MXD4 (MAX dimerization protein 4)

Gene

• Entrez ID: 10608
• Gene name: MAX dimerization protein 4
• Gene symbol: MXD4
• Synonyms (NCBI Gene): MAD4, MST149, MSTP149, bHLHc12
• Chromosome: 4
• Chromosome location: 4p16.3
• Summary: This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002761	hsa-miR-1-3p	Microarray	15685193
MIRT017888	hsa-miR-335-5p	Microarray	18185580
MIRT022628	hsa-miR-124-3p	Microarray	18668037
MIRT002761	hsa-miR-1-3p	Microarray;Other	15685193
MIRT043901	hsa-miR-378a-3p	CLASH	23622248
MIRT1167018	hsa-miR-138	CLIP-seq
MIRT1167019	hsa-miR-2110	CLIP-seq
MIRT1167020	hsa-miR-3064-5p	CLIP-seq
MIRT1167021	hsa-miR-3138	CLIP-seq
MIRT1167022	hsa-miR-3160-5p	CLIP-seq
MIRT1167023	hsa-miR-3202	CLIP-seq
MIRT1167024	hsa-miR-3616-3p	CLIP-seq
MIRT1167025	hsa-miR-3650	CLIP-seq
MIRT1167026	hsa-miR-3652	CLIP-seq
MIRT1167027	hsa-miR-3907	CLIP-seq
MIRT1167028	hsa-miR-3922-5p	CLIP-seq
MIRT1167029	hsa-miR-3977	CLIP-seq
MIRT1167030	hsa-miR-4271	CLIP-seq
MIRT1167031	hsa-miR-4430	CLIP-seq
MIRT1167032	hsa-miR-4455	CLIP-seq
MIRT1167033	hsa-miR-4481	CLIP-seq
MIRT1167034	hsa-miR-4487	CLIP-seq
MIRT1167035	hsa-miR-4505	CLIP-seq
MIRT1167036	hsa-miR-4520a-3p	CLIP-seq
MIRT1167037	hsa-miR-4659a-3p	CLIP-seq
MIRT1167038	hsa-miR-4659b-3p	CLIP-seq
MIRT1167039	hsa-miR-4667-5p	CLIP-seq
MIRT1167040	hsa-miR-4700-5p	CLIP-seq
MIRT1167041	hsa-miR-4708-3p	CLIP-seq
MIRT1167042	hsa-miR-4711-3p	CLIP-seq
MIRT1167043	hsa-miR-4721	CLIP-seq
MIRT1167044	hsa-miR-4725-3p	CLIP-seq
MIRT1167045	hsa-miR-4731-3p	CLIP-seq
MIRT1167046	hsa-miR-4731-5p	CLIP-seq
MIRT1167047	hsa-miR-4743	CLIP-seq
MIRT1167048	hsa-miR-4745-5p	CLIP-seq
MIRT1167049	hsa-miR-4747-5p	CLIP-seq
MIRT1167050	hsa-miR-4758-5p	CLIP-seq
MIRT1167051	hsa-miR-4778-3p	CLIP-seq
MIRT1167052	hsa-miR-4801	CLIP-seq
MIRT1167053	hsa-miR-548c-3p	CLIP-seq
MIRT1167054	hsa-miR-548q	CLIP-seq
MIRT1167055	hsa-miR-552	CLIP-seq
MIRT1167056	hsa-miR-609	CLIP-seq
MIRT1167057	hsa-miR-642b	CLIP-seq
MIRT1167058	hsa-miR-924	CLIP-seq
MIRT1551462	hsa-miR-1324	CLIP-seq
MIRT1551463	hsa-miR-184	CLIP-seq
MIRT1167036	hsa-miR-4520a-3p	CLIP-seq
MIRT2048234	hsa-miR-1	CLIP-seq
MIRT2048235	hsa-miR-103a	CLIP-seq
MIRT2048236	hsa-miR-107	CLIP-seq
MIRT2048237	hsa-miR-1202	CLIP-seq
MIRT2048238	hsa-miR-1207-3p	CLIP-seq
MIRT2048239	hsa-miR-1238	CLIP-seq
MIRT2048240	hsa-miR-124	CLIP-seq
MIRT2048241	hsa-miR-1252	CLIP-seq
MIRT2048242	hsa-miR-127-5p	CLIP-seq
MIRT2048243	hsa-miR-1299	CLIP-seq
MIRT2048244	hsa-miR-1301	CLIP-seq
MIRT1551462	hsa-miR-1324	CLIP-seq
