Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10691
Gene name	Glucocorticoid modulatory element binding protein 1
Gene symbol	GMEB1
Synonyms (NCBI Gene)	P96PIFPIF96
Chromosome	1
Chromosome location	1p35.3
Summary	This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene`s role is to modulate the transactivation of

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Show/Hide all (193)

miRTarBase ID	miRNA	Experiments	Reference
MIRT668091	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT668090	hsa-miR-3135b	HITS-CLIP	23824327
MIRT668089	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT668088	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT668087	hsa-miR-4284	HITS-CLIP	23824327
MIRT668086	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT668085	hsa-miR-3652	HITS-CLIP	23824327
MIRT668084	hsa-miR-4430	HITS-CLIP	23824327
MIRT668083	hsa-miR-4466	HITS-CLIP	23824327
MIRT668082	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT668081	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT668080	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT668079	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT668078	hsa-miR-8057	HITS-CLIP	23824327
MIRT668077	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT668076	hsa-miR-5698	HITS-CLIP	23824327
MIRT657768	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT657767	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT657765	hsa-miR-4775	HITS-CLIP	23824327
MIRT657766	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT657764	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT657763	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT657762	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT657761	hsa-miR-3176	HITS-CLIP	23824327
MIRT657760	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT657759	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT657758	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT657757	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT657756	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT657755	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT657754	hsa-miR-548s	HITS-CLIP	23824327
MIRT657753	hsa-miR-588	HITS-CLIP	23824327
MIRT657752	hsa-miR-4435	HITS-CLIP	23824327
MIRT657751	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT657750	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT657748	hsa-miR-5096	HITS-CLIP	23824327
MIRT657749	hsa-miR-1303	HITS-CLIP	23824327
MIRT668079	hsa-miR-4423-5p	HITS-CLIP	27418678
MIRT668080	hsa-miR-6501-5p	HITS-CLIP	27418678
MIRT668077	hsa-miR-744-3p	HITS-CLIP	27418678
MIRT668091	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT668090	hsa-miR-3135b	HITS-CLIP	23824327
MIRT668089	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT668088	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT668087	hsa-miR-4284	HITS-CLIP	23824327
MIRT668086	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT668085	hsa-miR-3652	HITS-CLIP	23824327
MIRT668084	hsa-miR-4430	HITS-CLIP	23824327
MIRT668083	hsa-miR-4466	HITS-CLIP	23824327
MIRT668082	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT668081	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT668080	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT668079	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT668078	hsa-miR-8057	HITS-CLIP	23824327
MIRT668077	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT668076	hsa-miR-5698	HITS-CLIP	23824327
