Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10906
Gene name	TRAF-type zinc finger domain containing 1
Gene symbol	TRAFD1
Synonyms (NCBI Gene)	FLN29
Chromosome	12
Chromosome location	12q24.13
Summary	The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]

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Show/Hide all (272)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018198	hsa-miR-335-5p	Microarray	18185580
MIRT029570	hsa-miR-26b-5p	Microarray	19088304
MIRT043867	hsa-miR-378a-3p	CLASH	23622248
MIRT043116	hsa-miR-324-5p	CLASH	23622248
MIRT040555	hsa-miR-92b-3p	CLASH	23622248
MIRT039607	hsa-miR-615-3p	CLASH	23622248
MIRT649983	hsa-miR-1911-3p	HITS-CLIP	23824327
MIRT649982	hsa-miR-6753-5p	HITS-CLIP	23824327
MIRT649981	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT649980	hsa-miR-8063	HITS-CLIP	23824327
MIRT649979	hsa-miR-181a-2-3p	HITS-CLIP	23824327
MIRT649978	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT649977	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT649976	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT649975	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT649974	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT649973	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT649972	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT649971	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT649970	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT439395	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT247463	hsa-miR-193a-3p	HITS-CLIP	22473208
MIRT247465	hsa-miR-193b-3p	HITS-CLIP	22473208
MIRT439395	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT649983	hsa-miR-1911-3p	HITS-CLIP	23824327
MIRT649982	hsa-miR-6753-5p	HITS-CLIP	23824327
MIRT649981	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT649980	hsa-miR-8063	HITS-CLIP	23824327
MIRT649979	hsa-miR-181a-2-3p	HITS-CLIP	23824327
MIRT649978	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT649977	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT649976	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT649975	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT649974	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT649973	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT649972	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT649971	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT649970	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT1451295	hsa-miR-1273	CLIP-seq
MIRT1451296	hsa-miR-1273c	CLIP-seq
MIRT1451297	hsa-miR-224	CLIP-seq
MIRT1451298	hsa-miR-29a	CLIP-seq
MIRT1451299	hsa-miR-29b	CLIP-seq
MIRT1451300	hsa-miR-29c	CLIP-seq
MIRT1451301	hsa-miR-3065-3p	CLIP-seq
MIRT1451302	hsa-miR-34a	CLIP-seq
MIRT1451303	hsa-miR-34c-5p	CLIP-seq
MIRT1451304	hsa-miR-370	CLIP-seq
MIRT1451305	hsa-miR-449a	CLIP-seq
MIRT1451306	hsa-miR-449b	CLIP-seq
MIRT1451307	hsa-miR-4688	CLIP-seq
MIRT1451308	hsa-miR-486-3p	CLIP-seq
MIRT1451309	hsa-miR-1224-5p	CLIP-seq
MIRT1451310	hsa-miR-4519	CLIP-seq
MIRT1451311	hsa-miR-4751	CLIP-seq
MIRT2134910	hsa-miR-1233	CLIP-seq