MIRT2048245	hsa-miR-146a	CLIP-seq
MIRT2048246	hsa-miR-146b-5p	CLIP-seq
MIRT1551463	hsa-miR-184	CLIP-seq
MIRT2048247	hsa-miR-1908	CLIP-seq
MIRT2048248	hsa-miR-1909	CLIP-seq
MIRT2048249	hsa-miR-1972	CLIP-seq
MIRT2048250	hsa-miR-200b	CLIP-seq
MIRT2048251	hsa-miR-200c	CLIP-seq
MIRT2048252	hsa-miR-206	CLIP-seq
MIRT1167019	hsa-miR-2110	CLIP-seq
MIRT2048253	hsa-miR-22	CLIP-seq
MIRT2048254	hsa-miR-2467-3p	CLIP-seq
MIRT1167021	hsa-miR-3138	CLIP-seq
MIRT2048255	hsa-miR-3177-3p	CLIP-seq
MIRT2048256	hsa-miR-3183	CLIP-seq
MIRT2048257	hsa-miR-3184	CLIP-seq
MIRT2048258	hsa-miR-3194-5p	CLIP-seq
MIRT2048259	hsa-miR-3200-5p	CLIP-seq
MIRT1167024	hsa-miR-3616-3p	CLIP-seq
MIRT1167026	hsa-miR-3652	CLIP-seq
MIRT2048260	hsa-miR-3660	CLIP-seq
MIRT2048261	hsa-miR-3667-3p	CLIP-seq
MIRT2048262	hsa-miR-3673	CLIP-seq
MIRT2048263	hsa-miR-3682-5p	CLIP-seq
MIRT2048264	hsa-miR-374c	CLIP-seq
MIRT2048265	hsa-miR-3908	CLIP-seq
MIRT2048266	hsa-miR-3972	CLIP-seq
MIRT2048267	hsa-miR-423-5p	CLIP-seq
MIRT2048268	hsa-miR-4251	CLIP-seq
MIRT2048269	hsa-miR-4256	CLIP-seq
MIRT2048270	hsa-miR-4269	CLIP-seq
MIRT1167030	hsa-miR-4271	CLIP-seq
MIRT2048271	hsa-miR-429	CLIP-seq
MIRT2048272	hsa-miR-4293	CLIP-seq
MIRT2048273	hsa-miR-4297	CLIP-seq
MIRT2048274	hsa-miR-4323	CLIP-seq
MIRT2048275	hsa-miR-4329	CLIP-seq
MIRT1167031	hsa-miR-4430	CLIP-seq
MIRT2048276	hsa-miR-4457	CLIP-seq
MIRT2048277	hsa-miR-4462	CLIP-seq
MIRT2048278	hsa-miR-4468	CLIP-seq
MIRT2048279	hsa-miR-4476	CLIP-seq
MIRT2048280	hsa-miR-4484	CLIP-seq
MIRT2048281	hsa-miR-4496	CLIP-seq
MIRT1167035	hsa-miR-4505	CLIP-seq
MIRT2048282	hsa-miR-4514	CLIP-seq
MIRT1167036	hsa-miR-4520a-3p	CLIP-seq
MIRT2048283	hsa-miR-4526	CLIP-seq
MIRT2048284	hsa-miR-4533	CLIP-seq
MIRT2048285	hsa-miR-4640-5p	CLIP-seq
MIRT1167039	hsa-miR-4667-5p	CLIP-seq
MIRT2048286	hsa-miR-4690-5p	CLIP-seq
MIRT2048287	hsa-miR-4692	CLIP-seq
MIRT1167040	hsa-miR-4700-5p	CLIP-seq
MIRT2048288	hsa-miR-4713-3p	CLIP-seq
MIRT2048289	hsa-miR-4723-3p	CLIP-seq
MIRT1167044	hsa-miR-4725-3p	CLIP-seq
MIRT2048290	hsa-miR-4726-5p	CLIP-seq
MIRT2048291	hsa-miR-4727-5p	CLIP-seq
MIRT2048292	hsa-miR-4728-5p	CLIP-seq
MIRT1167045	hsa-miR-4731-3p	CLIP-seq
MIRT1167046	hsa-miR-4731-5p	CLIP-seq
MIRT1167049	hsa-miR-4747-5p	CLIP-seq
MIRT2048293	hsa-miR-4749-3p	CLIP-seq
MIRT2048294	hsa-miR-4757-3p	CLIP-seq
MIRT2048295	hsa-miR-4769-3p	CLIP-seq
MIRT2048296	hsa-miR-4773	CLIP-seq
MIRT2048297	hsa-miR-4782-5p	CLIP-seq
MIRT2048298	hsa-miR-4795-5p	CLIP-seq
MIRT1167052	hsa-miR-4801	CLIP-seq
MIRT2048299	hsa-miR-486-3p	CLIP-seq