MIRT657768	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT657767	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT657765	hsa-miR-4775	HITS-CLIP	23824327
MIRT657766	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT657764	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT657763	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT657762	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT657761	hsa-miR-3176	HITS-CLIP	23824327
MIRT657760	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT657759	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT657758	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT657757	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT657756	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT657755	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT657754	hsa-miR-548s	HITS-CLIP	23824327
MIRT657753	hsa-miR-588	HITS-CLIP	23824327
MIRT657752	hsa-miR-4435	HITS-CLIP	23824327
MIRT657751	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT657750	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT657748	hsa-miR-5096	HITS-CLIP	23824327
MIRT657749	hsa-miR-1303	HITS-CLIP	23824327
MIRT1022455	hsa-miR-122	CLIP-seq
MIRT1022456	hsa-miR-3117-5p	CLIP-seq
MIRT1022457	hsa-miR-514	CLIP-seq
MIRT1022458	hsa-miR-514b-3p	CLIP-seq
MIRT1022459	hsa-miR-675	CLIP-seq
MIRT1022460	hsa-miR-720	CLIP-seq
MIRT1022461	hsa-miR-1197	CLIP-seq
MIRT1022455	hsa-miR-122	CLIP-seq
MIRT1022462	hsa-miR-1299	CLIP-seq
MIRT1022463	hsa-miR-1302	CLIP-seq
MIRT1022464	hsa-miR-192	CLIP-seq
MIRT1022465	hsa-miR-2052	CLIP-seq
MIRT1022466	hsa-miR-215	CLIP-seq
MIRT1022467	hsa-miR-2355-3p	CLIP-seq
MIRT1022468	hsa-miR-24	CLIP-seq
MIRT1022469	hsa-miR-299-3p	CLIP-seq
MIRT1022470	hsa-miR-3117-3p	CLIP-seq
MIRT1022471	hsa-miR-3155	CLIP-seq
MIRT1022472	hsa-miR-3155b	CLIP-seq
MIRT1022473	hsa-miR-3190	CLIP-seq
MIRT1022474	hsa-miR-3202	CLIP-seq
MIRT1022475	hsa-miR-3663-5p	CLIP-seq
MIRT1022476	hsa-miR-371-5p	CLIP-seq
MIRT1022477	hsa-miR-371b-5p	CLIP-seq
MIRT1022478	hsa-miR-4258	CLIP-seq
MIRT1022479	hsa-miR-4298	CLIP-seq
MIRT1022480	hsa-miR-4426	CLIP-seq
MIRT1022481	hsa-miR-4436b-3p	CLIP-seq
MIRT1022482	hsa-miR-4481	CLIP-seq
MIRT1022483	hsa-miR-4491	CLIP-seq
MIRT1022484	hsa-miR-4533	CLIP-seq
MIRT1022485	hsa-miR-4646-3p	CLIP-seq
MIRT1022486	hsa-miR-4647	CLIP-seq
MIRT1022487	hsa-miR-4648	CLIP-seq
MIRT1022488	hsa-miR-4657	CLIP-seq
MIRT1022489	hsa-miR-4662b	CLIP-seq
MIRT1022490	hsa-miR-4701-5p	CLIP-seq
MIRT1022491	hsa-miR-4745-5p	CLIP-seq
MIRT1022492	hsa-miR-4758-5p	CLIP-seq
MIRT1022493	hsa-miR-4782-5p	CLIP-seq
MIRT1022494	hsa-miR-484	CLIP-seq
MIRT1022495	hsa-miR-516b	CLIP-seq
MIRT1022496	hsa-miR-640	CLIP-seq
MIRT1022459	hsa-miR-675	CLIP-seq
MIRT1022497	hsa-miR-875-3p	CLIP-seq
MIRT1022498	hsa-miR-941	CLIP-seq
MIRT1022462	hsa-miR-1299	CLIP-seq
MIRT1022464	hsa-miR-192	CLIP-seq
MIRT1022466	hsa-miR-215	CLIP-seq
MIRT1022480	hsa-miR-4426	CLIP-seq
MIRT1022486	hsa-miR-4647	CLIP-seq
MIRT1022489	hsa-miR-4662b	CLIP-seq
MIRT1022490	hsa-miR-4701-5p	CLIP-seq
MIRT2002963	hsa-miR-578	CLIP-seq
MIRT2236042	hsa-miR-106a	CLIP-seq
MIRT2236043	hsa-miR-106b	CLIP-seq
MIRT1022455	hsa-miR-122	CLIP-seq
MIRT2236044	hsa-miR-17	CLIP-seq
MIRT2236045	hsa-miR-20a	CLIP-seq
MIRT2236046	hsa-miR-20b	CLIP-seq
MIRT2236047	hsa-miR-302a	CLIP-seq
MIRT2236048	hsa-miR-302b	CLIP-seq
MIRT2236049	hsa-miR-302c	CLIP-seq
MIRT2236050	hsa-miR-302d	CLIP-seq
MIRT2236051	hsa-miR-302e	CLIP-seq
MIRT2236052	hsa-miR-372	CLIP-seq
MIRT2236053	hsa-miR-373	CLIP-seq
MIRT1022478	hsa-miR-4258	CLIP-seq
MIRT2236054	hsa-miR-4731-5p	CLIP-seq
MIRT2236055	hsa-miR-512-3p	CLIP-seq
