Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10614
Gene name	HEXIM P-TEFb complex subunit 1
Gene symbol	HEXIM1
Synonyms (NCBI Gene)	CLP1EDG1HIS1MAQ1
Chromosome	17
Chromosome location	17q21.31
Summary	Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

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Show/Hide all (285)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051053	hsa-miR-17-5p	CLASH	23622248
MIRT050765	hsa-miR-17-3p	CLASH	23622248
MIRT050623	hsa-miR-20a-5p	CLASH	23622248
MIRT046764	hsa-miR-222-3p	CLASH	23622248
MIRT042951	hsa-miR-324-3p	CLASH	23622248
MIRT041122	hsa-miR-503-5p	CLASH	23622248
MIRT702980	hsa-miR-548av-3p	HITS-CLIP	23313552
MIRT702979	hsa-miR-1252-3p	HITS-CLIP	23313552
MIRT702978	hsa-miR-495-3p	HITS-CLIP	23313552
MIRT702977	hsa-miR-5688	HITS-CLIP	23313552
MIRT702976	hsa-miR-7-1-3p	HITS-CLIP	23313552
MIRT702975	hsa-miR-7-2-3p	HITS-CLIP	23313552
MIRT702974	hsa-miR-203a-3p	HITS-CLIP	23313552
MIRT702973	hsa-miR-3975	HITS-CLIP	23313552
MIRT702972	hsa-miR-2467-5p	HITS-CLIP	23313552
MIRT702971	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT702970	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT702969	hsa-miR-3188	HITS-CLIP	23313552
MIRT702968	hsa-miR-8065	HITS-CLIP	23313552
MIRT702967	hsa-miR-4697-3p	HITS-CLIP	23313552
MIRT702966	hsa-miR-223-3p	HITS-CLIP	23313552
MIRT702965	hsa-miR-5093	HITS-CLIP	23313552
MIRT702980	hsa-miR-548av-3p	HITS-CLIP	23313552
MIRT702979	hsa-miR-1252-3p	HITS-CLIP	23313552
MIRT702978	hsa-miR-495-3p	HITS-CLIP	23313552
MIRT702977	hsa-miR-5688	HITS-CLIP	23313552
MIRT702976	hsa-miR-7-1-3p	HITS-CLIP	23313552
MIRT702975	hsa-miR-7-2-3p	HITS-CLIP	23313552
MIRT702974	hsa-miR-203a-3p	HITS-CLIP	23313552
MIRT702973	hsa-miR-3975	HITS-CLIP	23313552
MIRT702972	hsa-miR-2467-5p	HITS-CLIP	23313552
MIRT702971	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT702970	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT702969	hsa-miR-3188	HITS-CLIP	23313552
MIRT702968	hsa-miR-8065	HITS-CLIP	23313552
MIRT702967	hsa-miR-4697-3p	HITS-CLIP	23313552
MIRT702966	hsa-miR-223-3p	HITS-CLIP	23313552
MIRT702965	hsa-miR-5093	HITS-CLIP	23313552
MIRT1044711	hsa-miR-1208	CLIP-seq
MIRT1044712	hsa-miR-1245	CLIP-seq
MIRT1044713	hsa-miR-1266	CLIP-seq
MIRT1044714	hsa-miR-1468	CLIP-seq
MIRT1044715	hsa-miR-181a	CLIP-seq
MIRT1044716	hsa-miR-181b	CLIP-seq
MIRT1044717	hsa-miR-181c	CLIP-seq
MIRT1044718	hsa-miR-181d	CLIP-seq
MIRT1044719	hsa-miR-18a	CLIP-seq
MIRT1044720	hsa-miR-18b	CLIP-seq
MIRT1044721	hsa-miR-2053	CLIP-seq
MIRT1044722	hsa-miR-2114	CLIP-seq
