Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10595
Gene name	Endoplasmic reticulum to nucleus signaling 2
Gene symbol	ERN2
Synonyms (NCBI Gene)	IRE1-BETAIRE1bIRE2phIRE2p
Chromosome	16
Chromosome location	16p12.2

155

Show/Hide all (155)

miRTarBase ID	miRNA	Experiments
MIRT969666	hsa-miR-1200	CLIP-seq
MIRT969667	hsa-miR-1207-3p	CLIP-seq
MIRT969668	hsa-miR-122	CLIP-seq
MIRT969669	hsa-miR-1224-3p	CLIP-seq
MIRT969670	hsa-miR-1245	CLIP-seq
MIRT969671	hsa-miR-1254	CLIP-seq
MIRT969672	hsa-miR-1260	CLIP-seq
MIRT969673	hsa-miR-1260b	CLIP-seq
MIRT969674	hsa-miR-1280	CLIP-seq
MIRT969675	hsa-miR-150	CLIP-seq
MIRT969676	hsa-miR-24	CLIP-seq
MIRT969677	hsa-miR-3116	CLIP-seq
MIRT969678	hsa-miR-3135b	CLIP-seq
MIRT969679	hsa-miR-3138	CLIP-seq
MIRT969680	hsa-miR-3155	CLIP-seq
MIRT969681	hsa-miR-3155b	CLIP-seq
MIRT969682	hsa-miR-3183	CLIP-seq
MIRT969683	hsa-miR-3194-5p	CLIP-seq
MIRT969684	hsa-miR-3199	CLIP-seq
MIRT969685	hsa-miR-3619-3p	CLIP-seq
MIRT969686	hsa-miR-3652	CLIP-seq
MIRT969687	hsa-miR-3663-5p	CLIP-seq
MIRT969688	hsa-miR-3670	CLIP-seq
MIRT969689	hsa-miR-4303	CLIP-seq
MIRT969690	hsa-miR-4324	CLIP-seq
MIRT969691	hsa-miR-4430	CLIP-seq
MIRT969692	hsa-miR-4435	CLIP-seq
MIRT969693	hsa-miR-4438	CLIP-seq
MIRT969694	hsa-miR-4649-3p	CLIP-seq
MIRT969695	hsa-miR-4691-3p	CLIP-seq
MIRT969696	hsa-miR-4713-5p	CLIP-seq
MIRT969697	hsa-miR-4723-3p	CLIP-seq
MIRT969698	hsa-miR-4755-3p	CLIP-seq
MIRT969699	hsa-miR-4776-5p	CLIP-seq
MIRT969700	hsa-miR-4794	CLIP-seq
MIRT969701	hsa-miR-4800-5p	CLIP-seq
MIRT969702	hsa-miR-484	CLIP-seq
MIRT969703	hsa-miR-5095	CLIP-seq
MIRT969704	hsa-miR-532-3p	CLIP-seq
MIRT969705	hsa-miR-544b	CLIP-seq
MIRT969706	hsa-miR-646	CLIP-seq
MIRT969707	hsa-miR-661	CLIP-seq
MIRT969667	hsa-miR-1207-3p	CLIP-seq
MIRT969684	hsa-miR-3199	CLIP-seq
MIRT969693	hsa-miR-4438	CLIP-seq
MIRT969703	hsa-miR-5095	CLIP-seq
MIRT969706	hsa-miR-646	CLIP-seq
MIRT1922025	hsa-miR-149	CLIP-seq
MIRT969676	hsa-miR-24	CLIP-seq
MIRT1922026	hsa-miR-3622b-5p	CLIP-seq
MIRT1922027	hsa-miR-4284	CLIP-seq
MIRT1987438	hsa-miR-1184	CLIP-seq
MIRT1922025	hsa-miR-149	CLIP-seq
MIRT969675	hsa-miR-150	CLIP-seq
MIRT969676	hsa-miR-24	CLIP-seq
MIRT1922027	hsa-miR-4284	CLIP-seq
MIRT1987439	hsa-miR-4418	CLIP-seq
MIRT1987440	hsa-miR-509-3-5p	CLIP-seq
MIRT1987441	hsa-miR-509-5p	CLIP-seq
MIRT1987438	hsa-miR-1184	CLIP-seq
MIRT969666	hsa-miR-1200	CLIP-seq
MIRT969667	hsa-miR-1207-3p	CLIP-seq
MIRT969669	hsa-miR-1224-3p	CLIP-seq
MIRT969670	hsa-miR-1245	CLIP-seq
MIRT969671	hsa-miR-1254	CLIP-seq
MIRT969672	hsa-miR-1260	CLIP-seq
MIRT969673	hsa-miR-1260b	CLIP-seq
MIRT969674	hsa-miR-1280	CLIP-seq
MIRT2221825	hsa-miR-1343	CLIP-seq
MIRT1922025	hsa-miR-149	CLIP-seq
MIRT969675	hsa-miR-150	CLIP-seq
MIRT969676	hsa-miR-24	CLIP-seq
MIRT969677	hsa-miR-3116	CLIP-seq
MIRT2221826	hsa-miR-3187-3p	CLIP-seq
