Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10721
Gene name	DNA polymerase theta
Gene symbol	POLQ
Synonyms (NCBI Gene)	PRO0327
Chromosome	3
Chromosome location	3q13.33

461

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016401	hsa-miR-193b-3p	Microarray	20304954
MIRT026348	hsa-miR-192-5p	Microarray	19074876
MIRT047989	hsa-miR-30c-5p	CLASH	23622248
MIRT722261	hsa-miR-4324	HITS-CLIP	19536157
MIRT722260	hsa-miR-544b	HITS-CLIP	19536157
MIRT622665	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT622664	hsa-miR-1976	HITS-CLIP	19536157
MIRT722259	hsa-miR-3670	HITS-CLIP	19536157
MIRT722258	hsa-miR-1200	HITS-CLIP	19536157
MIRT722257	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT722256	hsa-miR-3672	HITS-CLIP	19536157
MIRT722255	hsa-miR-6864-3p	HITS-CLIP	19536157
MIRT722254	hsa-miR-8055	HITS-CLIP	19536157
MIRT722253	hsa-miR-129-5p	HITS-CLIP	19536157
MIRT666881	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT666880	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT666879	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT666878	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT666877	hsa-miR-3615	HITS-CLIP	23824327
MIRT571054	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT666876	hsa-miR-4634	HITS-CLIP	23824327
MIRT622671	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT622670	hsa-miR-8062	HITS-CLIP	23824327
MIRT622669	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT622668	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT622667	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT622666	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT622665	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT622664	hsa-miR-1976	HITS-CLIP	23824327
MIRT654934	hsa-miR-4279	HITS-CLIP	23824327
MIRT632581	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT632580	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT632579	hsa-miR-25-3p	HITS-CLIP	23824327
MIRT632578	hsa-miR-32-5p	HITS-CLIP	23824327
MIRT632577	hsa-miR-363-3p	HITS-CLIP	23824327
MIRT632576	hsa-miR-367-3p	HITS-CLIP	23824327
MIRT632575	hsa-miR-92a-3p	HITS-CLIP	23824327
MIRT632574	hsa-miR-92b-3p	HITS-CLIP	23824327
MIRT521834	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT632571	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT632570	hsa-miR-4794	HITS-CLIP	23824327
MIRT632569	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT632568	hsa-miR-4672	HITS-CLIP	23824327
MIRT632567	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT632566	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT632565	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT160692	hsa-miR-7703	HITS-CLIP	23824327
MIRT632581	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT632580	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT521834	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT632573	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT632572	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT632571	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT632570	hsa-miR-4794	HITS-CLIP	23824327
MIRT632569	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT632568	hsa-miR-4672	HITS-CLIP	23824327
MIRT632567	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT632566	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT160692	hsa-miR-7703	HITS-CLIP	23824327
MIRT622671	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT622668	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT622667	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT622666	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT632582	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT622665	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT622664	hsa-miR-1976	HITS-CLIP	23824327
MIRT632581	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT632580	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT632579	hsa-miR-25-3p	HITS-CLIP	23824327
MIRT632578	hsa-miR-32-5p	HITS-CLIP	23824327
MIRT632577	hsa-miR-363-3p	HITS-CLIP	23824327
MIRT632576	hsa-miR-367-3p	HITS-CLIP	23824327
MIRT632575	hsa-miR-92a-3p	HITS-CLIP	23824327
