MMP24 (matrix metallopeptidase 24)

Gene

• Entrez ID: 10893
• Gene name: Matrix metallopeptidase 24
• Gene symbol: MMP24
• Synonyms (NCBI Gene): MMP-24, MMP25, MT-MMP 5, MT-MMP5, MT5-MMP, MT5MMP, MTMMP5
• Chromosome: 20
• Chromosome location: 20q11.22
• Summary: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and t

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005385	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR	21305051
MIRT005386	hsa-miR-29c-3p	Luciferase reporter assay, qRT-PCR	21305051
MIRT005385	hsa-miR-29b-3p	Microarray	22942087
MIRT1153373	hsa-miR-106a	CLIP-seq
MIRT1153374	hsa-miR-106b	CLIP-seq
MIRT1153375	hsa-miR-1225-3p	CLIP-seq
MIRT1153376	hsa-miR-1260	CLIP-seq
MIRT1153377	hsa-miR-1260b	CLIP-seq
MIRT1153378	hsa-miR-1273e	CLIP-seq
MIRT1153379	hsa-miR-1287	CLIP-seq
MIRT1153380	hsa-miR-134	CLIP-seq
MIRT1153381	hsa-miR-142-5p	CLIP-seq
MIRT1153382	hsa-miR-17	CLIP-seq
MIRT1153383	hsa-miR-188-3p	CLIP-seq
MIRT1153384	hsa-miR-1976	CLIP-seq
MIRT1153385	hsa-miR-203	CLIP-seq
MIRT1153386	hsa-miR-20a	CLIP-seq
MIRT1153387	hsa-miR-20b	CLIP-seq
MIRT1153388	hsa-miR-2276	CLIP-seq
MIRT1153389	hsa-miR-29a	CLIP-seq
MIRT1153390	hsa-miR-29b	CLIP-seq
MIRT1153391	hsa-miR-29c	CLIP-seq
MIRT1153392	hsa-miR-3117-5p	CLIP-seq
MIRT1153393	hsa-miR-3118	CLIP-seq
MIRT1153394	hsa-miR-3127-3p	CLIP-seq
MIRT1153395	hsa-miR-3135b	CLIP-seq
MIRT1153396	hsa-miR-3136-5p	CLIP-seq
MIRT1153397	hsa-miR-3138	CLIP-seq
MIRT1153398	hsa-miR-3156-3p	CLIP-seq
MIRT1153399	hsa-miR-3158-3p	CLIP-seq
MIRT1153400	hsa-miR-3164	CLIP-seq
MIRT1153401	hsa-miR-3176	CLIP-seq
MIRT1153402	hsa-miR-3179	CLIP-seq
MIRT1153403	hsa-miR-320a	CLIP-seq
MIRT1153404	hsa-miR-320b	CLIP-seq
MIRT1153405	hsa-miR-320c	CLIP-seq
MIRT1153406	hsa-miR-320d	CLIP-seq
MIRT1153407	hsa-miR-320e	CLIP-seq
MIRT1153408	hsa-miR-3609	CLIP-seq
MIRT1153409	hsa-miR-3613-3p	CLIP-seq
MIRT1153410	hsa-miR-3662	CLIP-seq
MIRT1153411	hsa-miR-3663-3p	CLIP-seq
MIRT1153412	hsa-miR-3672	CLIP-seq
MIRT1153413	hsa-miR-370	CLIP-seq
MIRT1153414	hsa-miR-3914	CLIP-seq
MIRT1153415	hsa-miR-3922-3p	CLIP-seq
MIRT1153416	hsa-miR-3934	CLIP-seq
MIRT1153417	hsa-miR-3974	CLIP-seq
MIRT1153418	hsa-miR-4268	CLIP-seq
MIRT1153419	hsa-miR-4276	CLIP-seq
MIRT1153420	hsa-miR-4281	CLIP-seq
MIRT1153421	hsa-miR-4429	CLIP-seq
MIRT1153422	hsa-miR-4439	CLIP-seq
MIRT1153423	hsa-miR-4446-3p	CLIP-seq
MIRT1153424	hsa-miR-4463	CLIP-seq
MIRT1153425	hsa-miR-4473	CLIP-seq
MIRT1153426	hsa-miR-4494	CLIP-seq
MIRT1153427	hsa-miR-4501	CLIP-seq
MIRT1153428	hsa-miR-4504	CLIP-seq
MIRT1153429	hsa-miR-4513	CLIP-seq
MIRT1153430	hsa-miR-4520a-3p	CLIP-seq
MIRT1153431	hsa-miR-4640-5p	CLIP-seq
MIRT1153432	hsa-miR-4645-5p	CLIP-seq
MIRT1153433	hsa-miR-4671-5p	CLIP-seq
