POP4 (POP4 ribonuclease P/MRP subunit)

Gene

• Entrez ID: 10775
• Gene name: POP4 ribonuclease P/MRP subunit
• Gene symbol: POP4
• Synonyms (NCBI Gene): RPP29
• Chromosome: 19
• Chromosome location: 19q12
• Summary: This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029286	hsa-miR-26b-5p	Microarray	19088304
MIRT049425	hsa-miR-92a-3p	CLASH	23622248
MIRT045865	hsa-miR-128-3p	CLASH	23622248
MIRT650776	hsa-miR-4301	HITS-CLIP	23824327
MIRT650775	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT650774	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT650773	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT650772	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT650771	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT650770	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT650769	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT442653	hsa-miR-1264	PAR-CLIP	22100165
MIRT442651	hsa-miR-4499	PAR-CLIP	22100165
MIRT442652	hsa-miR-1178-5p	PAR-CLIP	22100165
MIRT442650	hsa-miR-4494	PAR-CLIP	22100165
MIRT442649	hsa-miR-499b-5p	PAR-CLIP	22100165
MIRT442648	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT442647	hsa-miR-4480	PAR-CLIP	22100165
MIRT442646	hsa-miR-6801-5p	PAR-CLIP	22100165
MIRT442653	hsa-miR-1264	PAR-CLIP	22100165
MIRT442651	hsa-miR-4499	PAR-CLIP	22100165
MIRT442652	hsa-miR-1178-5p	PAR-CLIP	22100165
MIRT442650	hsa-miR-4494	PAR-CLIP	22100165
MIRT442649	hsa-miR-499b-5p	PAR-CLIP	22100165
MIRT442648	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT442647	hsa-miR-4480	PAR-CLIP	22100165
MIRT442646	hsa-miR-6801-5p	PAR-CLIP	22100165
MIRT650776	hsa-miR-4301	HITS-CLIP	23824327
MIRT650775	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT650774	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT650773	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT650772	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT650771	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT650770	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT650769	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT442653	hsa-miR-1264	PAR-CLIP	22100165
MIRT442651	hsa-miR-4499	PAR-CLIP	22100165
MIRT442652	hsa-miR-1178-5p	PAR-CLIP	22100165
MIRT442650	hsa-miR-4494	PAR-CLIP	22100165
MIRT442649	hsa-miR-499b-5p	PAR-CLIP	22100165
MIRT442648	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT442647	hsa-miR-4480	PAR-CLIP	22100165
MIRT442646	hsa-miR-6801-5p	PAR-CLIP	22100165
MIRT442653	hsa-miR-1264	PAR-CLIP	22100165
MIRT442651	hsa-miR-4499	PAR-CLIP	22100165
MIRT442652	hsa-miR-1178-5p	PAR-CLIP	22100165
MIRT442650	hsa-miR-4494	PAR-CLIP	22100165
MIRT442649	hsa-miR-499b-5p	PAR-CLIP	22100165
MIRT442648	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT442647	hsa-miR-4480	PAR-CLIP	22100165
MIRT442646	hsa-miR-6801-5p	PAR-CLIP	22100165
