Gene Gene information from NCBI Gene database.
Entrez ID 10890
Gene name RAB10, member RAS oncogene family
Gene symbol RAB10
Synonyms (NCBI Gene)
-
Chromosome 2
Chromosome location 2p23.3
Summary RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]
miRNA miRNA information provided by mirtarbase database.
1225
miRTarBase ID miRNA Experiments Reference
MIRT019696 hsa-miR-375 qRT-PCR;Microarray 20584986
MIRT025986 hsa-miR-148a-3p Sequencing 20371350
MIRT052065 hsa-let-7b-5p CLASH 23622248
MIRT051750 hsa-let-7c-5p CLASH 23622248
MIRT037193 hsa-miR-877-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
75
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000145 Component Exocyst ISS
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IEA
GO:0003925 Function G protein activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612672 9759 ENSG00000084733
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61026
Protein name Ras-related protein Rab-10 (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form
PDB 5LPN , 5SZJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 11 172 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the hippocampus (PubMed:29562525). Expressed in neutrophils (at protein level) (PubMed:29127255). Expressed in the testis (at protein level) (PubMed:28067790). {ECO:0000269|PubMed:28067790, ECO:0000269|PubMed:29127255, ECO
Sequence
Sequence length 200
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocytosis
AMPK signaling pathway
  Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CIC-rearranged sarcoma not provided ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIGESTIVE SYSTEM DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Papillary renal cell carcinoma type 1 not provided ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 26082458, 33794991 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 37709911, 39375417 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 12450215 Stimulate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 37377893 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 38430146 Stimulate
★☆☆☆☆
Found in Text Mining only
Diabetes Complications Diabetes complications Pubtator 35806251 Associate
★☆☆☆☆
Found in Text Mining only
Esophageal Squamous Cell Carcinoma Esophageal squamous cell carcinoma Pubtator 29693138, 36636641 Associate
★☆☆☆☆
Found in Text Mining only
Glioma Glioma BEFREE 31812014
★☆☆☆☆
Found in Text Mining only
Glioma Glioma Pubtator 31812014 Associate
★☆☆☆☆
Found in Text Mining only
Hyperglycemia Hyperglycemia BEFREE 28793909
★☆☆☆☆
Found in Text Mining only