Gene Gene information from NCBI Gene database.
Entrez ID 10643
Gene name Insulin like growth factor 2 mRNA binding protein 3
Gene symbol IGF2BP3
Synonyms (NCBI Gene)
CT98IMP-3IMP3KOCKOC1VICKZ3
Chromosome 7
Chromosome location 7p15.3
Summary The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5` UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded prot
miRNA miRNA information provided by mirtarbase database.
529
miRTarBase ID miRNA Experiments Reference
MIRT025416 hsa-miR-34a-5p Proteomics 21566225
MIRT025416 hsa-miR-34a-5p Proteomics 21566225
MIRT025416 hsa-miR-34a-5p Proteomics 21566225
MIRT026059 hsa-miR-196a-5p Sequencing 20371350
MIRT032130 hsa-let-7d-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0000932 Component P-body IDA 29476152
GO:0000932 Component P-body IEA
GO:0001817 Process Regulation of cytokine production IC 9891060
GO:0001817 Process Regulation of cytokine production IEA
GO:0003676 Function Nucleic acid binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608259 28868 ENSG00000136231
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O00425
Protein name Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)
Protein function RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcr
PDB 2E44 , 6FQ1 , 6FQR , 6GQE , 6GX6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 4 69 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00076 RRM_1 83 150 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00013 KH_1 197 262 KH domain Domain
PF00013 KH_1 278 345 KH domain Domain
PF00013 KH_1 407 472 KH domain Domain
PF00013 KH_1 489 555 KH domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in tes
Sequence
Sequence length 579
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
20
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARCINOMA, HEPATOCELLULAR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Chronic lymphocytic leukemia/small lymphocytic lymphoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONGENITAL MICROCEPHALY Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 21414819
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 18499984
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 14755238, 28381175
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 21414819
★☆☆☆☆
Found in Text Mining only
Adult Oligodendroglioma Oligodendroglioma BEFREE 29308320
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 25183049, 25886367, 27210763
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Thoracic Thoracic aortic aneurysm Pubtator 35730141 Associate
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 36582238 Associate
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma Pubtator 23584203, 25521223 Associate
★☆☆☆☆
Found in Text Mining only
Autosomal Recessive Primary Microcephaly Primary microcephaly Pubtator 34402213 Associate
★☆☆☆☆
Found in Text Mining only