Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10799
Gene name	Ribonuclease P/MRP subunit p40
Gene symbol	RPP40
Synonyms (NCBI Gene)	RNASEP1bA428J1.3
Chromosome	6
Chromosome location	6p25.1

146

Show/Hide all (146)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023880	hsa-miR-1-3p	Proteomics	18668040
MIRT028558	hsa-miR-30a-5p	Proteomics	18668040
MIRT625685	hsa-miR-4282	HITS-CLIP	23824327
MIRT618673	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT618672	hsa-miR-4511	HITS-CLIP	23824327
MIRT618671	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618670	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT618669	hsa-miR-623	HITS-CLIP	23824327
MIRT618668	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618667	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618666	hsa-miR-3658	HITS-CLIP	23824327
MIRT618665	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618664	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618663	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT618673	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT618672	hsa-miR-4511	HITS-CLIP	23824327
MIRT644977	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT618671	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618670	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT644976	hsa-miR-520d-5p	HITS-CLIP	23824327
MIRT644975	hsa-miR-524-5p	HITS-CLIP	23824327
MIRT618669	hsa-miR-623	HITS-CLIP	23824327
MIRT618668	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618667	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618666	hsa-miR-3658	HITS-CLIP	23824327
MIRT618665	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618664	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618663	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT625685	hsa-miR-4282	HITS-CLIP	23824327
MIRT618673	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT618672	hsa-miR-4511	HITS-CLIP	23824327
MIRT618671	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618670	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT618669	hsa-miR-623	HITS-CLIP	23824327
MIRT618668	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618667	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618666	hsa-miR-3658	HITS-CLIP	23824327
MIRT618665	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618664	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618663	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT618673	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT618672	hsa-miR-4511	HITS-CLIP	23824327
MIRT618671	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618670	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT618669	hsa-miR-623	HITS-CLIP	23824327
MIRT618668	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618667	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618666	hsa-miR-3658	HITS-CLIP	23824327
MIRT618665	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618664	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618663	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT625685	hsa-miR-4282	HITS-CLIP	23824327
MIRT618673	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT618672	hsa-miR-4511	HITS-CLIP	23824327
MIRT618671	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618670	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT618669	hsa-miR-623	HITS-CLIP	23824327
MIRT618668	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618667	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618666	hsa-miR-3658	HITS-CLIP	23824327
MIRT618665	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618664	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618663	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT618673	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT618672	hsa-miR-4511	HITS-CLIP	23824327
MIRT618671	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618670	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT618669	hsa-miR-623	HITS-CLIP	23824327
MIRT618668	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618667	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618666	hsa-miR-3658	HITS-CLIP	23824327
MIRT618665	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618664	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618663	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT625685	hsa-miR-4282	HITS-CLIP	23824327
MIRT618673	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT618672	hsa-miR-4511	HITS-CLIP	23824327
MIRT618671	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618670	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT618669	hsa-miR-623	HITS-CLIP	23824327
MIRT618668	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618667	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618666	hsa-miR-3658	HITS-CLIP	23824327
MIRT618665	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618664	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618663	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT618673	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT618672	hsa-miR-4511	HITS-CLIP	23824327
MIRT644977	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT618671	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618670	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT644976	hsa-miR-520d-5p	HITS-CLIP	23824327
MIRT644975	hsa-miR-524-5p	HITS-CLIP	23824327
MIRT618669	hsa-miR-623	HITS-CLIP	23824327
MIRT618668	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618667	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618666	hsa-miR-3658	HITS-CLIP	23824327
MIRT618665	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618664	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618663	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT625685	hsa-miR-4282	HITS-CLIP	23824327
MIRT618673	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT618672	hsa-miR-4511	HITS-CLIP	23824327
MIRT618671	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618670	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT618669	hsa-miR-623	HITS-CLIP	23824327
MIRT618668	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618667	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618666	hsa-miR-3658	HITS-CLIP	23824327
MIRT618665	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618664	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618663	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT618673	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT618672	hsa-miR-4511	HITS-CLIP	23824327
MIRT618671	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618670	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT618669	hsa-miR-623	HITS-CLIP	23824327
MIRT618668	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618667	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618666	hsa-miR-3658	HITS-CLIP	23824327
MIRT618665	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618664	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618663	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT625685	hsa-miR-4282	HITS-CLIP	23824327
MIRT618673	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT618672	hsa-miR-4511	HITS-CLIP	23824327
MIRT618671	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618670	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT618669	hsa-miR-623	HITS-CLIP	23824327
MIRT618668	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618667	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618666	hsa-miR-3658	HITS-CLIP	23824327
MIRT618665	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618664	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618663	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT618673	hsa-miR-548b-3p	HITS-CLIP	23824327
MIRT618672	hsa-miR-4511	HITS-CLIP	23824327
MIRT618671	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618670	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT618669	hsa-miR-623	HITS-CLIP	23824327
MIRT618668	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618667	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618666	hsa-miR-3658	HITS-CLIP	23824327
MIRT618665	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618664	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618663	hsa-miR-4446-5p	HITS-CLIP	23824327

