IQGAP2 (IQ motif containing GTPase activating protein 2)

Gene

• Entrez ID: 10788
• Gene name: IQ motif containing GTPase activating protein 2
• Gene symbol: IQGAP2
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5q13.3
• Summary: This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, an

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT442395	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442394	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT442393	hsa-miR-641	PAR-CLIP	22100165
MIRT442392	hsa-miR-549a	PAR-CLIP	22100165
MIRT442391	hsa-miR-208a-3p	PAR-CLIP	22100165
MIRT442390	hsa-miR-208b-3p	PAR-CLIP	22100165
MIRT442389	hsa-miR-499a-5p	PAR-CLIP	22100165
MIRT442395	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442394	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT442393	hsa-miR-641	PAR-CLIP	22100165
MIRT442392	hsa-miR-549a	PAR-CLIP	22100165
MIRT442391	hsa-miR-208a-3p	PAR-CLIP	22100165
MIRT442390	hsa-miR-208b-3p	PAR-CLIP	22100165
MIRT442389	hsa-miR-499a-5p	PAR-CLIP	22100165
MIRT442395	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442394	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT442393	hsa-miR-641	PAR-CLIP	22100165
MIRT442392	hsa-miR-549a	PAR-CLIP	22100165
MIRT442391	hsa-miR-208a-3p	PAR-CLIP	22100165
MIRT442390	hsa-miR-208b-3p	PAR-CLIP	22100165
MIRT442389	hsa-miR-499a-5p	PAR-CLIP	22100165
MIRT442395	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442394	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT442393	hsa-miR-641	PAR-CLIP	22100165
MIRT442392	hsa-miR-549a	PAR-CLIP	22100165
MIRT442391	hsa-miR-208a-3p	PAR-CLIP	22100165
MIRT442390	hsa-miR-208b-3p	PAR-CLIP	22100165
MIRT442389	hsa-miR-499a-5p	PAR-CLIP	22100165
MIRT1070047	hsa-miR-101	CLIP-seq
MIRT1070048	hsa-miR-128	CLIP-seq
MIRT1070049	hsa-miR-133a	CLIP-seq
MIRT1070050	hsa-miR-133b	CLIP-seq
MIRT1070051	hsa-miR-27a	CLIP-seq
MIRT1070052	hsa-miR-27b	CLIP-seq
MIRT1070053	hsa-miR-3074-3p	CLIP-seq
MIRT1070054	hsa-miR-3616-5p	CLIP-seq
MIRT1070055	hsa-miR-3647-5p	CLIP-seq
MIRT1070056	hsa-miR-3671	CLIP-seq
MIRT1070057	hsa-miR-3691-5p	CLIP-seq
MIRT1070058	hsa-miR-3911	CLIP-seq
MIRT1070059	hsa-miR-4272	CLIP-seq
MIRT1070060	hsa-miR-4302	CLIP-seq
MIRT1070061	hsa-miR-4326	CLIP-seq
MIRT1070062	hsa-miR-4328	CLIP-seq
MIRT1070063	hsa-miR-4752	CLIP-seq
MIRT1070064	hsa-miR-4773	CLIP-seq
MIRT1070065	hsa-miR-4781-3p	CLIP-seq
MIRT1070066	hsa-miR-573	CLIP-seq
MIRT1070067	hsa-miR-607	CLIP-seq
MIRT2017192	hsa-miR-1225-5p	CLIP-seq
MIRT2017193	hsa-miR-181a	CLIP-seq
MIRT2017194	hsa-miR-181b	CLIP-seq
MIRT2017195	hsa-miR-181c	CLIP-seq
MIRT2017196	hsa-miR-181d	CLIP-seq
MIRT2017197	hsa-miR-4262	CLIP-seq
MIRT1070047	hsa-miR-101	CLIP-seq
MIRT1070048	hsa-miR-128	CLIP-seq
MIRT2249128	hsa-miR-190	CLIP-seq
MIRT2249129	hsa-miR-190b	CLIP-seq
MIRT2249130	hsa-miR-1911	CLIP-seq
MIRT1070051	hsa-miR-27a	CLIP-seq
MIRT1070052	hsa-miR-27b	CLIP-seq
MIRT1070053	hsa-miR-3074-3p	CLIP-seq
MIRT2249131	hsa-miR-3201	CLIP-seq
MIRT1070057	hsa-miR-3691-5p	CLIP-seq
MIRT1070058	hsa-miR-3911	CLIP-seq
MIRT1070060	hsa-miR-4302	CLIP-seq
MIRT2249132	hsa-miR-4307	CLIP-seq
MIRT1070063	hsa-miR-4752	CLIP-seq
MIRT2249133	hsa-miR-4760-3p	CLIP-seq
MIRT2249134	hsa-miR-4791	CLIP-seq
MIRT2249135	hsa-miR-513a-5p	CLIP-seq
MIRT2249136	hsa-miR-587	CLIP-seq
MIRT2249137	hsa-miR-664	CLIP-seq
MIRT2249138	hsa-miR-759	CLIP-seq
MIRT2249139	hsa-miR-885-5p	CLIP-seq
MIRT2389459	hsa-miR-579	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	TAS	8756646
GO:0005095	Function	GTPase inhibitor activity	IEA
GO:0005095	Function	GTPase inhibitor activity	TAS	8756646
GO:0005096	Function	GTPase activator activity	IBA
GO:0005516	Function	Calmodulin binding	IBA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005516	Function	Calmodulin binding	IPI	21299499
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	22493426
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IEA
GO:0005737	Component	Cytoplasm	IDA	12515716
GO:0005829	Component	Cytosol	TAS
GO:0005874	Component	Microtubule	IDA	21525035
GO:0005874	Component	Microtubule	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005902	Component	Microvillus	IEA
GO:0005938	Component	Cell cortex	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	8756646
GO:0009986	Component	Cell surface	IDA	12515716
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0015629	Component	Actin cytoskeleton	TAS	8756646
GO:0030027	Component	Lamellipodium	IDA	12515716
GO:0030175	Component	Filopodium	IDA	12515716
GO:0030667	Component	Secretory granule membrane	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031252	Component	Cell leading edge	IEA
GO:0031267	Function	Small GTPase binding	IDA	12515716
GO:0031267	Function	Small GTPase binding	IEA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IDA	12515716
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IDA	12515716
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IDA	12515716
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070493	Process	Thrombin-activated receptor signaling pathway	IDA	12515716
GO:0071933	Function	Arp2/3 complex binding	IDA	12515716
GO:0120025	Component	Plasma membrane bounded cell projection	IEA
GO:1903479	Process	Mitotic actomyosin contractile ring assembly actin filament organization	IBA

