Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10915
Gene name	Transcription elongation regulator 1
Gene symbol	TCERG1
Synonyms (NCBI Gene)	CA150TAF2SUrn1
Chromosome	5
Chromosome location	5q32
Summary	This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing

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Show/Hide all (175)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027828	hsa-miR-98-5p	Microarray	19088304
MIRT052589	hsa-let-7a-5p	CLASH	23622248
MIRT046720	hsa-miR-222-3p	CLASH	23622248
MIRT043747	hsa-miR-328-3p	CLASH	23622248
MIRT040393	hsa-miR-615-3p	CLASH	23622248
MIRT039212	hsa-miR-769-5p	CLASH	23622248
MIRT037086	hsa-miR-877-3p	CLASH	23622248
MIRT648477	hsa-miR-4418	HITS-CLIP	23824327
MIRT648476	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT648475	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT648474	hsa-miR-217	HITS-CLIP	23824327
MIRT648473	hsa-miR-6807-3p	HITS-CLIP	23824327
MIRT648472	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648471	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT648470	hsa-miR-1283	HITS-CLIP	23824327
MIRT648469	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT095688	hsa-miR-299-5p	PAR-CLIP	20371350
MIRT095689	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT561465	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT561464	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT329362	hsa-miR-3163	PAR-CLIP	20371350
MIRT561463	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT561462	hsa-miR-4703-3p	PAR-CLIP	20371350
MIRT357882	hsa-miR-5701	PAR-CLIP	20371350
MIRT095692	hsa-miR-3671	PAR-CLIP	20371350
MIRT561461	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT095690	hsa-miR-607	PAR-CLIP	20371350
MIRT648477	hsa-miR-4418	HITS-CLIP	23824327
MIRT648476	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT648475	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT648474	hsa-miR-217	HITS-CLIP	23824327
MIRT648473	hsa-miR-6807-3p	HITS-CLIP	23824327
MIRT648472	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648471	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT648470	hsa-miR-1283	HITS-CLIP	23824327
MIRT648469	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT095688	hsa-miR-299-5p	PAR-CLIP	20371350
MIRT095689	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT561465	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT561464	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT329362	hsa-miR-3163	PAR-CLIP	20371350
MIRT561463	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT561462	hsa-miR-4703-3p	PAR-CLIP	20371350
MIRT357882	hsa-miR-5701	PAR-CLIP	20371350
MIRT095692	hsa-miR-3671	PAR-CLIP	20371350
MIRT561461	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT095690	hsa-miR-607	PAR-CLIP	20371350
MIRT1415854	hsa-miR-1228	CLIP-seq
MIRT1415855	hsa-miR-1245b-3p	CLIP-seq
MIRT1415856	hsa-miR-1253	CLIP-seq
MIRT1415857	hsa-miR-1912	CLIP-seq
MIRT1415858	hsa-miR-3647-3p	CLIP-seq
MIRT1415859	hsa-miR-3658	CLIP-seq
MIRT1415860	hsa-miR-3688-3p	CLIP-seq
MIRT1415861	hsa-miR-3692	CLIP-seq
MIRT1415862	hsa-miR-380	CLIP-seq
MIRT1415863	hsa-miR-4251	CLIP-seq
MIRT1415864	hsa-miR-4324	CLIP-seq
MIRT1415865	hsa-miR-4495	CLIP-seq
MIRT1415866	hsa-miR-4749-3p	CLIP-seq
MIRT1415867	hsa-miR-4753-3p	CLIP-seq
MIRT1415868	hsa-miR-496	CLIP-seq
MIRT1415869	hsa-miR-548ac	CLIP-seq
MIRT1415870	hsa-miR-548ae	CLIP-seq
MIRT1415871	hsa-miR-548ag	CLIP-seq
MIRT1415872	hsa-miR-548ai	CLIP-seq
MIRT1415873	hsa-miR-548aj	CLIP-seq
MIRT1415874	hsa-miR-548am	CLIP-seq
MIRT1415875	hsa-miR-548d-3p	CLIP-seq
MIRT1415876	hsa-miR-548m	CLIP-seq
MIRT1415877	hsa-miR-548x	CLIP-seq