MIRT969684	hsa-miR-3199	CLIP-seq
MIRT969687	hsa-miR-3663-5p	CLIP-seq
MIRT969688	hsa-miR-3670	CLIP-seq
MIRT2221827	hsa-miR-378g	CLIP-seq
MIRT2221828	hsa-miR-3934	CLIP-seq
MIRT2221829	hsa-miR-4252	CLIP-seq
MIRT1922027	hsa-miR-4284	CLIP-seq
MIRT969690	hsa-miR-4324	CLIP-seq
MIRT1987439	hsa-miR-4418	CLIP-seq
MIRT2221830	hsa-miR-4423-5p	CLIP-seq
MIRT969692	hsa-miR-4435	CLIP-seq
MIRT2221831	hsa-miR-4437	CLIP-seq
MIRT969693	hsa-miR-4438	CLIP-seq
MIRT2221832	hsa-miR-4659a-5p	CLIP-seq
MIRT2221833	hsa-miR-4659b-5p	CLIP-seq
MIRT2221834	hsa-miR-4674	CLIP-seq
MIRT2221835	hsa-miR-4698	CLIP-seq
MIRT2221836	hsa-miR-4701-5p	CLIP-seq
MIRT969696	hsa-miR-4713-5p	CLIP-seq
MIRT2221837	hsa-miR-4716-5p	CLIP-seq
MIRT2221838	hsa-miR-4731-5p	CLIP-seq
MIRT2221839	hsa-miR-4735-5p	CLIP-seq
MIRT969698	hsa-miR-4755-3p	CLIP-seq
MIRT2221840	hsa-miR-4775	CLIP-seq
MIRT2221841	hsa-miR-4776-3p	CLIP-seq
MIRT2221842	hsa-miR-4781-3p	CLIP-seq
MIRT969700	hsa-miR-4794	CLIP-seq
MIRT1987440	hsa-miR-509-3-5p	CLIP-seq
MIRT969703	hsa-miR-5095	CLIP-seq
MIRT1987441	hsa-miR-509-5p	CLIP-seq
MIRT2221843	hsa-miR-512-5p	CLIP-seq
MIRT969704	hsa-miR-532-3p	CLIP-seq
MIRT969705	hsa-miR-544b	CLIP-seq
MIRT2221844	hsa-miR-548s	CLIP-seq
MIRT2221845	hsa-miR-552	CLIP-seq
MIRT2221846	hsa-miR-588	CLIP-seq
MIRT2221847	hsa-miR-590-3p	CLIP-seq
MIRT969706	hsa-miR-646	CLIP-seq
MIRT969707	hsa-miR-661	CLIP-seq
MIRT1987438	hsa-miR-1184	CLIP-seq
MIRT969669	hsa-miR-1224-3p	CLIP-seq
MIRT969671	hsa-miR-1254	CLIP-seq
MIRT969672	hsa-miR-1260	CLIP-seq
MIRT969673	hsa-miR-1260b	CLIP-seq
MIRT969674	hsa-miR-1280	CLIP-seq
MIRT2221825	hsa-miR-1343	CLIP-seq
MIRT969675	hsa-miR-150	CLIP-seq
MIRT969676	hsa-miR-24	CLIP-seq
MIRT969677	hsa-miR-3116	CLIP-seq
MIRT2221827	hsa-miR-378g	CLIP-seq
MIRT1922027	hsa-miR-4284	CLIP-seq
MIRT1987439	hsa-miR-4418	CLIP-seq
MIRT2221831	hsa-miR-4437	CLIP-seq
MIRT2221834	hsa-miR-4674	CLIP-seq
MIRT969696	hsa-miR-4713-5p	CLIP-seq
MIRT2221839	hsa-miR-4735-5p	CLIP-seq
MIRT2221840	hsa-miR-4775	CLIP-seq
MIRT969700	hsa-miR-4794	CLIP-seq
MIRT1987440	hsa-miR-509-3-5p	CLIP-seq
MIRT1987441	hsa-miR-509-5p	CLIP-seq
MIRT969704	hsa-miR-532-3p	CLIP-seq
MIRT2221847	hsa-miR-590-3p	CLIP-seq
MIRT969707	hsa-miR-661	CLIP-seq
MIRT969668	hsa-miR-122	CLIP-seq
MIRT1922025	hsa-miR-149	CLIP-seq
MIRT969676	hsa-miR-24	CLIP-seq
MIRT969678	hsa-miR-3135b	CLIP-seq
MIRT969679	hsa-miR-3138	CLIP-seq
MIRT969685	hsa-miR-3619-3p	CLIP-seq
MIRT1922026	hsa-miR-3622b-5p	CLIP-seq
MIRT969686	hsa-miR-3652	CLIP-seq
MIRT1922027	hsa-miR-4284	CLIP-seq
MIRT969691	hsa-miR-4430	CLIP-seq
MIRT969699	hsa-miR-4776-5p	CLIP-seq
MIRT969701	hsa-miR-4800-5p	CLIP-seq
MIRT969671	hsa-miR-1254	CLIP-seq
MIRT969677	hsa-miR-3116	CLIP-seq
MIRT969684	hsa-miR-3199	CLIP-seq
MIRT969693	hsa-miR-4438	CLIP-seq
MIRT969703	hsa-miR-5095	CLIP-seq
MIRT969707	hsa-miR-661	CLIP-seq

