Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10581
Gene name	Interferon induced transmembrane protein 2
Gene symbol	IFITM2
Synonyms (NCBI Gene)	1-8DDSPA2c
Chromosome	11
Chromosome location	11p15.5

195

Show/Hide all (195)

miRTarBase ID	miRNA	Experiments
MIRT1060544	hsa-miR-1185	CLIP-seq
MIRT1060545	hsa-miR-1207-5p	CLIP-seq
MIRT1060546	hsa-miR-1286	CLIP-seq
MIRT1060547	hsa-miR-1294	CLIP-seq
MIRT1060548	hsa-miR-1322	CLIP-seq
MIRT1060549	hsa-miR-15a	CLIP-seq
MIRT1060550	hsa-miR-15b	CLIP-seq
MIRT1060551	hsa-miR-16	CLIP-seq
MIRT1060552	hsa-miR-195	CLIP-seq
MIRT1060553	hsa-miR-29a	CLIP-seq
MIRT1060554	hsa-miR-29b	CLIP-seq
MIRT1060555	hsa-miR-29c	CLIP-seq
MIRT1060556	hsa-miR-3065-3p	CLIP-seq
MIRT1060557	hsa-miR-3144-5p	CLIP-seq
MIRT1060558	hsa-miR-3151	CLIP-seq
MIRT1060559	hsa-miR-3176	CLIP-seq
MIRT1060560	hsa-miR-3191	CLIP-seq
MIRT1060561	hsa-miR-3202	CLIP-seq
MIRT1060562	hsa-miR-326	CLIP-seq
MIRT1060563	hsa-miR-330-5p	CLIP-seq
MIRT1060564	hsa-miR-3605-5p	CLIP-seq
MIRT1060565	hsa-miR-3674	CLIP-seq
MIRT1060566	hsa-miR-3679-5p	CLIP-seq
MIRT1060567	hsa-miR-3922-3p	CLIP-seq
MIRT1060568	hsa-miR-424	CLIP-seq
MIRT1060569	hsa-miR-4316	CLIP-seq
MIRT1060570	hsa-miR-4436b-3p	CLIP-seq
MIRT1060571	hsa-miR-4446-3p	CLIP-seq
MIRT1060572	hsa-miR-4447	CLIP-seq
MIRT1060573	hsa-miR-4472	CLIP-seq
MIRT1060574	hsa-miR-4488	CLIP-seq
MIRT1060575	hsa-miR-4533	CLIP-seq
MIRT1060576	hsa-miR-4638-5p	CLIP-seq
MIRT1060577	hsa-miR-4649-5p	CLIP-seq
MIRT1060578	hsa-miR-4652-5p	CLIP-seq
MIRT1060579	hsa-miR-4654	CLIP-seq
MIRT1060580	hsa-miR-4656	CLIP-seq
MIRT1060581	hsa-miR-4662a-3p	CLIP-seq
MIRT1060582	hsa-miR-4667-5p	CLIP-seq
MIRT1060583	hsa-miR-4697-5p	CLIP-seq
MIRT1060584	hsa-miR-4700-5p	CLIP-seq
MIRT1060585	hsa-miR-4722-5p	CLIP-seq
MIRT1060586	hsa-miR-4757-5p	CLIP-seq
MIRT1060587	hsa-miR-4763-3p	CLIP-seq
MIRT1060588	hsa-miR-4769-5p	CLIP-seq
MIRT1060589	hsa-miR-4789-5p	CLIP-seq
MIRT1060590	hsa-miR-486-3p	CLIP-seq
MIRT1060591	hsa-miR-491-5p	CLIP-seq
MIRT1060592	hsa-miR-494	CLIP-seq
MIRT1060593	hsa-miR-497	CLIP-seq
MIRT1060594	hsa-miR-552	CLIP-seq
MIRT1060595	hsa-miR-637	CLIP-seq
MIRT1060596	hsa-miR-7	CLIP-seq
MIRT1060544	hsa-miR-1185	CLIP-seq
MIRT1060545	hsa-miR-1207-5p	CLIP-seq
MIRT1060547	hsa-miR-1294	CLIP-seq
MIRT1060559	hsa-miR-3176	CLIP-seq
MIRT1060562	hsa-miR-326	CLIP-seq
MIRT1060563	hsa-miR-330-5p	CLIP-seq
MIRT1060564	hsa-miR-3605-5p	CLIP-seq
MIRT1060566	hsa-miR-3679-5p	CLIP-seq
MIRT1060567	hsa-miR-3922-3p	CLIP-seq
MIRT1060569	hsa-miR-4316	CLIP-seq
MIRT1060571	hsa-miR-4446-3p	CLIP-seq
MIRT1060574	hsa-miR-4488	CLIP-seq
MIRT1060577	hsa-miR-4649-5p	CLIP-seq
MIRT1060580	hsa-miR-4656	CLIP-seq
MIRT1060581	hsa-miR-4662a-3p	CLIP-seq
MIRT1060582	hsa-miR-4667-5p	CLIP-seq
MIRT1060583	hsa-miR-4697-5p	CLIP-seq
MIRT1060584	hsa-miR-4700-5p	CLIP-seq
MIRT1060586	hsa-miR-4757-5p	CLIP-seq
MIRT1060587	hsa-miR-4763-3p	CLIP-seq