MIRT2048300	hsa-miR-490-3p	CLIP-seq
MIRT2048301	hsa-miR-5047	CLIP-seq
MIRT2048302	hsa-miR-506	CLIP-seq
MIRT2048303	hsa-miR-516b	CLIP-seq
MIRT2048304	hsa-miR-558	CLIP-seq
MIRT2048305	hsa-miR-564	CLIP-seq
MIRT2048306	hsa-miR-589	CLIP-seq
MIRT2048307	hsa-miR-613	CLIP-seq
MIRT2048308	hsa-miR-627	CLIP-seq
MIRT1167057	hsa-miR-642b	CLIP-seq
MIRT2048309	hsa-miR-655	CLIP-seq
MIRT2048310	hsa-miR-663	CLIP-seq
MIRT2048311	hsa-miR-873	CLIP-seq
MIRT2048312	hsa-miR-875-3p	CLIP-seq
MIRT1167058	hsa-miR-924	CLIP-seq
MIRT2048313	hsa-miR-940	CLIP-seq
MIRT2048234	hsa-miR-1	CLIP-seq
MIRT2048235	hsa-miR-103a	CLIP-seq
MIRT2048236	hsa-miR-107	CLIP-seq
MIRT2048237	hsa-miR-1202	CLIP-seq
MIRT2277103	hsa-miR-1207-5p	CLIP-seq
MIRT2277104	hsa-miR-1224-3p	CLIP-seq
MIRT2048240	hsa-miR-124	CLIP-seq
MIRT2277105	hsa-miR-125a-5p	CLIP-seq
MIRT2277106	hsa-miR-125b	CLIP-seq
MIRT2277107	hsa-miR-1260	CLIP-seq
MIRT2277108	hsa-miR-1260b	CLIP-seq
MIRT2277109	hsa-miR-1280	CLIP-seq
MIRT2277110	hsa-miR-1285	CLIP-seq
MIRT2277111	hsa-miR-1291	CLIP-seq
MIRT2277112	hsa-miR-1293	CLIP-seq
MIRT2048243	hsa-miR-1299	CLIP-seq
MIRT2048244	hsa-miR-1301	CLIP-seq
MIRT2277113	hsa-miR-1321	CLIP-seq
MIRT1167018	hsa-miR-138	CLIP-seq
MIRT2277114	hsa-miR-139-3p	CLIP-seq
MIRT2277115	hsa-miR-1587	CLIP-seq
MIRT2277116	hsa-miR-15a	CLIP-seq
MIRT2277117	hsa-miR-15b	CLIP-seq
MIRT2277118	hsa-miR-16	CLIP-seq
MIRT2048247	hsa-miR-1908	CLIP-seq
MIRT2277119	hsa-miR-1913	CLIP-seq
MIRT2277120	hsa-miR-195	CLIP-seq
MIRT2048249	hsa-miR-1972	CLIP-seq
MIRT2048250	hsa-miR-200b	CLIP-seq
MIRT2048251	hsa-miR-200c	CLIP-seq
MIRT2048252	hsa-miR-206	CLIP-seq
MIRT2048253	hsa-miR-22	CLIP-seq
MIRT2277121	hsa-miR-2355-5p	CLIP-seq
MIRT2048254	hsa-miR-2467-3p	CLIP-seq
MIRT2277122	hsa-miR-3126-5p	CLIP-seq
MIRT2277123	hsa-miR-3151	CLIP-seq
MIRT2277124	hsa-miR-3173-5p	CLIP-seq
MIRT2048257	hsa-miR-3184	CLIP-seq
MIRT2277125	hsa-miR-3187-5p	CLIP-seq
MIRT2277126	hsa-miR-3189-5p	CLIP-seq
MIRT2277127	hsa-miR-3192	CLIP-seq
MIRT2048258	hsa-miR-3194-5p	CLIP-seq
MIRT1167023	hsa-miR-3202	CLIP-seq
MIRT2277128	hsa-miR-324-3p	CLIP-seq
MIRT2277129	hsa-miR-346	CLIP-seq
MIRT2277130	hsa-miR-34a	CLIP-seq
MIRT2277131	hsa-miR-34c-5p	CLIP-seq
MIRT1167024	hsa-miR-3616-3p	CLIP-seq
MIRT1167025	hsa-miR-3650	CLIP-seq
MIRT1167026	hsa-miR-3652	CLIP-seq
MIRT2048260	hsa-miR-3660	CLIP-seq
MIRT2048262	hsa-miR-3673	CLIP-seq
MIRT2048263	hsa-miR-3682-5p	CLIP-seq
MIRT2277132	hsa-miR-3689a-3p	CLIP-seq
MIRT2277133	hsa-miR-3689c	CLIP-seq
MIRT2048264	hsa-miR-374c	CLIP-seq
MIRT1167027	hsa-miR-3907	CLIP-seq
