Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10602
Gene name	CDC42 effector protein 3
Gene symbol	CDC42EP3
Synonyms (NCBI Gene)	BORG2CEP3UB1
Chromosome	2
Chromosome location	2p22.2
Summary	This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is i

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Show/Hide all (214)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022352	hsa-miR-124-3p	Microarray	18668037
MIRT023231	hsa-miR-122-5p	Microarray	17612493
MIRT440970	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440970	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT878126	hsa-miR-202	CLIP-seq
MIRT878127	hsa-miR-3200-3p	CLIP-seq
MIRT878128	hsa-miR-4678	CLIP-seq
MIRT878129	hsa-miR-4723-5p	CLIP-seq
MIRT878130	hsa-miR-4724-3p	CLIP-seq
MIRT1546344	hsa-miR-2276	CLIP-seq
MIRT1546345	hsa-miR-3616-5p	CLIP-seq
MIRT1546346	hsa-miR-3647-5p	CLIP-seq
MIRT1546347	hsa-miR-4251	CLIP-seq
MIRT1546348	hsa-miR-4711-3p	CLIP-seq
MIRT1546349	hsa-miR-548b-3p	CLIP-seq
MIRT1546350	hsa-miR-573	CLIP-seq
MIRT1960261	hsa-miR-1273d	CLIP-seq
MIRT1960262	hsa-miR-1323	CLIP-seq
MIRT1960263	hsa-miR-4668-3p	CLIP-seq
MIRT1960264	hsa-miR-4672	CLIP-seq
MIRT1960265	hsa-miR-548a-3p	CLIP-seq
MIRT1960266	hsa-miR-548e	CLIP-seq
MIRT1960267	hsa-miR-548f	CLIP-seq
MIRT1960268	hsa-miR-548o	CLIP-seq
MIRT1960269	hsa-miR-605	CLIP-seq
MIRT2197069	hsa-miR-103b	CLIP-seq
MIRT2197070	hsa-miR-1183	CLIP-seq
MIRT2197071	hsa-miR-1236	CLIP-seq
MIRT2197072	hsa-miR-1273g	CLIP-seq
MIRT2197073	hsa-miR-129-3p	CLIP-seq
MIRT2197074	hsa-miR-141	CLIP-seq
MIRT2197075	hsa-miR-200a	CLIP-seq
MIRT2197076	hsa-miR-200b	CLIP-seq
MIRT2197077	hsa-miR-200c	CLIP-seq
MIRT2197078	hsa-miR-205	CLIP-seq
MIRT2197079	hsa-miR-3152-5p	CLIP-seq
MIRT2197080	hsa-miR-338-5p	CLIP-seq
MIRT2197081	hsa-miR-3660	CLIP-seq
MIRT2197082	hsa-miR-369-3p	CLIP-seq
MIRT2197083	hsa-miR-371-3p	CLIP-seq
MIRT2197084	hsa-miR-371b-3p	CLIP-seq
MIRT2197085	hsa-miR-374a	CLIP-seq
MIRT2197086	hsa-miR-374b	CLIP-seq
MIRT2197087	hsa-miR-376a	CLIP-seq
MIRT2197088	hsa-miR-376b	CLIP-seq
MIRT2197089	hsa-miR-3926	CLIP-seq
MIRT2197090	hsa-miR-3942-5p	CLIP-seq
MIRT2197091	hsa-miR-4282	CLIP-seq
MIRT2197092	hsa-miR-429	CLIP-seq
MIRT2197093	hsa-miR-4318	CLIP-seq
MIRT2197094	hsa-miR-4434	CLIP-seq
MIRT2197095	hsa-miR-4516	CLIP-seq
MIRT2197096	hsa-miR-4526	CLIP-seq
MIRT2197097	hsa-miR-4531	CLIP-seq
MIRT2197098	hsa-miR-4645-3p	CLIP-seq
MIRT2197099	hsa-miR-4690-3p	CLIP-seq
MIRT2197100	hsa-miR-4698	CLIP-seq
MIRT2197101	hsa-miR-4703-5p	CLIP-seq
MIRT2197102	hsa-miR-4710	CLIP-seq
MIRT1546348	hsa-miR-4711-3p	CLIP-seq
MIRT878130	hsa-miR-4724-3p	CLIP-seq
MIRT2197103	hsa-miR-4753-3p	CLIP-seq
MIRT2197104	hsa-miR-4774-3p	CLIP-seq
MIRT2197105	hsa-miR-4792	CLIP-seq
MIRT2197106	hsa-miR-515-3p	CLIP-seq
MIRT2197107	hsa-miR-519e	CLIP-seq
MIRT1546349	hsa-miR-548b-3p	CLIP-seq
MIRT2197108	hsa-miR-548s	CLIP-seq
MIRT2197109	hsa-miR-671-5p	CLIP-seq