MIRT1415878	hsa-miR-548z	CLIP-seq
MIRT1415879	hsa-miR-563	CLIP-seq
MIRT1415880	hsa-miR-587	CLIP-seq
MIRT1415881	hsa-miR-590-3p	CLIP-seq
MIRT1415882	hsa-miR-617	CLIP-seq
MIRT1415883	hsa-miR-7	CLIP-seq
MIRT1415884	hsa-miR-942	CLIP-seq
MIRT1415854	hsa-miR-1228	CLIP-seq
MIRT1415885	hsa-miR-1289	CLIP-seq
MIRT1415886	hsa-miR-1299	CLIP-seq
MIRT1415887	hsa-miR-141	CLIP-seq
MIRT1415857	hsa-miR-1912	CLIP-seq
MIRT1415888	hsa-miR-200a	CLIP-seq
MIRT1415889	hsa-miR-224	CLIP-seq
MIRT1415890	hsa-miR-24	CLIP-seq
MIRT1415891	hsa-miR-28-3p	CLIP-seq
MIRT1415892	hsa-miR-3198	CLIP-seq
MIRT1415858	hsa-miR-3647-3p	CLIP-seq
MIRT1415893	hsa-miR-3682-5p	CLIP-seq
MIRT1415894	hsa-miR-3691-3p	CLIP-seq
MIRT1415861	hsa-miR-3692	CLIP-seq
MIRT1415895	hsa-miR-369-3p	CLIP-seq
MIRT1415896	hsa-miR-374a	CLIP-seq
MIRT1415897	hsa-miR-374b	CLIP-seq
MIRT1415862	hsa-miR-380	CLIP-seq
MIRT1415898	hsa-miR-4276	CLIP-seq
MIRT1415899	hsa-miR-4284	CLIP-seq
MIRT1415900	hsa-miR-4294	CLIP-seq
MIRT1415901	hsa-miR-4302	CLIP-seq
MIRT1415902	hsa-miR-4309	CLIP-seq
MIRT1415903	hsa-miR-432	CLIP-seq
MIRT1415904	hsa-miR-4420	CLIP-seq
MIRT1415905	hsa-miR-4433	CLIP-seq
MIRT1415906	hsa-miR-4476	CLIP-seq
MIRT1415865	hsa-miR-4495	CLIP-seq
MIRT1415907	hsa-miR-4528	CLIP-seq
MIRT1415908	hsa-miR-4536	CLIP-seq
MIRT1415909	hsa-miR-4699-3p	CLIP-seq
MIRT1415869	hsa-miR-548ac	CLIP-seq
MIRT1415870	hsa-miR-548ae	CLIP-seq
MIRT1415871	hsa-miR-548ag	CLIP-seq
MIRT1415872	hsa-miR-548ai	CLIP-seq
MIRT1415873	hsa-miR-548aj	CLIP-seq
MIRT1415874	hsa-miR-548am	CLIP-seq
MIRT1415875	hsa-miR-548d-3p	CLIP-seq
MIRT1415876	hsa-miR-548m	CLIP-seq
MIRT1415877	hsa-miR-548x	CLIP-seq
MIRT1415878	hsa-miR-548z	CLIP-seq
MIRT1415910	hsa-miR-550b	CLIP-seq
MIRT1415879	hsa-miR-563	CLIP-seq
MIRT1415911	hsa-miR-578	CLIP-seq
MIRT1415881	hsa-miR-590-3p	CLIP-seq
MIRT1415882	hsa-miR-617	CLIP-seq
MIRT1415883	hsa-miR-7	CLIP-seq
MIRT1415912	hsa-miR-875-3p	CLIP-seq
MIRT1415913	hsa-miR-885-5p	CLIP-seq
MIRT2124760	hsa-miR-1237	CLIP-seq
MIRT1415855	hsa-miR-1245b-3p	CLIP-seq
MIRT2124761	hsa-miR-1248	CLIP-seq
MIRT2124762	hsa-miR-3182	CLIP-seq
MIRT2124763	hsa-miR-4279	CLIP-seq
MIRT2124764	hsa-miR-4652-3p	CLIP-seq
MIRT2124765	hsa-miR-4719	CLIP-seq
MIRT2124766	hsa-miR-4738-3p	CLIP-seq
MIRT2124767	hsa-miR-548g	CLIP-seq
MIRT2347176	hsa-miR-105	CLIP-seq
MIRT1415856	hsa-miR-1253	CLIP-seq
MIRT1415887	hsa-miR-141	CLIP-seq
MIRT2347177	hsa-miR-181a	CLIP-seq
MIRT2347178	hsa-miR-181b	CLIP-seq
MIRT2347179	hsa-miR-181c	CLIP-seq
MIRT2347180	hsa-miR-181d	CLIP-seq
MIRT1415857	hsa-miR-1912	CLIP-seq
MIRT1415888	hsa-miR-200a	CLIP-seq
MIRT1415889	hsa-miR-224	CLIP-seq
MIRT1415891	hsa-miR-28-3p	CLIP-seq
MIRT2347181	hsa-miR-3143	CLIP-seq
MIRT2347182	hsa-miR-3161	CLIP-seq
MIRT1415858	hsa-miR-3647-3p	CLIP-seq
MIRT1415859	hsa-miR-3658	CLIP-seq
MIRT1415893	hsa-miR-3682-5p	CLIP-seq
MIRT1415894	hsa-miR-3691-3p	CLIP-seq
MIRT1415862	hsa-miR-380	CLIP-seq
MIRT1415863	hsa-miR-4251	CLIP-seq
MIRT2347183	hsa-miR-4262	CLIP-seq
MIRT1415904	hsa-miR-4420	CLIP-seq
MIRT1415905	hsa-miR-4433	CLIP-seq
MIRT1415906	hsa-miR-4476	CLIP-seq
MIRT1415865	hsa-miR-4495	CLIP-seq
MIRT1415909	hsa-miR-4699-3p	CLIP-seq
MIRT2124765	hsa-miR-4719	CLIP-seq
MIRT2347184	hsa-miR-543	CLIP-seq
MIRT1415869	hsa-miR-548ac	CLIP-seq
MIRT1415870	hsa-miR-548ae	CLIP-seq
MIRT1415871	hsa-miR-548ag	CLIP-seq
MIRT1415872	hsa-miR-548ai	CLIP-seq
MIRT1415873	hsa-miR-548aj	CLIP-seq
MIRT1415874	hsa-miR-548am	CLIP-seq
MIRT1415875	hsa-miR-548d-3p	CLIP-seq
MIRT1415876	hsa-miR-548m	CLIP-seq
MIRT1415877	hsa-miR-548x	CLIP-seq
MIRT1415878	hsa-miR-548z	CLIP-seq
MIRT1415910	hsa-miR-550b	CLIP-seq
MIRT1415881	hsa-miR-590-3p	CLIP-seq