MIRT2134911	hsa-miR-3151	CLIP-seq
MIRT1451302	hsa-miR-34a	CLIP-seq
MIRT1451303	hsa-miR-34c-5p	CLIP-seq
MIRT2134912	hsa-miR-4283	CLIP-seq
MIRT2134913	hsa-miR-4447	CLIP-seq
MIRT2134914	hsa-miR-4472	CLIP-seq
MIRT2134915	hsa-miR-4489	CLIP-seq
MIRT2134916	hsa-miR-4492	CLIP-seq
MIRT2134917	hsa-miR-4498	CLIP-seq
MIRT1451305	hsa-miR-449a	CLIP-seq
MIRT1451306	hsa-miR-449b	CLIP-seq
MIRT2134918	hsa-miR-4505	CLIP-seq
MIRT2134919	hsa-miR-4687-5p	CLIP-seq
MIRT2134920	hsa-miR-4731-5p	CLIP-seq
MIRT1451308	hsa-miR-486-3p	CLIP-seq
MIRT2134921	hsa-miR-491-5p	CLIP-seq
MIRT2134922	hsa-miR-595	CLIP-seq
MIRT2134923	hsa-miR-762	CLIP-seq
MIRT1451309	hsa-miR-1224-5p	CLIP-seq
MIRT2356122	hsa-miR-193b	CLIP-seq
MIRT2356123	hsa-miR-2861	CLIP-seq
MIRT1451298	hsa-miR-29a	CLIP-seq
MIRT1451299	hsa-miR-29b	CLIP-seq
MIRT1451300	hsa-miR-29c	CLIP-seq
MIRT1451301	hsa-miR-3065-3p	CLIP-seq
MIRT2356124	hsa-miR-3117-5p	CLIP-seq
MIRT2356125	hsa-miR-3138	CLIP-seq
MIRT2356126	hsa-miR-3144-5p	CLIP-seq
MIRT2134911	hsa-miR-3151	CLIP-seq
MIRT2356127	hsa-miR-3176	CLIP-seq
MIRT2356128	hsa-miR-3179	CLIP-seq
MIRT2356129	hsa-miR-3191	CLIP-seq
MIRT2356130	hsa-miR-3202	CLIP-seq
MIRT2356131	hsa-miR-339-3p	CLIP-seq
MIRT1451302	hsa-miR-34a	CLIP-seq
MIRT1451303	hsa-miR-34c-5p	CLIP-seq
MIRT2356132	hsa-miR-3614-5p	CLIP-seq
MIRT2356133	hsa-miR-3660	CLIP-seq
MIRT2356134	hsa-miR-3663-3p	CLIP-seq
MIRT1451304	hsa-miR-370	CLIP-seq
MIRT2356135	hsa-miR-3911	CLIP-seq
MIRT2356136	hsa-miR-3922-3p	CLIP-seq
MIRT2356137	hsa-miR-4270	CLIP-seq
MIRT2356138	hsa-miR-4271	CLIP-seq
MIRT2134912	hsa-miR-4283	CLIP-seq
MIRT2356139	hsa-miR-4441	CLIP-seq
MIRT2134913	hsa-miR-4447	CLIP-seq
MIRT2134914	hsa-miR-4472	CLIP-seq
MIRT2134915	hsa-miR-4489	CLIP-seq
MIRT2134916	hsa-miR-4492	CLIP-seq
MIRT2134917	hsa-miR-4498	CLIP-seq
MIRT1451305	hsa-miR-449a	CLIP-seq
MIRT1451306	hsa-miR-449b	CLIP-seq
MIRT2134918	hsa-miR-4505	CLIP-seq
MIRT1451310	hsa-miR-4519	CLIP-seq
MIRT2356140	hsa-miR-4520a-3p	CLIP-seq
MIRT2356141	hsa-miR-4526	CLIP-seq
MIRT2356142	hsa-miR-4652-5p	CLIP-seq
MIRT2356143	hsa-miR-4725-3p	CLIP-seq
MIRT2134920	hsa-miR-4731-5p	CLIP-seq
MIRT2356144	hsa-miR-4747-5p	CLIP-seq
MIRT1451311	hsa-miR-4751	CLIP-seq
MIRT2356145	hsa-miR-4800-5p	CLIP-seq
MIRT2356146	hsa-miR-485-3p	CLIP-seq
MIRT1451308	hsa-miR-486-3p	CLIP-seq
MIRT2134921	hsa-miR-491-5p	CLIP-seq
MIRT2356147	hsa-miR-541	CLIP-seq
MIRT2356148	hsa-miR-574-5p	CLIP-seq
MIRT2134922	hsa-miR-595	CLIP-seq
MIRT2356149	hsa-miR-654-5p	CLIP-seq
MIRT2356150	hsa-miR-760	CLIP-seq
MIRT2134923	hsa-miR-762	CLIP-seq
MIRT2356151	hsa-miR-891b	CLIP-seq
MIRT1451309	hsa-miR-1224-5p	CLIP-seq
MIRT2649628	hsa-miR-1228	CLIP-seq
MIRT2134910	hsa-miR-1233	CLIP-seq
MIRT2649629	hsa-miR-1295	CLIP-seq
MIRT2356122	hsa-miR-193b	CLIP-seq
MIRT1451298	hsa-miR-29a	CLIP-seq
MIRT1451299	hsa-miR-29b	CLIP-seq
MIRT1451300	hsa-miR-29c	CLIP-seq
MIRT1451301	hsa-miR-3065-3p	CLIP-seq
MIRT2356124	hsa-miR-3117-5p	CLIP-seq
MIRT2649630	hsa-miR-3123	CLIP-seq
MIRT2649631	hsa-miR-3136-3p	CLIP-seq
MIRT2356125	hsa-miR-3138	CLIP-seq
MIRT2356126	hsa-miR-3144-5p	CLIP-seq
