TSPAN9 (tetraspanin 9)

Gene

• Entrez ID: 10867
• Gene name: Tetraspanin 9
• Gene symbol: TSPAN9
• Synonyms (NCBI Gene): NET-5, NET5, PP1057
• Chromosome: 12
• Chromosome location: 12p13.33-p13.32
• Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044686	hsa-miR-320a	CLASH	23622248
MIRT035946	hsa-miR-1180-3p	CLASH	23622248
MIRT1459930	hsa-miR-106a	CLIP-seq
MIRT1459931	hsa-miR-106b	CLIP-seq
MIRT1459932	hsa-miR-1287	CLIP-seq
MIRT1459933	hsa-miR-134	CLIP-seq
MIRT1459934	hsa-miR-17	CLIP-seq
MIRT1459935	hsa-miR-18a	CLIP-seq
MIRT1459936	hsa-miR-18b	CLIP-seq
MIRT1459937	hsa-miR-20a	CLIP-seq
MIRT1459938	hsa-miR-20b	CLIP-seq
MIRT1459939	hsa-miR-3118	CLIP-seq
MIRT1459940	hsa-miR-3135b	CLIP-seq
MIRT1459941	hsa-miR-4419a	CLIP-seq
MIRT1459942	hsa-miR-4510	CLIP-seq
MIRT1459943	hsa-miR-4641	CLIP-seq
MIRT1459944	hsa-miR-4735-3p	CLIP-seq
MIRT1459945	hsa-miR-4766-5p	CLIP-seq
MIRT1459946	hsa-miR-519a	CLIP-seq
MIRT1459947	hsa-miR-519b-3p	CLIP-seq
MIRT1459948	hsa-miR-519c-3p	CLIP-seq
MIRT1459949	hsa-miR-519d	CLIP-seq
MIRT1459950	hsa-miR-548q	CLIP-seq
MIRT1459951	hsa-miR-93	CLIP-seq
MIRT1459952	hsa-miR-10a	CLIP-seq
MIRT1459953	hsa-miR-10b	CLIP-seq
MIRT1459954	hsa-miR-1203	CLIP-seq
MIRT1459955	hsa-miR-125a-3p	CLIP-seq
MIRT1459956	hsa-miR-1271	CLIP-seq
MIRT1459957	hsa-miR-1468	CLIP-seq
MIRT1459958	hsa-miR-182	CLIP-seq
MIRT1459959	hsa-miR-218	CLIP-seq
MIRT1459960	hsa-miR-3117-5p	CLIP-seq
MIRT1459961	hsa-miR-3140-3p	CLIP-seq
MIRT1459962	hsa-miR-3163	CLIP-seq
MIRT1459963	hsa-miR-3173-3p	CLIP-seq
MIRT1459964	hsa-miR-339-5p	CLIP-seq
MIRT1459965	hsa-miR-3620	CLIP-seq
MIRT1459966	hsa-miR-3665	CLIP-seq
MIRT1459967	hsa-miR-3943	CLIP-seq
MIRT1459968	hsa-miR-4326	CLIP-seq
MIRT1459969	hsa-miR-4470	CLIP-seq
MIRT1459970	hsa-miR-4690-3p	CLIP-seq
MIRT1459971	hsa-miR-4691-5p	CLIP-seq
MIRT1459972	hsa-miR-4694-5p	CLIP-seq
MIRT1459973	hsa-miR-4736	CLIP-seq
MIRT1459974	hsa-miR-4779	CLIP-seq
MIRT1459975	hsa-miR-4800-3p	CLIP-seq
MIRT1459976	hsa-miR-486-3p	CLIP-seq
MIRT1459977	hsa-miR-514	CLIP-seq
MIRT1459978	hsa-miR-514b-3p	CLIP-seq
MIRT1459979	hsa-miR-548ac	CLIP-seq
MIRT1459980	hsa-miR-548ae	CLIP-seq
MIRT1459981	hsa-miR-548aj	CLIP-seq
MIRT1459982	hsa-miR-548am	CLIP-seq
MIRT1459983	hsa-miR-548d-3p	CLIP-seq
MIRT1459984	hsa-miR-548x	CLIP-seq
MIRT1459985	hsa-miR-548z	CLIP-seq
MIRT1459986	hsa-miR-587	CLIP-seq
MIRT1459987	hsa-miR-636	CLIP-seq
MIRT1459988	hsa-miR-642b	CLIP-seq
MIRT1459989	hsa-miR-671-5p	CLIP-seq
MIRT1459990	hsa-miR-9	CLIP-seq
MIRT1459991	hsa-miR-96	CLIP-seq
MIRT2138088	hsa-miR-103a	CLIP-seq
MIRT2138089	hsa-miR-107	CLIP-seq