MIRT1250176	hsa-miR-1200	CLIP-seq
MIRT1250177	hsa-miR-1224-5p	CLIP-seq
MIRT1250178	hsa-miR-1237	CLIP-seq
MIRT1250179	hsa-miR-1238	CLIP-seq
MIRT1250180	hsa-miR-1245b-3p	CLIP-seq
MIRT1250181	hsa-miR-1248	CLIP-seq
MIRT1250182	hsa-miR-1262	CLIP-seq
MIRT1250183	hsa-miR-1273g	CLIP-seq
MIRT1250184	hsa-miR-1291	CLIP-seq
MIRT1250185	hsa-miR-1293	CLIP-seq
MIRT1250186	hsa-miR-133a	CLIP-seq
MIRT1250187	hsa-miR-133b	CLIP-seq
MIRT1250188	hsa-miR-15a	CLIP-seq
MIRT1250189	hsa-miR-15b	CLIP-seq
MIRT1250190	hsa-miR-16	CLIP-seq
MIRT1250191	hsa-miR-195	CLIP-seq
MIRT1250192	hsa-miR-214	CLIP-seq
MIRT1250193	hsa-miR-2861	CLIP-seq
MIRT1250194	hsa-miR-3064-5p	CLIP-seq
MIRT1250195	hsa-miR-3135b	CLIP-seq
MIRT1250196	hsa-miR-3140-5p	CLIP-seq
MIRT1250197	hsa-miR-3173-5p	CLIP-seq
MIRT1250198	hsa-miR-3176	CLIP-seq
MIRT1250199	hsa-miR-3190	CLIP-seq
MIRT1250200	hsa-miR-3202	CLIP-seq
MIRT1250201	hsa-miR-328	CLIP-seq
MIRT1250202	hsa-miR-3616-5p	CLIP-seq
MIRT1250203	hsa-miR-3619-5p	CLIP-seq
MIRT1250204	hsa-miR-3647-5p	CLIP-seq
MIRT1250205	hsa-miR-3650	CLIP-seq
MIRT1250206	hsa-miR-3652	CLIP-seq
MIRT1250207	hsa-miR-3689d	CLIP-seq
MIRT1250208	hsa-miR-3922-3p	CLIP-seq
MIRT1250209	hsa-miR-3942-3p	CLIP-seq
MIRT1250210	hsa-miR-424	CLIP-seq
MIRT1250211	hsa-miR-4259	CLIP-seq
MIRT1250212	hsa-miR-4291	CLIP-seq
MIRT1250213	hsa-miR-4299	CLIP-seq
MIRT1250214	hsa-miR-4303	CLIP-seq
MIRT1250215	hsa-miR-4310	CLIP-seq
MIRT1250216	hsa-miR-4430	CLIP-seq
MIRT1250217	hsa-miR-4456	CLIP-seq
MIRT1250218	hsa-miR-4483	CLIP-seq
MIRT1250219	hsa-miR-4505	CLIP-seq
MIRT1250220	hsa-miR-4512	CLIP-seq
MIRT1250221	hsa-miR-4533	CLIP-seq
MIRT1250222	hsa-miR-4670-3p	CLIP-seq
MIRT1250223	hsa-miR-4701-3p	CLIP-seq
MIRT1250224	hsa-miR-4703-3p	CLIP-seq
MIRT1250225	hsa-miR-4715-5p	CLIP-seq
MIRT1250226	hsa-miR-4716-5p	CLIP-seq
MIRT1250227	hsa-miR-4751	CLIP-seq
MIRT1250228	hsa-miR-4795-5p	CLIP-seq
MIRT1250229	hsa-miR-497	CLIP-seq
MIRT1250230	hsa-miR-545	CLIP-seq
MIRT1250231	hsa-miR-548p	CLIP-seq
MIRT1250232	hsa-miR-548q	CLIP-seq
MIRT1250233	hsa-miR-573	CLIP-seq
MIRT1250234	hsa-miR-761	CLIP-seq
MIRT1250235	hsa-miR-892b	CLIP-seq
MIRT1250236	hsa-miR-922	CLIP-seq
MIRT1250193	hsa-miR-2861	CLIP-seq
MIRT1250200	hsa-miR-3202	CLIP-seq
MIRT1250220	hsa-miR-4512	CLIP-seq
MIRT1250221	hsa-miR-4533	CLIP-seq
MIRT1250178	hsa-miR-1237	CLIP-seq
MIRT1250181	hsa-miR-1248	CLIP-seq
MIRT2073868	hsa-miR-1275	CLIP-seq
MIRT1250186	hsa-miR-133a	CLIP-seq
MIRT1250187	hsa-miR-133b	CLIP-seq
MIRT2073869	hsa-miR-1343	CLIP-seq
MIRT2073870	hsa-miR-1910	CLIP-seq
MIRT2073871	hsa-miR-1976	CLIP-seq
MIRT2073872	hsa-miR-24	CLIP-seq
MIRT2073873	hsa-miR-3175	CLIP-seq
MIRT2073874	hsa-miR-3664-3p	CLIP-seq
MIRT2073875	hsa-miR-3682-5p	CLIP-seq
MIRT1250211	hsa-miR-4259	CLIP-seq
MIRT2073876	hsa-miR-4279	CLIP-seq
MIRT2073877	hsa-miR-4284	CLIP-seq
MIRT1250214	hsa-miR-4303	CLIP-seq
