Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10888
Gene name	G protein-coupled receptor 83
Gene symbol	GPR83
Synonyms (NCBI Gene)	GIRGPR72
Chromosome	11
Chromosome location	11q21

251

Show/Hide all (251)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021958	hsa-miR-128-3p	Microarray	17612493
MIRT023638	hsa-miR-1-3p	Microarray	18668037
MIRT025093	hsa-miR-181a-5p	Microarray	17612493
MIRT1031846	hsa-miR-1	CLIP-seq
MIRT1031847	hsa-miR-1255a	CLIP-seq
MIRT1031848	hsa-miR-1255b	CLIP-seq
MIRT1031849	hsa-miR-125a-3p	CLIP-seq
MIRT1031850	hsa-miR-1290	CLIP-seq
MIRT1031851	hsa-miR-1321	CLIP-seq
MIRT1031852	hsa-miR-1827	CLIP-seq
MIRT1031853	hsa-miR-1908	CLIP-seq
MIRT1031854	hsa-miR-1910	CLIP-seq
MIRT1031855	hsa-miR-206	CLIP-seq
MIRT1031856	hsa-miR-2114	CLIP-seq
MIRT1031857	hsa-miR-2355-5p	CLIP-seq
MIRT1031858	hsa-miR-2682	CLIP-seq
MIRT1031859	hsa-miR-3135	CLIP-seq
MIRT1031860	hsa-miR-3159	CLIP-seq
MIRT1031861	hsa-miR-3162-5p	CLIP-seq
MIRT1031862	hsa-miR-3165	CLIP-seq
MIRT1031863	hsa-miR-3605-5p	CLIP-seq
MIRT1031864	hsa-miR-3611	CLIP-seq
MIRT1031865	hsa-miR-3613-3p	CLIP-seq
MIRT1031866	hsa-miR-3622b-5p	CLIP-seq
MIRT1031867	hsa-miR-3665	CLIP-seq
MIRT1031868	hsa-miR-3673	CLIP-seq
MIRT1031869	hsa-miR-3689a-3p	CLIP-seq
MIRT1031870	hsa-miR-3689c	CLIP-seq
MIRT1031871	hsa-miR-371-5p	CLIP-seq
MIRT1031872	hsa-miR-371b-5p	CLIP-seq
MIRT1031873	hsa-miR-377	CLIP-seq
MIRT1031874	hsa-miR-3929	CLIP-seq
MIRT1031875	hsa-miR-3934	CLIP-seq
MIRT1031876	hsa-miR-3938	CLIP-seq
MIRT1031877	hsa-miR-4253	CLIP-seq
MIRT1031878	hsa-miR-4272	CLIP-seq
MIRT1031879	hsa-miR-4292	CLIP-seq
MIRT1031880	hsa-miR-4304	CLIP-seq
MIRT1031881	hsa-miR-4305	CLIP-seq
MIRT1031882	hsa-miR-4308	CLIP-seq
MIRT1031883	hsa-miR-4419b	CLIP-seq
MIRT1031884	hsa-miR-4433	CLIP-seq
MIRT1031885	hsa-miR-4453	CLIP-seq
MIRT1031886	hsa-miR-4459	CLIP-seq
MIRT1031887	hsa-miR-4477b	CLIP-seq
MIRT1031888	hsa-miR-4478	CLIP-seq
MIRT1031889	hsa-miR-449c	CLIP-seq
MIRT1031890	hsa-miR-4538	CLIP-seq
MIRT1031891	hsa-miR-455-3p	CLIP-seq
MIRT1031892	hsa-miR-4643	CLIP-seq
MIRT1031893	hsa-miR-4649-3p	CLIP-seq
MIRT1031894	hsa-miR-4683	CLIP-seq
MIRT1031895	hsa-miR-4705	CLIP-seq
MIRT1031896	hsa-miR-4713-5p	CLIP-seq
MIRT1031897	hsa-miR-4722-5p	CLIP-seq
MIRT1031898	hsa-miR-4728-5p	CLIP-seq
MIRT1031899	hsa-miR-4736	CLIP-seq
MIRT1031900	hsa-miR-4739	CLIP-seq
MIRT1031901	hsa-miR-4756-5p	CLIP-seq
MIRT1031902	hsa-miR-4768-3p	CLIP-seq
MIRT1031903	hsa-miR-4786-5p	CLIP-seq
MIRT1031904	hsa-miR-4793-5p	CLIP-seq
MIRT1031905	hsa-miR-4794	CLIP-seq
