YME1L1 (YME1 like 1 ATPase)

Gene

• Entrez ID: 10730
• Gene name: YME1 like 1 ATPase
• Gene symbol: YME1L1
• Synonyms (NCBI Gene): FTSH, MEG4, OPA11, PAMP, YME1L
• Chromosome: 10
• Chromosome location: 10p12.1
• Summary: The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mit

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1057519312	G>A,C	Pathogenic	Missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030882	hsa-miR-21-5p	Microarray	18591254
MIRT043391	hsa-miR-331-3p	CLASH	23622248
MIRT697597	hsa-miR-4779	HITS-CLIP	23313552
MIRT697596	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT697595	hsa-miR-151a-5p	HITS-CLIP	23313552
MIRT697594	hsa-miR-151b	HITS-CLIP	23313552
MIRT697593	hsa-miR-6089	HITS-CLIP	23313552
MIRT697592	hsa-miR-6804-5p	HITS-CLIP	23313552
MIRT697591	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT697590	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT697589	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT697587	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT697588	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT697586	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT697585	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT697584	hsa-miR-6745	HITS-CLIP	23313552
MIRT697583	hsa-miR-3165	HITS-CLIP	23313552
MIRT697582	hsa-miR-7977	HITS-CLIP	23313552
MIRT697581	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT697580	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT697579	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT697578	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT697577	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT697576	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT697575	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT697574	hsa-miR-3689c	HITS-CLIP	23313552
MIRT697573	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT697571	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT697572	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT697570	hsa-miR-3122	HITS-CLIP	23313552
MIRT697569	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT697568	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT697567	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT632223	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT632222	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT634145	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT634144	hsa-miR-4673	HITS-CLIP	23824327
MIRT634143	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT632221	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT632220	hsa-miR-4284	HITS-CLIP	23824327
MIRT632219	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634142	hsa-miR-3178	HITS-CLIP	23824327
MIRT663798	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT620097	hsa-miR-5693	HITS-CLIP	23824327
MIRT620095	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT620094	hsa-miR-4679	HITS-CLIP	23824327
MIRT620093	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT620092	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620091	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT620090	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT620089	hsa-miR-5698	HITS-CLIP	23824327
MIRT620097	hsa-miR-5693	HITS-CLIP	23824327
MIRT620095	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT620094	hsa-miR-4679	HITS-CLIP	23824327
MIRT620093	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT651425	hsa-miR-3135b	HITS-CLIP	23824327
MIRT620092	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620091	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT651424	hsa-miR-3652	HITS-CLIP	23824327
MIRT651423	hsa-miR-4430	HITS-CLIP	23824327
MIRT620090	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT620089	hsa-miR-5698	HITS-CLIP	23824327
MIRT634163	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT634162	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT634161	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT634160	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT634159	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT634158	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT634157	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT634156	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634155	hsa-miR-6131	HITS-CLIP	23824327
MIRT634154	hsa-miR-192-5p	HITS-CLIP	23824327
MIRT634153	hsa-miR-215-5p	HITS-CLIP	23824327
MIRT634152	hsa-miR-548s	HITS-CLIP	23824327
MIRT634151	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT634150	hsa-miR-588	HITS-CLIP	23824327