MIRT1044723	hsa-miR-2117	CLIP-seq
MIRT1044724	hsa-miR-23a	CLIP-seq
MIRT1044725	hsa-miR-23b	CLIP-seq
MIRT1044726	hsa-miR-23c	CLIP-seq
MIRT1044727	hsa-miR-300	CLIP-seq
MIRT1044728	hsa-miR-3074-3p	CLIP-seq
MIRT1044729	hsa-miR-3121-5p	CLIP-seq
MIRT1044730	hsa-miR-3127-3p	CLIP-seq
MIRT1044731	hsa-miR-3127-5p	CLIP-seq
MIRT1044732	hsa-miR-3133	CLIP-seq
MIRT1044733	hsa-miR-3152-5p	CLIP-seq
MIRT1044734	hsa-miR-3162-3p	CLIP-seq
MIRT1044735	hsa-miR-3168	CLIP-seq
MIRT1044736	hsa-miR-3173-3p	CLIP-seq
MIRT1044737	hsa-miR-3187-3p	CLIP-seq
MIRT1044738	hsa-miR-3545-3p	CLIP-seq
MIRT1044739	hsa-miR-3607-3p	CLIP-seq
MIRT1044740	hsa-miR-3613-3p	CLIP-seq
MIRT1044741	hsa-miR-361-3p	CLIP-seq
MIRT1044742	hsa-miR-3616-5p	CLIP-seq
MIRT1044743	hsa-miR-3647-5p	CLIP-seq
MIRT1044744	hsa-miR-3664-3p	CLIP-seq
MIRT1044745	hsa-miR-381	CLIP-seq
MIRT1044746	hsa-miR-3918	CLIP-seq
MIRT1044747	hsa-miR-409-3p	CLIP-seq
MIRT1044748	hsa-miR-410	CLIP-seq
MIRT1044749	hsa-miR-4262	CLIP-seq
MIRT1044750	hsa-miR-4273	CLIP-seq
MIRT1044751	hsa-miR-4313	CLIP-seq
MIRT1044752	hsa-miR-4330	CLIP-seq
MIRT1044753	hsa-miR-4428	CLIP-seq
MIRT1044754	hsa-miR-4435	CLIP-seq
MIRT1044755	hsa-miR-4450	CLIP-seq
MIRT1044756	hsa-miR-4452	CLIP-seq
MIRT1044757	hsa-miR-4477b	CLIP-seq
MIRT1044758	hsa-miR-4512	CLIP-seq
MIRT1044759	hsa-miR-4518	CLIP-seq
MIRT1044760	hsa-miR-4539	CLIP-seq
MIRT1044761	hsa-miR-4635	CLIP-seq
MIRT1044762	hsa-miR-4643	CLIP-seq
MIRT1044763	hsa-miR-466	CLIP-seq
MIRT1044764	hsa-miR-4677-5p	CLIP-seq
MIRT1044765	hsa-miR-4701-5p	CLIP-seq
MIRT1044766	hsa-miR-4735-3p	CLIP-seq
MIRT1044767	hsa-miR-4761-5p	CLIP-seq
MIRT1044768	hsa-miR-4768-3p	CLIP-seq
MIRT1044769	hsa-miR-4773	CLIP-seq
MIRT1044770	hsa-miR-4774-3p	CLIP-seq
MIRT1044771	hsa-miR-4779	CLIP-seq
MIRT1044772	hsa-miR-4789-3p	CLIP-seq
MIRT1044773	hsa-miR-4789-5p	CLIP-seq
MIRT1044774	hsa-miR-491-3p	CLIP-seq
MIRT1044775	hsa-miR-495	CLIP-seq
MIRT1044776	hsa-miR-513a-3p	CLIP-seq
MIRT1044777	hsa-miR-548ac	CLIP-seq
MIRT1044778	hsa-miR-548ae	CLIP-seq
MIRT1044779	hsa-miR-548aj	CLIP-seq
MIRT1044780	hsa-miR-548am	CLIP-seq
MIRT1044781	hsa-miR-548d-3p	CLIP-seq
MIRT1044782	hsa-miR-548s	CLIP-seq
MIRT1044783	hsa-miR-548x	CLIP-seq
MIRT1044784	hsa-miR-548z	CLIP-seq
MIRT1044785	hsa-miR-561	CLIP-seq
MIRT1044786	hsa-miR-573	CLIP-seq
MIRT1044787	hsa-miR-588	CLIP-seq
MIRT1044788	hsa-miR-599	CLIP-seq
MIRT1044789	hsa-miR-624	CLIP-seq
MIRT2009741	hsa-miR-1207-3p	CLIP-seq
MIRT1044711	hsa-miR-1208	CLIP-seq
MIRT2009742	hsa-miR-1224-5p	CLIP-seq
MIRT2009743	hsa-miR-1236	CLIP-seq
MIRT2009744	hsa-miR-1252	CLIP-seq