MIRT2134911	hsa-miR-3151	CLIP-seq
MIRT2356127	hsa-miR-3176	CLIP-seq
MIRT2356129	hsa-miR-3191	CLIP-seq
MIRT2649632	hsa-miR-329	CLIP-seq
MIRT2356131	hsa-miR-339-3p	CLIP-seq
MIRT1451302	hsa-miR-34a	CLIP-seq
MIRT1451303	hsa-miR-34c-5p	CLIP-seq
MIRT2356132	hsa-miR-3614-5p	CLIP-seq
MIRT2649633	hsa-miR-3620	CLIP-seq
MIRT2649634	hsa-miR-362-3p	CLIP-seq
MIRT2649635	hsa-miR-3649	CLIP-seq
MIRT2356134	hsa-miR-3663-3p	CLIP-seq
MIRT1451304	hsa-miR-370	CLIP-seq
MIRT2649636	hsa-miR-3714	CLIP-seq
MIRT2649637	hsa-miR-371-5p	CLIP-seq
MIRT2649638	hsa-miR-371b-5p	CLIP-seq
MIRT2356135	hsa-miR-3911	CLIP-seq
MIRT2649639	hsa-miR-3919	CLIP-seq
MIRT2356136	hsa-miR-3922-3p	CLIP-seq
MIRT2649640	hsa-miR-3941	CLIP-seq
MIRT2649641	hsa-miR-3942-3p	CLIP-seq
MIRT2649642	hsa-miR-3943	CLIP-seq
MIRT2356137	hsa-miR-4270	CLIP-seq
MIRT2134912	hsa-miR-4283	CLIP-seq
MIRT2649643	hsa-miR-4287	CLIP-seq
MIRT2649644	hsa-miR-4290	CLIP-seq
MIRT2649645	hsa-miR-4436b-3p	CLIP-seq
MIRT2356139	hsa-miR-4441	CLIP-seq
MIRT2134913	hsa-miR-4447	CLIP-seq
MIRT2649646	hsa-miR-4456	CLIP-seq
MIRT2134914	hsa-miR-4472	CLIP-seq
MIRT2134915	hsa-miR-4489	CLIP-seq
MIRT2134916	hsa-miR-4492	CLIP-seq
MIRT2134917	hsa-miR-4498	CLIP-seq
MIRT1451305	hsa-miR-449a	CLIP-seq
MIRT1451306	hsa-miR-449b	CLIP-seq
MIRT2134918	hsa-miR-4505	CLIP-seq
MIRT1451310	hsa-miR-4519	CLIP-seq
MIRT2356140	hsa-miR-4520a-3p	CLIP-seq
MIRT2356142	hsa-miR-4652-5p	CLIP-seq
MIRT2649647	hsa-miR-4685-3p	CLIP-seq
MIRT2134919	hsa-miR-4687-5p	CLIP-seq
MIRT1451307	hsa-miR-4688	CLIP-seq
MIRT2649648	hsa-miR-4690-3p	CLIP-seq
MIRT2134920	hsa-miR-4731-5p	CLIP-seq
MIRT2649649	hsa-miR-4747-3p	CLIP-seq
MIRT1451311	hsa-miR-4751	CLIP-seq
MIRT2356145	hsa-miR-4800-5p	CLIP-seq
MIRT2356146	hsa-miR-485-3p	CLIP-seq
MIRT1451308	hsa-miR-486-3p	CLIP-seq
MIRT2134921	hsa-miR-491-5p	CLIP-seq
MIRT2356148	hsa-miR-574-5p	CLIP-seq
MIRT2134922	hsa-miR-595	CLIP-seq
MIRT2649650	hsa-miR-602	CLIP-seq
MIRT2649651	hsa-miR-603	CLIP-seq
MIRT2649652	hsa-miR-642a	CLIP-seq
MIRT2134923	hsa-miR-762	CLIP-seq
MIRT2356151	hsa-miR-891b	CLIP-seq
MIRT1451309	hsa-miR-1224-5p	CLIP-seq
MIRT2649628	hsa-miR-1228	CLIP-seq
MIRT2134910	hsa-miR-1233	CLIP-seq
MIRT2649629	hsa-miR-1295	CLIP-seq
MIRT2356122	hsa-miR-193b	CLIP-seq
MIRT1451298	hsa-miR-29a	CLIP-seq
MIRT1451299	hsa-miR-29b	CLIP-seq
MIRT1451300	hsa-miR-29c	CLIP-seq
MIRT1451301	hsa-miR-3065-3p	CLIP-seq
MIRT2356124	hsa-miR-3117-5p	CLIP-seq
MIRT2649630	hsa-miR-3123	CLIP-seq
MIRT2649631	hsa-miR-3136-3p	CLIP-seq
MIRT2356125	hsa-miR-3138	CLIP-seq
MIRT2356126	hsa-miR-3144-5p	CLIP-seq
MIRT2134911	hsa-miR-3151	CLIP-seq
MIRT2356127	hsa-miR-3176	CLIP-seq
MIRT2356129	hsa-miR-3191	CLIP-seq
MIRT2649632	hsa-miR-329	CLIP-seq
MIRT2356131	hsa-miR-339-3p	CLIP-seq
MIRT1451302	hsa-miR-34a	CLIP-seq
MIRT1451303	hsa-miR-34c-5p	CLIP-seq
MIRT2356132	hsa-miR-3614-5p	CLIP-seq
MIRT2649633	hsa-miR-3620	CLIP-seq
MIRT2649634	hsa-miR-362-3p	CLIP-seq
MIRT2649635	hsa-miR-3649	CLIP-seq
MIRT2356134	hsa-miR-3663-3p	CLIP-seq
MIRT1451304	hsa-miR-370	CLIP-seq
MIRT2649637	hsa-miR-371-5p	CLIP-seq
MIRT2649638	hsa-miR-371b-5p	CLIP-seq