MIRT2236056	hsa-miR-519d	CLIP-seq
MIRT2236057	hsa-miR-520a-3p	CLIP-seq
MIRT2236058	hsa-miR-520b	CLIP-seq
MIRT2236059	hsa-miR-520c-3p	CLIP-seq
MIRT2236060	hsa-miR-520d-3p	CLIP-seq
MIRT2236061	hsa-miR-520e	CLIP-seq
MIRT2236062	hsa-miR-520g	CLIP-seq
MIRT2236063	hsa-miR-520h	CLIP-seq
MIRT1022459	hsa-miR-675	CLIP-seq
MIRT2236064	hsa-miR-93	CLIP-seq
MIRT1022498	hsa-miR-941	CLIP-seq
MIRT2236042	hsa-miR-106a	CLIP-seq
MIRT2236043	hsa-miR-106b	CLIP-seq
MIRT2388523	hsa-miR-1234	CLIP-seq
MIRT2388524	hsa-miR-150	CLIP-seq
MIRT2236044	hsa-miR-17	CLIP-seq
MIRT2236045	hsa-miR-20a	CLIP-seq
MIRT2236046	hsa-miR-20b	CLIP-seq
MIRT2236047	hsa-miR-302a	CLIP-seq
MIRT2236048	hsa-miR-302b	CLIP-seq
MIRT2236049	hsa-miR-302c	CLIP-seq
MIRT2236050	hsa-miR-302d	CLIP-seq
MIRT2236051	hsa-miR-302e	CLIP-seq
MIRT2236052	hsa-miR-372	CLIP-seq
MIRT2236053	hsa-miR-373	CLIP-seq
MIRT2236054	hsa-miR-4731-5p	CLIP-seq
MIRT2236055	hsa-miR-512-3p	CLIP-seq
MIRT2236056	hsa-miR-519d	CLIP-seq
MIRT2236057	hsa-miR-520a-3p	CLIP-seq
MIRT2236058	hsa-miR-520b	CLIP-seq
MIRT2236059	hsa-miR-520c-3p	CLIP-seq
MIRT2236060	hsa-miR-520d-3p	CLIP-seq
MIRT2236061	hsa-miR-520e	CLIP-seq
MIRT2236062	hsa-miR-520g	CLIP-seq
MIRT2236063	hsa-miR-520h	CLIP-seq
MIRT2236064	hsa-miR-93	CLIP-seq
MIRT1022460	hsa-miR-720	CLIP-seq
MIRT1022455	hsa-miR-122	CLIP-seq
MIRT1022468	hsa-miR-24	CLIP-seq
MIRT2539894	hsa-miR-4297	CLIP-seq
MIRT1022459	hsa-miR-675	CLIP-seq
MIRT1022460	hsa-miR-720	CLIP-seq
MIRT1022455	hsa-miR-122	CLIP-seq
MIRT1022468	hsa-miR-24	CLIP-seq
MIRT2539894	hsa-miR-4297	CLIP-seq
MIRT1022459	hsa-miR-675	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	10386584
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	TAS	10386584
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	10894151, 32514408, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	10386584
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	10386584
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0042802	Function	Identical protein binding	IPI	10386584, 10894151
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051008	Function	Hsp27 protein binding	IPI	10386584
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
604409	4370	ENSG00000162419

Q9Y692

Protein name

Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (DNA-binding protein p96PIF) (Parvovirus initiation factor p96) (PIF p96)

Protein function

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promote

PDB

1OQJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01342	SAND	89 → 165	SAND domain	Family

Sequence

MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGLFIDGHFYNRIYEAGSE
NNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKC
VKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRS
TKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMA
TEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTD
AAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKS
QTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMG
NIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQ
DGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAV
ILETELRTEEKVVAEMEEHQHQVHNVEIVVLED

Sequence length

573

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTINODULAR GOITER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Neoplasms	Neoplasms	BEFREE	31046799	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	18455874	★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31046799	★★★★★ ★☆☆☆☆ Found in Text Mining only

GMEB1 (glucocorticoid modulatory element binding protein 1)