MIRT2009745	hsa-miR-125a-3p	CLIP-seq
MIRT1044715	hsa-miR-181a	CLIP-seq
MIRT1044716	hsa-miR-181b	CLIP-seq
MIRT1044717	hsa-miR-181c	CLIP-seq
MIRT1044718	hsa-miR-181d	CLIP-seq
MIRT2009746	hsa-miR-216a	CLIP-seq
MIRT1044724	hsa-miR-23a	CLIP-seq
MIRT1044725	hsa-miR-23b	CLIP-seq
MIRT1044726	hsa-miR-23c	CLIP-seq
MIRT1044729	hsa-miR-3121-5p	CLIP-seq
MIRT1044730	hsa-miR-3127-3p	CLIP-seq
MIRT1044732	hsa-miR-3133	CLIP-seq
MIRT2009747	hsa-miR-3169	CLIP-seq
MIRT2009748	hsa-miR-340	CLIP-seq
MIRT1044739	hsa-miR-3607-3p	CLIP-seq
MIRT2009749	hsa-miR-3612	CLIP-seq
MIRT1044740	hsa-miR-3613-3p	CLIP-seq
MIRT1044741	hsa-miR-361-3p	CLIP-seq
MIRT2009750	hsa-miR-3662	CLIP-seq
MIRT2009751	hsa-miR-3665	CLIP-seq
MIRT1044747	hsa-miR-409-3p	CLIP-seq
MIRT1044748	hsa-miR-410	CLIP-seq
MIRT1044749	hsa-miR-4262	CLIP-seq
MIRT1044751	hsa-miR-4313	CLIP-seq
MIRT2009752	hsa-miR-4436b-3p	CLIP-seq
MIRT1044755	hsa-miR-4450	CLIP-seq
MIRT1044756	hsa-miR-4452	CLIP-seq
MIRT2009753	hsa-miR-4459	CLIP-seq
MIRT2009754	hsa-miR-4515	CLIP-seq
MIRT1044762	hsa-miR-4643	CLIP-seq
MIRT1044763	hsa-miR-466	CLIP-seq
MIRT2009755	hsa-miR-4695-5p	CLIP-seq
MIRT2009756	hsa-miR-4698	CLIP-seq
MIRT2009757	hsa-miR-4712-5p	CLIP-seq
MIRT2009758	hsa-miR-4729	CLIP-seq
MIRT2009759	hsa-miR-4736	CLIP-seq
MIRT2009760	hsa-miR-4751	CLIP-seq
MIRT2009761	hsa-miR-4777-3p	CLIP-seq
MIRT1044772	hsa-miR-4789-3p	CLIP-seq
MIRT1044773	hsa-miR-4789-5p	CLIP-seq
MIRT1044788	hsa-miR-599	CLIP-seq
MIRT2009762	hsa-miR-605	CLIP-seq
MIRT2009763	hsa-miR-642b	CLIP-seq
MIRT2009764	hsa-miR-650	CLIP-seq
MIRT2009765	hsa-miR-770-5p	CLIP-seq
MIRT1044711	hsa-miR-1208	CLIP-seq
MIRT2009743	hsa-miR-1236	CLIP-seq
MIRT2009744	hsa-miR-1252	CLIP-seq
MIRT2009745	hsa-miR-125a-3p	CLIP-seq
MIRT1044715	hsa-miR-181a	CLIP-seq
MIRT1044716	hsa-miR-181b	CLIP-seq
MIRT1044717	hsa-miR-181c	CLIP-seq
MIRT1044718	hsa-miR-181d	CLIP-seq
MIRT2242095	hsa-miR-1910	CLIP-seq
MIRT1044723	hsa-miR-2117	CLIP-seq
MIRT1044724	hsa-miR-23a	CLIP-seq
MIRT1044725	hsa-miR-23b	CLIP-seq
MIRT1044726	hsa-miR-23c	CLIP-seq
MIRT1044729	hsa-miR-3121-5p	CLIP-seq
MIRT1044730	hsa-miR-3127-3p	CLIP-seq
MIRT2242096	hsa-miR-3167	CLIP-seq
MIRT2009747	hsa-miR-3169	CLIP-seq
MIRT2242097	hsa-miR-3182	CLIP-seq
MIRT1044737	hsa-miR-3187-3p	CLIP-seq
MIRT2009748	hsa-miR-340	CLIP-seq
MIRT1044739	hsa-miR-3607-3p	CLIP-seq
MIRT1044740	hsa-miR-3613-3p	CLIP-seq
MIRT1044741	hsa-miR-361-3p	CLIP-seq
MIRT2009751	hsa-miR-3665	CLIP-seq
MIRT2242098	hsa-miR-3920	CLIP-seq
MIRT1044747	hsa-miR-409-3p	CLIP-seq
MIRT1044748	hsa-miR-410	CLIP-seq
MIRT1044749	hsa-miR-4262	CLIP-seq