MIRT634149	hsa-miR-4435	HITS-CLIP	23824327
MIRT634148	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT634147	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT634146	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT632223	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT632222	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT634145	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT634144	hsa-miR-4673	HITS-CLIP	23824327
MIRT634143	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT632221	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT632220	hsa-miR-4284	HITS-CLIP	23824327
MIRT632219	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634142	hsa-miR-3178	HITS-CLIP	23824327
MIRT632225	hsa-miR-141-3p	HITS-CLIP	23824327
MIRT632224	hsa-miR-200a-3p	HITS-CLIP	23824327
MIRT632223	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT632222	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT632221	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT632220	hsa-miR-4284	HITS-CLIP	23824327
MIRT632219	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT620097	hsa-miR-5693	HITS-CLIP	23824327
MIRT620095	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT620094	hsa-miR-4679	HITS-CLIP	23824327
MIRT620093	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT620092	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620091	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT620090	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT620089	hsa-miR-5698	HITS-CLIP	23824327
MIRT439270	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT439270	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT697597	hsa-miR-4779	HITS-CLIP	23313552
MIRT697596	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT697595	hsa-miR-151a-5p	HITS-CLIP	23313552
MIRT697594	hsa-miR-151b	HITS-CLIP	23313552
MIRT697593	hsa-miR-6089	HITS-CLIP	23313552
MIRT697592	hsa-miR-6804-5p	HITS-CLIP	23313552
MIRT697591	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT697590	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT697589	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT697587	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT697588	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT697586	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT697585	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT697584	hsa-miR-6745	HITS-CLIP	23313552
MIRT697583	hsa-miR-3165	HITS-CLIP	23313552
MIRT697582	hsa-miR-7977	HITS-CLIP	23313552
MIRT697581	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT697580	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT697579	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT697578	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT697577	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT697576	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT697575	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT697574	hsa-miR-3689c	HITS-CLIP	23313552
MIRT697573	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT697571	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT697572	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT697570	hsa-miR-3122	HITS-CLIP	23313552
MIRT697569	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT697568	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT697567	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT632223	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT632222	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT634145	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT634144	hsa-miR-4673	HITS-CLIP	23824327
MIRT634143	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT632221	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT632220	hsa-miR-4284	HITS-CLIP	23824327
MIRT632219	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634142	hsa-miR-3178	HITS-CLIP	23824327
MIRT663798	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT620097	hsa-miR-5693	HITS-CLIP	23824327
MIRT620095	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT620094	hsa-miR-4679	HITS-CLIP	23824327
MIRT620093	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT620092	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620091	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT620090	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT620089	hsa-miR-5698	HITS-CLIP	23824327
MIRT620097	hsa-miR-5693	HITS-CLIP	23824327