MIRT632574	hsa-miR-92b-3p	HITS-CLIP	23824327
MIRT521834	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT632573	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT632572	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT632571	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT632570	hsa-miR-4794	HITS-CLIP	23824327
MIRT632569	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT632568	hsa-miR-4672	HITS-CLIP	23824327
MIRT632567	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT632566	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT632565	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT160692	hsa-miR-7703	HITS-CLIP	23824327
MIRT622671	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT622670	hsa-miR-8062	HITS-CLIP	23824327
MIRT622669	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT622668	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT622667	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT622666	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT622665	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT622664	hsa-miR-1976	HITS-CLIP	23824327
MIRT622663	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT622662	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT571059	hsa-miR-4519	PAR-CLIP	20371350
MIRT571060	hsa-miR-922	PAR-CLIP	20371350
MIRT571058	hsa-miR-214-3p	PAR-CLIP	20371350
MIRT571057	hsa-miR-3619-5p	PAR-CLIP	20371350
MIRT571056	hsa-miR-761	PAR-CLIP	20371350
MIRT571055	hsa-miR-194-3p	PAR-CLIP	20371350
MIRT571053	hsa-miR-6773-3p	PAR-CLIP	20371350
MIRT571054	hsa-miR-215-3p	PAR-CLIP	20371350
MIRT571052	hsa-miR-4654	PAR-CLIP	20371350
MIRT571051	hsa-miR-4769-5p	PAR-CLIP	20371350
MIRT571050	hsa-miR-4291	PAR-CLIP	20371350
MIRT571049	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT521834	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT521833	hsa-miR-4252	PAR-CLIP	23446348
MIRT521832	hsa-miR-6511b-5p	PAR-CLIP	23446348
MIRT521831	hsa-miR-6811-5p	PAR-CLIP	23446348
MIRT160683	hsa-miR-5683	PAR-CLIP	23592263
MIRT160682	hsa-miR-1295b-5p	PAR-CLIP	23592263
MIRT160662	hsa-miR-1912	PAR-CLIP	23592263
MIRT460914	hsa-miR-3130-5p	PAR-CLIP	23592263
MIRT460913	hsa-miR-4482-5p	PAR-CLIP	23592263
MIRT460912	hsa-miR-576-3p	PAR-CLIP	23592263
MIRT460911	hsa-miR-4491	PAR-CLIP	23592263
MIRT460910	hsa-miR-4657	PAR-CLIP	23592263
MIRT160660	hsa-miR-1324	PAR-CLIP	23592263
MIRT460909	hsa-miR-299-5p	PAR-CLIP	23592263
MIRT460908	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT460907	hsa-miR-5591-3p	PAR-CLIP	23592263
MIRT460906	hsa-miR-6833-5p	PAR-CLIP	23592263
MIRT460905	hsa-miR-6875-3p	PAR-CLIP	23592263
MIRT460904	hsa-miR-4659a-3p	PAR-CLIP	23592263
MIRT460903	hsa-miR-4659b-3p	PAR-CLIP	23592263
MIRT439935	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439933	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439935	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT726906	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT726905	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT726903	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT726904	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT439933	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT722261	hsa-miR-4324	HITS-CLIP	19536157
MIRT722260	hsa-miR-544b	HITS-CLIP	19536157
MIRT622665	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT622664	hsa-miR-1976	HITS-CLIP	19536157
MIRT722259	hsa-miR-3670	HITS-CLIP	19536157
MIRT722258	hsa-miR-1200	HITS-CLIP	19536157
MIRT722257	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT722256	hsa-miR-3672	HITS-CLIP	19536157
MIRT722255	hsa-miR-6864-3p	HITS-CLIP	19536157
MIRT722254	hsa-miR-8055	HITS-CLIP	19536157
MIRT722253	hsa-miR-129-5p	HITS-CLIP	19536157
MIRT666881	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT666880	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT666879	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT666878	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT666877	hsa-miR-3615	HITS-CLIP	23824327
MIRT571054	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT666876	hsa-miR-4634	HITS-CLIP	23824327