MIRT1060590	hsa-miR-486-3p	CLIP-seq
MIRT1060595	hsa-miR-637	CLIP-seq
MIRT1060596	hsa-miR-7	CLIP-seq
MIRT1060545	hsa-miR-1207-5p	CLIP-seq
MIRT1060548	hsa-miR-1322	CLIP-seq
MIRT1060557	hsa-miR-3144-5p	CLIP-seq
MIRT1060558	hsa-miR-3151	CLIP-seq
MIRT1060559	hsa-miR-3176	CLIP-seq
MIRT1060560	hsa-miR-3191	CLIP-seq
MIRT1060562	hsa-miR-326	CLIP-seq
MIRT1060563	hsa-miR-330-5p	CLIP-seq
MIRT1060567	hsa-miR-3922-3p	CLIP-seq
MIRT1060572	hsa-miR-4447	CLIP-seq
MIRT1060573	hsa-miR-4472	CLIP-seq
MIRT1060574	hsa-miR-4488	CLIP-seq
MIRT1060577	hsa-miR-4649-5p	CLIP-seq
MIRT1060578	hsa-miR-4652-5p	CLIP-seq
MIRT1060579	hsa-miR-4654	CLIP-seq
MIRT1060581	hsa-miR-4662a-3p	CLIP-seq
MIRT1060582	hsa-miR-4667-5p	CLIP-seq
MIRT1060583	hsa-miR-4697-5p	CLIP-seq
MIRT1060584	hsa-miR-4700-5p	CLIP-seq
MIRT1060586	hsa-miR-4757-5p	CLIP-seq
MIRT1060587	hsa-miR-4763-3p	CLIP-seq
MIRT1060588	hsa-miR-4769-5p	CLIP-seq
MIRT1060590	hsa-miR-486-3p	CLIP-seq
MIRT1060591	hsa-miR-491-5p	CLIP-seq
MIRT1060594	hsa-miR-552	CLIP-seq
MIRT1060595	hsa-miR-637	CLIP-seq
MIRT1060596	hsa-miR-7	CLIP-seq
MIRT1060570	hsa-miR-4436b-3p	CLIP-seq
MIRT1060594	hsa-miR-552	CLIP-seq
MIRT1060548	hsa-miR-1322	CLIP-seq
MIRT1060559	hsa-miR-3176	CLIP-seq
MIRT1060567	hsa-miR-3922-3p	CLIP-seq
MIRT1060579	hsa-miR-4654	CLIP-seq
MIRT1060581	hsa-miR-4662a-3p	CLIP-seq
MIRT1060586	hsa-miR-4757-5p	CLIP-seq
MIRT1060588	hsa-miR-4769-5p	CLIP-seq
MIRT1060594	hsa-miR-552	CLIP-seq
MIRT1060596	hsa-miR-7	CLIP-seq
MIRT1060544	hsa-miR-1185	CLIP-seq
MIRT1060545	hsa-miR-1207-5p	CLIP-seq
MIRT1060546	hsa-miR-1286	CLIP-seq
MIRT1060547	hsa-miR-1294	CLIP-seq
MIRT1060557	hsa-miR-3144-5p	CLIP-seq
MIRT1060558	hsa-miR-3151	CLIP-seq
MIRT1060559	hsa-miR-3176	CLIP-seq
MIRT1060560	hsa-miR-3191	CLIP-seq
MIRT1060561	hsa-miR-3202	CLIP-seq
MIRT1060562	hsa-miR-326	CLIP-seq
MIRT1060563	hsa-miR-330-5p	CLIP-seq
MIRT1060564	hsa-miR-3605-5p	CLIP-seq
MIRT1060565	hsa-miR-3674	CLIP-seq
MIRT1060566	hsa-miR-3679-5p	CLIP-seq
MIRT1060567	hsa-miR-3922-3p	CLIP-seq
MIRT1060569	hsa-miR-4316	CLIP-seq
MIRT1060570	hsa-miR-4436b-3p	CLIP-seq
MIRT1060571	hsa-miR-4446-3p	CLIP-seq
MIRT1060572	hsa-miR-4447	CLIP-seq
MIRT1060573	hsa-miR-4472	CLIP-seq
MIRT1060574	hsa-miR-4488	CLIP-seq
MIRT1060575	hsa-miR-4533	CLIP-seq
MIRT1060576	hsa-miR-4638-5p	CLIP-seq
MIRT1060577	hsa-miR-4649-5p	CLIP-seq
MIRT1060578	hsa-miR-4652-5p	CLIP-seq
MIRT1060579	hsa-miR-4654	CLIP-seq
MIRT1060580	hsa-miR-4656	CLIP-seq
MIRT1060581	hsa-miR-4662a-3p	CLIP-seq
MIRT1060582	hsa-miR-4667-5p	CLIP-seq
MIRT1060583	hsa-miR-4697-5p	CLIP-seq
MIRT1060584	hsa-miR-4700-5p	CLIP-seq
MIRT1060585	hsa-miR-4722-5p	CLIP-seq
MIRT1060586	hsa-miR-4757-5p	CLIP-seq
MIRT1060587	hsa-miR-4763-3p	CLIP-seq
MIRT1060588	hsa-miR-4769-5p	CLIP-seq
MIRT1060589	hsa-miR-4789-5p	CLIP-seq
MIRT1060590	hsa-miR-486-3p	CLIP-seq
MIRT1060591	hsa-miR-491-5p	CLIP-seq
MIRT1060594	hsa-miR-552	CLIP-seq
