Gene Gene information from NCBI Gene database.
Entrez ID 10553
Gene name HIV-1 Tat interactive protein 2
Gene symbol HTATIP2
Synonyms (NCBI Gene)
CC3SDR44U1TIP30
Chromosome 11
Chromosome location 11p15.1
miRNA miRNA information provided by mirtarbase database.
218
miRTarBase ID miRNA Experiments Reference
MIRT002630 hsa-miR-124-3p Microarray 15685193
MIRT002630 hsa-miR-124-3p Microarray 15685193
MIRT002630 hsa-miR-124-3p Microarray 18668037
MIRT437374 hsa-miR-10b-5p Luciferase reporter assayqRT-PCRWestern blot 24096486
MIRT437374 hsa-miR-10b-5p Luciferase reporter assayqRT-PCRWestern blot 24096486
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0003824 Function Catalytic activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IDA 10698937
GO:0005515 Function Protein binding IPI 15282309, 30614533, 32296183
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA 15282309
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605628 16637 ENSG00000109854
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BUP3
Protein name Protein HTATIP2 (30 kDa HIV-1 TAT-interacting protein) (HIV-1 TAT-interactive protein 2)
Protein function Represses translation by preventing reactivation of elongation factor eEF1A (By similarity). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors (PubMed:15282309). Ha
PDB 2BKA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13460 NAD_binding_10 25 214 NAD(P)H-binding Domain
Tissue specificity TISSUE SPECIFICITY: High levels in liver, lung, skeletal muscle, pancreas and placenta (PubMed:9174052). Moderate levels in heart and kidney (PubMed:9174052). Low levels in brain (PubMed:9174052). Not expressed or low levels in variant small cell lung car
Sequence
Sequence length 242
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BELL'S PALSY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OBESITY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
THYROID CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 22733137
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 24037692
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 25612666
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 25612666
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 30249892
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 15931508, 17097132
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 15931508 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 15633220, 17997990, 25008315 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of bladder Bladder carcinoma BEFREE 30249892
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 19349353, 30099830
★☆☆☆☆
Found in Text Mining only