MIRT2197110	hsa-miR-942	CLIP-seq
MIRT2197074	hsa-miR-141	CLIP-seq
MIRT2197075	hsa-miR-200a	CLIP-seq
MIRT2427223	hsa-miR-101	CLIP-seq
MIRT2427224	hsa-miR-144	CLIP-seq
MIRT2197076	hsa-miR-200b	CLIP-seq
MIRT2197077	hsa-miR-200c	CLIP-seq
MIRT2197079	hsa-miR-3152-5p	CLIP-seq
MIRT2197082	hsa-miR-369-3p	CLIP-seq
MIRT2197085	hsa-miR-374a	CLIP-seq
MIRT2197086	hsa-miR-374b	CLIP-seq
MIRT2197091	hsa-miR-4282	CLIP-seq
MIRT2197092	hsa-miR-429	CLIP-seq
MIRT2197098	hsa-miR-4645-3p	CLIP-seq
MIRT2197100	hsa-miR-4698	CLIP-seq
MIRT1546348	hsa-miR-4711-3p	CLIP-seq
MIRT2197104	hsa-miR-4774-3p	CLIP-seq
MIRT2427225	hsa-miR-582-5p	CLIP-seq
MIRT2197091	hsa-miR-4282	CLIP-seq
MIRT2197098	hsa-miR-4645-3p	CLIP-seq
MIRT2197100	hsa-miR-4698	CLIP-seq
MIRT2500301	hsa-miR-124	CLIP-seq
MIRT2500302	hsa-miR-183	CLIP-seq
MIRT2500303	hsa-miR-22	CLIP-seq
MIRT1546344	hsa-miR-2276	CLIP-seq
MIRT2500304	hsa-miR-302a	CLIP-seq
MIRT2500305	hsa-miR-302b	CLIP-seq
MIRT2500306	hsa-miR-302c	CLIP-seq
MIRT2500307	hsa-miR-302d	CLIP-seq
MIRT2500308	hsa-miR-302e	CLIP-seq
MIRT2197079	hsa-miR-3152-5p	CLIP-seq
MIRT2500309	hsa-miR-3154	CLIP-seq
MIRT2500310	hsa-miR-3163	CLIP-seq
MIRT2500311	hsa-miR-3170	CLIP-seq
MIRT2500312	hsa-miR-3171	CLIP-seq
MIRT2500313	hsa-miR-3189-3p	CLIP-seq
MIRT2500314	hsa-miR-3617	CLIP-seq
MIRT2500315	hsa-miR-3622a-5p	CLIP-seq
MIRT2500316	hsa-miR-3654	CLIP-seq
MIRT2500317	hsa-miR-3662	CLIP-seq
MIRT2500318	hsa-miR-3668	CLIP-seq
MIRT2500319	hsa-miR-3680	CLIP-seq
MIRT2500320	hsa-miR-372	CLIP-seq
MIRT2500321	hsa-miR-373	CLIP-seq
MIRT2500322	hsa-miR-378	CLIP-seq
MIRT2500323	hsa-miR-378b	CLIP-seq
MIRT2500324	hsa-miR-378c	CLIP-seq
MIRT2500325	hsa-miR-378d	CLIP-seq
MIRT2500326	hsa-miR-378e	CLIP-seq
MIRT2500327	hsa-miR-378f	CLIP-seq
MIRT2500328	hsa-miR-378h	CLIP-seq
MIRT2500329	hsa-miR-378i	CLIP-seq
MIRT2500330	hsa-miR-422a	CLIP-seq
MIRT2500331	hsa-miR-4290	CLIP-seq
MIRT2500332	hsa-miR-4464	CLIP-seq
MIRT2500333	hsa-miR-4480	CLIP-seq
MIRT2500334	hsa-miR-4502	CLIP-seq
MIRT2500335	hsa-miR-4520a-5p	CLIP-seq
MIRT2500336	hsa-miR-4520b-5p	CLIP-seq
MIRT2500337	hsa-miR-4522	CLIP-seq
MIRT2500338	hsa-miR-4655-3p	CLIP-seq
MIRT2500339	hsa-miR-4662a-3p	CLIP-seq
MIRT2500340	hsa-miR-4684-5p	CLIP-seq
MIRT2500341	hsa-miR-4696	CLIP-seq
MIRT2500342	hsa-miR-4718	CLIP-seq
MIRT2500343	hsa-miR-4738-3p	CLIP-seq
MIRT2500344	hsa-miR-4748	CLIP-seq
MIRT2500345	hsa-miR-4772-3p	CLIP-seq
MIRT2197104	hsa-miR-4774-3p	CLIP-seq
MIRT2500346	hsa-miR-4776-3p	CLIP-seq
MIRT2500347	hsa-miR-4796-5p	CLIP-seq
MIRT2500348	hsa-miR-506	CLIP-seq
MIRT2500349	hsa-miR-5095	CLIP-seq
MIRT2500350	hsa-miR-519a	CLIP-seq
MIRT2500351	hsa-miR-519b-3p	CLIP-seq
MIRT2500352	hsa-miR-519c-3p	CLIP-seq
MIRT2500353	hsa-miR-520a-3p	CLIP-seq
MIRT2500354	hsa-miR-520b	CLIP-seq
MIRT2500355	hsa-miR-520c-3p	CLIP-seq
MIRT2500356	hsa-miR-520d-3p	CLIP-seq
MIRT2500357	hsa-miR-520e	CLIP-seq
MIRT2500358	hsa-miR-544	CLIP-seq