MIRT620095	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT620094	hsa-miR-4679	HITS-CLIP	23824327
MIRT620093	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT651425	hsa-miR-3135b	HITS-CLIP	23824327
MIRT620092	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620091	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT651424	hsa-miR-3652	HITS-CLIP	23824327
MIRT651423	hsa-miR-4430	HITS-CLIP	23824327
MIRT620090	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT620089	hsa-miR-5698	HITS-CLIP	23824327
MIRT634163	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT634162	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT634161	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT634160	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT634159	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT634158	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT634157	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT634156	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT634155	hsa-miR-6131	HITS-CLIP	23824327
MIRT634154	hsa-miR-192-5p	HITS-CLIP	23824327
MIRT634153	hsa-miR-215-5p	HITS-CLIP	23824327
MIRT634152	hsa-miR-548s	HITS-CLIP	23824327
MIRT634151	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT634150	hsa-miR-588	HITS-CLIP	23824327
MIRT634149	hsa-miR-4435	HITS-CLIP	23824327
MIRT634148	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT634147	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT634146	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT632223	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT632222	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT634145	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT634144	hsa-miR-4673	HITS-CLIP	23824327
MIRT634143	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT632221	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT632220	hsa-miR-4284	HITS-CLIP	23824327
MIRT632219	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT634142	hsa-miR-3178	HITS-CLIP	23824327
MIRT632225	hsa-miR-141-3p	HITS-CLIP	23824327
MIRT632224	hsa-miR-200a-3p	HITS-CLIP	23824327
MIRT632223	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT632222	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT632221	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT632220	hsa-miR-4284	HITS-CLIP	23824327
MIRT632219	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT620097	hsa-miR-5693	HITS-CLIP	23824327
MIRT620095	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT620094	hsa-miR-4679	HITS-CLIP	23824327
MIRT620093	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT620092	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620091	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT620090	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT620089	hsa-miR-5698	HITS-CLIP	23824327
MIRT1499117	hsa-miR-1206	CLIP-seq
MIRT1499118	hsa-miR-1267	CLIP-seq
MIRT1499119	hsa-miR-1276	CLIP-seq
MIRT1499120	hsa-miR-1279	CLIP-seq
MIRT1499121	hsa-miR-129-5p	CLIP-seq
MIRT1499122	hsa-miR-1297	CLIP-seq
MIRT1499123	hsa-miR-1304	CLIP-seq
MIRT1499124	hsa-miR-1305	CLIP-seq
MIRT1499125	hsa-miR-1343	CLIP-seq
MIRT1499126	hsa-miR-1827	CLIP-seq
MIRT1499127	hsa-miR-2054	CLIP-seq
MIRT1499128	hsa-miR-24	CLIP-seq
MIRT1499129	hsa-miR-26a	CLIP-seq
MIRT1499130	hsa-miR-26b	CLIP-seq
MIRT1499131	hsa-miR-3137	CLIP-seq
MIRT1499132	hsa-miR-3168	CLIP-seq
MIRT1499133	hsa-miR-3194-3p	CLIP-seq
MIRT1499134	hsa-miR-323b-3p	CLIP-seq
MIRT1499135	hsa-miR-323b-5p	CLIP-seq
MIRT1499136	hsa-miR-337-3p	CLIP-seq
MIRT1499137	hsa-miR-371b-5p	CLIP-seq
MIRT1499138	hsa-miR-3935	CLIP-seq
MIRT1499139	hsa-miR-431	CLIP-seq
MIRT1499140	hsa-miR-4423-5p	CLIP-seq
MIRT1499141	hsa-miR-4465	CLIP-seq
MIRT1499142	hsa-miR-450b-5p	CLIP-seq
MIRT1499143	hsa-miR-4659a-5p	CLIP-seq
MIRT1499144	hsa-miR-4659b-5p	CLIP-seq
MIRT1499145	hsa-miR-4666-3p	CLIP-seq
MIRT1499146	hsa-miR-4715-3p	CLIP-seq
MIRT1499147	hsa-miR-4722-3p	CLIP-seq
MIRT1499148	hsa-miR-4735-5p	CLIP-seq
MIRT1499149	hsa-miR-4772-3p	CLIP-seq
MIRT1499150	hsa-miR-4775	CLIP-seq
MIRT1499151	hsa-miR-4776-3p	CLIP-seq
MIRT1499152	hsa-miR-489	CLIP-seq
MIRT1499153	hsa-miR-498	CLIP-seq
MIRT1499154	hsa-miR-513c	CLIP-seq
MIRT1499155	hsa-miR-514b-5p	CLIP-seq
MIRT1499156	hsa-miR-548aa	CLIP-seq
MIRT1499157	hsa-miR-562	CLIP-seq
MIRT1499158	hsa-miR-590-3p	CLIP-seq
MIRT1499159	hsa-miR-630	CLIP-seq
MIRT1499160	hsa-miR-634	CLIP-seq
MIRT1499161	hsa-miR-643	CLIP-seq
MIRT1499162	hsa-miR-924	CLIP-seq
MIRT1499163	hsa-miR-122	CLIP-seq
MIRT1499164	hsa-miR-1273f	CLIP-seq
MIRT1499121	hsa-miR-129-5p	CLIP-seq