MIRT1031906	hsa-miR-485-5p	CLIP-seq
MIRT1031907	hsa-miR-542-3p	CLIP-seq
MIRT1031908	hsa-miR-548ag	CLIP-seq
MIRT1031909	hsa-miR-548ai	CLIP-seq
MIRT1031910	hsa-miR-563	CLIP-seq
MIRT1031911	hsa-miR-570	CLIP-seq
MIRT1031912	hsa-miR-581	CLIP-seq
MIRT1031913	hsa-miR-613	CLIP-seq
MIRT1031914	hsa-miR-651	CLIP-seq
MIRT1031915	hsa-miR-663	CLIP-seq
MIRT1031916	hsa-miR-670	CLIP-seq
MIRT1031917	hsa-miR-764	CLIP-seq
MIRT1031918	hsa-miR-940	CLIP-seq
MIRT2006058	hsa-miR-1227	CLIP-seq
MIRT2006059	hsa-miR-1245b-3p	CLIP-seq
MIRT1031852	hsa-miR-1827	CLIP-seq
MIRT1031853	hsa-miR-1908	CLIP-seq
MIRT2006060	hsa-miR-214	CLIP-seq
MIRT2006061	hsa-miR-224	CLIP-seq
MIRT1031858	hsa-miR-2682	CLIP-seq
MIRT2006062	hsa-miR-3122	CLIP-seq
MIRT1031859	hsa-miR-3135	CLIP-seq
MIRT2006063	hsa-miR-3145-5p	CLIP-seq
MIRT1031862	hsa-miR-3165	CLIP-seq
MIRT2006064	hsa-miR-3202	CLIP-seq
MIRT2006065	hsa-miR-3612	CLIP-seq
MIRT2006066	hsa-miR-3619-5p	CLIP-seq
MIRT1031867	hsa-miR-3665	CLIP-seq
MIRT1031869	hsa-miR-3689a-3p	CLIP-seq
MIRT1031870	hsa-miR-3689c	CLIP-seq
MIRT2006067	hsa-miR-3913-5p	CLIP-seq
MIRT2006068	hsa-miR-3942-3p	CLIP-seq
MIRT2006069	hsa-miR-4252	CLIP-seq
MIRT2006070	hsa-miR-4291	CLIP-seq
MIRT1031884	hsa-miR-4433	CLIP-seq
MIRT2006071	hsa-miR-4446-3p	CLIP-seq
MIRT1031886	hsa-miR-4459	CLIP-seq
MIRT2006072	hsa-miR-4476	CLIP-seq
MIRT1031889	hsa-miR-449c	CLIP-seq
MIRT2006073	hsa-miR-4539	CLIP-seq
MIRT2006074	hsa-miR-4675	CLIP-seq
MIRT2006075	hsa-miR-4680-5p	CLIP-seq
MIRT1031894	hsa-miR-4683	CLIP-seq
MIRT2006076	hsa-miR-4724-5p	CLIP-seq
MIRT1031898	hsa-miR-4728-5p	CLIP-seq
MIRT2006077	hsa-miR-4733-5p	CLIP-seq
MIRT1031899	hsa-miR-4736	CLIP-seq
MIRT2006078	hsa-miR-4741	CLIP-seq
MIRT1031902	hsa-miR-4768-3p	CLIP-seq
MIRT2006079	hsa-miR-490-3p	CLIP-seq
MIRT2006080	hsa-miR-650	CLIP-seq
MIRT1031915	hsa-miR-663	CLIP-seq
MIRT2006081	hsa-miR-761	CLIP-seq
MIRT2006082	hsa-miR-922	CLIP-seq
MIRT1031918	hsa-miR-940	CLIP-seq
MIRT2238604	hsa-miR-101	CLIP-seq
MIRT2238605	hsa-miR-1178	CLIP-seq
MIRT2006059	hsa-miR-1245b-3p	CLIP-seq
MIRT2238606	hsa-miR-1286	CLIP-seq
MIRT2238607	hsa-miR-129-5p	CLIP-seq
MIRT1031851	hsa-miR-1321	CLIP-seq
MIRT2238608	hsa-miR-140-3p	CLIP-seq
MIRT2238609	hsa-miR-144	CLIP-seq
MIRT1031852	hsa-miR-1827	CLIP-seq
MIRT1031853	hsa-miR-1908	CLIP-seq
MIRT1031856	hsa-miR-2114	CLIP-seq
MIRT2006061	hsa-miR-224	CLIP-seq
MIRT1031858	hsa-miR-2682	CLIP-seq
MIRT2006062	hsa-miR-3122	CLIP-seq
MIRT2238610	hsa-miR-3126-3p	CLIP-seq
MIRT1031859	hsa-miR-3135	CLIP-seq