MIRT2500359	hsa-miR-548an	CLIP-seq
MIRT2500360	hsa-miR-548c-3p	CLIP-seq
MIRT2500361	hsa-miR-549	CLIP-seq
MIRT2500362	hsa-miR-555	CLIP-seq
MIRT2500363	hsa-miR-600	CLIP-seq
MIRT2500364	hsa-miR-615-5p	CLIP-seq
MIRT2500365	hsa-miR-641	CLIP-seq
MIRT2500302	hsa-miR-183	CLIP-seq
MIRT2500303	hsa-miR-22	CLIP-seq
MIRT1546344	hsa-miR-2276	CLIP-seq
MIRT2500304	hsa-miR-302a	CLIP-seq
MIRT2500305	hsa-miR-302b	CLIP-seq
MIRT2500306	hsa-miR-302c	CLIP-seq
MIRT2500307	hsa-miR-302d	CLIP-seq
MIRT2500308	hsa-miR-302e	CLIP-seq
MIRT2197079	hsa-miR-3152-5p	CLIP-seq
MIRT2500310	hsa-miR-3163	CLIP-seq
MIRT2500311	hsa-miR-3170	CLIP-seq
MIRT2500312	hsa-miR-3171	CLIP-seq
MIRT2500313	hsa-miR-3189-3p	CLIP-seq
MIRT2500314	hsa-miR-3617	CLIP-seq
MIRT2500316	hsa-miR-3654	CLIP-seq
MIRT2500317	hsa-miR-3662	CLIP-seq
MIRT2500318	hsa-miR-3668	CLIP-seq
MIRT2500320	hsa-miR-372	CLIP-seq
MIRT2500321	hsa-miR-373	CLIP-seq
MIRT2500322	hsa-miR-378	CLIP-seq
MIRT2500323	hsa-miR-378b	CLIP-seq
MIRT2500324	hsa-miR-378c	CLIP-seq
MIRT2500325	hsa-miR-378d	CLIP-seq
MIRT2500326	hsa-miR-378e	CLIP-seq
MIRT2500327	hsa-miR-378f	CLIP-seq
MIRT2500328	hsa-miR-378h	CLIP-seq
MIRT2500329	hsa-miR-378i	CLIP-seq
MIRT2500330	hsa-miR-422a	CLIP-seq
MIRT2500331	hsa-miR-4290	CLIP-seq
MIRT2500334	hsa-miR-4502	CLIP-seq
MIRT2500335	hsa-miR-4520a-5p	CLIP-seq
MIRT2500336	hsa-miR-4520b-5p	CLIP-seq
MIRT2500337	hsa-miR-4522	CLIP-seq
MIRT2500338	hsa-miR-4655-3p	CLIP-seq
MIRT2500340	hsa-miR-4684-5p	CLIP-seq
MIRT2500341	hsa-miR-4696	CLIP-seq
MIRT2500342	hsa-miR-4718	CLIP-seq
MIRT2500343	hsa-miR-4738-3p	CLIP-seq
MIRT2500345	hsa-miR-4772-3p	CLIP-seq
MIRT2197104	hsa-miR-4774-3p	CLIP-seq
MIRT2500347	hsa-miR-4796-5p	CLIP-seq
MIRT2500349	hsa-miR-5095	CLIP-seq
MIRT2500350	hsa-miR-519a	CLIP-seq
MIRT2500351	hsa-miR-519b-3p	CLIP-seq
MIRT2500352	hsa-miR-519c-3p	CLIP-seq
MIRT2500353	hsa-miR-520a-3p	CLIP-seq
MIRT2500354	hsa-miR-520b	CLIP-seq
MIRT2500355	hsa-miR-520c-3p	CLIP-seq
MIRT2500356	hsa-miR-520d-3p	CLIP-seq
MIRT2500357	hsa-miR-520e	CLIP-seq
MIRT2500358	hsa-miR-544	CLIP-seq
MIRT2500361	hsa-miR-549	CLIP-seq
MIRT2500362	hsa-miR-555	CLIP-seq
MIRT2500363	hsa-miR-600	CLIP-seq
MIRT2500364	hsa-miR-615-5p	CLIP-seq
MIRT2500365	hsa-miR-641	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24947832, 29513927, 32296183
GO:0005519	Function	Cytoskeletal regulatory protein binding	TAS	11035016
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0007165	Process	Signal transduction	TAS	11035016
GO:0007266	Process	Rho protein signal transduction	IBA
GO:0008360	Process	Regulation of cell shape	IBA
GO:0008360	Process	Regulation of cell shape	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016020	Component	Membrane	IEA
GO:0030838	Process	Positive regulation of actin filament polymerization	IBA
GO:0031267	Function	Small GTPase binding	IBA
GO:0031274	Process	Positive regulation of pseudopodium assembly	IBA