MIRT1499165	hsa-miR-154	CLIP-seq
MIRT1499166	hsa-miR-197	CLIP-seq
MIRT1499127	hsa-miR-2054	CLIP-seq
MIRT1499167	hsa-miR-3126-5p	CLIP-seq
MIRT1499131	hsa-miR-3137	CLIP-seq
MIRT1499168	hsa-miR-3140-3p	CLIP-seq
MIRT1499169	hsa-miR-3170	CLIP-seq
MIRT1499134	hsa-miR-323b-3p	CLIP-seq
MIRT1499135	hsa-miR-323b-5p	CLIP-seq
MIRT1499170	hsa-miR-335	CLIP-seq
MIRT1499171	hsa-miR-3622b-5p	CLIP-seq
MIRT1499172	hsa-miR-3662	CLIP-seq
MIRT1499138	hsa-miR-3935	CLIP-seq
MIRT1499173	hsa-miR-411	CLIP-seq
MIRT1499174	hsa-miR-4419a	CLIP-seq
MIRT1499140	hsa-miR-4423-5p	CLIP-seq
MIRT1499175	hsa-miR-4424	CLIP-seq
MIRT1499176	hsa-miR-4461	CLIP-seq
MIRT1499142	hsa-miR-450b-5p	CLIP-seq
MIRT1499177	hsa-miR-4510	CLIP-seq
MIRT1499145	hsa-miR-4666-3p	CLIP-seq
MIRT1499178	hsa-miR-4695-3p	CLIP-seq
MIRT1499179	hsa-miR-4698	CLIP-seq
MIRT1499180	hsa-miR-4726-3p	CLIP-seq
MIRT1499149	hsa-miR-4772-3p	CLIP-seq
MIRT1499150	hsa-miR-4775	CLIP-seq
MIRT1499181	hsa-miR-507	CLIP-seq
MIRT1499182	hsa-miR-5096	CLIP-seq
MIRT1499183	hsa-miR-557	CLIP-seq
MIRT1499184	hsa-miR-577	CLIP-seq
MIRT1499158	hsa-miR-590-3p	CLIP-seq
MIRT1499185	hsa-miR-664	CLIP-seq
MIRT2150297	hsa-miR-106a	CLIP-seq
MIRT2150298	hsa-miR-106b	CLIP-seq
MIRT1499163	hsa-miR-122	CLIP-seq
MIRT1499118	hsa-miR-1267	CLIP-seq
MIRT1499121	hsa-miR-129-5p	CLIP-seq
MIRT1499124	hsa-miR-1305	CLIP-seq
MIRT2150299	hsa-miR-17	CLIP-seq
MIRT1499126	hsa-miR-1827	CLIP-seq
MIRT1499166	hsa-miR-197	CLIP-seq
MIRT2150300	hsa-miR-20a	CLIP-seq
MIRT2150301	hsa-miR-20b	CLIP-seq
MIRT2150302	hsa-miR-217	CLIP-seq
MIRT2150303	hsa-miR-2277-3p	CLIP-seq
MIRT2150304	hsa-miR-3155	CLIP-seq
MIRT2150305	hsa-miR-3155b	CLIP-seq
MIRT1499133	hsa-miR-3194-3p	CLIP-seq
MIRT1499171	hsa-miR-3622b-5p	CLIP-seq
MIRT1499139	hsa-miR-431	CLIP-seq
MIRT2150306	hsa-miR-4418	CLIP-seq
MIRT1499140	hsa-miR-4423-5p	CLIP-seq
MIRT2150307	hsa-miR-4639-3p	CLIP-seq
MIRT1499149	hsa-miR-4772-3p	CLIP-seq
MIRT1499150	hsa-miR-4775	CLIP-seq
MIRT2150308	hsa-miR-484	CLIP-seq
MIRT2150309	hsa-miR-509-3-5p	CLIP-seq
MIRT2150310	hsa-miR-509-5p	CLIP-seq
MIRT1499182	hsa-miR-5096	CLIP-seq
MIRT2150311	hsa-miR-519d	CLIP-seq
MIRT2150312	hsa-miR-548t	CLIP-seq
MIRT1499158	hsa-miR-590-3p	CLIP-seq
MIRT1499161	hsa-miR-643	CLIP-seq
MIRT1499162	hsa-miR-924	CLIP-seq
MIRT2150313	hsa-miR-93	CLIP-seq
MIRT1499150	hsa-miR-4775	CLIP-seq
MIRT1499158	hsa-miR-590-3p	CLIP-seq
MIRT2150297	hsa-miR-106a	CLIP-seq
MIRT2150298	hsa-miR-106b	CLIP-seq
MIRT1499117	hsa-miR-1206	CLIP-seq
MIRT1499163	hsa-miR-122	CLIP-seq
MIRT2370598	hsa-miR-1228	CLIP-seq
MIRT2370599	hsa-miR-1256	CLIP-seq
MIRT1499118	hsa-miR-1267	CLIP-seq
MIRT1499120	hsa-miR-1279	CLIP-seq
MIRT1499121	hsa-miR-129-5p	CLIP-seq
MIRT1499124	hsa-miR-1305	CLIP-seq
MIRT2370600	hsa-miR-1306	CLIP-seq
MIRT1499125	hsa-miR-1343	CLIP-seq
MIRT1499165	hsa-miR-154	CLIP-seq
MIRT2150299	hsa-miR-17	CLIP-seq
MIRT2370601	hsa-miR-1914	CLIP-seq
MIRT1499166	hsa-miR-197	CLIP-seq
MIRT2370602	hsa-miR-1976	CLIP-seq
MIRT1499127	hsa-miR-2054	CLIP-seq
MIRT2150300	hsa-miR-20a	CLIP-seq
MIRT2150301	hsa-miR-20b	CLIP-seq
MIRT2150302	hsa-miR-217	CLIP-seq
MIRT1499128	hsa-miR-24	CLIP-seq
MIRT2370603	hsa-miR-302a	CLIP-seq
MIRT2370604	hsa-miR-302b	CLIP-seq
MIRT2370605	hsa-miR-302c	CLIP-seq
MIRT2370606	hsa-miR-302d	CLIP-seq
MIRT2370607	hsa-miR-302e	CLIP-seq
MIRT2370608	hsa-miR-30a	CLIP-seq
MIRT2370609	hsa-miR-30b	CLIP-seq
MIRT2370610	hsa-miR-30c	CLIP-seq
MIRT2370611	hsa-miR-30d	CLIP-seq
MIRT2370612	hsa-miR-30e	CLIP-seq
MIRT1499167	hsa-miR-3126-5p	CLIP-seq
MIRT1499168	hsa-miR-3140-3p	CLIP-seq
MIRT2370613	hsa-miR-3153	CLIP-seq
MIRT2370614	hsa-miR-3171	CLIP-seq
MIRT2370615	hsa-miR-3184	CLIP-seq
MIRT1499133	hsa-miR-3194-3p	CLIP-seq
MIRT2370616	hsa-miR-3199	CLIP-seq
MIRT1499135	hsa-miR-323b-5p	CLIP-seq
MIRT2370617	hsa-miR-328	CLIP-seq
MIRT2370618	hsa-miR-361-3p	CLIP-seq
MIRT1499171	hsa-miR-3622b-5p	CLIP-seq
MIRT1499172	hsa-miR-3662	CLIP-seq
MIRT2370619	hsa-miR-3692	CLIP-seq
MIRT2370620	hsa-miR-372	CLIP-seq
MIRT2370621	hsa-miR-373	CLIP-seq
MIRT2370622	hsa-miR-3924	CLIP-seq
MIRT1499173	hsa-miR-411	CLIP-seq
MIRT2370623	hsa-miR-423-5p	CLIP-seq
MIRT2370624	hsa-miR-4256	CLIP-seq
MIRT2370625	hsa-miR-4275	CLIP-seq
MIRT2370626	hsa-miR-4279	CLIP-seq
MIRT1499139	hsa-miR-431	CLIP-seq
MIRT2370627	hsa-miR-4312	CLIP-seq
MIRT2150306	hsa-miR-4418	CLIP-seq
MIRT1499174	hsa-miR-4419a	CLIP-seq
MIRT1499140	hsa-miR-4423-5p	CLIP-seq
MIRT2370628	hsa-miR-4427	CLIP-seq
MIRT2370629	hsa-miR-4436b-5p	CLIP-seq
MIRT1499177	hsa-miR-4510	CLIP-seq
MIRT2370630	hsa-miR-4642	CLIP-seq
MIRT2370631	hsa-miR-4652-5p	CLIP-seq