MIRT2138090	hsa-miR-1184	CLIP-seq
MIRT2138091	hsa-miR-1207-5p	CLIP-seq
MIRT2138092	hsa-miR-1827	CLIP-seq
MIRT2138093	hsa-miR-1909	CLIP-seq
MIRT2138094	hsa-miR-3150a-3p	CLIP-seq
MIRT2138095	hsa-miR-3151	CLIP-seq
MIRT2138096	hsa-miR-3175	CLIP-seq
MIRT2138097	hsa-miR-346	CLIP-seq
MIRT2138098	hsa-miR-3909	CLIP-seq
MIRT2138099	hsa-miR-4288	CLIP-seq
MIRT2138100	hsa-miR-4418	CLIP-seq
MIRT2138101	hsa-miR-4436b-3p	CLIP-seq
MIRT2138102	hsa-miR-4447	CLIP-seq
MIRT2138103	hsa-miR-4472	CLIP-seq
MIRT2138104	hsa-miR-4649-3p	CLIP-seq
MIRT2138105	hsa-miR-4651	CLIP-seq
MIRT2138106	hsa-miR-4663	CLIP-seq
MIRT2138107	hsa-miR-4763-3p	CLIP-seq
MIRT2138108	hsa-miR-491-5p	CLIP-seq
MIRT2138109	hsa-miR-509-3-5p	CLIP-seq
MIRT2138110	hsa-miR-509-5p	CLIP-seq
MIRT2138111	hsa-miR-595	CLIP-seq
MIRT2138112	hsa-miR-608	CLIP-seq
MIRT2138113	hsa-miR-632	CLIP-seq
MIRT2138114	hsa-miR-765	CLIP-seq
MIRT2138115	hsa-miR-939	CLIP-seq
MIRT2138116	hsa-miR-940	CLIP-seq
MIRT2358985	hsa-miR-1	CLIP-seq
MIRT2138088	hsa-miR-103a	CLIP-seq
MIRT2138089	hsa-miR-107	CLIP-seq
MIRT2358986	hsa-miR-1178	CLIP-seq
MIRT2358987	hsa-miR-1197	CLIP-seq
MIRT2138091	hsa-miR-1207-5p	CLIP-seq
MIRT2358988	hsa-miR-1224-3p	CLIP-seq
MIRT2358989	hsa-miR-1253	CLIP-seq
MIRT2358990	hsa-miR-1267	CLIP-seq
MIRT2358991	hsa-miR-1293	CLIP-seq
MIRT2358992	hsa-miR-1294	CLIP-seq
MIRT2358993	hsa-miR-1321	CLIP-seq
MIRT2358994	hsa-miR-1324	CLIP-seq
MIRT2358995	hsa-miR-150	CLIP-seq
MIRT2358996	hsa-miR-185	CLIP-seq
MIRT2358997	hsa-miR-187	CLIP-seq
MIRT2138093	hsa-miR-1909	CLIP-seq
MIRT2358998	hsa-miR-1915	CLIP-seq
MIRT2358999	hsa-miR-1972	CLIP-seq
MIRT2359000	hsa-miR-206	CLIP-seq
MIRT2359001	hsa-miR-2276	CLIP-seq
MIRT2359002	hsa-miR-2467-5p	CLIP-seq
MIRT2359003	hsa-miR-298	CLIP-seq
MIRT2359004	hsa-miR-299-3p	CLIP-seq
MIRT2359005	hsa-miR-3119	CLIP-seq
MIRT2359006	hsa-miR-3126-3p	CLIP-seq
MIRT1459940	hsa-miR-3135b	CLIP-seq
MIRT1459961	hsa-miR-3140-3p	CLIP-seq
MIRT2359007	hsa-miR-3144-5p	CLIP-seq
MIRT2359008	hsa-miR-3145-3p	CLIP-seq
MIRT2138095	hsa-miR-3151	CLIP-seq
MIRT2359009	hsa-miR-3173-5p	CLIP-seq
MIRT2138096	hsa-miR-3175	CLIP-seq
MIRT2359010	hsa-miR-3188	CLIP-seq
MIRT2359011	hsa-miR-3191	CLIP-seq
MIRT2359012	hsa-miR-3194-3p	CLIP-seq
MIRT2359013	hsa-miR-3202	CLIP-seq
MIRT2359014	hsa-miR-342-5p	CLIP-seq
MIRT2359015	hsa-miR-3652	CLIP-seq
MIRT2359016	hsa-miR-3660	CLIP-seq
MIRT1459966	hsa-miR-3665	CLIP-seq
MIRT2359017	hsa-miR-3714	CLIP-seq
MIRT2359018	hsa-miR-383	CLIP-seq
MIRT2359019	hsa-miR-3935	CLIP-seq
MIRT2359020	hsa-miR-3944-5p	CLIP-seq
MIRT2359021	hsa-miR-3975	CLIP-seq
MIRT2359022	hsa-miR-4251	CLIP-seq