MIM	HGNC	e!Ensembl
606133	16943	ENSG00000163171

Q9UKI2

Protein name

Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein)

Protein function

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269|PubMed:10490598, ECO:0000269

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00786	PBD	30 → 86	P21-Rho-binding domain	Domain
PF14957	BORG_CEP	102 → 253	Cdc42 effector	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in the heart and weakly in the brain. {ECO:0000269|PubMed:10490598}.

Sequence

MPAKTPIYLKAANNKKGKKFKLRDILSPDMISPPLGDFRHTIHIGKEGQHDVFGDISFLQ
GNYELLPGNQEKAHLGQFPGHNEFFRANSTSDSVFTETPSPVLKNAISLPTIGGSQALML
PLLSPVTFNSKQESFGPAKLPRLSCEPVMEEKAQEKSSLLENGTVHQGDTSWGSSGSASQ
SSQGRDSHSSSLSEQYPDWPAEDMFDHPTPCELIKGKTKSEESLSDLTGSLLSLQLDLGP
SLLDEVLNVMDKNK

Sequence length

254

Interactions

View interactions

	Reactome
			MAPK6/MAPK4 signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	BEFREE	22538453		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	24802410		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	24802410		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	19547694		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	25022385	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35365622	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	19547694	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28124285		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	19547694		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	24802410		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22511634		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	GWASCAT_DG	30891314		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	BEFREE	20385374		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	20385374		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma	Carcinoma	BEFREE	25022385		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	24816430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urothelial Carcinoma	Urothelial Carcinoma	BEFREE	11229514		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal Melanoma	BEFREE	22511634, 25442074		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	22511634	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CDC42EP3 (CDC42 effector protein 3)