MIRT1153434	hsa-miR-4673	CLIP-seq
MIRT1153435	hsa-miR-4704-3p	CLIP-seq
MIRT1153436	hsa-miR-4726-5p	CLIP-seq
MIRT1153437	hsa-miR-4757-5p	CLIP-seq
MIRT1153438	hsa-miR-4796-3p	CLIP-seq
MIRT1153439	hsa-miR-493	CLIP-seq
MIRT1153440	hsa-miR-498	CLIP-seq
MIRT1153441	hsa-miR-512-3p	CLIP-seq
MIRT1153442	hsa-miR-519d	CLIP-seq
MIRT1153443	hsa-miR-520f	CLIP-seq
MIRT1153444	hsa-miR-542-3p	CLIP-seq
MIRT1153445	hsa-miR-548ah	CLIP-seq
MIRT1153446	hsa-miR-552	CLIP-seq
MIRT1153447	hsa-miR-610	CLIP-seq
MIRT1153448	hsa-miR-93	CLIP-seq
MIRT1153388	hsa-miR-2276	CLIP-seq
MIRT1153424	hsa-miR-4463	CLIP-seq
MIRT1153426	hsa-miR-4494	CLIP-seq
MIRT1153432	hsa-miR-4645-5p	CLIP-seq
MIRT1153434	hsa-miR-4673	CLIP-seq
MIRT1153444	hsa-miR-542-3p	CLIP-seq
MIRT2043918	hsa-miR-1913	CLIP-seq
MIRT2043919	hsa-miR-3173-5p	CLIP-seq
MIRT2043920	hsa-miR-324-3p	CLIP-seq
MIRT2043921	hsa-miR-326	CLIP-seq
MIRT2043922	hsa-miR-330-5p	CLIP-seq
MIRT2043923	hsa-miR-4749-3p	CLIP-seq
MIRT2043924	hsa-miR-760	CLIP-seq
MIRT2273310	hsa-miR-1256	CLIP-seq
MIRT2273311	hsa-miR-3121-5p	CLIP-seq
MIRT2273312	hsa-miR-3134	CLIP-seq
MIRT2043921	hsa-miR-326	CLIP-seq
MIRT2043922	hsa-miR-330-5p	CLIP-seq
MIRT2273313	hsa-miR-342-5p	CLIP-seq
MIRT2273314	hsa-miR-3929	CLIP-seq
MIRT2273315	hsa-miR-3945	CLIP-seq
MIRT2273316	hsa-miR-4253	CLIP-seq
MIRT2273317	hsa-miR-4419b	CLIP-seq
MIRT2273318	hsa-miR-4478	CLIP-seq
MIRT2273319	hsa-miR-4534	CLIP-seq
MIRT2273320	hsa-miR-4651	CLIP-seq
MIRT2273321	hsa-miR-4664-5p	CLIP-seq
MIRT1153444	hsa-miR-542-3p	CLIP-seq
MIRT2273322	hsa-miR-608	CLIP-seq
MIRT2273323	hsa-miR-615-5p	CLIP-seq
MIRT1153380	hsa-miR-134	CLIP-seq
MIRT1153385	hsa-miR-203	CLIP-seq
MIRT1153392	hsa-miR-3117-5p	CLIP-seq
MIRT1153393	hsa-miR-3118	CLIP-seq
MIRT1153396	hsa-miR-3136-5p	CLIP-seq
MIRT1153400	hsa-miR-3164	CLIP-seq
MIRT1153410	hsa-miR-3662	CLIP-seq
MIRT2390981	hsa-miR-4271	CLIP-seq
MIRT1153422	hsa-miR-4439	CLIP-seq
MIRT1153427	hsa-miR-4501	CLIP-seq
MIRT1153429	hsa-miR-4513	CLIP-seq
MIRT2390982	hsa-miR-4725-3p	CLIP-seq
MIRT2454304	hsa-miR-1291	CLIP-seq
MIRT1153385	hsa-miR-203	CLIP-seq
MIRT2454305	hsa-miR-2278	CLIP-seq
MIRT2454306	hsa-miR-2964a-5p	CLIP-seq
MIRT2454307	hsa-miR-296-5p	CLIP-seq
MIRT1153392	hsa-miR-3117-5p	CLIP-seq
MIRT1153397	hsa-miR-3138	CLIP-seq
MIRT2454308	hsa-miR-3607-5p	CLIP-seq
MIRT2454309	hsa-miR-361-3p	CLIP-seq
MIRT1153416	hsa-miR-3934	CLIP-seq
MIRT2454310	hsa-miR-4302	CLIP-seq
MIRT2454311	hsa-miR-4426	CLIP-seq
MIRT2454312	hsa-miR-4481	CLIP-seq
MIRT2454313	hsa-miR-4519	CLIP-seq
MIRT1153430	hsa-miR-4520a-3p	CLIP-seq
MIRT2454314	hsa-miR-4647	CLIP-seq
MIRT2454315	hsa-miR-4648	CLIP-seq
MIRT2454316	hsa-miR-4654	CLIP-seq
MIRT2454317	hsa-miR-4662b	CLIP-seq
MIRT2454318	hsa-miR-4679	CLIP-seq
MIRT2454319	hsa-miR-4745-5p	CLIP-seq