Show/Hide all (46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	11175748
GO:0000287	Function	Magnesium ion binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004519	Function	Endonuclease activity	IDA	11175748
GO:0004519	Function	Endonuclease activity	IEA
GO:0004521	Function	RNA endonuclease activity	IBA
GO:0004521	Function	RNA endonuclease activity	IEA
GO:0004540	Function	RNA nuclease activity	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	11175748
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IDA	11175748
GO:0005524	Function	ATP binding	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006401	Process	RNA catabolic process	IEA
GO:0006468	Process	Protein phosphorylation	IDA	11175748
GO:0006915	Process	Apoptotic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016075	Process	RRNA catabolic process	IDA	11175748
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030263	Process	Apoptotic chromosome condensation	IMP	11175748
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	TAS	22013210
GO:0036498	Process	IRE1-mediated unfolded protein response	IBA
GO:0044322	Component	Endoplasmic reticulum quality control compartment	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	11175748
GO:0046330	Process	Positive regulation of JNK cascade	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051082	Function	Unfolded protein binding	IBA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IBA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1990604	Component	IRE1-TRAF2-ASK1 complex	IBA
GO:1990604	Component	IRE1-TRAF2-ASK1 complex	IEA
GO:1990604	Component	IRE1-TRAF2-ASK1 complex	ISS

MIM	HGNC	e!Ensembl
604034	16942	ENSG00000134398

Q76MJ5

Protein name

Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]

Protein function

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	520 → 781	Protein kinase domain	Domain
PF06479	Ribonuc_2-5A	787 → 910	Ribonuclease 2-5A	Family

Sequence

MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDL
KWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSS
DGVFYTGRKQDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNT
TYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGL
RQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVS
KALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLI
GHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEK
TPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQ
SLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQF
EGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQE
YVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSD
FGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGG
SHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPF
FWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRS
YKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSC
ASESLFLPYYPPDSEARRPCPGATGR

Sequence length

926

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LYMPHEDEMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	37653101	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	28454221		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	31524632		★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	30973754		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31101416		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	32881299	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28454221, 30936991, 31101416		★★★★★ ★☆☆☆☆ Found in Text Mining only

ERN2 (endoplasmic reticulum to nucleus signaling 2)