MIRT622671	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT622670	hsa-miR-8062	HITS-CLIP	23824327
MIRT622669	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT622668	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT622667	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT622666	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT622665	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT622664	hsa-miR-1976	HITS-CLIP	23824327
MIRT654934	hsa-miR-4279	HITS-CLIP	23824327
MIRT632581	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT632580	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT632579	hsa-miR-25-3p	HITS-CLIP	23824327
MIRT632578	hsa-miR-32-5p	HITS-CLIP	23824327
MIRT632577	hsa-miR-363-3p	HITS-CLIP	23824327
MIRT632576	hsa-miR-367-3p	HITS-CLIP	23824327
MIRT632575	hsa-miR-92a-3p	HITS-CLIP	23824327
MIRT632574	hsa-miR-92b-3p	HITS-CLIP	23824327
MIRT521834	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT632571	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT632570	hsa-miR-4794	HITS-CLIP	23824327
MIRT632569	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT632568	hsa-miR-4672	HITS-CLIP	23824327
MIRT632567	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT632566	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT632565	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT160692	hsa-miR-7703	HITS-CLIP	23824327
MIRT632581	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT632580	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT521834	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT632573	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT632572	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT632571	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT632570	hsa-miR-4794	HITS-CLIP	23824327
MIRT632569	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT632568	hsa-miR-4672	HITS-CLIP	23824327
MIRT632567	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT632566	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT160692	hsa-miR-7703	HITS-CLIP	23824327
MIRT622671	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT622668	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT622667	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT622666	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT632582	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT622665	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT622664	hsa-miR-1976	HITS-CLIP	23824327
MIRT632581	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT632580	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT632579	hsa-miR-25-3p	HITS-CLIP	23824327
MIRT632578	hsa-miR-32-5p	HITS-CLIP	23824327
MIRT632577	hsa-miR-363-3p	HITS-CLIP	23824327
MIRT632576	hsa-miR-367-3p	HITS-CLIP	23824327
MIRT632575	hsa-miR-92a-3p	HITS-CLIP	23824327
MIRT632574	hsa-miR-92b-3p	HITS-CLIP	23824327
MIRT521834	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT632573	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT632572	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT632571	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT632570	hsa-miR-4794	HITS-CLIP	23824327
MIRT632569	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT632568	hsa-miR-4672	HITS-CLIP	23824327
MIRT632567	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT632566	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT632565	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT160692	hsa-miR-7703	HITS-CLIP	23824327
MIRT622671	hsa-miR-4661-5p	HITS-CLIP	23824327
MIRT622670	hsa-miR-8062	HITS-CLIP	23824327
MIRT622669	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT622668	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT622667	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT622666	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT622665	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT622664	hsa-miR-1976	HITS-CLIP	23824327
MIRT622663	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT622662	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT571059	hsa-miR-4519	PAR-CLIP	20371350
MIRT571060	hsa-miR-922	PAR-CLIP	20371350
MIRT571058	hsa-miR-214-3p	PAR-CLIP	20371350
