Gene Gene information from NCBI Gene database.
Entrez ID 10628
Gene name Thioredoxin interacting protein
Gene symbol TXNIP
Synonyms (NCBI Gene)
ARRDC6EST01027HHCPA78THIFVDUP1
Chromosome 1
Chromosome location 1q21.1
Summary This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inh
miRNA miRNA information provided by mirtarbase database.
1791
miRTarBase ID miRNA Experiments Reference
MIRT005561 hsa-miR-373-3p Luciferase reporter assayqRT-PCRWestern blot 21271679
MIRT019486 hsa-miR-148b-3p Microarray 17612493
MIRT022063 hsa-miR-128-3p Microarray 17612493
MIRT025014 hsa-miR-183-5p Sequencing 20371350
MIRT025554 hsa-miR-34a-5p Sequencing 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
10
Transcription factor Regulation Reference
FOXO1 Repression 23803610
FOXO3 Activation 20656682
HDAC1 Repression 19351825
HDAC10 Repression 20680488
KLF6 Unknown 19808645
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0004857 Function Enzyme inhibitor activity IDA 17603038
GO:0004857 Function Enzyme inhibitor activity IEA
GO:0005515 Function Protein binding IPI 10814541, 14632196, 17260951, 23880345, 26919541, 28514442, 32296183, 38270169
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606599 16952 ENSG00000265972
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H3M7
Protein name Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
Protein function May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translo
PDB 4GEI , 4GEJ , 4GFX , 4LL1 , 4LL4 , 4ROF , 4ROJ , 5CQ2 , 5DF6 , 5DWS , 5DZD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00339 Arrestin_N 10 152 Arrestin (or S-antigen), N-terminal domain Domain
PF02752 Arrestin_C 174 300 Arrestin (or S-antigen), C-terminal domain Domain
Sequence
Sequence length 391
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  NOD-like receptor signaling pathway   The NLRP3 inflammasome
Purinergic signaling in leishmaniasis infection
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ARTHRITIS, RHEUMATOID CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHIES CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acidosis Lactic Lactic acidosis Pubtator 30755400 Associate
★☆☆☆☆
Found in Text Mining only
Acidosis Lactic Lactic acidosis Pubtator 38195466 Stimulate
★☆☆☆☆
Found in Text Mining only
ACTH-Secreting Pituitary Adenoma Pituitary adenoma BEFREE 23315031
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 19327827, 21734239
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 12821938
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 29934340
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia BEFREE 14983878
★☆☆☆☆
Found in Text Mining only
Age related macular degeneration Age-related macular degeneration BEFREE 31615975
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 30741672 Stimulate
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 34153352, 36422510 Associate
★☆☆☆☆
Found in Text Mining only