MIRT2242099	hsa-miR-4264	CLIP-seq
MIRT2242100	hsa-miR-4267	CLIP-seq
MIRT1044750	hsa-miR-4273	CLIP-seq
MIRT1044751	hsa-miR-4313	CLIP-seq
MIRT2242101	hsa-miR-4328	CLIP-seq
MIRT1044752	hsa-miR-4330	CLIP-seq
MIRT1044754	hsa-miR-4435	CLIP-seq
MIRT2009752	hsa-miR-4436b-3p	CLIP-seq
MIRT1044755	hsa-miR-4450	CLIP-seq
MIRT1044756	hsa-miR-4452	CLIP-seq
MIRT1044757	hsa-miR-4477b	CLIP-seq
MIRT2242102	hsa-miR-4493	CLIP-seq
MIRT2009754	hsa-miR-4515	CLIP-seq
MIRT2242103	hsa-miR-455-3p	CLIP-seq
MIRT1044764	hsa-miR-4677-5p	CLIP-seq
MIRT1044765	hsa-miR-4701-5p	CLIP-seq
MIRT2009759	hsa-miR-4736	CLIP-seq
MIRT2242104	hsa-miR-4753-3p	CLIP-seq
MIRT2242105	hsa-miR-4762-3p	CLIP-seq
MIRT2242106	hsa-miR-4768-5p	CLIP-seq
MIRT1044782	hsa-miR-548s	CLIP-seq
MIRT1044787	hsa-miR-588	CLIP-seq
MIRT2242107	hsa-miR-592	CLIP-seq
MIRT2242108	hsa-miR-597	CLIP-seq
MIRT2009762	hsa-miR-605	CLIP-seq
MIRT2009763	hsa-miR-642b	CLIP-seq
MIRT2242109	hsa-miR-876-5p	CLIP-seq
MIRT2009744	hsa-miR-1252	CLIP-seq
MIRT2009745	hsa-miR-125a-3p	CLIP-seq
MIRT1044715	hsa-miR-181a	CLIP-seq
MIRT1044716	hsa-miR-181b	CLIP-seq
MIRT1044717	hsa-miR-181c	CLIP-seq
MIRT1044718	hsa-miR-181d	CLIP-seq
MIRT2009746	hsa-miR-216a	CLIP-seq
MIRT2009747	hsa-miR-3169	CLIP-seq
MIRT2009750	hsa-miR-3662	CLIP-seq
MIRT2009751	hsa-miR-3665	CLIP-seq
MIRT1044747	hsa-miR-409-3p	CLIP-seq
MIRT1044748	hsa-miR-410	CLIP-seq
MIRT1044749	hsa-miR-4262	CLIP-seq
MIRT2009752	hsa-miR-4436b-3p	CLIP-seq
MIRT2009754	hsa-miR-4515	CLIP-seq
MIRT1044762	hsa-miR-4643	CLIP-seq
MIRT1044763	hsa-miR-466	CLIP-seq
MIRT2009756	hsa-miR-4698	CLIP-seq
MIRT2009759	hsa-miR-4736	CLIP-seq
MIRT1044772	hsa-miR-4789-3p	CLIP-seq
MIRT1044773	hsa-miR-4789-5p	CLIP-seq
MIRT2009763	hsa-miR-642b	CLIP-seq
MIRT2451133	hsa-miR-4798-5p	CLIP-seq
MIRT2009744	hsa-miR-1252	CLIP-seq
MIRT2009745	hsa-miR-125a-3p	CLIP-seq
MIRT2545748	hsa-miR-129-5p	CLIP-seq
MIRT2545749	hsa-miR-2052	CLIP-seq
MIRT2009746	hsa-miR-216a	CLIP-seq
MIRT2009747	hsa-miR-3169	CLIP-seq
MIRT2009749	hsa-miR-3612	CLIP-seq
MIRT2009750	hsa-miR-3662	CLIP-seq
MIRT2009751	hsa-miR-3665	CLIP-seq
MIRT2545750	hsa-miR-4260	CLIP-seq
MIRT2009752	hsa-miR-4436b-3p	CLIP-seq
MIRT2009753	hsa-miR-4459	CLIP-seq
MIRT2009754	hsa-miR-4515	CLIP-seq
MIRT1044760	hsa-miR-4539	CLIP-seq
MIRT2545751	hsa-miR-4652-3p	CLIP-seq
MIRT2009755	hsa-miR-4695-5p	CLIP-seq
MIRT2009756	hsa-miR-4698	CLIP-seq
MIRT2009757	hsa-miR-4712-5p	CLIP-seq
MIRT2009759	hsa-miR-4736	CLIP-seq
MIRT2009761	hsa-miR-4777-3p	CLIP-seq
MIRT2545752	hsa-miR-486-3p	CLIP-seq
MIRT2009762	hsa-miR-605	CLIP-seq
