Gene Gene information from NCBI Gene database.
Entrez ID 10904
Gene name BLCAP apoptosis inducing factor
Gene symbol BLCAP
Synonyms (NCBI Gene)
BC10
Chromosome 20
Chromosome location 20q11.23
Summary This gene encodes a protein that reduces cell growth by stimulating apoptosis. Alternative splicing and the use of alternative promoters result in multiple transcript variants encoding the same protein. This gene is imprinted in brain where different tran
miRNA miRNA information provided by mirtarbase database.
1656
miRTarBase ID miRNA Experiments Reference
MIRT002760 hsa-miR-1-3p Microarray 15685193
MIRT006865 hsa-miR-138-5p Luciferase reporter assayMicroarray 22921398
MIRT020294 hsa-miR-130b-3p Sequencing 20371350
MIRT002760 hsa-miR-1-3p Microarray 18668037
MIRT002760 hsa-miR-1-3p Microarray 15685193
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
6
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21217774, 25416956, 31515488, 32296183
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IEA
GO:0006915 Process Apoptotic process IEA
GO:0016020 Component Membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613110 1055 ENSG00000166619
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62952
Protein name Apoptosis inducing factor BLCAP (Bladder cancer 10 kDa protein) (Bc10) (Bladder cancer-associated protein)
Protein function Acts as a tumor suppressor; induces growth arrest at G(1)/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent mechanisms (PubMed:16675915, PubMed:17031575, PubMed:21844121, PubMed:26986503). Modulates expression
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06726 BC10 1 65 Family
Tissue specificity TISSUE SPECIFICITY: Cervical tissues (at protein level) (PubMed:22969892). Urothelium (at protein level) (PubMed:19783793, PubMed:29190807). Endothelial cells of urinary bladder vessels (at protein level) (PubMed:19783793). Urinary bladder stromal cells (
Sequence
Sequence length 87
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTROCYTOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Astrocytoma Astrocytoma BEFREE 19908260
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Astrocytoma Astrocytoma Pubtator 19908260 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Bladder Neoplasm Bladder Neoplasm BEFREE 11072240, 11920613, 16918124, 19783793, 23049907, 29190807
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 23049907, 30683807
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 23049907, 30683807 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 28455960 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 28455960
★☆☆☆☆
Found in Text Mining only
Carcinoma of bladder Bladder carcinoma BEFREE 11072240, 11920613, 16918124, 17031575, 19783793, 19908260, 23049907, 29190807, 29655784
★☆☆☆☆
Found in Text Mining only
cervical cancer Cervical Cancer BEFREE 16675915, 28455960
★☆☆☆☆
Found in Text Mining only
Cervix carcinoma Cervix carcinoma BEFREE 16675915, 28455960
★☆☆☆☆
Found in Text Mining only