MIRT571057	hsa-miR-3619-5p	PAR-CLIP	20371350
MIRT571056	hsa-miR-761	PAR-CLIP	20371350
MIRT571055	hsa-miR-194-3p	PAR-CLIP	20371350
MIRT571053	hsa-miR-6773-3p	PAR-CLIP	20371350
MIRT571054	hsa-miR-215-3p	PAR-CLIP	20371350
MIRT571052	hsa-miR-4654	PAR-CLIP	20371350
MIRT571051	hsa-miR-4769-5p	PAR-CLIP	20371350
MIRT571050	hsa-miR-4291	PAR-CLIP	20371350
MIRT571049	hsa-miR-5089-5p	PAR-CLIP	20371350
MIRT521834	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT521833	hsa-miR-4252	PAR-CLIP	23446348
MIRT521832	hsa-miR-6511b-5p	PAR-CLIP	23446348
MIRT521831	hsa-miR-6811-5p	PAR-CLIP	23446348
MIRT160683	hsa-miR-5683	PAR-CLIP	23592263
MIRT160682	hsa-miR-1295b-5p	PAR-CLIP	23592263
MIRT160662	hsa-miR-1912	PAR-CLIP	23592263
MIRT460914	hsa-miR-3130-5p	PAR-CLIP	23592263
MIRT460913	hsa-miR-4482-5p	PAR-CLIP	23592263
MIRT460912	hsa-miR-576-3p	PAR-CLIP	23592263
MIRT460911	hsa-miR-4491	PAR-CLIP	23592263
MIRT460910	hsa-miR-4657	PAR-CLIP	23592263
MIRT160660	hsa-miR-1324	PAR-CLIP	23592263
MIRT460909	hsa-miR-299-5p	PAR-CLIP	23592263
MIRT460908	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT460907	hsa-miR-5591-3p	PAR-CLIP	23592263
MIRT460906	hsa-miR-6833-5p	PAR-CLIP	23592263
MIRT460905	hsa-miR-6875-3p	PAR-CLIP	23592263
MIRT460904	hsa-miR-4659a-3p	PAR-CLIP	23592263
MIRT460903	hsa-miR-4659b-3p	PAR-CLIP	23592263
MIRT1248080	hsa-let-7a	CLIP-seq
MIRT1248081	hsa-let-7b	CLIP-seq
MIRT1248082	hsa-let-7c	CLIP-seq
MIRT1248083	hsa-let-7d	CLIP-seq
MIRT1248084	hsa-let-7e	CLIP-seq
MIRT1248085	hsa-let-7f	CLIP-seq
MIRT1248086	hsa-let-7g	CLIP-seq
MIRT1248087	hsa-let-7i	CLIP-seq
MIRT1248088	hsa-miR-106a	CLIP-seq
MIRT1248089	hsa-miR-106b	CLIP-seq
MIRT1248090	hsa-miR-1229	CLIP-seq
MIRT1248091	hsa-miR-1252	CLIP-seq
MIRT1248092	hsa-miR-1304	CLIP-seq
MIRT1248093	hsa-miR-1305	CLIP-seq
MIRT1248094	hsa-miR-17	CLIP-seq
MIRT1248095	hsa-miR-1827	CLIP-seq
MIRT1248096	hsa-miR-202	CLIP-seq
MIRT1248097	hsa-miR-2052	CLIP-seq
MIRT1248098	hsa-miR-20a	CLIP-seq
MIRT1248099	hsa-miR-20b	CLIP-seq
MIRT1248100	hsa-miR-216a	CLIP-seq
MIRT1248101	hsa-miR-216b	CLIP-seq
MIRT1248102	hsa-miR-297	CLIP-seq
MIRT1248103	hsa-miR-302a	CLIP-seq
MIRT1248104	hsa-miR-302b	CLIP-seq
MIRT1248105	hsa-miR-302c	CLIP-seq
MIRT1248106	hsa-miR-302d	CLIP-seq
MIRT1248107	hsa-miR-302e	CLIP-seq
MIRT1248108	hsa-miR-3120-3p	CLIP-seq
MIRT1248109	hsa-miR-3149	CLIP-seq
MIRT1248110	hsa-miR-3162-5p	CLIP-seq
MIRT1248111	hsa-miR-3190	CLIP-seq
MIRT1248112	hsa-miR-372	CLIP-seq
MIRT1248113	hsa-miR-373	CLIP-seq
MIRT1248114	hsa-miR-376a	CLIP-seq
MIRT1248115	hsa-miR-376b	CLIP-seq
MIRT1248116	hsa-miR-3920	CLIP-seq
MIRT1248117	hsa-miR-3973	CLIP-seq
MIRT1248118	hsa-miR-421	CLIP-seq
MIRT1248119	hsa-miR-4289	CLIP-seq
MIRT1248120	hsa-miR-4307	CLIP-seq
MIRT1248121	hsa-miR-4310	CLIP-seq
MIRT1248122	hsa-miR-4427	CLIP-seq
MIRT1248123	hsa-miR-4458	CLIP-seq
MIRT1248124	hsa-miR-448	CLIP-seq
MIRT1248125	hsa-miR-4482	CLIP-seq
MIRT1248126	hsa-miR-4500	CLIP-seq
MIRT1248127	hsa-miR-450b-3p	CLIP-seq
MIRT1248128	hsa-miR-4533	CLIP-seq
MIRT1248129	hsa-miR-4639-5p	CLIP-seq
MIRT1248130	hsa-miR-4663	CLIP-seq
MIRT1248131	hsa-miR-4680-3p	CLIP-seq
MIRT1248132	hsa-miR-4709-5p	CLIP-seq
MIRT1248133	hsa-miR-4713-3p	CLIP-seq
MIRT1248134	hsa-miR-4719	CLIP-seq
MIRT1248135	hsa-miR-4747-5p	CLIP-seq
MIRT1248136	hsa-miR-4760-3p	CLIP-seq
MIRT1248137	hsa-miR-488	CLIP-seq
MIRT1248138	hsa-miR-498	CLIP-seq
MIRT1248139	hsa-miR-509-3p	CLIP-seq
MIRT1248140	hsa-miR-519a	CLIP-seq
MIRT1248141	hsa-miR-519b-3p	CLIP-seq
MIRT1248142	hsa-miR-519c-3p	CLIP-seq
MIRT1248143	hsa-miR-519d	CLIP-seq
MIRT1248144	hsa-miR-520a-3p	CLIP-seq
MIRT1248145	hsa-miR-520b	CLIP-seq
MIRT1248146	hsa-miR-520c-3p	CLIP-seq
MIRT1248147	hsa-miR-520d-3p	CLIP-seq
MIRT1248148	hsa-miR-520e	CLIP-seq
MIRT1248149	hsa-miR-520g	CLIP-seq
MIRT1248150	hsa-miR-520h	CLIP-seq
MIRT1248151	hsa-miR-545	CLIP-seq
MIRT1248152	hsa-miR-548ac	CLIP-seq
MIRT1248153	hsa-miR-548ae	CLIP-seq
MIRT1248154	hsa-miR-548aj	CLIP-seq
MIRT1248155	hsa-miR-548am	CLIP-seq
MIRT1248156	hsa-miR-548an	CLIP-seq
MIRT1248157	hsa-miR-548d-3p	CLIP-seq
MIRT1248158	hsa-miR-548k	CLIP-seq
MIRT1248159	hsa-miR-548p	CLIP-seq
MIRT1248160	hsa-miR-548x	CLIP-seq
