Gene Gene information from NCBI Gene database.
Entrez ID 10690
Gene name Fucosyltransferase 9
Gene symbol FUT9
Synonyms (NCBI Gene)
Fuc-TIX
Chromosome 6
Chromosome location 6q16.1
Summary The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one
miRNA miRNA information provided by mirtarbase database.
565
miRTarBase ID miRNA Experiments Reference
MIRT017457 hsa-miR-335-5p Microarray 18185580
MIRT725510 hsa-miR-3121-3p HITS-CLIP 19536157
MIRT725509 hsa-miR-576-3p HITS-CLIP 19536157
MIRT725508 hsa-miR-186-3p HITS-CLIP 19536157
MIRT725507 hsa-miR-5696 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
45
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0000271 Process Polysaccharide biosynthetic process IEA
GO:0000271 Process Polysaccharide biosynthetic process ISS
GO:0005515 Function Protein binding IPI 28514442, 32296183, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606865 4020 ENSG00000172461
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y231
Protein name 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (EC 2.4.1.152) (Fucosyltransferase 9) (Fucosyltransferase IX) (Fuc-TIX) (FucT-IX) (Galactoside 3-L-fucosyltransferase)
Protein function Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc-) glycan attached to glycolipids and N- or O-linked glycoprote
PDB 8D0O , 8D0P , 8D0Q , 8D0R , 8D0S , 8D0U , 8D0W , 8D0X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17039 Glyco_tran_10_N 61 169 Fucosyltransferase, N-terminal Domain
PF00852 Glyco_transf_10 185 357 Glycosyltransferase family 10 (fucosyltransferase) C-term Family
Tissue specificity TISSUE SPECIFICITY: Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus (PubMed:10386598). Highly expressed in
Sequence
Sequence length 359
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Mannose type O-glycan biosynthesis
Glycosphingolipid biosynthesis - lacto and neolacto series
Glycosphingolipid biosynthesis - globo and isoglobo series
Metabolic pathways
  Lewis blood group biosynthesis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 8981094
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 8542587, 9128982
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 29196508
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 15666088
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 8542587
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 29196508
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 29196508
★☆☆☆☆
Found in Text Mining only
Sarcoidosis Sarcoidosis Pubtator 24845555 Associate
★☆☆☆☆
Found in Text Mining only