MIRT2454320	hsa-miR-4747-5p	CLIP-seq
MIRT2454321	hsa-miR-4758-5p	CLIP-seq
MIRT2454322	hsa-miR-4769-5p	CLIP-seq
MIRT1153446	hsa-miR-552	CLIP-seq
MIRT1153447	hsa-miR-610	CLIP-seq
MIRT2454304	hsa-miR-1291	CLIP-seq
MIRT2043919	hsa-miR-3173-5p	CLIP-seq
MIRT2465642	hsa-miR-328	CLIP-seq
MIRT1153411	hsa-miR-3663-3p	CLIP-seq
MIRT1153413	hsa-miR-370	CLIP-seq
MIRT2465643	hsa-miR-4299	CLIP-seq
MIRT2465644	hsa-miR-4710	CLIP-seq
MIRT2465645	hsa-miR-4792	CLIP-seq
MIRT2572207	hsa-miR-1244	CLIP-seq
MIRT2454304	hsa-miR-1291	CLIP-seq
MIRT2043919	hsa-miR-3173-5p	CLIP-seq
MIRT2465642	hsa-miR-328	CLIP-seq
MIRT1153411	hsa-miR-3663-3p	CLIP-seq
MIRT1153413	hsa-miR-370	CLIP-seq
MIRT2465643	hsa-miR-4299	CLIP-seq
MIRT2572208	hsa-miR-4436a	CLIP-seq
MIRT2465644	hsa-miR-4710	CLIP-seq
MIRT2465645	hsa-miR-4792	CLIP-seq
MIRT2572207	hsa-miR-1244	CLIP-seq
MIRT2454304	hsa-miR-1291	CLIP-seq
MIRT2685153	hsa-miR-193a-3p	CLIP-seq
MIRT2685154	hsa-miR-193b	CLIP-seq
MIRT2043919	hsa-miR-3173-5p	CLIP-seq
MIRT2465642	hsa-miR-328	CLIP-seq
MIRT1153411	hsa-miR-3663-3p	CLIP-seq
MIRT1153413	hsa-miR-370	CLIP-seq
MIRT2465643	hsa-miR-4299	CLIP-seq
MIRT2572208	hsa-miR-4436a	CLIP-seq
MIRT2465644	hsa-miR-4710	CLIP-seq
MIRT2465645	hsa-miR-4792	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	ISS
GO:0004222	Function	Metalloendopeptidase activity	TAS	10363975
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS	10363975
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	ISS
GO:0006508	Process	Proteolysis	TAS	10363975
GO:0007155	Process	Cell adhesion	IEA
GO:0008047	Function	Enzyme activator activity	TAS	10363975
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010001	Process	Glial cell differentiation	IEA
GO:0010001	Process	Glial cell differentiation	ISS
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030574	Process	Collagen catabolic process	IBA
GO:0031012	Component	Extracellular matrix	IEA
GO:0032588	Component	Trans-Golgi network membrane	IEA
GO:0032588	Component	Trans-Golgi network membrane	ISS
GO:0044331	Process	Cell-cell adhesion mediated by cadherin	IEA
GO:0044331	Process	Cell-cell adhesion mediated by cadherin	ISS
GO:0045296	Function	Cadherin binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050965	Process	Detection of temperature stimulus involved in sensory perception of pain	IEA
GO:0050965	Process	Detection of temperature stimulus involved in sensory perception of pain	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0097150	Process	Neuronal stem cell population maintenance	IEA
GO:0097150	Process	Neuronal stem cell population maintenance	ISS
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IEA
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	ISS