MIRT1060595	hsa-miR-637	CLIP-seq
MIRT1060596	hsa-miR-7	CLIP-seq
MIRT1060544	hsa-miR-1185	CLIP-seq
MIRT1060545	hsa-miR-1207-5p	CLIP-seq
MIRT1060546	hsa-miR-1286	CLIP-seq
MIRT1060547	hsa-miR-1294	CLIP-seq
MIRT1060557	hsa-miR-3144-5p	CLIP-seq
MIRT1060558	hsa-miR-3151	CLIP-seq
MIRT1060559	hsa-miR-3176	CLIP-seq
MIRT1060560	hsa-miR-3191	CLIP-seq
MIRT1060561	hsa-miR-3202	CLIP-seq
MIRT1060562	hsa-miR-326	CLIP-seq
MIRT1060563	hsa-miR-330-5p	CLIP-seq
MIRT1060564	hsa-miR-3605-5p	CLIP-seq
MIRT1060565	hsa-miR-3674	CLIP-seq
MIRT1060566	hsa-miR-3679-5p	CLIP-seq
MIRT1060567	hsa-miR-3922-3p	CLIP-seq
MIRT1060569	hsa-miR-4316	CLIP-seq
MIRT1060570	hsa-miR-4436b-3p	CLIP-seq
MIRT1060571	hsa-miR-4446-3p	CLIP-seq
MIRT1060572	hsa-miR-4447	CLIP-seq
MIRT1060573	hsa-miR-4472	CLIP-seq
MIRT1060574	hsa-miR-4488	CLIP-seq
MIRT1060575	hsa-miR-4533	CLIP-seq
MIRT1060576	hsa-miR-4638-5p	CLIP-seq
MIRT1060577	hsa-miR-4649-5p	CLIP-seq
MIRT1060578	hsa-miR-4652-5p	CLIP-seq
MIRT1060579	hsa-miR-4654	CLIP-seq
MIRT1060580	hsa-miR-4656	CLIP-seq
MIRT1060581	hsa-miR-4662a-3p	CLIP-seq
MIRT1060582	hsa-miR-4667-5p	CLIP-seq
MIRT1060583	hsa-miR-4697-5p	CLIP-seq
MIRT1060584	hsa-miR-4700-5p	CLIP-seq
MIRT1060585	hsa-miR-4722-5p	CLIP-seq
MIRT1060586	hsa-miR-4757-5p	CLIP-seq
MIRT1060587	hsa-miR-4763-3p	CLIP-seq
MIRT1060588	hsa-miR-4769-5p	CLIP-seq
MIRT1060590	hsa-miR-486-3p	CLIP-seq
MIRT1060591	hsa-miR-491-5p	CLIP-seq
MIRT1060594	hsa-miR-552	CLIP-seq
MIRT1060595	hsa-miR-637	CLIP-seq
MIRT1060596	hsa-miR-7	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	26354436
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	TAS	1906403
GO:0009615	Process	Response to virus	IDA	20943977, 21253575, 22479637
GO:0016020	Component	Membrane	IEA
GO:0031902	Component	Late endosome membrane	IDA	26354436
GO:0031902	Component	Late endosome membrane	IEA
GO:0032991	Component	Protein-containing complex	IDA	28246125
GO:0034341	Process	Response to type II interferon	IBA
GO:0034341	Process	Response to type II interferon	IDA	21253575
GO:0035455	Process	Response to interferon-alpha	IBA
GO:0035455	Process	Response to interferon-alpha	IDA	22479637
GO:0035456	Process	Response to interferon-beta	IBA
GO:0035456	Process	Response to interferon-beta	IDA	21253575
GO:0035458	Process	Cellular response to interferon-beta	IDA	33563656
GO:0045071	Process	Negative regulation of viral genome replication	IBA
GO:0045071	Process	Negative regulation of viral genome replication	IDA	21253575
GO:0045087	Process	Innate immune response	IEA
GO:0046597	Process	Host-mediated suppression of symbiont invasion	IBA
GO:0046597	Process	Host-mediated suppression of symbiont invasion	IDA	21253575, 23358889, 26354436, 33563656
GO:0051607	Process	Defense response to virus	IBA
GO:0051607	Process	Defense response to virus	IEA
GO:0060337	Process	Type I interferon-mediated signaling pathway	IBA