Other IDs

• MIM: 605401
• HGNC: 6111
• e!Ensembl: ENSG00000145703

Protein

• UniProt ID: Q13576
• Protein name: Ras GTPase-activating-like protein IQGAP2
• Protein function: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
• PDB: 3IEZ, 4EZA, 5CJP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	41 → 158	Calponin homology (CH) domain	Domain
  PF00612	IQ	691 → 711	IQ calmodulin-binding motif	Motif
  PF00612	IQ	721 → 741	IQ calmodulin-binding motif	Motif
  PF00616	RasGAP	938 → 1150	GTPase-activator protein for Ras-like GTPase	Family
  PF03836	RasGAP_C	1367 → 1498	RasGAP C-terminus	Family

• Tissue specificity: TISSUE SPECIFICITY: Isoform 2 expression is enhanced in testis.
• Sequence:

  MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELP
  PTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAM
  ESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEIS
  NMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNP
  NAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINK
  VNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYL
  AHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVK
  LEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPT
  ANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDKDRAKQWVT
  LVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSW
  LKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSAS
  EELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDN
  TDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPP
  LTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRI
  TLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLA
  KLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTG
  NPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTG
  EASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVL
  KNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGS
  VAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDL
  VTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVD
  PNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLT
  EILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRT
  LEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQIN
  YYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQT
  NQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVN
  VNLLIYLLNKKFYGK

• Sequence length: 1575

Pathways

KEGG:

Regulation of actin cytoskeleton

Reactome:

RHO GTPases activate IQGAPs
Neutrophil degranulation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANGIOEDEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRAIN NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING LOSS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN SEROUS CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Benign neoplasm of brain, unspecified	Brain Neoplasms	CTD_human_DG	27935819		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	CTD_human_DG	27935819		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Brain Tumor, Primary	Brain Neoplasms	CTD_human_DG	27935819		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	20977743, 24998570, 36320006	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	26549344		★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	26047140		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29073199		★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic retinopathy	Pubtator	34935307	Associate	★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	21968151		★☆☆☆☆ Found in Text Mining only
Hepatic Adenomas Familial	Hepatic adenoma	Pubtator	20977743	Associate	★☆☆☆☆ Found in Text Mining only
Hepatitis C	Hepatitis c	Pubtator	27401546	Associate	★☆☆☆☆ Found in Text Mining only
Hirschsprung Disease	Hirschsprung disease	Pubtator	23270508	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	26047140		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	20977743, 22406297, 23951254, 24998570		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	20977743		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	40171809	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of brain	Brain Neoplasms	CTD_human_DG	27935819		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	20977743		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	26549344		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	22406297, 30428404		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	17957782, 22406297		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26047140		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	37504571	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19433088, 22406297, 23951254, 24998570, 26549344, 27488117, 30428404		★☆☆☆☆ Found in Text Mining only
Neoplasms, Intracranial	Intracranial Neoplasm	CTD_human_DG	27935819		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	26549344		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	21487324	Associate	★☆☆☆☆ Found in Text Mining only
Primary malignant neoplasm of brain	Brain Neoplasms	CTD_human_DG	27935819		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	22406297, 30428404		★☆☆☆☆ Found in Text Mining only
Prostatic Intraepithelial Neoplasias	Prostatic Neoplasms	BEFREE	22406297		★☆☆☆☆ Found in Text Mining only
Rectal Carcinoma	Rectal Carcinoma	BEFREE	26865277		★☆☆☆☆ Found in Text Mining only
Recurrent Brain Neoplasm	Brain Neoplasms	CTD_human_DG	27935819		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	27846195		★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	21968151		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	17957782, 22406297		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	LHGDN	17957782		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	29073199, 34034707	Inhibit	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	32183047	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	40171809	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	36362301	Inhibit	★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular disease	Pubtator	34935307	Associate	★☆☆☆☆ Found in Text Mining only