MIRT2073878	hsa-miR-4525	CLIP-seq
MIRT2073879	hsa-miR-455-3p	CLIP-seq
MIRT2073880	hsa-miR-4660	CLIP-seq
MIRT2073881	hsa-miR-4665-5p	CLIP-seq
MIRT2073882	hsa-miR-4691-5p	CLIP-seq
MIRT1250224	hsa-miR-4703-3p	CLIP-seq
MIRT1250225	hsa-miR-4715-5p	CLIP-seq
MIRT1250226	hsa-miR-4716-5p	CLIP-seq
MIRT2073883	hsa-miR-4723-5p	CLIP-seq
MIRT2073884	hsa-miR-4773	CLIP-seq
MIRT2073885	hsa-miR-625	CLIP-seq
MIRT2073886	hsa-miR-637	CLIP-seq
MIRT2073887	hsa-miR-885-3p	CLIP-seq
MIRT1250177	hsa-miR-1224-5p	CLIP-seq
MIRT1250178	hsa-miR-1237	CLIP-seq
MIRT1250180	hsa-miR-1245b-3p	CLIP-seq
MIRT1250181	hsa-miR-1248	CLIP-seq
MIRT1250186	hsa-miR-133a	CLIP-seq
MIRT1250187	hsa-miR-133b	CLIP-seq
MIRT2300714	hsa-miR-1914	CLIP-seq
MIRT2300715	hsa-miR-2682	CLIP-seq
MIRT1250194	hsa-miR-3064-5p	CLIP-seq
MIRT2300716	hsa-miR-3120-5p	CLIP-seq
MIRT1250206	hsa-miR-3652	CLIP-seq
MIRT2300717	hsa-miR-3688-5p	CLIP-seq
MIRT2300718	hsa-miR-3714	CLIP-seq
MIRT2300719	hsa-miR-3942-5p	CLIP-seq
MIRT1250211	hsa-miR-4259	CLIP-seq
MIRT1250214	hsa-miR-4303	CLIP-seq
MIRT1250216	hsa-miR-4430	CLIP-seq
MIRT2300720	hsa-miR-4457	CLIP-seq
MIRT2300721	hsa-miR-4484	CLIP-seq
MIRT2300722	hsa-miR-449c	CLIP-seq
MIRT1250219	hsa-miR-4505	CLIP-seq
MIRT1250224	hsa-miR-4703-3p	CLIP-seq
MIRT2300723	hsa-miR-4703-5p	CLIP-seq
MIRT1250225	hsa-miR-4715-5p	CLIP-seq
MIRT1250226	hsa-miR-4716-5p	CLIP-seq
MIRT1250227	hsa-miR-4751	CLIP-seq
MIRT2300724	hsa-miR-548an	CLIP-seq
MIRT2392849	hsa-miR-103a	CLIP-seq
MIRT2392850	hsa-miR-107	CLIP-seq
MIRT1250177	hsa-miR-1224-5p	CLIP-seq
MIRT1250178	hsa-miR-1237	CLIP-seq
MIRT1250180	hsa-miR-1245b-3p	CLIP-seq
MIRT1250181	hsa-miR-1248	CLIP-seq
MIRT1250186	hsa-miR-133a	CLIP-seq
MIRT1250187	hsa-miR-133b	CLIP-seq
MIRT2300714	hsa-miR-1914	CLIP-seq
MIRT1250193	hsa-miR-2861	CLIP-seq
MIRT2300716	hsa-miR-3120-5p	CLIP-seq
MIRT1250200	hsa-miR-3202	CLIP-seq
MIRT1250206	hsa-miR-3652	CLIP-seq
MIRT2300717	hsa-miR-3688-5p	CLIP-seq
MIRT1250211	hsa-miR-4259	CLIP-seq
MIRT1250214	hsa-miR-4303	CLIP-seq
MIRT1250216	hsa-miR-4430	CLIP-seq
MIRT1250219	hsa-miR-4505	CLIP-seq
MIRT1250220	hsa-miR-4512	CLIP-seq
MIRT1250221	hsa-miR-4533	CLIP-seq
MIRT1250224	hsa-miR-4703-3p	CLIP-seq
MIRT1250225	hsa-miR-4715-5p	CLIP-seq
MIRT1250226	hsa-miR-4716-5p	CLIP-seq
MIRT1250227	hsa-miR-4751	CLIP-seq
MIRT2597556	hsa-miR-122	CLIP-seq
MIRT2597557	hsa-miR-1321	CLIP-seq
MIRT2597558	hsa-miR-145	CLIP-seq
MIRT1250188	hsa-miR-15a	CLIP-seq
MIRT1250189	hsa-miR-15b	CLIP-seq
MIRT1250190	hsa-miR-16	CLIP-seq
MIRT1250191	hsa-miR-195	CLIP-seq
MIRT2597559	hsa-miR-198	CLIP-seq
MIRT1250192	hsa-miR-214	CLIP-seq
MIRT2597560	hsa-miR-2909	CLIP-seq
MIRT2597561	hsa-miR-3138	CLIP-seq
MIRT2597562	hsa-miR-3148	CLIP-seq
MIRT2597563	hsa-miR-3162-5p	CLIP-seq
MIRT2597564	hsa-miR-345	CLIP-seq
MIRT1250203	hsa-miR-3619-5p	CLIP-seq
MIRT2597565	hsa-miR-3646	CLIP-seq
MIRT2597566	hsa-miR-3647-3p	CLIP-seq
