Gene Gene information from NCBI Gene database.
Entrez ID 10625
Gene name Influenza virus NS1A binding protein
Gene symbol IVNS1ABP
Synonyms (NCBI Gene)
ARA3FLARA3HSPC068IMD70KLHL39ND1NS-1NS1-BPNS1BP
Chromosome 1
Chromosome location 1q25.3
miRNA miRNA information provided by mirtarbase database.
259
miRTarBase ID miRNA Experiments Reference
MIRT026996 hsa-miR-103a-3p Sequencing 20371350
MIRT029013 hsa-miR-26b-5p Microarray 19088304
MIRT030741 hsa-miR-21-5p Microarray 18591254
MIRT031511 hsa-miR-16-5p Sequencing 20371350
MIRT044680 hsa-miR-320a CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 23825951, 25619834
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IEA
GO:0005667 Component Transcription regulator complex TAS 9696811
GO:0005681 Component Spliceosomal complex TAS 9696811
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609209 16951 ENSG00000116679
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y6Y0
Protein name Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39)
Protein function Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin f
PDB 5YY8 , 6N34 , 6N3H
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 22 128 BTB/POZ domain Domain
PF07707 BACK 134 228 BTB And C-terminal Kelch Domain
PF01344 Kelch_1 357 402 Kelch motif Repeat
PF01344 Kelch_1 404 450 Kelch motif Repeat
PF01344 Kelch_1 452 499 Kelch motif Repeat
PF01344 Kelch_1 501 546 Kelch motif Repeat
PF01344 Kelch_1 548 593 Kelch motif Repeat
PF01344 Kelch_1 595 638 Kelch motif Repeat
Sequence
Sequence length 642
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Immunodeficiency 70 Pathogenic rs756921311, rs1665467187 RCV001250914
RCV001250915
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
IVNS1ABP-related disorder Uncertain significance; Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anemia Anemia BEFREE 29133942
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 15383603
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 24992002 Associate
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma BEFREE 31569658
★☆☆☆☆
Found in Text Mining only
Ataxia Telangiectasia Ataxia telangiectasia Pubtator 28264028 Associate
★☆☆☆☆
Found in Text Mining only
Biliary Atresia Biliary Atresia BEFREE 17479159
★☆☆☆☆
Found in Text Mining only
Biliary Atresia Biliary atresia Pubtator 17479159 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 9159034 Associate
★☆☆☆☆
Found in Text Mining only
Cardiomyopathies Cardiomyopathy Pubtator 18523634 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 30277651
★☆☆☆☆
Found in Text Mining only