POLR3G (RNA polymerase III subunit G)

Gene

• Entrez ID: 10622
• Gene name: RNA polymerase III subunit G
• Gene symbol: POLR3G
• Synonyms (NCBI Gene): C31, RPC32, RPC7
• Chromosome: 5
• Chromosome location: 5q14.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002588	hsa-miR-124-3p	Microarray	15685193
MIRT029218	hsa-miR-26b-5p	Sequencing	20371350
MIRT029218	hsa-miR-26b-5p	Microarray	19088304
MIRT052000	hsa-let-7b-5p	CLASH	23622248
MIRT438226	hsa-miR-223-3p	Luciferase reporter assay	24324762
MIRT438226	hsa-miR-223-3p	Luciferase reporter assay	24324762
MIRT167373	hsa-miR-4274	HITS-CLIP	23824327
MIRT661646	hsa-miR-1910-5p	HITS-CLIP	23824327
MIRT639153	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT639152	hsa-miR-5193	HITS-CLIP	23824327
MIRT639151	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT639150	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT639149	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT639148	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT639147	hsa-miR-3136-3p	HITS-CLIP	23824327
MIRT639146	hsa-miR-7155-3p	HITS-CLIP	23824327
MIRT639145	hsa-miR-1260a	HITS-CLIP	23824327
MIRT639144	hsa-miR-1260b	HITS-CLIP	23824327
MIRT661645	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639143	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT639142	hsa-miR-328-3p	HITS-CLIP	23824327
MIRT639153	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT639152	hsa-miR-5193	HITS-CLIP	23824327
MIRT639151	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT639150	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT639149	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT639148	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT639147	hsa-miR-3136-3p	HITS-CLIP	23824327
MIRT639146	hsa-miR-7155-3p	HITS-CLIP	23824327
MIRT639145	hsa-miR-1260a	HITS-CLIP	23824327
MIRT639144	hsa-miR-1260b	HITS-CLIP	23824327
MIRT639143	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT639142	hsa-miR-328-3p	HITS-CLIP	23824327
MIRT512465	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT512463	hsa-miR-6085	PAR-CLIP	23446348
MIRT512464	hsa-miR-6813-5p	PAR-CLIP	23446348
MIRT512462	hsa-miR-362-5p	PAR-CLIP	23446348
MIRT512461	hsa-miR-500b-5p	PAR-CLIP	23446348
MIRT512460	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT512459	hsa-miR-6841-3p	PAR-CLIP	23446348
MIRT512458	hsa-miR-1915-5p	PAR-CLIP	23446348
MIRT512457	hsa-miR-18a-3p	PAR-CLIP	23446348
MIRT512455	hsa-miR-5699-5p	PAR-CLIP	23446348
MIRT512456	hsa-miR-4758-3p	PAR-CLIP	23446348
MIRT512454	hsa-miR-3189-5p	PAR-CLIP	23446348
MIRT512453	hsa-miR-7976	PAR-CLIP	23446348
MIRT512452	hsa-miR-3173-5p	PAR-CLIP	23446348
MIRT512451	hsa-miR-6799-3p	PAR-CLIP	23446348
MIRT512450	hsa-miR-146b-3p	PAR-CLIP	23446348
MIRT512449	hsa-miR-6829-5p	PAR-CLIP	23446348
MIRT512448	hsa-miR-185-3p	PAR-CLIP	23446348
MIRT512447	hsa-miR-502-5p	PAR-CLIP	23446348
MIRT512446	hsa-miR-874-3p	PAR-CLIP	23446348
MIRT097606	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT097603	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT097633	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT097606	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT097602	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT097613	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT097604	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT097621	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT097603	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT097631	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT029218	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT097633	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT167373	hsa-miR-4274	HITS-CLIP	23824327
MIRT661646	hsa-miR-1910-5p	HITS-CLIP	23824327
MIRT639153	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT639152	hsa-miR-5193	HITS-CLIP	23824327
MIRT639151	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT639150	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT639149	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT639148	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT639147	hsa-miR-3136-3p	HITS-CLIP	23824327