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Transcription factor	Regulation	Reference
SF1	Repression	11604498

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	20956529
GO:0003711	Function	Transcription elongation factor activity	TAS	20215116
GO:0003712	Function	Transcription coregulator activity	IBA
GO:0003713	Function	Transcription coactivator activity	TAS	9315662
GO:0003714	Function	Transcription corepressor activity	IDA	20956529
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	15383276, 17500595
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9315662
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006397	Process	MRNA processing	IDA	20215116
GO:0008380	Process	RNA splicing	IDA	20215116
GO:0016607	Component	Nuclear speck	TAS	20215116
GO:0032968	Process	Positive regulation of transcription elongation by RNA polymerase II	TAS	20215116
GO:0034244	Process	Negative regulation of transcription elongation by RNA polymerase II	TAS	20215116
GO:0042802	Function	Identical protein binding	IPI	17060612
GO:0044390	Function	Ubiquitin-like protein conjugating enzyme binding	IPI	20215116
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	20215116
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	20956529
GO:0070063	Function	RNA polymerase binding	IBA
GO:0070063	Function	RNA polymerase binding	IEA
GO:0070063	Function	RNA polymerase binding	TAS	20215116

MIM	HGNC	e!Ensembl
605409	15630	ENSG00000113649

O14776

Protein name

Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150)

Protein function

Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodefi

PDB

2DK7 , 2DOD , 2DOE , 2DOF , 2E71 , 2KIQ , 2KIS , 2MW9 , 2MWA , 2MWB , 2MWD , 2MWE , 2MWF , 2N4R , 2N4S , 2N4T , 2N4U , 2N4V , 2N4W , 2NNT , 3HFH , 3Q1I , 4FQG , 7ABF , 7ABG , 8Q7N , 8QO9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00397	WW	134 → 162	WW domain	Domain
PF00397	WW	432 → 460	WW domain	Domain
PF01846	FF	661 → 709	FF domain	Family
PF01846	FF	727 → 776	FF domain	Family
PF01846	FF	794 → 843	FF domain	Family
PF01846	FF	898 → 949	FF domain	Family
PF01846	FF	956 → 1007	FF domain	Family
PF01846	FF	1014 → 1074	FF domain	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in brain neurons. {ECO:0000269|PubMed:11172033}.

Sequence

MAERGGDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRGPPPLMRPPPPFGMMRGPP
PPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPGMMFPPGMP
PVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRESAWTKPDGVKVIQQSELTPMLAAQ
AQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQ
AQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTSSSTPSSTTSTTTTATSVAQTVSTPT
TQDQTPSSAVSVATPTVSVSTPAPTATPVQTVPQPHPQTLPPAVPHSVPQPTTAIPAFPP
VMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPIVPMIHPQVAIA
ASPATLAGATAVSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKEKLEEKIKEPIKEP
SEEPLPMETEEEDPKEEPIKEIKEEPKEEEMTEEEKAAQKAKPVATAPIPGTPWCVVWTG
DERVFFYNPTTRLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKW
QFSMSAIKEEQELMEEINEDEPVKAKKRKRDDNKDIDSEKEAAMEAEIKAARERAIVPLE
ARMKQFKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERRE
KKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKMKDREALFNEFVAAA
RKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDLF
KQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQHKREEAI
QNFKALLSDMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEALTKKKREH
FRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDKYITAKADFR
TLLKETKFITYRSKKLIQESDQHLKDVEKILQNDKRYLVLDCVPEERRKLIVAYVDDLDR
RGPPPPPTASEPTRRSTK

Sequence length

1098

Interactions

View interactions

	KEGG
	Spliceosome

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Colorectal cancer	Pathogenic	rs1762720125	RCV001293848	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHRONIC VENOUS HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Huntington Disease	Huntington Disease	BEFREE	12821179, 17018562, 27844289		★★★★★ ★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	LHGDN	17018562		★★★★★ ★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington disease	Pubtator	17018562	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	31805175	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★★★★★ ★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	27844289		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	27844289		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	27844289		★★★★★ ★☆☆☆☆ Found in Text Mining only

TCERG1 (transcription elongation regulator 1)