MIRT2370632	hsa-miR-4680-3p	CLIP-seq
MIRT2370633	hsa-miR-4684-5p	CLIP-seq
MIRT1499178	hsa-miR-4695-3p	CLIP-seq
MIRT1499179	hsa-miR-4698	CLIP-seq
MIRT2370634	hsa-miR-4719	CLIP-seq
MIRT1499147	hsa-miR-4722-3p	CLIP-seq
MIRT2370635	hsa-miR-4731-5p	CLIP-seq
MIRT2370636	hsa-miR-4740-5p	CLIP-seq
MIRT2370637	hsa-miR-4760-5p	CLIP-seq
MIRT2370638	hsa-miR-4762-3p	CLIP-seq
MIRT1499149	hsa-miR-4772-3p	CLIP-seq
MIRT1499150	hsa-miR-4775	CLIP-seq
MIRT1499153	hsa-miR-498	CLIP-seq
MIRT2150309	hsa-miR-509-3-5p	CLIP-seq
MIRT2150310	hsa-miR-509-5p	CLIP-seq
MIRT2370639	hsa-miR-512-3p	CLIP-seq
MIRT2370640	hsa-miR-513b	CLIP-seq
MIRT2150311	hsa-miR-519d	CLIP-seq
MIRT2370641	hsa-miR-520a-3p	CLIP-seq
MIRT2370642	hsa-miR-520b	CLIP-seq
MIRT2370643	hsa-miR-520c-3p	CLIP-seq
MIRT2370644	hsa-miR-520d-3p	CLIP-seq
MIRT2370645	hsa-miR-520e	CLIP-seq
MIRT2370646	hsa-miR-548a-5p	CLIP-seq
MIRT1499156	hsa-miR-548aa	CLIP-seq
MIRT2370647	hsa-miR-548ab	CLIP-seq
MIRT2370648	hsa-miR-548ak	CLIP-seq
MIRT2370649	hsa-miR-548b-5p	CLIP-seq
MIRT2370650	hsa-miR-548c-5p	CLIP-seq
MIRT2370651	hsa-miR-548d-5p	CLIP-seq
MIRT2370652	hsa-miR-548h	CLIP-seq
MIRT2370653	hsa-miR-548i	CLIP-seq
MIRT2370654	hsa-miR-548j	CLIP-seq
MIRT2370655	hsa-miR-548n	CLIP-seq
MIRT2150312	hsa-miR-548t	CLIP-seq
MIRT2370656	hsa-miR-548w	CLIP-seq
MIRT2370657	hsa-miR-548y	CLIP-seq
MIRT2370658	hsa-miR-559	CLIP-seq
MIRT2370659	hsa-miR-576-3p	CLIP-seq
MIRT1499158	hsa-miR-590-3p	CLIP-seq
MIRT1499160	hsa-miR-634	CLIP-seq
MIRT1499162	hsa-miR-924	CLIP-seq
MIRT2150313	hsa-miR-93	CLIP-seq
MIRT2370660	hsa-miR-942	CLIP-seq
MIRT1499125	hsa-miR-1343	CLIP-seq
MIRT2370598	hsa-miR-1228	CLIP-seq
MIRT2441716	hsa-miR-330-3p	CLIP-seq
MIRT2441717	hsa-miR-377	CLIP-seq
MIRT2370625	hsa-miR-4275	CLIP-seq
MIRT2441718	hsa-miR-4422	CLIP-seq
MIRT2150297	hsa-miR-106a	CLIP-seq
MIRT2150298	hsa-miR-106b	CLIP-seq
MIRT1499163	hsa-miR-122	CLIP-seq
MIRT2370598	hsa-miR-1228	CLIP-seq
MIRT2664274	hsa-miR-125a-3p	CLIP-seq
MIRT1499118	hsa-miR-1267	CLIP-seq
MIRT1499164	hsa-miR-1273f	CLIP-seq
MIRT1499121	hsa-miR-129-5p	CLIP-seq
MIRT1499122	hsa-miR-1297	CLIP-seq
MIRT2664275	hsa-miR-1299	CLIP-seq
MIRT1499125	hsa-miR-1343	CLIP-seq
MIRT2664276	hsa-miR-149	CLIP-seq
MIRT2664277	hsa-miR-150	CLIP-seq
MIRT2664278	hsa-miR-155	CLIP-seq
MIRT2150299	hsa-miR-17	CLIP-seq
MIRT1499126	hsa-miR-1827	CLIP-seq
MIRT2370601	hsa-miR-1914	CLIP-seq
MIRT2664279	hsa-miR-1915	CLIP-seq
MIRT2664280	hsa-miR-192	CLIP-seq
MIRT1499166	hsa-miR-197	CLIP-seq
MIRT2370602	hsa-miR-1976	CLIP-seq
MIRT2150300	hsa-miR-20a	CLIP-seq
MIRT2150301	hsa-miR-20b	CLIP-seq
MIRT2664281	hsa-miR-215	CLIP-seq
MIRT2150302	hsa-miR-217	CLIP-seq
MIRT1499128	hsa-miR-24	CLIP-seq
MIRT1499129	hsa-miR-26a	CLIP-seq
MIRT1499130	hsa-miR-26b	CLIP-seq
MIRT2370603	hsa-miR-302a	CLIP-seq
MIRT2370604	hsa-miR-302b	CLIP-seq
MIRT2370605	hsa-miR-302c	CLIP-seq
MIRT2370606	hsa-miR-302d	CLIP-seq
MIRT2370607	hsa-miR-302e	CLIP-seq
MIRT2664282	hsa-miR-3133	CLIP-seq
MIRT1499168	hsa-miR-3140-3p	CLIP-seq
MIRT2370613	hsa-miR-3153	CLIP-seq
MIRT2150304	hsa-miR-3155	CLIP-seq
MIRT2150305	hsa-miR-3155b	CLIP-seq
MIRT1499169	hsa-miR-3170	CLIP-seq
MIRT2370615	hsa-miR-3184	CLIP-seq
MIRT1499133	hsa-miR-3194-3p	CLIP-seq
MIRT2370616	hsa-miR-3199	CLIP-seq
MIRT2370617	hsa-miR-328	CLIP-seq
MIRT2441716	hsa-miR-330-3p	CLIP-seq
MIRT2370618	hsa-miR-361-3p	CLIP-seq
MIRT1499171	hsa-miR-3622b-5p	CLIP-seq
MIRT2664283	hsa-miR-3647-3p	CLIP-seq
MIRT2664284	hsa-miR-371-5p	CLIP-seq
MIRT1499137	hsa-miR-371b-5p	CLIP-seq
MIRT2370620	hsa-miR-372	CLIP-seq
MIRT2370621	hsa-miR-373	CLIP-seq
MIRT2441717	hsa-miR-377	CLIP-seq
MIRT2664285	hsa-miR-3934	CLIP-seq
MIRT1499173	hsa-miR-411	CLIP-seq
MIRT2370623	hsa-miR-423-5p	CLIP-seq
MIRT2370625	hsa-miR-4275	CLIP-seq
MIRT2370626	hsa-miR-4279	CLIP-seq
MIRT1499139	hsa-miR-431	CLIP-seq
MIRT2370627	hsa-miR-4312	CLIP-seq
MIRT2150306	hsa-miR-4418	CLIP-seq
MIRT2441718	hsa-miR-4422	CLIP-seq
MIRT1499140	hsa-miR-4423-5p	CLIP-seq
MIRT2664286	hsa-miR-4438	CLIP-seq
MIRT1499141	hsa-miR-4465	CLIP-seq
MIRT1499142	hsa-miR-450b-5p	CLIP-seq
MIRT2664287	hsa-miR-4645-3p	CLIP-seq
MIRT2370631	hsa-miR-4652-5p	CLIP-seq
MIRT2370633	hsa-miR-4684-5p	CLIP-seq
MIRT1499178	hsa-miR-4695-3p	CLIP-seq
MIRT2664288	hsa-miR-4707-3p	CLIP-seq
MIRT2664289	hsa-miR-4713-5p	CLIP-seq
MIRT1499146	hsa-miR-4715-3p	CLIP-seq
MIRT1499147	hsa-miR-4722-3p	CLIP-seq
MIRT1499180	hsa-miR-4726-3p	CLIP-seq
MIRT2370635	hsa-miR-4731-5p	CLIP-seq
MIRT2664290	hsa-miR-4733-5p	CLIP-seq
MIRT2664291	hsa-miR-4757-5p	CLIP-seq
MIRT2370637	hsa-miR-4760-5p	CLIP-seq
MIRT2664292	hsa-miR-4766-5p	CLIP-seq