MIRT2048265	hsa-miR-3908	CLIP-seq
MIRT1167028	hsa-miR-3922-5p	CLIP-seq
MIRT2277134	hsa-miR-3944-5p	CLIP-seq
MIRT2048266	hsa-miR-3972	CLIP-seq
MIRT1167029	hsa-miR-3977	CLIP-seq
MIRT2048267	hsa-miR-423-5p	CLIP-seq
MIRT2277135	hsa-miR-424	CLIP-seq
MIRT2277136	hsa-miR-4265	CLIP-seq
MIRT2048270	hsa-miR-4269	CLIP-seq
MIRT2277137	hsa-miR-4270	CLIP-seq
MIRT2277138	hsa-miR-4288	CLIP-seq
MIRT2048271	hsa-miR-429	CLIP-seq
MIRT2277139	hsa-miR-4296	CLIP-seq
MIRT2277140	hsa-miR-4300	CLIP-seq
MIRT2277141	hsa-miR-4319	CLIP-seq
MIRT2277142	hsa-miR-4322	CLIP-seq
MIRT2048274	hsa-miR-4323	CLIP-seq
MIRT2277143	hsa-miR-4324	CLIP-seq
MIRT2048275	hsa-miR-4329	CLIP-seq
MIRT2277144	hsa-miR-4417	CLIP-seq
MIRT1167031	hsa-miR-4430	CLIP-seq
MIRT2277145	hsa-miR-4441	CLIP-seq
MIRT2048276	hsa-miR-4457	CLIP-seq
MIRT2048277	hsa-miR-4462	CLIP-seq
MIRT2277146	hsa-miR-4464	CLIP-seq
MIRT2048278	hsa-miR-4468	CLIP-seq
MIRT2277147	hsa-miR-4483	CLIP-seq
MIRT1167034	hsa-miR-4487	CLIP-seq
MIRT2277148	hsa-miR-4492	CLIP-seq
MIRT2048281	hsa-miR-4496	CLIP-seq
MIRT2277149	hsa-miR-4498	CLIP-seq
MIRT2277150	hsa-miR-449a	CLIP-seq
MIRT2277151	hsa-miR-449b	CLIP-seq
MIRT1167035	hsa-miR-4505	CLIP-seq
MIRT2048282	hsa-miR-4514	CLIP-seq
MIRT2048283	hsa-miR-4526	CLIP-seq
MIRT2277152	hsa-miR-4530	CLIP-seq
MIRT2048284	hsa-miR-4533	CLIP-seq
MIRT2048285	hsa-miR-4640-5p	CLIP-seq
MIRT2277153	hsa-miR-4645-5p	CLIP-seq
MIRT2277154	hsa-miR-4656	CLIP-seq
MIRT1167039	hsa-miR-4667-5p	CLIP-seq
MIRT2277155	hsa-miR-4673	CLIP-seq
MIRT2277156	hsa-miR-4675	CLIP-seq
MIRT2277157	hsa-miR-4688	CLIP-seq
MIRT2277158	hsa-miR-4690-3p	CLIP-seq
MIRT2048287	hsa-miR-4692	CLIP-seq
MIRT1167040	hsa-miR-4700-5p	CLIP-seq
MIRT2277159	hsa-miR-4726-3p	CLIP-seq
MIRT2048290	hsa-miR-4726-5p	CLIP-seq
MIRT2048292	hsa-miR-4728-5p	CLIP-seq
MIRT1167045	hsa-miR-4731-3p	CLIP-seq
MIRT1167046	hsa-miR-4731-5p	CLIP-seq
MIRT2277160	hsa-miR-4732-3p	CLIP-seq
MIRT2277161	hsa-miR-4736	CLIP-seq
MIRT2277162	hsa-miR-4739	CLIP-seq
MIRT2277163	hsa-miR-4741	CLIP-seq
MIRT2277164	hsa-miR-4742-5p	CLIP-seq
MIRT1167049	hsa-miR-4747-5p	CLIP-seq
MIRT2277165	hsa-miR-4748	CLIP-seq
MIRT2277166	hsa-miR-4755-3p	CLIP-seq
MIRT2277167	hsa-miR-4756-5p	CLIP-seq
MIRT2048294	hsa-miR-4757-3p	CLIP-seq
MIRT2277168	hsa-miR-4758-3p	CLIP-seq
MIRT2277169	hsa-miR-4763-3p	CLIP-seq
MIRT2048297	hsa-miR-4782-5p	CLIP-seq
MIRT2048298	hsa-miR-4795-5p	CLIP-seq
MIRT1167052	hsa-miR-4801	CLIP-seq
MIRT2048299	hsa-miR-486-3p	CLIP-seq
MIRT2277170	hsa-miR-497	CLIP-seq
MIRT2048301	hsa-miR-5047	CLIP-seq
