLIP-seq
MIRT904244	hsa-miR-4477a	CLIP-seq
MIRT2507216	hsa-miR-4492	CLIP-seq
MIRT2507217	hsa-miR-4498	CLIP-seq
MIRT2507218	hsa-miR-4509	CLIP-seq
MIRT1968125	hsa-miR-4518	CLIP-seq
MIRT904245	hsa-miR-452	CLIP-seq
MIRT904246	hsa-miR-4526	CLIP-seq
MIRT904247	hsa-miR-4637	CLIP-seq
MIRT2507219	hsa-miR-4641	CLIP-seq
MIRT1968126	hsa-miR-4652-3p	CLIP-seq
MIRT2507220	hsa-miR-4656	CLIP-seq
MIRT2507221	hsa-miR-4663	CLIP-seq
MIRT1968127	hsa-miR-4675	CLIP-seq
MIRT904248	hsa-miR-4676-3p	CLIP-seq
MIRT904249	hsa-miR-4698	CLIP-seq
MIRT2507222	hsa-miR-4720-3p	CLIP-seq
MIRT2507223	hsa-miR-4722-5p	CLIP-seq
MIRT1968129	hsa-miR-4727-3p	CLIP-seq
MIRT2507224	hsa-miR-4728-3p	CLIP-seq
MIRT1968130	hsa-miR-4741	CLIP-seq
MIRT1968131	hsa-miR-4742-3p	CLIP-seq
MIRT2507225	hsa-miR-4744	CLIP-seq
MIRT1968132	hsa-miR-4768-3p	CLIP-seq
MIRT904250	hsa-miR-4791	CLIP-seq
MIRT1968133	hsa-miR-4797-3p	CLIP-seq
MIRT904251	hsa-miR-4798-3p	CLIP-seq
MIRT2507226	hsa-miR-4804-3p	CLIP-seq
MIRT904252	hsa-miR-484	CLIP-seq
MIRT904253	hsa-miR-494	CLIP-seq
MIRT2507227	hsa-miR-495	CLIP-seq
MIRT904254	hsa-miR-515-5p	CLIP-seq
MIRT1968134	hsa-miR-520d-5p	CLIP-seq
MIRT1968135	hsa-miR-520g	CLIP-seq
MIRT1968136	hsa-miR-520h	CLIP-seq
MIRT2507228	hsa-miR-522	CLIP-seq
MIRT1968137	hsa-miR-524-5p	CLIP-seq
MIRT2678467	hsa-miR-548al	CLIP-seq
MIRT2507229	hsa-miR-548c-3p	CLIP-seq
MIRT1968138	hsa-miR-548u	CLIP-seq
MIRT2507230	hsa-miR-561	CLIP-seq
MIRT2507231	hsa-miR-582-3p	CLIP-seq
MIRT904255	hsa-miR-583	CLIP-seq
MIRT904256	hsa-miR-589	CLIP-seq
MIRT1968139	hsa-miR-600	CLIP-seq
MIRT2507232	hsa-miR-601	CLIP-seq
MIRT1968140	hsa-miR-760	CLIP-seq
MIRT2507233	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000338	Process	Protein deneddylation	IDA	19141280
GO:0000338	Process	Protein deneddylation	IEA
GO:0005515	Function	Protein binding	IPI	20399188, 25043011, 25416956, 27173435, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	24421388
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005634	Component	Nucleus	TAS	8689678
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	24421388
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IDA	9535219
GO:0007250	Process	Activation of NF-kappaB-inducing kinase activity	IMP	22992343
GO:0008180	Component	COP9 signalosome	IBA
GO:0008180	Component	COP9 signalosome	IDA	9535219, 18850735
GO:0008180	Component	COP9 signalosome	IEA
GO:0008180	Component	COP9 signalosome	IPI	25043011
GO:0008180	Component	COP9 signalosome	ISS
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	23689509
GO:0010387	Process	COP9 signalosome assembly	IEA
GO:0045116	Process	Protein neddylation	NAS	24421388
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	9535219
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:2000434	Process	Regulation of protein neddylation	NAS	24421388

Other IDs

• MIM: 616011
• HGNC: 24335
• e!Ensembl: ENSG00000198612

Protein

• UniProt ID: Q99627
• Protein name: COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)
• Protein function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the culli
• PDB: 4D10, 4D18, 4WSN, 6R6H, 6R7F, 6R7H, 6R7I, 6R7N, 8H38, 8H3A, 8H3F
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10075	CSN8_PSD8_EIF3K	31 → 171	CSN8/PSMD8/EIF3K family	Family

• Sequence:

  MPVAVMAESAFSFKKLLDQCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRI
  PPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFAL
  VSQAYTSIIADDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFI
  PLSEPAPVPPIPNEQQLARLTDYVAFLEN

• Sequence length: 209

Pathways

Reactome:

DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	27375289		★☆☆☆☆ Found in Text Mining only
Cancer of Urinary Tract	Urinary Tract Cancer	BEFREE	26944622		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	21499307	Associate	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	31195722		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	35854198	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	33261601	Associate	★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	33261601	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	33261601	Stimulate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	27375289		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of kidney	Kidney Cancer	BEFREE	28063109		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	21876386		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27903243		★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	28063109		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	21317535		★☆☆☆☆ Found in Text Mining only