MIRT2356135	hsa-miR-3911	CLIP-seq
MIRT2649639	hsa-miR-3919	CLIP-seq
MIRT2356136	hsa-miR-3922-3p	CLIP-seq
MIRT2649640	hsa-miR-3941	CLIP-seq
MIRT2649641	hsa-miR-3942-3p	CLIP-seq
MIRT2649642	hsa-miR-3943	CLIP-seq
MIRT2356137	hsa-miR-4270	CLIP-seq
MIRT2134912	hsa-miR-4283	CLIP-seq
MIRT2649643	hsa-miR-4287	CLIP-seq
MIRT2649644	hsa-miR-4290	CLIP-seq
MIRT2649645	hsa-miR-4436b-3p	CLIP-seq
MIRT2356139	hsa-miR-4441	CLIP-seq
MIRT2134913	hsa-miR-4447	CLIP-seq
MIRT2649646	hsa-miR-4456	CLIP-seq
MIRT2134914	hsa-miR-4472	CLIP-seq
MIRT2134915	hsa-miR-4489	CLIP-seq
MIRT2134916	hsa-miR-4492	CLIP-seq
MIRT2134917	hsa-miR-4498	CLIP-seq
MIRT1451305	hsa-miR-449a	CLIP-seq
MIRT1451306	hsa-miR-449b	CLIP-seq
MIRT2134918	hsa-miR-4505	CLIP-seq
MIRT1451310	hsa-miR-4519	CLIP-seq
MIRT2356140	hsa-miR-4520a-3p	CLIP-seq
MIRT2356142	hsa-miR-4652-5p	CLIP-seq
MIRT2649647	hsa-miR-4685-3p	CLIP-seq
MIRT2134919	hsa-miR-4687-5p	CLIP-seq
MIRT1451307	hsa-miR-4688	CLIP-seq
MIRT2649648	hsa-miR-4690-3p	CLIP-seq
MIRT2134920	hsa-miR-4731-5p	CLIP-seq
MIRT2649649	hsa-miR-4747-3p	CLIP-seq
MIRT1451311	hsa-miR-4751	CLIP-seq
MIRT2356145	hsa-miR-4800-5p	CLIP-seq
MIRT2356146	hsa-miR-485-3p	CLIP-seq
MIRT1451308	hsa-miR-486-3p	CLIP-seq
MIRT2134921	hsa-miR-491-5p	CLIP-seq
MIRT2356148	hsa-miR-574-5p	CLIP-seq
MIRT2134922	hsa-miR-595	CLIP-seq
MIRT2649650	hsa-miR-602	CLIP-seq
MIRT2649651	hsa-miR-603	CLIP-seq
MIRT2649652	hsa-miR-642a	CLIP-seq
MIRT2134923	hsa-miR-762	CLIP-seq
MIRT2356151	hsa-miR-891b	CLIP-seq

Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17500595, 23275563, 25416956, 26618866, 31515488, 32296183, 35156780, 36012204
GO:0005739	Component	Mitochondrion	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0045824	Process	Negative regulation of innate immune response	IBA
GO:0045824	Process	Negative regulation of innate immune response	IEA
GO:0045824	Process	Negative regulation of innate immune response	ISS
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
613197	24808	ENSG00000135148

O14545

Protein name

TRAF-type zinc finger domain-containing protein 1 (Protein FLN29)

Protein function

Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of

PDB

2D9K

Family and domains

Sequence

MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC
QVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCG
RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMR
LPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANL
DFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELY
PEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSH
PVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPR
RRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSS
PCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGAS
GRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE

Sequence length

582

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Coronary heart disease	Coronary Heart Disease	GWASDB_DG	23364394	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	GWASDB_DG	21642993	★★★★★ ★☆☆☆☆ Found in Text Mining only

TRAFD1 (TRAF-type zinc finger domain containing 1)