MIRT1248161	hsa-miR-548z	CLIP-seq
MIRT1248162	hsa-miR-561	CLIP-seq
MIRT1248163	hsa-miR-579	CLIP-seq
MIRT1248164	hsa-miR-600	CLIP-seq
MIRT1248165	hsa-miR-628-5p	CLIP-seq
MIRT1248166	hsa-miR-629	CLIP-seq
MIRT1248167	hsa-miR-638	CLIP-seq
MIRT1248168	hsa-miR-642a	CLIP-seq
MIRT1248169	hsa-miR-646	CLIP-seq
MIRT1248170	hsa-miR-769-3p	CLIP-seq
MIRT1248171	hsa-miR-93	CLIP-seq
MIRT1248172	hsa-miR-98	CLIP-seq
MIRT1248080	hsa-let-7a	CLIP-seq
MIRT1248081	hsa-let-7b	CLIP-seq
MIRT1248082	hsa-let-7c	CLIP-seq
MIRT1248083	hsa-let-7d	CLIP-seq
MIRT1248084	hsa-let-7e	CLIP-seq
MIRT1248085	hsa-let-7f	CLIP-seq
MIRT1248086	hsa-let-7g	CLIP-seq
MIRT1248087	hsa-let-7i	CLIP-seq
MIRT2073241	hsa-miR-1264	CLIP-seq
MIRT1248096	hsa-miR-202	CLIP-seq
MIRT1248097	hsa-miR-2052	CLIP-seq
MIRT1248118	hsa-miR-421	CLIP-seq
MIRT1248120	hsa-miR-4307	CLIP-seq
MIRT1248123	hsa-miR-4458	CLIP-seq
MIRT1248125	hsa-miR-4482	CLIP-seq
MIRT1248126	hsa-miR-4500	CLIP-seq
MIRT1248130	hsa-miR-4663	CLIP-seq
MIRT1248132	hsa-miR-4709-5p	CLIP-seq
MIRT1248136	hsa-miR-4760-3p	CLIP-seq
MIRT1248137	hsa-miR-488	CLIP-seq
MIRT1248162	hsa-miR-561	CLIP-seq
MIRT1248163	hsa-miR-579	CLIP-seq
MIRT1248165	hsa-miR-628-5p	CLIP-seq
MIRT1248172	hsa-miR-98	CLIP-seq
MIRT1248080	hsa-let-7a	CLIP-seq
MIRT1248081	hsa-let-7b	CLIP-seq
MIRT1248082	hsa-let-7c	CLIP-seq
MIRT1248083	hsa-let-7d	CLIP-seq
MIRT1248084	hsa-let-7e	CLIP-seq
MIRT1248085	hsa-let-7f	CLIP-seq
MIRT1248086	hsa-let-7g	CLIP-seq
MIRT1248087	hsa-let-7i	CLIP-seq
MIRT1248088	hsa-miR-106a	CLIP-seq
MIRT1248089	hsa-miR-106b	CLIP-seq
MIRT2300355	hsa-miR-1231	CLIP-seq
MIRT2300356	hsa-miR-125a-3p	CLIP-seq
MIRT2073241	hsa-miR-1264	CLIP-seq
MIRT1248093	hsa-miR-1305	CLIP-seq
MIRT2300357	hsa-miR-134	CLIP-seq
MIRT2300358	hsa-miR-135a	CLIP-seq
MIRT2300359	hsa-miR-135b	CLIP-seq
MIRT1248094	hsa-miR-17	CLIP-seq
MIRT1248096	hsa-miR-202	CLIP-seq
MIRT1248097	hsa-miR-2052	CLIP-seq
MIRT1248098	hsa-miR-20a	CLIP-seq
MIRT1248099	hsa-miR-20b	CLIP-seq
MIRT2300360	hsa-miR-2116	CLIP-seq
MIRT1248100	hsa-miR-216a	CLIP-seq
MIRT1248101	hsa-miR-216b	CLIP-seq
MIRT2300361	hsa-miR-217	CLIP-seq
MIRT2300362	hsa-miR-224	CLIP-seq
MIRT1248103	hsa-miR-302a	CLIP-seq
MIRT1248104	hsa-miR-302b	CLIP-seq
MIRT1248105	hsa-miR-302c	CLIP-seq
MIRT1248106	hsa-miR-302d	CLIP-seq
MIRT1248107	hsa-miR-302e	CLIP-seq
MIRT2300363	hsa-miR-3118	CLIP-seq
MIRT2300364	hsa-miR-3120-5p	CLIP-seq
MIRT2300365	hsa-miR-3124-3p	CLIP-seq
MIRT2300366	hsa-miR-3148	CLIP-seq
MIRT2300367	hsa-miR-3163	CLIP-seq
MIRT2300368	hsa-miR-3180-5p	CLIP-seq
MIRT1248111	hsa-miR-3190	CLIP-seq
MIRT1248112	hsa-miR-372	CLIP-seq
MIRT1248113	hsa-miR-373	CLIP-seq
MIRT2300369	hsa-miR-377	CLIP-seq
MIRT1248116	hsa-miR-3920	CLIP-seq
MIRT1248117	hsa-miR-3973	CLIP-seq
MIRT1248118	hsa-miR-421	CLIP-seq
MIRT2300370	hsa-miR-4282	CLIP-seq
MIRT1248123	hsa-miR-4458	CLIP-seq
MIRT1248124	hsa-miR-448	CLIP-seq
MIRT1248125	hsa-miR-4482	CLIP-seq
MIRT1248126	hsa-miR-4500	CLIP-seq
MIRT1248129	hsa-miR-4639-5p	CLIP-seq
MIRT1248130	hsa-miR-4663	CLIP-seq
MIRT2300371	hsa-miR-4677-5p	CLIP-seq
MIRT2300372	hsa-miR-4686	CLIP-seq
MIRT1248132	hsa-miR-4709-5p	CLIP-seq
MIRT2300373	hsa-miR-4738-3p	CLIP-seq
MIRT1248136	hsa-miR-4760-3p	CLIP-seq
MIRT2300374	hsa-miR-4762-5p	CLIP-seq
MIRT1248137	hsa-miR-488	CLIP-seq
MIRT1248138	hsa-miR-498	CLIP-seq
MIRT1248139	hsa-miR-509-3p	CLIP-seq
MIRT1248140	hsa-miR-519a	CLIP-seq
MIRT1248141	hsa-miR-519b-3p	CLIP-seq
MIRT1248142	hsa-miR-519c-3p	CLIP-seq
MIRT1248143	hsa-miR-519d	CLIP-seq
MIRT1248144	hsa-miR-520a-3p	CLIP-seq
MIRT1248145	hsa-miR-520b	CLIP-seq
MIRT1248146	hsa-miR-520c-3p	CLIP-seq
MIRT1248147	hsa-miR-520d-3p	CLIP-seq
MIRT1248148	hsa-miR-520e	CLIP-seq
MIRT1248149	hsa-miR-520g	CLIP-seq
MIRT1248150	hsa-miR-520h	CLIP-seq
MIRT1248158	hsa-miR-548k	CLIP-seq
MIRT1248162	hsa-miR-561	CLIP-seq
MIRT1248163	hsa-miR-579	CLIP-seq
MIRT2300375	hsa-miR-604	CLIP-seq
MIRT2300376	hsa-miR-626	CLIP-seq
MIRT1248165	hsa-miR-628-5p	CLIP-seq
MIRT2300377	hsa-miR-645	CLIP-seq
MIRT2300378	hsa-miR-647	CLIP-seq
MIRT2300379	hsa-miR-664	CLIP-seq
MIRT1248171	hsa-miR-93	CLIP-seq
MIRT1248172	hsa-miR-98	CLIP-seq
MIRT1248163	hsa-miR-579	CLIP-seq
MIRT1248169	hsa-miR-646	CLIP-seq