MIRT2359023	hsa-miR-4252	CLIP-seq
MIRT2359024	hsa-miR-4270	CLIP-seq
MIRT2359025	hsa-miR-4286	CLIP-seq
MIRT2359026	hsa-miR-4306	CLIP-seq
MIRT2359027	hsa-miR-432	CLIP-seq
MIRT2359028	hsa-miR-4329	CLIP-seq
MIRT1459941	hsa-miR-4419a	CLIP-seq
MIRT2359029	hsa-miR-4430	CLIP-seq
MIRT2359030	hsa-miR-4436a	CLIP-seq
MIRT2138101	hsa-miR-4436b-3p	CLIP-seq
MIRT2359031	hsa-miR-4441	CLIP-seq
MIRT2359032	hsa-miR-4443	CLIP-seq
MIRT2138102	hsa-miR-4447	CLIP-seq
MIRT2359033	hsa-miR-4455	CLIP-seq
MIRT2359034	hsa-miR-4457	CLIP-seq
MIRT1459969	hsa-miR-4470	CLIP-seq
MIRT2138103	hsa-miR-4472	CLIP-seq
MIRT2359035	hsa-miR-4483	CLIP-seq
MIRT2359036	hsa-miR-4488	CLIP-seq
MIRT2359037	hsa-miR-4492	CLIP-seq
MIRT2359038	hsa-miR-4498	CLIP-seq
MIRT1459942	hsa-miR-4510	CLIP-seq
MIRT2359039	hsa-miR-4514	CLIP-seq
MIRT2359040	hsa-miR-4522	CLIP-seq
MIRT2359041	hsa-miR-4526	CLIP-seq
MIRT2359042	hsa-miR-4533	CLIP-seq
MIRT2359043	hsa-miR-4644	CLIP-seq
MIRT2359044	hsa-miR-4645-3p	CLIP-seq
MIRT2138105	hsa-miR-4651	CLIP-seq
MIRT2359045	hsa-miR-4652-5p	CLIP-seq
MIRT2359046	hsa-miR-4664-5p	CLIP-seq
MIRT2359047	hsa-miR-4677-3p	CLIP-seq
MIRT2359048	hsa-miR-4679	CLIP-seq
MIRT2359049	hsa-miR-4688	CLIP-seq
MIRT2359050	hsa-miR-4690-5p	CLIP-seq
MIRT2359051	hsa-miR-4692	CLIP-seq
MIRT2359052	hsa-miR-4697-5p	CLIP-seq
MIRT2359053	hsa-miR-4713-5p	CLIP-seq
MIRT2359054	hsa-miR-4731-5p	CLIP-seq
MIRT1459973	hsa-miR-4736	CLIP-seq
MIRT2359055	hsa-miR-4739	CLIP-seq
MIRT2359056	hsa-miR-4755-3p	CLIP-seq
MIRT2359057	hsa-miR-4756-5p	CLIP-seq
MIRT2359058	hsa-miR-4758-3p	CLIP-seq
MIRT2359059	hsa-miR-4761-3p	CLIP-seq
MIRT2138107	hsa-miR-4763-3p	CLIP-seq
MIRT1459974	hsa-miR-4779	CLIP-seq
MIRT2359060	hsa-miR-4786-3p	CLIP-seq
MIRT2359061	hsa-miR-485-5p	CLIP-seq
MIRT1459976	hsa-miR-486-3p	CLIP-seq
MIRT2359062	hsa-miR-490-5p	CLIP-seq
MIRT2138108	hsa-miR-491-5p	CLIP-seq
MIRT2359063	hsa-miR-492	CLIP-seq
MIRT1459946	hsa-miR-519a	CLIP-seq
MIRT1459947	hsa-miR-519b-3p	CLIP-seq
MIRT1459948	hsa-miR-519c-3p	CLIP-seq
MIRT2359064	hsa-miR-520g	CLIP-seq
MIRT2359065	hsa-miR-520h	CLIP-seq
MIRT2359066	hsa-miR-532-3p	CLIP-seq
MIRT2359067	hsa-miR-541	CLIP-seq
MIRT2359068	hsa-miR-582-3p	CLIP-seq
MIRT2138112	hsa-miR-608	CLIP-seq
MIRT2359069	hsa-miR-613	CLIP-seq
MIRT2359070	hsa-miR-637	CLIP-seq
MIRT2359071	hsa-miR-645	CLIP-seq
MIRT2359072	hsa-miR-649	CLIP-seq
MIRT2359073	hsa-miR-654-3p	CLIP-seq
MIRT2359074	hsa-miR-654-5p	CLIP-seq
MIRT1459989	hsa-miR-671-5p	CLIP-seq
MIRT2359075	hsa-miR-760	CLIP-seq
MIRT2359076	hsa-miR-762	CLIP-seq
MIRT2359077	hsa-miR-767-3p	CLIP-seq