MIRT1499149	hsa-miR-4772-3p	CLIP-seq
MIRT1499150	hsa-miR-4775	CLIP-seq
MIRT2664293	hsa-miR-4794	CLIP-seq
MIRT2150308	hsa-miR-484	CLIP-seq
MIRT1499153	hsa-miR-498	CLIP-seq
MIRT2664294	hsa-miR-501-3p	CLIP-seq
MIRT2664295	hsa-miR-502-3p	CLIP-seq
MIRT1499181	hsa-miR-507	CLIP-seq
MIRT2150309	hsa-miR-509-3-5p	CLIP-seq
MIRT2664296	hsa-miR-5095	CLIP-seq
MIRT2150310	hsa-miR-509-5p	CLIP-seq
MIRT1499182	hsa-miR-5096	CLIP-seq
MIRT2370639	hsa-miR-512-3p	CLIP-seq
MIRT1499154	hsa-miR-513c	CLIP-seq
MIRT1499155	hsa-miR-514b-5p	CLIP-seq
MIRT2150311	hsa-miR-519d	CLIP-seq
MIRT2370641	hsa-miR-520a-3p	CLIP-seq
MIRT2370642	hsa-miR-520b	CLIP-seq
MIRT2370643	hsa-miR-520c-3p	CLIP-seq
MIRT2370644	hsa-miR-520d-3p	CLIP-seq
MIRT2370645	hsa-miR-520e	CLIP-seq
MIRT2664297	hsa-miR-532-3p	CLIP-seq
MIRT1499156	hsa-miR-548aa	CLIP-seq
MIRT2370655	hsa-miR-548n	CLIP-seq
MIRT2150312	hsa-miR-548t	CLIP-seq
MIRT1499183	hsa-miR-557	CLIP-seq
MIRT1499157	hsa-miR-562	CLIP-seq
MIRT1499158	hsa-miR-590-3p	CLIP-seq
MIRT1499159	hsa-miR-630	CLIP-seq
MIRT1499160	hsa-miR-634	CLIP-seq
MIRT1499161	hsa-miR-643	CLIP-seq
MIRT1499185	hsa-miR-664	CLIP-seq
MIRT2664298	hsa-miR-760	CLIP-seq
MIRT2664299	hsa-miR-764	CLIP-seq
MIRT2664300	hsa-miR-767-5p	CLIP-seq
MIRT2664301	hsa-miR-875-3p	CLIP-seq
MIRT1499162	hsa-miR-924	CLIP-seq
MIRT2150313	hsa-miR-93	CLIP-seq
MIRT2370660	hsa-miR-942	CLIP-seq
MIRT2150297	hsa-miR-106a	CLIP-seq
MIRT2150298	hsa-miR-106b	CLIP-seq
MIRT1499163	hsa-miR-122	CLIP-seq
MIRT2370598	hsa-miR-1228	CLIP-seq
MIRT2664274	hsa-miR-125a-3p	CLIP-seq
MIRT1499118	hsa-miR-1267	CLIP-seq
MIRT1499164	hsa-miR-1273f	CLIP-seq
MIRT1499121	hsa-miR-129-5p	CLIP-seq
MIRT1499122	hsa-miR-1297	CLIP-seq
MIRT2664275	hsa-miR-1299	CLIP-seq
MIRT1499125	hsa-miR-1343	CLIP-seq
MIRT2664276	hsa-miR-149	CLIP-seq
MIRT2664277	hsa-miR-150	CLIP-seq
MIRT2150299	hsa-miR-17	CLIP-seq
MIRT1499126	hsa-miR-1827	CLIP-seq
MIRT2370601	hsa-miR-1914	CLIP-seq
MIRT2664279	hsa-miR-1915	CLIP-seq
MIRT2664280	hsa-miR-192	CLIP-seq
MIRT1499166	hsa-miR-197	CLIP-seq
MIRT2370602	hsa-miR-1976	CLIP-seq
MIRT2150300	hsa-miR-20a	CLIP-seq
MIRT2150301	hsa-miR-20b	CLIP-seq
MIRT2664281	hsa-miR-215	CLIP-seq
MIRT2150302	hsa-miR-217	CLIP-seq
MIRT1499128	hsa-miR-24	CLIP-seq
MIRT1499129	hsa-miR-26a	CLIP-seq
MIRT1499130	hsa-miR-26b	CLIP-seq
MIRT2370603	hsa-miR-302a	CLIP-seq
MIRT2370604	hsa-miR-302b	CLIP-seq
MIRT2370605	hsa-miR-302c	CLIP-seq
MIRT2370606	hsa-miR-302d	CLIP-seq
MIRT2370607	hsa-miR-302e	CLIP-seq
MIRT1499168	hsa-miR-3140-3p	CLIP-seq
MIRT2370613	hsa-miR-3153	CLIP-seq
MIRT2150304	hsa-miR-3155	CLIP-seq
MIRT2150305	hsa-miR-3155b	CLIP-seq
MIRT1499169	hsa-miR-3170	CLIP-seq
MIRT2370615	hsa-miR-3184	CLIP-seq
MIRT1499133	hsa-miR-3194-3p	CLIP-seq
MIRT2370617	hsa-miR-328	CLIP-seq
MIRT2441716	hsa-miR-330-3p	CLIP-seq
MIRT2370618	hsa-miR-361-3p	CLIP-seq
MIRT1499171	hsa-miR-3622b-5p	CLIP-seq
MIRT2664284	hsa-miR-371-5p	CLIP-seq
MIRT1499137	hsa-miR-371b-5p	CLIP-seq
MIRT2370620	hsa-miR-372	CLIP-seq
MIRT2370621	hsa-miR-373	CLIP-seq
MIRT2441717	hsa-miR-377	CLIP-seq
MIRT2664285	hsa-miR-3934	CLIP-seq
MIRT1499173	hsa-miR-411	CLIP-seq
MIRT2370623	hsa-miR-423-5p	CLIP-seq
MIRT2370625	hsa-miR-4275	CLIP-seq
MIRT2370626	hsa-miR-4279	CLIP-seq
MIRT1499139	hsa-miR-431	CLIP-seq
MIRT2370627	hsa-miR-4312	CLIP-seq
MIRT2150306	hsa-miR-4418	CLIP-seq
MIRT2441718	hsa-miR-4422	CLIP-seq
MIRT1499140	hsa-miR-4423-5p	CLIP-seq
MIRT2664286	hsa-miR-4438	CLIP-seq
MIRT1499141	hsa-miR-4465	CLIP-seq
MIRT1499142	hsa-miR-450b-5p	CLIP-seq
MIRT2370633	hsa-miR-4684-5p	CLIP-seq
MIRT1499178	hsa-miR-4695-3p	CLIP-seq
MIRT2664288	hsa-miR-4707-3p	CLIP-seq
MIRT2664289	hsa-miR-4713-5p	CLIP-seq
MIRT1499146	hsa-miR-4715-3p	CLIP-seq
MIRT1499147	hsa-miR-4722-3p	CLIP-seq
MIRT1499180	hsa-miR-4726-3p	CLIP-seq
MIRT2370635	hsa-miR-4731-5p	CLIP-seq
MIRT2664290	hsa-miR-4733-5p	CLIP-seq
MIRT2664291	hsa-miR-4757-5p	CLIP-seq
MIRT2370637	hsa-miR-4760-5p	CLIP-seq
MIRT2664292	hsa-miR-4766-5p	CLIP-seq
MIRT1499149	hsa-miR-4772-3p	CLIP-seq
MIRT1499150	hsa-miR-4775	CLIP-seq
MIRT2150308	hsa-miR-484	CLIP-seq
MIRT1499153	hsa-miR-498	CLIP-seq
MIRT2664294	hsa-miR-501-3p	CLIP-seq
MIRT2664295	hsa-miR-502-3p	CLIP-seq
MIRT1499181	hsa-miR-507	CLIP-seq
MIRT2150309	hsa-miR-509-3-5p	CLIP-seq
MIRT2664296	hsa-miR-5095	CLIP-seq
MIRT2150310	hsa-miR-509-5p	CLIP-seq
MIRT1499182	hsa-miR-5096	CLIP-seq
MIRT2370639	hsa-miR-512-3p	CLIP-seq
MIRT1499154	hsa-miR-513c	CLIP-seq
MIRT1499155	hsa-miR-514b-5p	CLIP-seq
MIRT2150311	hsa-miR-519d	CLIP-seq
MIRT2370641	hsa-miR-520a-3p	CLIP-seq
MIRT2370642	hsa-miR-520b	CLIP-seq