MIRT639146	hsa-miR-7155-3p	HITS-CLIP	23824327
MIRT639145	hsa-miR-1260a	HITS-CLIP	23824327
MIRT639144	hsa-miR-1260b	HITS-CLIP	23824327
MIRT661645	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639143	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT639142	hsa-miR-328-3p	HITS-CLIP	23824327
MIRT639153	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT639152	hsa-miR-5193	HITS-CLIP	23824327
MIRT639151	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT639150	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT639149	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT639148	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT639147	hsa-miR-3136-3p	HITS-CLIP	23824327
MIRT639146	hsa-miR-7155-3p	HITS-CLIP	23824327
MIRT639145	hsa-miR-1260a	HITS-CLIP	23824327
MIRT639144	hsa-miR-1260b	HITS-CLIP	23824327
MIRT639143	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT639142	hsa-miR-328-3p	HITS-CLIP	23824327
MIRT512465	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT512463	hsa-miR-6085	PAR-CLIP	23446348
MIRT512464	hsa-miR-6813-5p	PAR-CLIP	23446348
MIRT512462	hsa-miR-362-5p	PAR-CLIP	23446348
MIRT512461	hsa-miR-500b-5p	PAR-CLIP	23446348
MIRT512460	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT512459	hsa-miR-6841-3p	PAR-CLIP	23446348
MIRT512458	hsa-miR-1915-5p	PAR-CLIP	23446348
MIRT512457	hsa-miR-18a-3p	PAR-CLIP	23446348
MIRT512455	hsa-miR-5699-5p	PAR-CLIP	23446348
MIRT512456	hsa-miR-4758-3p	PAR-CLIP	23446348
MIRT512454	hsa-miR-3189-5p	PAR-CLIP	23446348
MIRT512453	hsa-miR-7976	PAR-CLIP	23446348
MIRT512452	hsa-miR-3173-5p	PAR-CLIP	23446348
MIRT512451	hsa-miR-6799-3p	PAR-CLIP	23446348
MIRT512450	hsa-miR-146b-3p	PAR-CLIP	23446348
MIRT512449	hsa-miR-6829-5p	PAR-CLIP	23446348
MIRT512448	hsa-miR-185-3p	PAR-CLIP	23446348
MIRT512447	hsa-miR-502-5p	PAR-CLIP	23446348
MIRT512446	hsa-miR-874-3p	PAR-CLIP	23446348
MIRT1249277	hsa-miR-106a	CLIP-seq
MIRT1249278	hsa-miR-106b	CLIP-seq
MIRT1249279	hsa-miR-1178	CLIP-seq
MIRT1249280	hsa-miR-1297	CLIP-seq
MIRT1249281	hsa-miR-142-5p	CLIP-seq
MIRT1249282	hsa-miR-17	CLIP-seq
MIRT1249283	hsa-miR-203	CLIP-seq
MIRT1249284	hsa-miR-20a	CLIP-seq
MIRT1249285	hsa-miR-20b	CLIP-seq
MIRT1249286	hsa-miR-23a	CLIP-seq
MIRT1249287	hsa-miR-23b	CLIP-seq
MIRT1249288	hsa-miR-23c	CLIP-seq
MIRT1249289	hsa-miR-26a	CLIP-seq
MIRT1249290	hsa-miR-26b	CLIP-seq
MIRT1249291	hsa-miR-302a	CLIP-seq
MIRT1249292	hsa-miR-302b	CLIP-seq
MIRT1249293	hsa-miR-302c	CLIP-seq
MIRT1249294	hsa-miR-302d	CLIP-seq
MIRT1249295	hsa-miR-302e	CLIP-seq
MIRT1249296	hsa-miR-3065-5p	CLIP-seq
MIRT1249297	hsa-miR-3074-3p	CLIP-seq
MIRT1249298	hsa-miR-31	CLIP-seq
MIRT1249299	hsa-miR-3120-3p	CLIP-seq
MIRT1249300	hsa-miR-3123	CLIP-seq
MIRT1249301	hsa-miR-3143	CLIP-seq
MIRT1249302	hsa-miR-3156-5p	CLIP-seq
MIRT1249303	hsa-miR-3161	CLIP-seq
MIRT1249304	hsa-miR-3163	CLIP-seq
MIRT1249305	hsa-miR-3609	CLIP-seq
MIRT1249306	hsa-miR-369-3p	CLIP-seq
MIRT1249307	hsa-miR-372	CLIP-seq
MIRT1249308	hsa-miR-373	CLIP-seq
MIRT1249309	hsa-miR-374a	CLIP-seq
MIRT1249310	hsa-miR-374b	CLIP-seq
MIRT1249311	hsa-miR-375	CLIP-seq
MIRT1249312	hsa-miR-376c	CLIP-seq
MIRT1249313	hsa-miR-3908	CLIP-seq
MIRT1249314	hsa-miR-3923	CLIP-seq
MIRT1249315	hsa-miR-3924	CLIP-seq
MIRT1249316	hsa-miR-3935	CLIP-seq
MIRT1249317	hsa-miR-3942-5p	CLIP-seq
MIRT1249318	hsa-miR-410	CLIP-seq
MIRT1249319	hsa-miR-421	CLIP-seq
MIRT1249320	hsa-miR-4328	CLIP-seq
MIRT1249321	hsa-miR-433	CLIP-seq
MIRT1249322	hsa-miR-4465	CLIP-seq
MIRT1249323	hsa-miR-4517	CLIP-seq
MIRT1249324	hsa-miR-4643	CLIP-seq
MIRT1249325	hsa-miR-4698	CLIP-seq
MIRT1249326	hsa-miR-4703-5p	CLIP-seq
MIRT1249327	hsa-miR-4718	CLIP-seq
MIRT1249328	hsa-miR-4720-3p	CLIP-seq
MIRT1249329	hsa-miR-4742-3p	CLIP-seq
MIRT1249330	hsa-miR-4766-3p	CLIP-seq
MIRT1249331	hsa-miR-4796-3p	CLIP-seq
MIRT1249332	hsa-miR-4804-3p	CLIP-seq
MIRT1249333	hsa-miR-495	CLIP-seq
MIRT1249334	hsa-miR-519d	CLIP-seq
MIRT1249335	hsa-miR-520a-3p	CLIP-seq
MIRT1249336	hsa-miR-520b	CLIP-seq