MIRT2138116	hsa-miR-940	CLIP-seq
MIRT2138090	hsa-miR-1184	CLIP-seq
MIRT2396427	hsa-miR-1205	CLIP-seq
MIRT1459957	hsa-miR-1468	CLIP-seq
MIRT2396428	hsa-miR-2467-3p	CLIP-seq
MIRT1459960	hsa-miR-3117-5p	CLIP-seq
MIRT2396429	hsa-miR-3158-5p	CLIP-seq
MIRT2396430	hsa-miR-3678-3p	CLIP-seq
MIRT2396431	hsa-miR-3919	CLIP-seq
MIRT2396432	hsa-miR-3929	CLIP-seq
MIRT2396433	hsa-miR-4324	CLIP-seq
MIRT2396434	hsa-miR-4419b	CLIP-seq
MIRT2396435	hsa-miR-4478	CLIP-seq
MIRT1459972	hsa-miR-4694-5p	CLIP-seq
MIRT1459975	hsa-miR-4800-3p	CLIP-seq
MIRT2396436	hsa-miR-627	CLIP-seq
MIRT2396437	hsa-miR-924	CLIP-seq
MIRT2358995	hsa-miR-150	CLIP-seq
MIRT2358998	hsa-miR-1915	CLIP-seq
MIRT2462502	hsa-miR-3155	CLIP-seq
MIRT2462503	hsa-miR-3155b	CLIP-seq
MIRT2462504	hsa-miR-3189-3p	CLIP-seq
MIRT2462505	hsa-miR-3686	CLIP-seq
MIRT2462506	hsa-miR-4279	CLIP-seq
MIRT2462507	hsa-miR-450b-3p	CLIP-seq
MIRT2462508	hsa-miR-4652-3p	CLIP-seq
MIRT2462509	hsa-miR-4659a-3p	CLIP-seq
MIRT2462510	hsa-miR-4659b-3p	CLIP-seq
MIRT2462511	hsa-miR-4713-3p	CLIP-seq
MIRT2359053	hsa-miR-4713-5p	CLIP-seq
MIRT2462512	hsa-miR-4726-3p	CLIP-seq
MIRT2462513	hsa-miR-4742-3p	CLIP-seq
MIRT2462514	hsa-miR-484	CLIP-seq
MIRT2359066	hsa-miR-532-3p	CLIP-seq
MIRT2462515	hsa-miR-638	CLIP-seq
MIRT2462516	hsa-miR-769-3p	CLIP-seq
MIRT2462517	hsa-miR-942	CLIP-seq
MIRT2652226	hsa-miR-1236	CLIP-seq
MIRT2652227	hsa-miR-2964a-5p	CLIP-seq
MIRT2652228	hsa-miR-3183	CLIP-seq
MIRT2652229	hsa-miR-3654	CLIP-seq
MIRT2138098	hsa-miR-3909	CLIP-seq
MIRT2652230	hsa-miR-4463	CLIP-seq
MIRT2652231	hsa-miR-4520a-3p	CLIP-seq
MIRT2652232	hsa-miR-4638-3p	CLIP-seq
MIRT2652233	hsa-miR-4723-3p	CLIP-seq
MIRT2652226	hsa-miR-1236	CLIP-seq
MIRT2652227	hsa-miR-2964a-5p	CLIP-seq
MIRT2652228	hsa-miR-3183	CLIP-seq
MIRT2652229	hsa-miR-3654	CLIP-seq
MIRT2138098	hsa-miR-3909	CLIP-seq
MIRT2652230	hsa-miR-4463	CLIP-seq
MIRT2652231	hsa-miR-4520a-3p	CLIP-seq
MIRT2652232	hsa-miR-4638-3p	CLIP-seq
MIRT2652233	hsa-miR-4723-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001780	Process	Neutrophil homeostasis	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	18795891
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0016020	Component	Membrane	IEA
GO:0038063	Process	Collagen-activated tyrosine kinase receptor signaling pathway	IEA
GO:0051881	Process	Regulation of mitochondrial membrane potential	IEA
GO:0070527	Process	Platelet aggregation	IEA
GO:0097197	Component	Tetraspanin-enriched microdomain	IDA	18795891
GO:0098953	Process	Receptor diffusion trapping	IEA
GO:0140494	Component	Migrasome	IEA
GO:0160040	Process	Mitocytosis	IEA