Other IDs

• MIM: 604871
• HGNC: 7172
• e!Ensembl: ENSG00000125966

Protein

• UniProt ID: Q9Y5R2
• Protein name: Matrix metalloproteinase-24 (MMP-24) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (MTMMP5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MT5MMP) [Cleaved into: Processed matrix metalloproteinase-24]
• Protein function: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediati
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01471	PG_binding_1	76 → 134	Putative peptidoglycan binding domain	Domain
  PF00413	Peptidase_M10	162 → 327	Matrixin	Domain
  PF00045	Hemopexin	384 → 427	Hemopexin	Repeat
  PF00045	Hemopexin	429 → 472	Hemopexin	Repeat
  PF00045	Hemopexin	476 → 522	Hemopexin	Repeat
  PF00045	Hemopexin	524 → 569	Hemopexin	Repeat
  PF11857	DUF3377	575 → 645	Domain of unknown function (DUF3377)	Family

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas. {ECO:0000269|PubMed:10363975}.
• Sequence:

  MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAG
  NRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGI
  PVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVG
  ELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGG
  FLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIM
  APFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR
  PPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQ
  FWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTAL
  RWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYK
  GRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSV
  NAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV

• Sequence length: 645

Pathways

KEGG:

Parathyroid hormone synthesis, secretion and action

Reactome:

Activation of Matrix Metalloproteinases

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-MELANOMA SKIN CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	33892965, 34359875	Associate	★☆☆☆☆ Found in Text Mining only
Atrophy	Atrophy	Pubtator	11457723	Associate	★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	10363975		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	19531263, 35177031	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23568046	Stimulate	★☆☆☆☆ Found in Text Mining only
Chronic kidney disease stage 5	Kidney Disease	BEFREE	11457723		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	11457723		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	11457723		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	11457723	Stimulate	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	39273639	Inhibit	★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	BEFREE	17952761		★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	Pubtator	17952761	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	10363975		★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	16933466		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	26202697		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	35018451	Associate	★☆☆☆☆ Found in Text Mining only
Kidney Failure Chronic	Kidney failure	Pubtator	11457723	Associate	★☆☆☆☆ Found in Text Mining only
Kidney Failure, Chronic	Kidney Failure	BEFREE	11457723		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	34166375	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	24669030, 27869830		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	17996844		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	32043788	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	19726693		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10363975, 29903032		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	15928670, 32669958	Associate	★☆☆☆☆ Found in Text Mining only
Skin Neoplasms	Skin neoplasm	Pubtator	35018451	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	24669030, 27869830		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	22677901	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	24669030	Stimulate	★☆☆☆☆ Found in Text Mining only