Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10695
Gene name	Canopy FGF signaling regulator 3
Gene symbol	CNPY3
Synonyms (NCBI Gene)	CAG4ADEE60EIEE60ERDA5PRAT4ATNRC5
Chromosome	6
Chromosome location	6p21.1
Summary	This gene encodes a protein that binds members of the toll-like receptor protein family and functions as a chaperone to aid in folding and export of these proteins. Alternative splicing results in multiple transcript variants. Naturally occuring readthrou

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Show/Hide all (131)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004231	hsa-miR-346	Microarray	16822819
MIRT029859	hsa-miR-26b-5p	Microarray	19088304
MIRT031881	hsa-miR-16-5p	Proteomics	18668040
MIRT901326	hsa-miR-1234	CLIP-seq
MIRT901327	hsa-miR-4722-3p	CLIP-seq
MIRT901328	hsa-miR-4749-3p	CLIP-seq
MIRT901329	hsa-miR-4763-5p	CLIP-seq
MIRT1967385	hsa-miR-1910	CLIP-seq
MIRT1967386	hsa-miR-3126-5p	CLIP-seq
MIRT1967387	hsa-miR-3169	CLIP-seq
MIRT1967388	hsa-miR-3925-3p	CLIP-seq
MIRT1967389	hsa-miR-4283	CLIP-seq
MIRT1967390	hsa-miR-4419a	CLIP-seq
MIRT1967391	hsa-miR-4510	CLIP-seq
MIRT1967392	hsa-miR-4740-5p	CLIP-seq
MIRT1967393	hsa-miR-548q	CLIP-seq
MIRT901326	hsa-miR-1234	CLIP-seq
MIRT1967385	hsa-miR-1910	CLIP-seq
MIRT2203009	hsa-miR-3922-5p	CLIP-seq
MIRT1967389	hsa-miR-4283	CLIP-seq
MIRT2203010	hsa-miR-4457	CLIP-seq
MIRT2203011	hsa-miR-4489	CLIP-seq
MIRT2203012	hsa-miR-4493	CLIP-seq
MIRT2203013	hsa-miR-4682	CLIP-seq
MIRT901327	hsa-miR-4722-3p	CLIP-seq
MIRT901328	hsa-miR-4749-3p	CLIP-seq
MIRT901329	hsa-miR-4763-5p	CLIP-seq
MIRT2203014	hsa-miR-581	CLIP-seq
MIRT2203015	hsa-miR-592	CLIP-seq
MIRT2203016	hsa-miR-599	CLIP-seq
MIRT2505944	hsa-miR-1200	CLIP-seq
MIRT2505945	hsa-miR-1266	CLIP-seq
MIRT2505946	hsa-miR-1289	CLIP-seq
MIRT2505947	hsa-miR-1343	CLIP-seq
MIRT2505948	hsa-miR-185	CLIP-seq
MIRT1967385	hsa-miR-1910	CLIP-seq
MIRT2505949	hsa-miR-1913	CLIP-seq
MIRT2505950	hsa-miR-2110	CLIP-seq
MIRT2505951	hsa-miR-3124-3p	CLIP-seq
MIRT2505952	hsa-miR-3140-5p	CLIP-seq
MIRT2505953	hsa-miR-3150a-3p	CLIP-seq
MIRT2505954	hsa-miR-3153	CLIP-seq
MIRT2505955	hsa-miR-3175	CLIP-seq
MIRT2505956	hsa-miR-3198	CLIP-seq
MIRT2505957	hsa-miR-324-3p	CLIP-seq
MIRT2505958	hsa-miR-3605-5p	CLIP-seq
MIRT2505959	hsa-miR-3614-5p	CLIP-seq
MIRT2505960	hsa-miR-3664-3p	CLIP-seq
MIRT2505961	hsa-miR-377	CLIP-seq
MIRT2505962	hsa-miR-3921	CLIP-seq
MIRT2203009	hsa-miR-3922-5p	CLIP-seq
MIRT1967389	hsa-miR-4283	CLIP-seq
MIRT2505963	hsa-miR-4292	CLIP-seq
MIRT2505964	hsa-miR-4294	CLIP-seq
MIRT2505965	hsa-miR-4306	CLIP-seq
MIRT2505966	hsa-miR-4309	CLIP-seq
MIRT2505967	hsa-miR-4324	CLIP-seq
MIRT2505968	hsa-miR-4417	CLIP-seq
MIRT2505969	hsa-miR-4433	CLIP-seq
MIRT2505970	hsa-miR-4436a	CLIP-seq
MIRT2203010	hsa-miR-4457	CLIP-seq
MIRT2505971	hsa-miR-4459	CLIP-seq
MIRT2203011	hsa-miR-4489	CLIP-seq
MIRT2505972	hsa-miR-4518	CLIP-seq
MIRT2505973	hsa-miR-4644	CLIP-seq
MIRT2505974	hsa-miR-4653-5p	CLIP-seq
MIRT2505975	hsa-miR-4667-3p	CLIP-seq
MIRT2203013	hsa-miR-4682	CLIP-seq
MIRT2505976	hsa-miR-4698	CLIP-seq
MIRT2505977	hsa-miR-4711-3p	CLIP-seq
MIRT2505978	hsa-miR-4728-5p	CLIP-seq
MIRT901328	hsa-miR-4749-3p	CLIP-seq
MIRT901329	hsa-miR-4763-5p	CLIP-seq
MIRT2505979	hsa-miR-4768-3p	CLIP-seq
MIRT2505980	hsa-miR-502-5p	CLIP-seq
MIRT2505981	hsa-miR-511	CLIP-seq
MIRT2505982	hsa-miR-544b	CLIP-seq
MIRT2203014	hsa-miR-581	CLIP-seq
MIRT2203015	hsa-miR-592	CLIP-seq
MIRT2203016	hsa-miR-599	CLIP-seq
MIRT2505983	hsa-miR-660	CLIP-seq
MIRT2505984	hsa-miR-760	CLIP-seq
MIRT2505985	hsa-miR-939	CLIP-seq
MIRT2505944	hsa-miR-1200	CLIP-seq
MIRT2505946	hsa-miR-1289	CLIP-seq
MIRT2505947	hsa-miR-1343	CLIP-seq
MIRT2505948	hsa-miR-185	CLIP-seq
MIRT1967385	hsa-miR-1910	CLIP-seq
MIRT2505949	hsa-miR-1913	CLIP-seq
MIRT2505950	hsa-miR-2110	CLIP-seq
MIRT2505951	hsa-miR-3124-3p	CLIP-seq
MIRT2505952	hsa-miR-3140-5p	CLIP-seq
MIRT2505953	hsa-miR-3150a-3p	CLIP-seq
MIRT2505954	hsa-miR-3153	CLIP-seq
MIRT2505955	hsa-miR-3175	CLIP-seq
MIRT2505956	hsa-miR-3198	CLIP-seq
MIRT2505957	hsa-miR-324-3p	CLIP-seq
MIRT2505959	hsa-miR-3614-5p	CLIP-seq
MIRT2505961	hsa-miR-377	CLIP-seq
MIRT2505962	hsa-miR-3921	CLIP-seq
MIRT2203009	hsa-miR-3922-5p	CLIP-seq
MIRT1967389	hsa-miR-4283	CLIP-seq
MIRT2505963	hsa-miR-4292	CLIP-seq
MIRT2505964	hsa-miR-4294	CLIP-seq
MIRT2505965	hsa-miR-4306	CLIP-seq
MIRT2505966	hsa-miR-4309	CLIP-seq
MIRT2505967	hsa-miR-4324	CLIP-seq
MIRT2505968	hsa-miR-4417	CLIP-seq
MIRT2505969	hsa-miR-4433	CLIP-seq
MIRT2203010	hsa-miR-4457	CLIP-seq
MIRT2505971	hsa-miR-4459	CLIP-seq
MIRT2203011	hsa-miR-4489	CLIP-seq
MIRT2505973	hsa-miR-4644	CLIP-seq
MIRT2505974	hsa-miR-4653-5p	CLIP-seq
MIRT2505975	hsa-miR-4667-3p	CLIP-seq
MIRT2203013	hsa-miR-4682	CLIP-seq
MIRT2505976	hsa-miR-4698	CLIP-seq
MIRT2505977	hsa-miR-4711-3p	CLIP-seq
MIRT2505978	hsa-miR-4728-5p	CLIP-seq
MIRT901328	hsa-miR-4749-3p	CLIP-seq
MIRT901329	hsa-miR-4763-5p	CLIP-seq
MIRT2505979	hsa-miR-4768-3p	CLIP-seq
MIRT2505980	hsa-miR-502-5p	CLIP-seq
MIRT2505981	hsa-miR-511	CLIP-seq
MIRT2505982	hsa-miR-544b	CLIP-seq
MIRT2203014	hsa-miR-581	CLIP-seq
MIRT2203015	hsa-miR-592	CLIP-seq
MIRT2203016	hsa-miR-599	CLIP-seq
MIRT2505983	hsa-miR-660	CLIP-seq
MIRT2505984	hsa-miR-760	CLIP-seq
MIRT2505985	hsa-miR-939	CLIP-seq

Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 32814053, 33961781
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0045087	Process	Innate immune response	IEA

MIM	HGNC	e!Ensembl
610774	11968	ENSG00000137161

Q9BT09

Protein name

Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein)

Protein function

Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (B

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11938	DUF3456	48 → 206	TLR4 regulator and MIR-interacting MSAP	Family

Sequence

MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELK
SAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSN
RFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDW
YRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKKGDTAALGGKKSKKKSSRAKAAGGRS
SSSKQRKELGGLEGDPSPEEDEGIQKASPLTHSPPDEL

Sequence length

278

Interactions

View interactions

	Reactome
			Trafficking and processing of endosomal TLR

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Developmental and epileptic encephalopathy, 60	Pathogenic; Likely pathogenic	rs2481078839, rs1554292759, rs1554123960, rs1554292820, rs1581718297, rs1768394971, rs1197219692	RCV003228772 RCV000615970 RCV000604665 RCV000610672 RCV000985216 RCV001089720 RCV001199204 View all (2 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CNPY3-related disorder	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 60	—	Disgenet, HPO Disgenet, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WEST SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (16)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Asthma, Aspirin-Induced	Asthma	BEFREE	26646719		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Diseases	Brain disease	Pubtator	35334124	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	40171811	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental regression	Developmental regression	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Epileptic encephalopathy	Epileptic encephalopathy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 60	Epileptic encephalopathy	UNIPROT_DG	29394991		★★★★★ ★☆☆☆☆ Found in Text Mining only
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 60	Epileptic encephalopathy	GENOMICS_ENGLAND_DG	29394991		★★★★★ ★☆☆☆☆ Found in Text Mining only
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 60	Epileptic encephalopathy	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	40171811	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	29180379	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Infantile spasms syndrome	Spasms Syndrome	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure Chronic	Kidney failure	Pubtator	30212930	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Spastic Quadriplegia	Spastic Quadriplegia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
West Syndrome	West Syndrome	BEFREE	29394991		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
West Syndrome	West Syndrome	ORPHANET_DG	29394991		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
West Syndrome	West Syndrome	HPO_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

CNPY3 (canopy FGF signaling regulator 3)