MIRT2009763	hsa-miR-642b	CLIP-seq
MIRT2009764	hsa-miR-650	CLIP-seq
MIRT2009765	hsa-miR-770-5p	CLIP-seq
MIRT2009744	hsa-miR-1252	CLIP-seq
MIRT2009745	hsa-miR-125a-3p	CLIP-seq
MIRT2009747	hsa-miR-3169	CLIP-seq
MIRT2009749	hsa-miR-3612	CLIP-seq
MIRT2009750	hsa-miR-3662	CLIP-seq
MIRT2009751	hsa-miR-3665	CLIP-seq
MIRT2009752	hsa-miR-4436b-3p	CLIP-seq
MIRT2009753	hsa-miR-4459	CLIP-seq
MIRT2009754	hsa-miR-4515	CLIP-seq
MIRT2009755	hsa-miR-4695-5p	CLIP-seq
MIRT2009756	hsa-miR-4698	CLIP-seq
MIRT2682275	hsa-miR-4713-5p	CLIP-seq
MIRT2009759	hsa-miR-4736	CLIP-seq
MIRT2009763	hsa-miR-642b	CLIP-seq
MIRT2009764	hsa-miR-650	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	18483487
GO:0002218	Process	Activation of innate immune response	IDA	28712728
GO:0002376	Process	Immune system process	IEA
GO:0004860	Function	Protein kinase inhibitor activity	IDA	28431135
GO:0004861	Function	Cyclin-dependent protein serine/threonine kinase inhibitor activity	IBA
GO:0004861	Function	Cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA	14580347
GO:0004861	Function	Cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA
GO:0005515	Function	Protein binding	IPI	12832472, 14580347, 15713661, 15941832, 17724342, 18281698, 18483487, 19387490, 19883659, 20562857, 21044950, 21533037, 23455922, 24360279, 24981860, 25470060, 28514442, 30824372, 32296183, 32707033, 33961781, 35271311, 39251607
GO:0005634	Component	Nucleus	IDA	12581153, 28712728
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	12581153
GO:0005737	Component	Cytoplasm	IEA
GO:0007507	Process	Heart development	IEA
GO:0017069	Function	SnRNA binding	IDA	14580347
GO:0017069	Function	SnRNA binding	IEA
GO:0032897	Process	Negative regulation of viral transcription	IMP	18249148
GO:0034244	Process	Negative regulation of transcription elongation by RNA polymerase II	IC	18483487
GO:0034244	Process	Negative regulation of transcription elongation by RNA polymerase II	IDA	14580347
GO:0042802	Function	Identical protein binding	IPI	17724342, 31515488
GO:0045087	Process	Innate immune response	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0097322	Function	7SK snRNA binding	IBA
GO:0097322	Function	7SK snRNA binding	IDA	12832472, 18249148, 18483487, 19883659, 28431135
GO:0106140	Function	P-TEFb complex binding	IDA	18249148, 18483487, 28431135
GO:0120259	Component	7SK snRNP	IDA	18249148, 18483487, 28431135
GO:0140416	Function	Transcription regulator inhibitor activity	IDA	14580347
GO:1901798	Process	Positive regulation of signal transduction by p53 class mediator	IMP	22948151