MIRT2370643	hsa-miR-520c-3p	CLIP-seq
MIRT2370644	hsa-miR-520d-3p	CLIP-seq
MIRT2370645	hsa-miR-520e	CLIP-seq
MIRT2664297	hsa-miR-532-3p	CLIP-seq
MIRT1499156	hsa-miR-548aa	CLIP-seq
MIRT2370655	hsa-miR-548n	CLIP-seq
MIRT2150312	hsa-miR-548t	CLIP-seq
MIRT1499183	hsa-miR-557	CLIP-seq
MIRT1499157	hsa-miR-562	CLIP-seq
MIRT1499158	hsa-miR-590-3p	CLIP-seq
MIRT1499159	hsa-miR-630	CLIP-seq
MIRT1499160	hsa-miR-634	CLIP-seq
MIRT1499161	hsa-miR-643	CLIP-seq
MIRT1499185	hsa-miR-664	CLIP-seq
MIRT2664298	hsa-miR-760	CLIP-seq
MIRT2664299	hsa-miR-764	CLIP-seq
MIRT2664300	hsa-miR-767-5p	CLIP-seq
MIRT2664301	hsa-miR-875-3p	CLIP-seq
MIRT1499162	hsa-miR-924	CLIP-seq
MIRT2150313	hsa-miR-93	CLIP-seq
MIRT2370660	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004176	Function	ATP-dependent peptidase activity	IBA
GO:0004176	Function	ATP-dependent peptidase activity	IDA	24315374, 27786171, 31695197, 33237841, 36206740
GO:0004176	Function	ATP-dependent peptidase activity	IEA
GO:0004176	Function	ATP-dependent peptidase activity	IMP	27495975
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	26759378
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	27495975
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IDA	22262461
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0006515	Process	Protein quality control for misfolded or incompletely synthesized proteins	IBA
GO:0006515	Process	Protein quality control for misfolded or incompletely synthesized proteins	IMP	22262461
GO:0007005	Process	Mitochondrion organization	IBA
GO:0007005	Process	Mitochondrion organization	IMP	22262461, 27495975
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008283	Process	Cell population proliferation	IMP	22262461
GO:0009267	Process	Cellular response to starvation	IDA	31695197
GO:0010636	Process	Positive regulation of mitochondrial fusion	IDA	33237841
GO:0010636	Process	Positive regulation of mitochondrial fusion	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0034214	Process	Protein hexamerization	IDA	27786171
GO:0034982	Process	Mitochondrial protein processing	IEA
GO:0034982	Process	Mitochondrial protein processing	IMP	27495975
GO:0035694	Process	Mitochondrial protein catabolic process	IMP	27495975, 27786171
GO:0043066	Process	Negative regulation of apoptotic process	IMP	22262461
GO:0046872	Function	Metal ion binding	IEA
GO:0097150	Process	Neuronal stem cell population maintenance	IEA
GO:0097150	Process	Neuronal stem cell population maintenance	ISS
GO:2000035	Process	Regulation of stem cell division	IEA
GO:2000035	Process	Regulation of stem cell division	ISS

Other IDs

• MIM: 607472
• HGNC: 12843
• e!Ensembl: ENSG00000136758

Protein

• UniProt ID: Q96TA2
• Protein name: ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (EC 3.6.-.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1)
• Protein function: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:24315374, PubMed:26923599, PubMed:27786171, PubMed:31695197, PubMed:33
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00004	AAA	375 → 506	ATPase family associated with various cellular activities (AAA)	Domain
  PF17862	AAA_lid_3	528 → 572	AAA+ lid domain	Domain
  PF01434	Peptidase_M41	586 → 764	Peptidase family M41	Domain

• Tissue specificity: TISSUE SPECIFICITY: High expression in cardiac and skeletal muscle mitochondria. {ECO:0000269|PubMed:22262461}.
• Sequence:

  MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSECMFS
  DFLTKLNIVSIGKGKIFEGYRSMFMEPAKRMKKSLDTTDNWHIRPEPFSLSIPPSLNLRD
  LGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYGNLDIFSTLRSSC
  LYRHHSRALQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFL
  LRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVL
  LLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKN
  PQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRI
  RNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIG
  ATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVG
  FSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHE
  SGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVA
  EELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQE
  IRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR

• Sequence length: 773

Pathways

Reactome:

Processing of SMDT1