MIRT1249337	hsa-miR-520c-3p	CLIP-seq
MIRT1249338	hsa-miR-520d-3p	CLIP-seq
MIRT1249339	hsa-miR-520e	CLIP-seq
MIRT1249340	hsa-miR-543	CLIP-seq
MIRT1249341	hsa-miR-548a-5p	CLIP-seq
MIRT1249342	hsa-miR-548ab	CLIP-seq
MIRT1249343	hsa-miR-548ah	CLIP-seq
MIRT1249344	hsa-miR-548ak	CLIP-seq
MIRT1249345	hsa-miR-548b-5p	CLIP-seq
MIRT1249346	hsa-miR-548c-5p	CLIP-seq
MIRT1249347	hsa-miR-548d-5p	CLIP-seq
MIRT1249348	hsa-miR-548h	CLIP-seq
MIRT1249349	hsa-miR-548i	CLIP-seq
MIRT1249350	hsa-miR-548j	CLIP-seq
MIRT1249351	hsa-miR-548k	CLIP-seq
MIRT1249352	hsa-miR-548l	CLIP-seq
MIRT1249353	hsa-miR-548u	CLIP-seq
MIRT1249354	hsa-miR-548w	CLIP-seq
MIRT1249355	hsa-miR-548y	CLIP-seq
MIRT1249356	hsa-miR-559	CLIP-seq
MIRT1249357	hsa-miR-577	CLIP-seq
MIRT1249358	hsa-miR-586	CLIP-seq
MIRT1249359	hsa-miR-590-3p	CLIP-seq
MIRT1249360	hsa-miR-633	CLIP-seq
MIRT1249361	hsa-miR-656	CLIP-seq
MIRT1249362	hsa-miR-93	CLIP-seq
MIRT1249280	hsa-miR-1297	CLIP-seq
MIRT1249289	hsa-miR-26a	CLIP-seq
MIRT1249290	hsa-miR-26b	CLIP-seq
MIRT2073640	hsa-miR-3668	CLIP-seq
MIRT1249315	hsa-miR-3924	CLIP-seq
MIRT1249322	hsa-miR-4465	CLIP-seq
MIRT2073641	hsa-miR-4654	CLIP-seq
MIRT2073642	hsa-miR-4769-5p	CLIP-seq
MIRT2073643	hsa-miR-4773	CLIP-seq
MIRT2073644	hsa-miR-556-3p	CLIP-seq
MIRT2073645	hsa-miR-582-5p	CLIP-seq
MIRT2300609	hsa-miR-1264	CLIP-seq
MIRT1249280	hsa-miR-1297	CLIP-seq
MIRT2300610	hsa-miR-140-5p	CLIP-seq
MIRT2300611	hsa-miR-199a-3p	CLIP-seq
MIRT2300612	hsa-miR-199b-3p	CLIP-seq
MIRT2300613	hsa-miR-2052	CLIP-seq
MIRT2300614	hsa-miR-223	CLIP-seq
MIRT1249289	hsa-miR-26a	CLIP-seq
MIRT1249290	hsa-miR-26b	CLIP-seq
MIRT1249297	hsa-miR-3074-3p	CLIP-seq
MIRT2300615	hsa-miR-30a	CLIP-seq
MIRT2300616	hsa-miR-30b	CLIP-seq
MIRT2300617	hsa-miR-30c	CLIP-seq
MIRT2300618	hsa-miR-30d	CLIP-seq
MIRT2300619	hsa-miR-30e	CLIP-seq
MIRT2300620	hsa-miR-3129-5p	CLIP-seq
MIRT2300621	hsa-miR-329	CLIP-seq
MIRT2300622	hsa-miR-362-3p	CLIP-seq
MIRT2073640	hsa-miR-3668	CLIP-seq
MIRT2300623	hsa-miR-376a	CLIP-seq
MIRT2300624	hsa-miR-376b	CLIP-seq
MIRT2300625	hsa-miR-377	CLIP-seq
MIRT1249315	hsa-miR-3924	CLIP-seq
MIRT2300626	hsa-miR-3973	CLIP-seq
MIRT2300627	hsa-miR-4464	CLIP-seq
MIRT1249322	hsa-miR-4465	CLIP-seq
MIRT2300628	hsa-miR-4477a	CLIP-seq
MIRT2300629	hsa-miR-4495	CLIP-seq
MIRT1249324	hsa-miR-4643	CLIP-seq
MIRT2073641	hsa-miR-4654	CLIP-seq
MIRT2300630	hsa-miR-4697-3p	CLIP-seq
MIRT2300631	hsa-miR-4748	CLIP-seq
MIRT2073642	hsa-miR-4769-5p	CLIP-seq
MIRT2073643	hsa-miR-4773	CLIP-seq
MIRT1249331	hsa-miR-4796-3p	CLIP-seq
MIRT2300632	hsa-miR-520g	CLIP-seq
MIRT2300633	hsa-miR-520h	CLIP-seq
MIRT2073644	hsa-miR-556-3p	CLIP-seq
MIRT2073645	hsa-miR-582-5p	CLIP-seq
MIRT1249360	hsa-miR-633	CLIP-seq
MIRT2300634	hsa-miR-888	CLIP-seq
MIRT2300635	hsa-miR-935	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000428	Component	DNA-directed RNA polymerase complex	IEA
GO:0002376	Process	Immune system process	IEA
GO:0003682	Function	Chromatin binding	IDA	24107381
GO:0003899	Function	DNA-directed RNA polymerase activity	TAS	9171375
GO:0005515	Function	Protein binding	IPI	20154270, 21358628, 32296183, 35271311
GO:0005634	Component	Nucleus	IDA	20154270
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005666	Component	RNA polymerase III complex	IBA
GO:0005666	Component	RNA polymerase III complex	IDA	24107381, 33335104, 34675218
GO:0005666	Component	RNA polymerase III complex	TAS	9171375
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006359	Process	Regulation of transcription by RNA polymerase III	TAS	9171375
GO:0006383	Process	Transcription by RNA polymerase III	IDA	20154270
GO:0006383	Process	Transcription by RNA polymerase III	IEA
GO:0008283	Process	Cell population proliferation	IBA
GO:0008283	Process	Cell population proliferation	IEP	24107381
GO:0016604	Component	Nuclear body	IDA
GO:0032728	Process	Positive regulation of interferon-beta production	IMP	19609254, 19631370
GO:0045087	Process	Innate immune response	IEA
GO:0045089	Process	Positive regulation of innate immune response	IMP	19609254, 19631370
GO:0051607	Process	Defense response to virus	IEA

