Gene Gene information from NCBI Gene database.
Entrez ID 10630
Gene name Podoplanin
Gene symbol PDPN
Synonyms (NCBI Gene)
AGGRUSD2-40GP36GP40Gp38HT1A-1OTS8PA2.26T1AT1A-2T1A2TI1A
Chromosome 1
Chromosome location 1p36.21
Summary This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a di
miRNA miRNA information provided by mirtarbase database.
157
miRTarBase ID miRNA Experiments Reference
MIRT007320 hsa-miR-363-3p Luciferase reporter assay 23246488
MIRT007320 hsa-miR-363-3p Luciferase reporter assay 23246488
MIRT007320 hsa-miR-363-3p Luciferase reporter assay 23246488
MIRT667012 hsa-miR-302f HITS-CLIP 23706177
MIRT667009 hsa-miR-4695-5p HITS-CLIP 23706177
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
72
GO ID Ontology Definition Evidence Reference
GO:0001726 Component Ruffle ISS
GO:0001946 Process Lymphangiogenesis ISS
GO:0005102 Function Signaling receptor binding IDA 18215137
GO:0005372 Function Water transmembrane transporter activity ISS
GO:0005515 Function Protein binding IPI 17046996, 17616532, 18215137, 18541721, 19268462, 20962267, 25458834, 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608863 29602 ENSG00000162493
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86YL7
Protein name Podoplanin (Aggrus) (Glycoprotein 36) (Gp36) (PA2.26 antigen) (T1-alpha) (T1A) [Cleaved into: 29kDa cytosolic podoplanin intracellular domain (PICD)]
Protein function Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activa
PDB 3WSR , 4YO0 , 5XCV , 7C94 , 7CQC , 7CQD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05808 Podoplanin 28 161 Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in
Sequence
Sequence length 162
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    GPVI-mediated activation cascade
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
1P36 DELETION SYNDROME Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHROMOSOME 1P36 DELETION SYNDROME Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
IGA GLOMERULONEPHRITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MESOTHELIOMA, MALIGNANT CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute intermittent porphyria Intermittent Porphyria BEFREE 30515871
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 29550835
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 18546264
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 20923309, 30257286, 31319967
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 21610106, 25388165, 25648219, 28656229, 28881047, 29290263, 29511884, 30527194, 31134329
★☆☆☆☆
Found in Text Mining only
Aicardi Syndrome Aicardi syndrome Pubtator 31452946 Stimulate
★☆☆☆☆
Found in Text Mining only
Alveolar Soft Part Sarcoma Alveolar Sarcoma BEFREE 21234520
★☆☆☆☆
Found in Text Mining only
Ameloblastoma Ameloblastoma BEFREE 19691459, 25820557, 27859616
★☆☆☆☆
Found in Text Mining only
Ameloblastoma Ameloblastoma Pubtator 25820557 Associate
★☆☆☆☆
Found in Text Mining only
Anaplastic astrocytoma Anaplastic Astrocytoma BEFREE 16596424
★☆☆☆☆
Found in Text Mining only