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Optic atrophy 11	Pathogenic	rs1057519312	RCV000415698	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTOSOMAL RECESSIVE ISOLATED OPTIC ATROPHY	—	Disgenet, Orphanet Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL RECESSIVE OPTIC ATROPHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma susceptibility 1	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Long QT syndrome	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Microcephaly	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL DISEASE	—	CTD, ClinGen	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL DISEASES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Retinal dystrophy	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
YME1L1-related disorder	Benign; Uncertain significance; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	26687188	Stimulate	★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	31695197		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	26079624		★☆☆☆☆ Found in Text Mining only
Autosomal recessive isolated optic atrophy	Optic Atrophy	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Brain atrophy	Brain atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cerebellar Hypoplasia	Cerebellar Hypoplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cerebral atrophy	Cerebral Atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	31439414		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	28356157	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	28356157	Associate	★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	29490017		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	24556692		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	25092567		★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Encephalitis	Encephalitis	BEFREE	31439414		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	19602686	Associate	★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	29490017		★☆☆☆☆ Found in Text Mining only
Hidradenitis Suppurativa	Hidradenitis suppurativa	BEFREE	31688984		★☆☆☆☆ Found in Text Mining only
Hyperopia	Hyperopia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Leukoencephalopathy	Leukoencephalopathy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Leukopenia	Leukopenia	BEFREE	26932183		★☆☆☆☆ Found in Text Mining only
Macrocephaly	Macrocephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Macrotia	Macrotia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26392082		★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	HPO_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Microphthalmos	Microphthalmos	BEFREE	30389680		★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	24176854, 27495975	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple Sclerosis	Multiple Sclerosis	BEFREE	30897575		★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29904904, 30859632		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	30859632		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	30859632	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	30859632	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	10843804, 30859632		★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	BEFREE	26932183		★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	BEFREE	29785003		★☆☆☆☆ Found in Text Mining only
Optic Atrophy	Optic Atrophy	BEFREE	27495975		★☆☆☆☆ Found in Text Mining only
Optic Atrophy	Optic atrophy	Pubtator	27495975	Associate	★☆☆☆☆ Found in Text Mining only
Optic Atrophy	Optic Atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Optic Atrophy 1	Optic Atrophy	BEFREE	28174208, 30544562, 31125351		★☆☆☆☆ Found in Text Mining only
OPTIC ATROPHY 11	Optic Atrophy	GENOMICS_ENGLAND_DG	27495975, 30544562		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
OPTIC ATROPHY 11	Optic Atrophy	UNIPROT_DG	27495975		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
OPTIC ATROPHY 11	Optic Atrophy	CTD_human_DG			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	36423401	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	31695197		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	24556692		★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	GENOMICS_ENGLAND_DG	30544562		★☆☆☆☆ Found in Text Mining only
Sleep Deprivation	Sleep deprivation	Pubtator	24176854	Inhibit	★☆☆☆☆ Found in Text Mining only
Sleep Deprivation	Sleep deprivation	Pubtator	27495975	Associate	★☆☆☆☆ Found in Text Mining only
Sleep Deprivation	Sleep deprivation	Pubtator	30859632	Stimulate	★☆☆☆☆ Found in Text Mining only
Spastic Paraplegia, Hereditary	Spastic paraplegia	BEFREE	10843804		★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	HPO_DG			★☆☆☆☆ Found in Text Mining only