MIRT1031861	hsa-miR-3162-5p	CLIP-seq
MIRT1031862	hsa-miR-3165	CLIP-seq
MIRT2238611	hsa-miR-3192	CLIP-seq
MIRT2238612	hsa-miR-329	CLIP-seq
MIRT2006065	hsa-miR-3612	CLIP-seq
MIRT1031866	hsa-miR-3622b-5p	CLIP-seq
MIRT2238613	hsa-miR-362-3p	CLIP-seq
MIRT1031867	hsa-miR-3665	CLIP-seq
MIRT2238614	hsa-miR-3682-5p	CLIP-seq
MIRT1031869	hsa-miR-3689a-3p	CLIP-seq
MIRT1031870	hsa-miR-3689c	CLIP-seq
MIRT1031873	hsa-miR-377	CLIP-seq
MIRT2006067	hsa-miR-3913-5p	CLIP-seq
MIRT1031874	hsa-miR-3929	CLIP-seq
MIRT2006068	hsa-miR-3942-3p	CLIP-seq
MIRT2238615	hsa-miR-3973	CLIP-seq
MIRT2238616	hsa-miR-3974	CLIP-seq
MIRT1031877	hsa-miR-4253	CLIP-seq
MIRT1031880	hsa-miR-4304	CLIP-seq
MIRT2238617	hsa-miR-4327	CLIP-seq
MIRT1031883	hsa-miR-4419b	CLIP-seq
MIRT1031884	hsa-miR-4433	CLIP-seq
MIRT1031886	hsa-miR-4459	CLIP-seq
MIRT2238618	hsa-miR-4469	CLIP-seq
MIRT1031888	hsa-miR-4478	CLIP-seq
MIRT1031889	hsa-miR-449c	CLIP-seq
MIRT1031892	hsa-miR-4643	CLIP-seq
MIRT1031893	hsa-miR-4649-3p	CLIP-seq
MIRT1031894	hsa-miR-4683	CLIP-seq
MIRT1031895	hsa-miR-4705	CLIP-seq
MIRT1031897	hsa-miR-4722-5p	CLIP-seq
MIRT1031898	hsa-miR-4728-5p	CLIP-seq
MIRT2006077	hsa-miR-4733-5p	CLIP-seq
MIRT1031899	hsa-miR-4736	CLIP-seq
MIRT1031900	hsa-miR-4739	CLIP-seq
MIRT1031901	hsa-miR-4756-5p	CLIP-seq
MIRT1031902	hsa-miR-4768-3p	CLIP-seq
MIRT1031903	hsa-miR-4786-5p	CLIP-seq
MIRT1031904	hsa-miR-4793-5p	CLIP-seq
MIRT1031905	hsa-miR-4794	CLIP-seq
MIRT1031906	hsa-miR-485-5p	CLIP-seq
MIRT2006079	hsa-miR-490-3p	CLIP-seq
MIRT2238619	hsa-miR-5096	CLIP-seq
MIRT2238620	hsa-miR-514	CLIP-seq
MIRT2238621	hsa-miR-514b-3p	CLIP-seq
MIRT2238622	hsa-miR-520g	CLIP-seq
MIRT2238623	hsa-miR-520h	CLIP-seq
MIRT2238624	hsa-miR-526b	CLIP-seq
MIRT2238625	hsa-miR-642b	CLIP-seq
MIRT2006080	hsa-miR-650	CLIP-seq
MIRT1031915	hsa-miR-663	CLIP-seq
MIRT1031918	hsa-miR-940	CLIP-seq
MIRT1031858	hsa-miR-2682	CLIP-seq
MIRT2006063	hsa-miR-3145-5p	CLIP-seq
MIRT1031862	hsa-miR-3165	CLIP-seq
MIRT2388677	hsa-miR-3607-5p	CLIP-seq
MIRT1031867	hsa-miR-3665	CLIP-seq
MIRT1031869	hsa-miR-3689a-3p	CLIP-seq
MIRT1031870	hsa-miR-3689c	CLIP-seq
MIRT2006069	hsa-miR-4252	CLIP-seq
MIRT1031889	hsa-miR-449c	CLIP-seq
MIRT2006073	hsa-miR-4539	CLIP-seq
MIRT2006075	hsa-miR-4680-5p	CLIP-seq
MIRT2006076	hsa-miR-4724-5p	CLIP-seq
MIRT1031898	hsa-miR-4728-5p	CLIP-seq
MIRT1031899	hsa-miR-4736	CLIP-seq
MIRT2006079	hsa-miR-490-3p	CLIP-seq
MIRT1031918	hsa-miR-940	CLIP-seq
MIRT2429465	hsa-miR-3607-3p	CLIP-seq
MIRT2429466	hsa-miR-3686	CLIP-seq
MIRT2429467	hsa-miR-4652-3p	CLIP-seq