MIM	HGNC	e!Ensembl
605578	5413	ENSG00000185201

Q01629

Protein name

Interferon-induced transmembrane protein 2 (Dispanin subfamily A member 2c) (DSPA2c) (Interferon-inducible protein 1-8D)

Protein function

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol (PubMed:26354436, PubMed:33563656). Activ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04505	CD225	53 → 120	Interferon-induced transmembrane protein	Family

Sequence

MNHIVQTFSPVNSGQPPNYEMLKEEQEVAMLGVPHNPAPPMSTVIHIRSETSVPDHVVWS
LFNTLFMNTCCLGFIAFAYSVKSRDRKMVGDVTGAQAYASTAKCLNIWALILGIFMTILL
IIIPVLVVQAQR

Sequence length

132

Interactions

View interactions

	Reactome
			Interferon alpha/beta signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTOIMMUNE THYROID DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	BEFREE	15099960		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	34108016	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	18071348, 19544527		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	22445417		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	22445417		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	18776587	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	33308825	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	28223169		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	36131282	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	38038362	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	35283406	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28223169, 28864347		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Pulmonary fibrosis	Pubtator	36555339	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	15099960		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	28223169		★★★★★ ★☆☆☆☆ Found in Text Mining only

IFITM2 (interferon induced transmembrane protein 2)