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000171	Function	Ribonuclease MRP activity	IBA
GO:0000172	Component	Ribonuclease MRP complex	IBA
GO:0000447	Process	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0001682	Process	TRNA 5'-leader removal	IBA
GO:0001682	Process	TRNA 5'-leader removal	IDA	30454648
GO:0001682	Process	TRNA 5'-leader removal	IEA
GO:0003723	Function	RNA binding	IEA
GO:0004526	Function	Ribonuclease P activity	IBA
GO:0004526	Function	Ribonuclease P activity	IDA	30454648
GO:0004526	Function	Ribonuclease P activity	IEA
GO:0004526	Function	Ribonuclease P activity	TAS	9630247
GO:0005515	Function	Protein binding	IPI	15096576, 30454648, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9630247
GO:0005654	Component	Nucleoplasm	TAS
GO:0005655	Component	Nucleolar ribonuclease P complex	TAS	9630247
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0030677	Component	Ribonuclease P complex	IEA
GO:0030681	Component	Multimeric ribonuclease P complex	IBA
GO:0030681	Component	Multimeric ribonuclease P complex	IDA	30454648
GO:0033204	Function	Ribonuclease P RNA binding	IDA	30454648

MIM	HGNC	e!Ensembl
606117	20992	ENSG00000124787

O75818

Protein name

Ribonuclease P protein subunit p40 (RNaseP protein p40) (RNase P subunit 1)

Protein function

Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed

PDB

6AHR , 6AHU , 6AHV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08584	Ribonuc_P_40	75 → 346	Ribonuclease P 40kDa (Rpp40) subunit	Family

Sequence

MATLRRLREAPRHLLVCEKSNFGNHKSRHRHLVQTHYYNYRVSFLIPECGILSEELKNLV
MNTGPYYFVKNLPLHELITPEFISTFIKKGSCYALTYNTHIDEDNTVALLPNGKLILSLD
KDTYEETGLQGHPSQFSGRKIMKFIVSIDLMELSLNLDSKKYERISWSFKEKKPLKFDFL
LAWHKTGSEESTMMSYFSKYQIQEHQPKVALSTLRDLQCPVLQSSELEGTPEVSCRALEL
FDWLGAVFSNVDLNNEPNNFISTYCCPEPSTVVAKAYLCTITGFILPEKICLLLEHLCHY
FDEPKLAPWVTLSVQGFADSPVSWEKNEHGFRKGGEHLYNFVIFNNQDYWLQMAVGANDH
CPP

Sequence length

363

Interactions

View interactions

	KEGG		Reactome
	Ribosome biogenesis in eukaryotes		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BASAL CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KERATINOCYTE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SMALL CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

RPP40 (ribonuclease P/MRP subunit p40)