MIRT1031851	hsa-miR-1321	CLIP-seq
MIRT1031856	hsa-miR-2114	CLIP-seq
MIRT1031861	hsa-miR-3162-5p	CLIP-seq
MIRT2388677	hsa-miR-3607-5p	CLIP-seq
MIRT1031874	hsa-miR-3929	CLIP-seq
MIRT1031877	hsa-miR-4253	CLIP-seq
MIRT1031883	hsa-miR-4419b	CLIP-seq
MIRT1031888	hsa-miR-4478	CLIP-seq
MIRT2450663	hsa-miR-4684-5p	CLIP-seq
MIRT2450664	hsa-miR-4699-5p	CLIP-seq
MIRT1031900	hsa-miR-4739	CLIP-seq
MIRT1031901	hsa-miR-4756-5p	CLIP-seq
MIRT1031906	hsa-miR-485-5p	CLIP-seq
MIRT2450665	hsa-miR-548c-3p	CLIP-seq
MIRT2450666	hsa-miR-580	CLIP-seq
MIRT2388677	hsa-miR-3607-5p	CLIP-seq
MIRT2450663	hsa-miR-4684-5p	CLIP-seq
MIRT2450664	hsa-miR-4699-5p	CLIP-seq
MIRT2450665	hsa-miR-548c-3p	CLIP-seq
MIRT2450666	hsa-miR-580	CLIP-seq
MIRT1031858	hsa-miR-2682	CLIP-seq
MIRT2006062	hsa-miR-3122	CLIP-seq
MIRT1031859	hsa-miR-3135	CLIP-seq
MIRT1031862	hsa-miR-3165	CLIP-seq
MIRT1031865	hsa-miR-3613-3p	CLIP-seq
MIRT1031867	hsa-miR-3665	CLIP-seq
MIRT1031869	hsa-miR-3689a-3p	CLIP-seq
MIRT1031870	hsa-miR-3689c	CLIP-seq
MIRT1031871	hsa-miR-371-5p	CLIP-seq
MIRT1031872	hsa-miR-371b-5p	CLIP-seq
MIRT2006067	hsa-miR-3913-5p	CLIP-seq
MIRT1031889	hsa-miR-449c	CLIP-seq
MIRT2450663	hsa-miR-4684-5p	CLIP-seq
MIRT1031898	hsa-miR-4728-5p	CLIP-seq
MIRT2006077	hsa-miR-4733-5p	CLIP-seq
MIRT1031899	hsa-miR-4736	CLIP-seq
MIRT2450665	hsa-miR-548c-3p	CLIP-seq
MIRT1031918	hsa-miR-940	CLIP-seq
MIRT1031865	hsa-miR-3613-3p	CLIP-seq
MIRT1031869	hsa-miR-3689a-3p	CLIP-seq
MIRT1031870	hsa-miR-3689c	CLIP-seq
MIRT1031871	hsa-miR-371-5p	CLIP-seq
MIRT1031872	hsa-miR-371b-5p	CLIP-seq
MIRT2450663	hsa-miR-4684-5p	CLIP-seq
MIRT1031898	hsa-miR-4728-5p	CLIP-seq
MIRT2450665	hsa-miR-548c-3p	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	ISS
GO:0004930	Function	G protein-coupled receptor activity	TAS	10760605
GO:0004983	Function	Neuropeptide Y receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005929	Component	Cilium	IDA	28154160
GO:0005929	Component	Cilium	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	ISS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007218	Process	Neuropeptide signaling pathway	IEA
GO:0007218	Process	Neuropeptide signaling pathway	ISS
GO:0007631	Process	Feeding behavior	IEA
GO:0008188	Function	Neuropeptide receptor activity	IBA
GO:0008188	Function	Neuropeptide receptor activity	IEA
GO:0008188	Function	Neuropeptide receptor activity	ISS
GO:0016020	Component	Membrane	IEA
GO:0051384	Process	Response to glucocorticoid	IEA
GO:0097730	Component	Non-motile cilium	IEA