Other IDs

• MIM: 613137
• HGNC: 21640
• e!Ensembl: ENSG00000011105

Protein

• UniProt ID: O75954
• Protein name: Tetraspanin-9 (Tspan-9) (Tetraspan NET-5)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00335	Tetraspanin	9 → 229	Tetraspanin family	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in megakaryocytes and platelets (at protein level). {ECO:0000269|PubMed:18795891}.
• Sequence:

  MARGCLCCLKYMMFLFNLIFWLCGCGLLGVGIWLSVSQGNFATFSPSFPSLSAANLVIAI
  GTIVMVTGFLGCLGAIKENKCLLLSFFIVLLVILLAELILLILFFVYMDKVNENAKKDLK
  EGLLLYHTENNVGLKNAWNIIQAEMRCCGVTDYTDWYPVLGENTVPDRCCMENSQGCGRN
  ATTPLWRTGCYEKVKMWFDDNKHVLGTVGMCILIMQILGMAFSMTLFQHIHRTGKKYDA

• Sequence length: 239

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CUTANEOUS LEISHMANIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPORADIC AMYOTROPHIC LATERAL SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35600044	Inhibit	★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	GWASCAT_DG	29212778		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diverticular Diseases	Diverticular Diseases	GWASCAT_DG	30177863		★☆☆☆☆ Found in Text Mining only
Encephalitis	Encephalitis	Pubtator	26865714	Associate	★☆☆☆☆ Found in Text Mining only
Hypospadias	Hypospadias	Pubtator	32728162	Associate	★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	29986096	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	27177197, 31242895		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	GWASDB_DG	21211798		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Carcinoma	Stomach Carcinoma	BEFREE	27177197, 31242895		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	31242895	Inhibit	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	32019179	Associate	★☆☆☆☆ Found in Text Mining only