Show/Hide all (58)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	25775267
GO:0000731	Process	DNA synthesis involved in DNA repair	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003678	Function	DNA helicase activity	IDA	36455556
GO:0003678	Function	DNA helicase activity	IEA
GO:0003682	Function	Chromatin binding	IDA	25642963
GO:0003684	Function	Damaged DNA binding	TAS	10395804
GO:0003824	Function	Catalytic activity	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	IBA
GO:0003887	Function	DNA-directed DNA polymerase activity	IDA	14576298, 25643323, 25775267, 27311885, 27591252, 31562312, 34140467, 34179826
GO:0003887	Function	DNA-directed DNA polymerase activity	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	IMP	22135286
GO:0003887	Function	DNA-directed DNA polymerase activity	TAS	10395804
GO:0003964	Function	RNA-directed DNA polymerase activity	TAS	34117057
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	25642963, 30021884, 35271311, 37440612
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	29509408
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS	10395804
GO:0005694	Component	Chromosome	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006260	Process	DNA replication	IEA
GO:0006261	Process	DNA-templated DNA replication	IEA
GO:0006278	Process	RNA-templated DNA biosynthetic process	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	TAS	10395804
GO:0006284	Process	Base-excision repair	IDA	19188258
GO:0006302	Process	Double-strand break repair	IDA	22135286
GO:0006974	Process	DNA damage response	IDA	25642963, 25643323
GO:0006974	Process	DNA damage response	IEA
GO:0016446	Process	Somatic hypermutation of immunoglobulin genes	IEA
GO:0016446	Process	Somatic hypermutation of immunoglobulin genes	ISS
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0017116	Function	Single-stranded DNA helicase activity	IDA	14576298
GO:0031297	Process	Replication fork processing	IDA	30655289
GO:0034061	Function	DNA polymerase activity	IEA
GO:0035861	Component	Site of double-strand break	IDA	37440612, 37674080
GO:0042276	Process	Error-prone translesion synthesis	IDA	30655289
GO:0042645	Component	Mitochondrial nucleoid	IDA	29509408
GO:0042802	Function	Identical protein binding	IPI	26636256
GO:0051260	Process	Protein homooligomerization	IDA	25643323
GO:0051575	Function	5'-deoxyribose-5-phosphate lyase activity	IDA	19188258
GO:0090734	Component	Site of DNA damage	IDA	34179826
GO:0097681	Process	Double-strand break repair via alternative nonhomologous end joining	IBA
GO:0097681	Process	Double-strand break repair via alternative nonhomologous end joining	IDA	25643323, 25775267, 27311885, 27591252, 31562312, 32234782, 34179826, 36455556, 37440612, 37674080
GO:0097681	Process	Double-strand break repair via alternative nonhomologous end joining	IEA
GO:2000042	Process	Negative regulation of double-strand break repair via homologous recombination	IDA	25642963, 36455556
GO:2000042	Process	Negative regulation of double-strand break repair via homologous recombination	IEA
GO:2000042	Process	Negative regulation of double-strand break repair via homologous recombination	IMP	28695890

