Gene Gene information from NCBI Gene database.
Entrez ID 10666
Gene name CD226 molecule
Gene symbol CD226
Synonyms (NCBI Gene)
DNAM-1DNAM1PTA1TLiSA1
Chromosome 18
Chromosome location 18q22.2
Summary This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and me
miRNA miRNA information provided by mirtarbase database.
273
miRTarBase ID miRNA Experiments Reference
MIRT018110 hsa-miR-335-5p Microarray 18185580
MIRT715737 hsa-miR-6830-3p HITS-CLIP 19536157
MIRT715736 hsa-miR-511-5p HITS-CLIP 19536157
MIRT715735 hsa-miR-2681-5p HITS-CLIP 19536157
MIRT525272 hsa-miR-548a-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
GO ID Ontology Definition Evidence Reference
GO:0002729 Process Positive regulation of natural killer cell cytokine production IEA
GO:0002729 Process Positive regulation of natural killer cell cytokine production IEA
GO:0002860 Process Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP 12913096
GO:0002891 Process Positive regulation of immunoglobulin mediated immune response IBA
GO:0002891 Process Positive regulation of immunoglobulin mediated immune response IDA 16831868
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605397 16961 ENSG00000150637
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15762
Protein name CD226 antigen (DNAX accessory molecule 1) (DNAM-1) (CD antigen CD226)
Protein function Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells (PubMed:8673704, PubMed:97120
PDB 6ISB , 6O3O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 24 126 Immunoglobulin V-set domain Domain
PF07686 V-set 136 241 Immunoglobulin V-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed by peripheral blood T-lymphocytes. {ECO:0000269|PubMed:8673704}.
Sequence
Sequence length 336
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell adhesion molecules   Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
21
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANKYLOSING SPONDYLITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTOIMMUNE DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTOIMMUNE THYROID DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BILIARY LIVER CIRRHOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Addison Disease Addison`s Disease BEFREE 21521299
★☆☆☆☆
Found in Text Mining only
Ankylosing spondylitis Ankylosing Spondylitis GWASCAT_DG 26974007
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Antiphospholipid Syndrome Antiphospholipid syndrome Pubtator 38386917 Associate
★☆☆☆☆
Found in Text Mining only
Anxiety Anxiety Disorder BEFREE 29299389
★☆☆☆☆
Found in Text Mining only
Anxiety Disorders Anxiety Disorder BEFREE 29299389
★☆☆☆☆
Found in Text Mining only
Arthritis Psoriatic Psoriatic arthritis Pubtator 33452865 Associate
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 18971939, 20444755, 21765104, 23999715, 24673109 Associate
★☆☆☆☆
Found in Text Mining only
Arthritis, Psoriatic Psoriatic Arthritis BEFREE 27440135
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 16210593 Associate
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorders Autism Spectrum Disorder BEFREE 29788201
★☆☆☆☆
Found in Text Mining only