MIRT2048302	hsa-miR-506	CLIP-seq
MIRT2048303	hsa-miR-516b	CLIP-seq
MIRT2277171	hsa-miR-532-3p	CLIP-seq
MIRT2277172	hsa-miR-545	CLIP-seq
MIRT1167054	hsa-miR-548q	CLIP-seq
MIRT2048305	hsa-miR-564	CLIP-seq
MIRT2277173	hsa-miR-612	CLIP-seq
MIRT2048307	hsa-miR-613	CLIP-seq
MIRT2277174	hsa-miR-615-5p	CLIP-seq
MIRT2277175	hsa-miR-632	CLIP-seq
MIRT1167057	hsa-miR-642b	CLIP-seq
MIRT2277176	hsa-miR-646	CLIP-seq
MIRT2048309	hsa-miR-655	CLIP-seq
MIRT2048310	hsa-miR-663	CLIP-seq
MIRT2277177	hsa-miR-670	CLIP-seq
MIRT2277178	hsa-miR-762	CLIP-seq
MIRT2277179	hsa-miR-764	CLIP-seq
MIRT2048312	hsa-miR-875-3p	CLIP-seq
MIRT2277180	hsa-miR-920	CLIP-seq
MIRT2048313	hsa-miR-940	CLIP-seq
MIRT2277104	hsa-miR-1224-3p	CLIP-seq
MIRT1167035	hsa-miR-4505	CLIP-seq
MIRT2277154	hsa-miR-4656	CLIP-seq
MIRT1167045	hsa-miR-4731-3p	CLIP-seq
MIRT1167052	hsa-miR-4801	CLIP-seq
MIRT2277171	hsa-miR-532-3p	CLIP-seq
MIRT2391207	hsa-miR-767-5p	CLIP-seq
MIRT1167058	hsa-miR-924	CLIP-seq
MIRT1167045	hsa-miR-4731-3p	CLIP-seq
MIRT1167052	hsa-miR-4801	CLIP-seq
MIRT1167045	hsa-miR-4731-3p	CLIP-seq
MIRT1167052	hsa-miR-4801	CLIP-seq
MIRT2277111	hsa-miR-1291	CLIP-seq
MIRT1167045	hsa-miR-4731-3p	CLIP-seq
MIRT1167052	hsa-miR-4801	CLIP-seq
MIRT2048238	hsa-miR-1207-3p	CLIP-seq
MIRT2277116	hsa-miR-15a	CLIP-seq
MIRT2277117	hsa-miR-15b	CLIP-seq
MIRT2277118	hsa-miR-16	CLIP-seq
MIRT2454633	hsa-miR-1914	CLIP-seq
MIRT2277120	hsa-miR-195	CLIP-seq
MIRT2454634	hsa-miR-1976	CLIP-seq
MIRT2454635	hsa-miR-2115	CLIP-seq
MIRT2454636	hsa-miR-3130-3p	CLIP-seq
MIRT2454637	hsa-miR-3135b	CLIP-seq
MIRT2454638	hsa-miR-3166	CLIP-seq
MIRT2277134	hsa-miR-3944-5p	CLIP-seq
MIRT2277135	hsa-miR-424	CLIP-seq
MIRT2277152	hsa-miR-4530	CLIP-seq
MIRT2454639	hsa-miR-4633-3p	CLIP-seq
MIRT2454640	hsa-miR-4650-5p	CLIP-seq
MIRT2277158	hsa-miR-4690-3p	CLIP-seq
MIRT2048293	hsa-miR-4749-3p	CLIP-seq
MIRT2277166	hsa-miR-4755-3p	CLIP-seq
MIRT2454641	hsa-miR-4771	CLIP-seq
MIRT2277170	hsa-miR-497	CLIP-seq
MIRT2277176	hsa-miR-646	CLIP-seq
MIRT2391207	hsa-miR-767-5p	CLIP-seq
MIRT1167020	hsa-miR-3064-5p	CLIP-seq
MIRT2048257	hsa-miR-3184	CLIP-seq
MIRT2048267	hsa-miR-423-5p	CLIP-seq
MIRT2048292	hsa-miR-4728-5p	CLIP-seq
MIRT2575984	hsa-miR-604	CLIP-seq
MIRT2575985	hsa-miR-647	CLIP-seq
MIRT2575986	hsa-miR-671-5p	CLIP-seq
MIRT2685582	hsa-miR-3121-3p	CLIP-seq
MIRT2685583	hsa-miR-3647-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	15469726, 21988832
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0046983	Function	Protein dimerization activity	IEA