Other IDs

• MIM: 617456
• HGNC: 30075
• e!Ensembl: ENSG00000113356

Protein

• UniProt ID: O15318
• Protein name: DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) (DNA-directed RNA polymerase III subunit G) (RNA polymerase III 32 kDa apha subunit) (RPC32-alpha) (RNA polymerase III 32 kDa subunit) (RPC32)
• Protein function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymer
• PDB: 7A6H, 7AE1, 7AE3, 7AEA, 7D58, 7D59, 7DN3, 7DU2, 7FJI, 7FJJ, 8ITY, 8IUE, 8IUH, 9FSO, 9FSP, 9FSQ, 9FSR, 9FSS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11705	RNA_pol_3_Rpc31	2 → 209	DNA-directed RNA polymerase III subunit Rpc31	Family

• Tissue specificity: TISSUE SPECIFICITY: Barely detectable in differentiated tissues. Expressed in embryonic stem cells and in other dividing cells, such as some tumor cell lines. {ECO:0000269|PubMed:20154270, ECO:0000269|PubMed:24107381, ECO:0000269|PubMed:28494942}.
• Sequence:

  MAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPDTDYKPVPLKTGEGEEYMLAL
  KQELRETMKRMPYFIETPEERQDIERYSKRYMKVYKEEWIPDWRRLPREMMPRNKCKKAG
  PKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKSDEENEEKEGSKEKSKEGDDDDDD
  DAAEQEEYDEEEQEEENDYINSYFEDGDDFGADSDDNMDEATY

• Sequence length: 223

Pathways

KEGG:

RNA polymerase
Cytosolic DNA-sensing pathway

Reactome:

Cytosolic sensors of pathogen-associated DNA
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Autism	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Hypoxia	Hypoxia	Pubtator	34165034	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	30820548		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27643433		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	34165034	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26701879		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	30820548		★☆☆☆☆ Found in Text Mining only