MIM	HGNC	e!Ensembl
604419	9186	ENSG00000051341

O75417

Protein name

DNA polymerase theta (DNA polymerase eta) [Includes: Helicase POLQ (EC 3.6.4.12); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)]

Protein function

Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:145762

PDB

4X0P , 4X0Q , 5A9F , 5A9J , 5AGA , 6XBU , 7ZUS , 7ZX0 , 7ZX1 , 8E23 , 8E24 , 8GD7 , 8W0A , 9ASJ , 9ASK , 9ASL , 9AU8 , 9AU9 , 9BH6 , 9BH7 , 9BH8 , 9BH9 , 9BHA , 9BP9 , 9BPA , 9C5Q

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00270	DEAD	93 → 274	DEAD/DEAH box helicase	Domain
PF00271	Helicase_C	324 → 485	Helicase conserved C-terminal domain	Family
PF00476	DNA_pol_A	2096 → 2584	DNA polymerase family A	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis. {ECO:0000269|PubMed:14576298}.

Sequence

MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKR
KLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGA
SWGELKDFDV

Sequence length

2590

Interactions

View interactions

	Reactome
			HDR through MMEJ (alt-NHEJ)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CUTANEOUS MASTOCYTOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary breast ovarian cancer syndrome	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE MYELOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLQ-related disorder	Benign; Likely benign; Uncertain significance; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Teratoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

POLQ (DNA polymerase theta)