MIM	HGNC	e!Ensembl
607328	24953	ENSG00000186834

O94992

Protein name

Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1)

Protein function

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a lar

PDB

2GD7 , 3S9G

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15313	HEXIM	164 → 301	Hexamethylene bis-acetamide-inducible protein	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. {ECO:0000269|PubMed:12941847, ECO:0000269|PubMed:15713661}.

Sequence

MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQLGGRPG
PEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGDFPPPAEVEPTPEAELLAQ
PCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDE
KQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDD
FMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSR
MEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD

Sequence length

359

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHILDHOOD ONSET ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (32)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Erythroblastic Leukemia	Erythroblastic Leukemia	BEFREE	16222702		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of prostate	Prostate adenocarcinoma	BEFREE	22095517		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amelogenesis Imperfecta	Amelogenesis imperfecta	BEFREE	11037750		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	28013147		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	28013147		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	26734838, 28213333		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	26734838	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28213333, 33273553, 34864989	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	28951318		★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	BEFREE	31467394		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	23300697		★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic pulmonary arterial hypertension	Pulmonary arterial hypertension	BEFREE	23300697		★★★★★ ★☆☆☆☆ Found in Text Mining only
Left Ventricular Hypertrophy	Left Ventricular Hypertrophy	BEFREE	23300697, 28013147		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	9094986		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	27732946, 33273553	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	18371977		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	22098666		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26734838, 28213333		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	22095517, 28213333		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	17671421, 27058786, 27903752, 28013147, 28073847, 31805991		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	27238569, 31805991		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	27058786, 27102073		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	33273553	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia	Myeloid Leukemia	BEFREE	1682866		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopathy	Myopathy	BEFREE	22479198		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22098666, 27058786, 27102073, 27238569, 27903752, 28484091, 29491412, 31776402, 31805991		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	16222702		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	14599962		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	22095517, 28213333		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	24844355, 34864989	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	28213333	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Right Ventricular Hypertrophy	Ventricular hypertrophy	BEFREE	23300697, 25301555		★★★★★ ★☆☆☆☆ Found in Text Mining only

HEXIM1 (HEXIM P-TEFb complex subunit 1)