Other IDs

• MIM: 620016
• HGNC: 13906
• e!Ensembl: ENSG00000123933

Protein

• UniProt ID: Q14582
• Protein name: Max dimerization protein 4 (Max dimerizer 4) (Class C basic helix-loop-helix protein 12) (bHLHc12) (Max-associated protein 4) (Max-interacting transcriptional repressor MAD4)
• Protein function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00010	HLH	54 → 106	Helix-loop-helix DNA-binding domain	Domain

• Sequence:

  MELNSLLILLEAAEYLERRDREAEHGYASVLPFDGDFAREKTKAAGLVRKAPNNRSSHNE
  LEKHRRAKLRLYLEQLKQLVPLGPDSTRHTTLSLLKRAKVHIKKLEEQDRRALSIKEQLQ
  QEHRFLKRRLEQLSVQSVERVRTDSTGSAVSTDDSEQEVDIEGMEFGPGELDSVGSSSDA
  DDHYSLQSGTGGDSGFGPHCRRLGRPALS

• Sequence length: 209

Pathways

Reactome:

Nuclear signaling by ERBB4

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adult Oligodendroglioma	Oligodendroglioma	BEFREE	10746685		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	10746685		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	10746685		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	37097595	Associate	★☆☆☆☆ Found in Text Mining only
Childhood Oligodendroglioma	Oligodendroglioma	BEFREE	10746685		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	19789310	Associate	★☆☆☆☆ Found in Text Mining only
Ependymoma	Ependymoma	BEFREE	10746685		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	22895069		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	22895069	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	22895069		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	36302855	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Myeloid leukemia	Pubtator	36302855	Associate	★☆☆☆☆ Found in Text Mining only
Liposarcoma Myxoid	Liposarcoma	Pubtator	30723300	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11914404, 12429619, 14506971, 30338611		★☆☆☆☆ Found in Text Mining only
oligodendroglioma	Oligodendroglioma	BEFREE	10746685		★☆☆☆☆ Found in Text Mining only
Ovarian Diseases	Ovarian diseases	Pubtator	30338611	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	34232599	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoma, Spindle Cell	Sarcoma	BEFREE	30723300		★☆☆☆☆ Found in Text Mining only
Well Differentiated Oligodendroglioma	Oligodendroglioma	BEFREE	10746685		★☆☆☆☆ Found in Text Mining only