MIRT2597567	hsa-miR-3662	CLIP-seq
MIRT2597568	hsa-miR-377	CLIP-seq
MIRT2597569	hsa-miR-3909	CLIP-seq
MIRT1250210	hsa-miR-424	CLIP-seq
MIRT1250212	hsa-miR-4291	CLIP-seq
MIRT2597570	hsa-miR-4311	CLIP-seq
MIRT2597571	hsa-miR-4328	CLIP-seq
MIRT2597572	hsa-miR-4640-5p	CLIP-seq
MIRT2597573	hsa-miR-4643	CLIP-seq
MIRT2597574	hsa-miR-4698	CLIP-seq
MIRT2597575	hsa-miR-4717-3p	CLIP-seq
MIRT2597576	hsa-miR-4726-5p	CLIP-seq
MIRT2597577	hsa-miR-4739	CLIP-seq
MIRT2597578	hsa-miR-4756-5p	CLIP-seq
MIRT2597579	hsa-miR-488	CLIP-seq
MIRT1250229	hsa-miR-497	CLIP-seq
MIRT2597580	hsa-miR-499a-5p	CLIP-seq
MIRT2597581	hsa-miR-539	CLIP-seq
MIRT1250230	hsa-miR-545	CLIP-seq
MIRT2597582	hsa-miR-548c-3p	CLIP-seq
MIRT2597583	hsa-miR-548l	CLIP-seq
MIRT2597584	hsa-miR-548n	CLIP-seq
MIRT1250231	hsa-miR-548p	CLIP-seq
MIRT2597585	hsa-miR-642b	CLIP-seq
MIRT1250234	hsa-miR-761	CLIP-seq
MIRT1250236	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000172	Component	Ribonuclease MRP complex	IBA
GO:0000172	Component	Ribonuclease MRP complex	IEA
GO:0000172	Component	Ribonuclease MRP complex	TAS	10352175
GO:0001682	Process	TRNA 5'-leader removal	IDA	16723659, 30454648
GO:0001682	Process	TRNA 5'-leader removal	IEA
GO:0003723	Function	RNA binding	IEA
GO:0004526	Function	Ribonuclease P activity	IDA	30454648
GO:0004526	Function	Ribonuclease P activity	IEA
GO:0005515	Function	Protein binding	IPI	15096576, 28514442, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	10444065
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IBA
GO:0006396	Process	RNA processing	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0030677	Component	Ribonuclease P complex	IBA
GO:0030677	Component	Ribonuclease P complex	IEA
GO:0030681	Component	Multimeric ribonuclease P complex	IDA	16723659, 30454648
GO:0033204	Function	Ribonuclease P RNA binding	IBA
GO:0033204	Function	Ribonuclease P RNA binding	IDA	16723659, 30454648
GO:0033204	Function	Ribonuclease P RNA binding	IEA

Other IDs

• MIM: 606114
• HGNC: 30081
• e!Ensembl: ENSG00000105171

Protein

• UniProt ID: O95707
• Protein name: Ribonuclease P protein subunit p29 (hPOP4)
• Protein function: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
• PDB: 6AHR, 6AHU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01868	UPF0086	128 → 210	Domain of unknown function UPF0086	Family

• Sequence:

  MKSVIYHALSQKEANDSDVQPSGAQRAEAFVRAFLKRSTPRMSPQAREDQLQRKAVVLEY
  FTRHKRKEKKKKAKGLSARQRRELRLFDIKPEQQRYSLFLPLHELWKQYIRDLCSGLKPD
  TQPQMIQAKLLKADLHGAIISVTKSKCPSYVGITGILLQETKHIFKIITKEDRLKVIPKL
  NCVFTVETDGFISYIYGSKFQLRSSERSAKKFKAKGTIDL

• Sequence length: 220

Pathways

KEGG:

Ribosome biogenesis in eukaryotes

Reactome:

tRNA processing in the nucleus

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTROCYTOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations