Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	1059
Gene name	Centromere protein B
Gene symbol	CENPB
Synonyms (NCBI Gene)	-
Chromosome	20
Chromosome location	20p13
Summary	This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and

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miRTarBase ID	miRNA	Experiments	Reference
MIRT032351	hsa-let-7b-5p	Proteomics	18668040
MIRT045539	hsa-miR-149-5p	CLASH	23622248
MIRT043157	hsa-miR-324-5p	CLASH	23622248
MIRT884651	hsa-miR-1184	CLIP-seq
MIRT884652	hsa-miR-1234	CLIP-seq
MIRT884653	hsa-miR-1286	CLIP-seq
MIRT884654	hsa-miR-1293	CLIP-seq
MIRT884655	hsa-miR-1301	CLIP-seq
MIRT884656	hsa-miR-1538	CLIP-seq
MIRT884657	hsa-miR-218	CLIP-seq
MIRT884658	hsa-miR-224	CLIP-seq
MIRT884659	hsa-miR-24	CLIP-seq
MIRT884660	hsa-miR-2861	CLIP-seq
MIRT884661	hsa-miR-298	CLIP-seq
MIRT884662	hsa-miR-29a	CLIP-seq
MIRT884663	hsa-miR-29b	CLIP-seq
MIRT884664	hsa-miR-29c	CLIP-seq
MIRT884665	hsa-miR-3138	CLIP-seq
MIRT884666	hsa-miR-3150a-3p	CLIP-seq
MIRT884667	hsa-miR-3150b-3p	CLIP-seq
MIRT884668	hsa-miR-3155	CLIP-seq
MIRT884669	hsa-miR-3155b	CLIP-seq
MIRT884670	hsa-miR-3174	CLIP-seq
MIRT884671	hsa-miR-3175	CLIP-seq
MIRT884672	hsa-miR-3199	CLIP-seq
MIRT884673	hsa-miR-342-5p	CLIP-seq
MIRT884674	hsa-miR-3622b-5p	CLIP-seq
MIRT884675	hsa-miR-3664-3p	CLIP-seq
MIRT884676	hsa-miR-3675-5p	CLIP-seq
MIRT884677	hsa-miR-3687	CLIP-seq
MIRT884678	hsa-miR-3689d	CLIP-seq
MIRT884679	hsa-miR-3907	CLIP-seq
MIRT884680	hsa-miR-3918	CLIP-seq
MIRT884681	hsa-miR-3919	CLIP-seq
MIRT884682	hsa-miR-3922-5p	CLIP-seq
MIRT884683	hsa-miR-3926	CLIP-seq
MIRT884684	hsa-miR-3978	CLIP-seq
MIRT884685	hsa-miR-4261	CLIP-seq
MIRT884686	hsa-miR-4271	CLIP-seq
MIRT884687	hsa-miR-4283	CLIP-seq
MIRT884688	hsa-miR-4292	CLIP-seq
MIRT884689	hsa-miR-432	CLIP-seq
MIRT884690	hsa-miR-4424	CLIP-seq
MIRT884691	hsa-miR-4433	CLIP-seq
MIRT884692	hsa-miR-4442	CLIP-seq
MIRT884693	hsa-miR-4447	CLIP-seq
MIRT884694	hsa-miR-4459	CLIP-seq
MIRT884695	hsa-miR-4472	CLIP-seq
MIRT884696	hsa-miR-4475	CLIP-seq
MIRT884697	hsa-miR-4483	CLIP-seq
MIRT884698	hsa-miR-4489	CLIP-seq
MIRT884699	hsa-miR-4509	CLIP-seq
MIRT884700	hsa-miR-4514	CLIP-seq
MIRT884701	hsa-miR-4515	CLIP-seq
MIRT884702	hsa-miR-4520a-3p	CLIP-seq
MIRT884703	hsa-miR-4536	CLIP-seq
MIRT884704	hsa-miR-4640-5p	CLIP-seq
MIRT884705	hsa-miR-4651	CLIP-seq
MIRT884706	hsa-miR-4660	CLIP-seq
MIRT884707	hsa-miR-4664-5p	CLIP-seq
MIRT884708	hsa-miR-4667-5p	CLIP-seq
MIRT884709	hsa-miR-4684-3p	CLIP-seq
MIRT884710	hsa-miR-4687-3p	CLIP-seq
MIRT884711	hsa-miR-4690-5p	CLIP-seq
MIRT884712	hsa-miR-4692	CLIP-seq
MIRT884713	hsa-miR-4700-5p	CLIP-seq
MIRT884714	hsa-miR-4717-3p	CLIP-seq
MIRT884715	hsa-miR-4722-5p	CLIP-seq
MIRT884716	hsa-miR-4725-3p	CLIP-seq
MIRT884717	hsa-miR-4726-5p	CLIP-seq
MIRT884718	hsa-miR-4745-3p	CLIP-seq
MIRT884719	hsa-miR-4757-5p	CLIP-seq
MIRT884720	hsa-miR-4768-3p	CLIP-seq
MIRT884721	hsa-miR-4784	CLIP-seq
MIRT884722	hsa-miR-4802-3p	CLIP-seq
MIRT884723	hsa-miR-484	CLIP-seq
MIRT884724	hsa-miR-5047	CLIP-seq
MIRT884725	hsa-miR-513c	CLIP-seq
MIRT884726	hsa-miR-514b-5p	CLIP-seq
MIRT884727	hsa-miR-548ad	CLIP-seq
MIRT884728	hsa-miR-548g	CLIP-seq
MIRT884729	hsa-miR-608	CLIP-seq
MIRT884730	hsa-miR-636	CLIP-seq
MIRT884731	hsa-miR-637	CLIP-seq
MIRT884732	hsa-miR-647	CLIP-seq
MIRT884733	hsa-miR-661	CLIP-seq
MIRT884734	hsa-miR-939	CLIP-seq
MIRT884711	hsa-miR-4690-5p	CLIP-seq
MIRT1962371	hsa-miR-1207-3p	CLIP-seq
MIRT1962372	hsa-miR-1273g	CLIP-seq
MIRT1962373	hsa-miR-1275	CLIP-seq
MIRT884653	hsa-miR-1286	CLIP-seq
MIRT884654	hsa-miR-1293	CLIP-seq
MIRT1962374	hsa-miR-1299	CLIP-seq
MIRT1962375	hsa-miR-146b-3p	CLIP-seq
MIRT1962376	hsa-miR-149	CLIP-seq
MIRT884656	hsa-miR-1538	CLIP-seq
MIRT1962377	hsa-miR-184	CLIP-seq
MIRT1962378	hsa-miR-1913	CLIP-seq
MIRT884658	hsa-miR-224	CLIP-seq
MIRT884659	hsa-miR-24	CLIP-seq
MIRT884660	hsa-miR-2861	CLIP-seq
MIRT884661	hsa-miR-298	CLIP-seq
MIRT1962379	hsa-miR-3064-5p	CLIP-seq
MIRT1962380	hsa-miR-3130-3p	CLIP-seq
MIRT884666	hsa-miR-3150a-3p	CLIP-seq
MIRT884668	hsa-miR-3155	CLIP-seq
MIRT884669	hsa-miR-3155b	CLIP-seq
MIRT1962381	hsa-miR-3173-5p	CLIP-seq
MIRT884671	hsa-miR-3175	CLIP-seq
MIRT1962382	hsa-miR-3194-3p	CLIP-seq
MIRT884672	hsa-miR-3199	CLIP-seq
MIRT1962383	hsa-miR-324-3p	CLIP-seq
MIRT1962384	hsa-miR-326	CLIP-seq
MIRT1962385	hsa-miR-330-5p	CLIP-seq
MIRT884673	hsa-miR-342-5p	CLIP-seq
MIRT1962386	hsa-miR-3652	CLIP-seq
MIRT1962387	hsa-miR-3656	CLIP-seq
MIRT884675	hsa-miR-3664-3p	CLIP-seq
MIRT1962388	hsa-miR-3682-5p	CLIP-seq
MIRT884678	hsa-miR-3689d	CLIP-seq
MIRT1962389	hsa-miR-378	CLIP-seq
MIRT1962390	hsa-miR-378b	CLIP-seq
MIRT1962391	hsa-miR-378c	CLIP-seq
MIRT1962392	hsa-miR-378d	CLIP-seq
MIRT1962393	hsa-miR-378e	CLIP-seq
MIRT1962394	hsa-miR-378f	CLIP-seq
MIRT1962395	hsa-miR-378h	CLIP-seq
MIRT1962396	hsa-miR-378i	CLIP-seq
MIRT884679	hsa-miR-3907	CLIP-seq
MIRT1962397	hsa-miR-3909	CLIP-seq
MIRT884680	hsa-miR-3918	CLIP-seq
MIRT884681	hsa-miR-3919	CLIP-seq
MIRT884683	hsa-miR-3926	CLIP-seq
MIRT884684	hsa-miR-3978	CLIP-seq
MIRT1962398	hsa-miR-409-5p	CLIP-seq
MIRT1962399	hsa-miR-422a	CLIP-seq
MIRT884685	hsa-miR-4261	CLIP-seq
MIRT884686	hsa-miR-4271	CLIP-seq
MIRT884687	hsa-miR-4283	CLIP-seq
MIRT884688	hsa-miR-4292	CLIP-seq
MIRT1962400	hsa-miR-4308	CLIP-seq
MIRT884689	hsa-miR-432	CLIP-seq
MIRT1962401	hsa-miR-4430	CLIP-seq
MIRT884691	hsa-miR-4433	CLIP-seq
MIRT884693	hsa-miR-4447	CLIP-seq
MIRT884694	hsa-miR-4459	CLIP-seq
MIRT884695	hsa-miR-4472	CLIP-seq
MIRT884696	hsa-miR-4475	CLIP-seq
MIRT884697	hsa-miR-4483	CLIP-seq
MIRT1962402	hsa-miR-4488	CLIP-seq
MIRT884698	hsa-miR-4489	CLIP-seq
MIRT884699	hsa-miR-4509	CLIP-seq
MIRT884700	hsa-miR-4514	CLIP-seq
MIRT884701	hsa-miR-4515	CLIP-seq
MIRT884702	hsa-miR-4520a-3p	CLIP-seq
MIRT1962403	hsa-miR-4522	CLIP-seq
MIRT1962404	hsa-miR-4540	CLIP-seq
MIRT1962405	hsa-miR-4639-3p	CLIP-seq
MIRT884704	hsa-miR-4640-5p	CLIP-seq
MIRT884705	hsa-miR-4651	CLIP-seq
MIRT884707	hsa-miR-4664-5p	CLIP-seq
MIRT1962406	hsa-miR-4665-5p	CLIP-seq
MIRT884708	hsa-miR-4667-5p	CLIP-seq
MIRT884709	hsa-miR-4684-3p	CLIP-seq
MIRT1962407	hsa-miR-4685-5p	CLIP-seq
MIRT884711	hsa-miR-4690-5p	CLIP-seq
MIRT884712	hsa-miR-4692	CLIP-seq
MIRT1962408	hsa-miR-4697-5p	CLIP-seq
MIRT884713	hsa-miR-4700-5p	CLIP-seq
MIRT884714	hsa-miR-4717-3p	CLIP-seq
MIRT884715	hsa-miR-4722-5p	CLIP-seq
MIRT884716	hsa-miR-4725-3p	CLIP-seq
MIRT884717	hsa-miR-4726-5p	CLIP-seq
MIRT884718	hsa-miR-4745-3p	CLIP-seq
MIRT884719	hsa-miR-4757-5p	CLIP-seq
MIRT884720	hsa-miR-4768-3p	CLIP-seq
MIRT1962409	hsa-miR-4793-3p	CLIP-seq
MIRT1962410	hsa-miR-4794	CLIP-seq
MIRT884722	hsa-miR-4802-3p	CLIP-seq
MIRT1962411	hsa-miR-4804-5p	CLIP-seq
MIRT884723	hsa-miR-484	CLIP-seq
MIRT1962412	hsa-miR-548aa	CLIP-seq
MIRT1962413	hsa-miR-604	CLIP-seq
MIRT884729	hsa-miR-608	CLIP-seq
MIRT884731	hsa-miR-637	CLIP-seq
MIRT1962414	hsa-miR-646	CLIP-seq
MIRT884732	hsa-miR-647	CLIP-seq
MIRT1962415	hsa-miR-760	CLIP-seq
MIRT1962416	hsa-miR-874	CLIP-seq
MIRT1962417	hsa-miR-875-3p	CLIP-seq
MIRT884734	hsa-miR-939	CLIP-seq
MIRT1962373	hsa-miR-1275	CLIP-seq
MIRT884654	hsa-miR-1293	CLIP-seq
MIRT1962374	hsa-miR-1299	CLIP-seq
MIRT1962375	hsa-miR-146b-3p	CLIP-seq
MIRT2198772	hsa-miR-1825	CLIP-seq
MIRT1962378	hsa-miR-1913	CLIP-seq
MIRT2198773	hsa-miR-199a-5p	CLIP-seq
MIRT2198774	hsa-miR-199b-5p	CLIP-seq
MIRT884658	hsa-miR-224	CLIP-seq
MIRT884661	hsa-miR-298	CLIP-seq
MIRT884666	hsa-miR-3150a-3p	CLIP-seq
MIRT884668	hsa-miR-3155	CLIP-seq
MIRT884669	hsa-miR-3155b	CLIP-seq
MIRT1962381	hsa-miR-3173-5p	CLIP-seq
MIRT884671	hsa-miR-3175	CLIP-seq
MIRT884672	hsa-miR-3199	CLIP-seq
MIRT1962383	hsa-miR-324-3p	CLIP-seq
MIRT884673	hsa-miR-342-5p	CLIP-seq
MIRT884678	hsa-miR-3689d	CLIP-seq
MIRT884679	hsa-miR-3907	CLIP-seq
MIRT1962397	hsa-miR-3909	CLIP-seq