MIM	HGNC	e!Ensembl
605569	4523	ENSG00000123901

Q9NYM4

Protein name

G-protein coupled receptor 83 (G-protein coupled receptor 72)

Protein function

G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN (PubMed:27117253). Plays a role in food intake and

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	88 → 345	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in the brain and spinal cord, and found in lower concentrations in the thymus and other tissues. {ECO:0000269|PubMed:11720708}.

Sequence

MVPHLLLLCLLPLVRATEPHEGRADEQSAEAALAVPNASHFFSWNNYTFSDWQNFVGRRR
YGAESQNPTVKALLIVAYSFIIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMI
TLLNTPFTLVRFVNSTWIFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPR
ISITKGVIYIAVIWTMATFFSLPHAICQKLFTFKYSEDIVRSLCLPDFPEPADLFWKYLD
LATFILLYILPLLIISVAYARVAKKLWLCNMIGDVTTEQYFALRRKKKKTIKMLMLVVVL
FALCWFPLNCYVLLLSSKVIRTNNALYFAFHWFAMSSTCYNPFIYCWLNENFRIELKALL
SMCQRPPKPQEDRPPSPVPSFRVAWTEKNDGQRAPLANNLLPTSQLQSGKTDLSSVEPIV
TMS

Sequence length

423

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHAGAS CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSTRUCTIVE SLEEP APNEA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Hyperinsulinemic hypoglycemia	Hyperinsulinemic hypoglycemia	BEFREE	30232594	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperinsulinism	Hyperinsulinism	BEFREE	10844412	★★★★★ ★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune System Diseases	BEFREE	30340784	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	10844412, 23744028	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	22246378, 28771628	★★★★★ ★☆☆☆☆ Found in Text Mining only

GPR83 (G protein-coupled receptor 83)