MIRT884680	hsa-miR-3918	CLIP-seq
MIRT884681	hsa-miR-3919	CLIP-seq
MIRT884683	hsa-miR-3926	CLIP-seq
MIRT884684	hsa-miR-3978	CLIP-seq
MIRT884688	hsa-miR-4292	CLIP-seq
MIRT884696	hsa-miR-4475	CLIP-seq
MIRT884697	hsa-miR-4483	CLIP-seq
MIRT1962402	hsa-miR-4488	CLIP-seq
MIRT884700	hsa-miR-4514	CLIP-seq
MIRT884701	hsa-miR-4515	CLIP-seq
MIRT884702	hsa-miR-4520a-3p	CLIP-seq
MIRT1962405	hsa-miR-4639-3p	CLIP-seq
MIRT884704	hsa-miR-4640-5p	CLIP-seq
MIRT884705	hsa-miR-4651	CLIP-seq
MIRT884707	hsa-miR-4664-5p	CLIP-seq
MIRT1962406	hsa-miR-4665-5p	CLIP-seq
MIRT884708	hsa-miR-4667-5p	CLIP-seq
MIRT884711	hsa-miR-4690-5p	CLIP-seq
MIRT884712	hsa-miR-4692	CLIP-seq
MIRT1962408	hsa-miR-4697-5p	CLIP-seq
MIRT884713	hsa-miR-4700-5p	CLIP-seq
MIRT884714	hsa-miR-4717-3p	CLIP-seq
MIRT884717	hsa-miR-4726-5p	CLIP-seq
MIRT884722	hsa-miR-4802-3p	CLIP-seq
MIRT884723	hsa-miR-484	CLIP-seq
MIRT1962412	hsa-miR-548aa	CLIP-seq
MIRT884729	hsa-miR-608	CLIP-seq
MIRT1962416	hsa-miR-874	CLIP-seq
MIRT1962417	hsa-miR-875-3p	CLIP-seq
MIRT884734	hsa-miR-939	CLIP-seq
MIRT884659	hsa-miR-24	CLIP-seq
MIRT884661	hsa-miR-298	CLIP-seq
MIRT884668	hsa-miR-3155	CLIP-seq
MIRT884669	hsa-miR-3155b	CLIP-seq
MIRT884675	hsa-miR-3664-3p	CLIP-seq
MIRT884691	hsa-miR-4433	CLIP-seq
MIRT884694	hsa-miR-4459	CLIP-seq
MIRT884705	hsa-miR-4651	CLIP-seq
MIRT884711	hsa-miR-4690-5p	CLIP-seq
MIRT884720	hsa-miR-4768-3p	CLIP-seq
MIRT884723	hsa-miR-484	CLIP-seq
MIRT884729	hsa-miR-608	CLIP-seq
MIRT884656	hsa-miR-1538	CLIP-seq
MIRT2446844	hsa-miR-3929	CLIP-seq
MIRT2446845	hsa-miR-4419b	CLIP-seq
MIRT2446846	hsa-miR-4478	CLIP-seq
MIRT2446847	hsa-miR-4690-3p	CLIP-seq
MIRT884718	hsa-miR-4745-3p	CLIP-seq
MIRT884656	hsa-miR-1538	CLIP-seq
MIRT2446844	hsa-miR-3929	CLIP-seq
MIRT2446845	hsa-miR-4419b	CLIP-seq
MIRT2446846	hsa-miR-4478	CLIP-seq
MIRT2446847	hsa-miR-4690-3p	CLIP-seq
MIRT884718	hsa-miR-4745-3p	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IDA	2022189, 11084331, 11682612
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000779	Component	Condensed chromosome, centromeric region	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003682	Function	Chromatin binding	NAS	1893793
GO:0003696	Function	Satellite DNA binding	NAS	1893793
GO:0005515	Function	Protein binding	IPI	21900206, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IDA	2022189
GO:0005694	Component	Chromosome	IEA
GO:0005721	Component	Pericentric heterochromatin	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0019237	Function	Centromeric DNA binding	IC	11682612
GO:0043565	Function	Sequence-specific DNA binding	TAS	11682612

MIM	HGNC	e!Ensembl
117140	1852	ENSG00000125817

P07199

Protein name

Major centromere autoantigen B (Centromere protein B) (CENP-B)

Protein function

Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which

PDB

1BW6 , 1HLV , 1UFI , 6KDR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04218	CENP-B_N	2 → 56	CENP-B N-terminal DNA-binding domain	Domain
PF03221	HTH_Tnp_Tc5	74 → 135	Tc5 transposase DNA-binding domain	Domain
PF03184	DDE_1	222 → 384	DDE superfamily endonuclease	Family
PF09026	CENP-B_dimeris	499 → 598	Centromere protein B dimerisation domain	Domain

Sequence

MGPKRRQLTFREKSRIIQEVEENPDLRKGEIARRFNIPPSTLSTILKNKRAILASERKYG
VASTCRKTNKLSPYDKLEGLLIAWFQQIRAAGLPVKGIILKEKALRIAEELGMDDFTASN
GWLDRFRRRHGVVSCSGVARARARNAAPRTPAAPASPAAVPSEGSGGSTTGWRAREEQPP
SVAEGYASQDVFSATETSLWYDFLPDQAAGLCGGDGRPRQATQRLSVLLCANADGSEKLP
PLVAGKSAKPRAGQAGLPCDYTANSKGGVTTQALAKYLKALDTRMAAESRRVLLLAGRLA
AQSLDTSGLRHVQLAFFPPGTVHPLERGVVQQVKGHYRQAMLLKAMAALEGQDPSGLQLG
LTEALHFVAAAWQAVEPSDIAACFREAGFGGGPNATITTSLKSEGEEEEEEEEEEEEEEG
EGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEESSSEGLEAEDWAQGV
VEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVP
VPSFGEAMAYFAMVKRYLTSFPIDDRVQSHILHLEHDLVHVTRKNHARQAGVRGLGHQS

Sequence length

599

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BILIARY CIRRHOSIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DISEASES OF INNER EAR	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY BILIARY CHOLANGITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autoimmune Diseases	Autoimmune disease	Pubtator	1377670, 1730770	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35894385, 37925172	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	28259924		★★★★★ ★☆☆☆☆ Found in Text Mining only
Isodicentric Chromosome 15 Syndrome	Isodicentric Chromosome 15 Syndrome	BEFREE	10398268		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases, Interstitial	Lung Diseases	BEFREE	30685360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Nephritis	Lupus nephritis	Pubtator	36581379	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Raynaud Disease	Raynaud disease	Pubtator	36581379	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Scleroderma Systemic	Systemic sclerosis	Pubtator	1377670, 1712488, 36581379	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	28749191, 30685360, 8187334		★★★★★ ★☆☆☆☆ Found in Text Mining only

CENPB (centromere protein B)