ARL6IP5 (ARF like GTPase 6 interacting protein 5)

Gene

• Entrez ID: 10550
• Gene name: ARF like GTPase 6 interacting protein 5
• Gene symbol: ARL6IP5
• Synonyms (NCBI Gene): DERP11, GTRAP3-18, HSPC127, JWA, PRAF3, Yip6b, addicsin, hp22, jmx
• Chromosome: 3
• Chromosome location: 3p14.1
• Summary: Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell me

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021065	hsa-miR-155-5p	Proteomics	18668040
MIRT021065	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT021502	hsa-miR-145-5p	Reporter assay;Microarray	21351259
MIRT038939	hsa-miR-31-3p	CLASH	23622248
MIRT021065	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT021065	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT798553	hsa-miR-1231	CLIP-seq
MIRT798554	hsa-miR-1234	CLIP-seq
MIRT798555	hsa-miR-1262	CLIP-seq
MIRT798556	hsa-miR-1284	CLIP-seq
MIRT798557	hsa-miR-1293	CLIP-seq
MIRT798558	hsa-miR-129-5p	CLIP-seq
MIRT798559	hsa-miR-142-5p	CLIP-seq
MIRT798560	hsa-miR-181a	CLIP-seq
MIRT798561	hsa-miR-181b	CLIP-seq
MIRT798562	hsa-miR-181c	CLIP-seq
MIRT798563	hsa-miR-181d	CLIP-seq
MIRT798564	hsa-miR-194	CLIP-seq
MIRT798565	hsa-miR-198	CLIP-seq
MIRT798566	hsa-miR-19a	CLIP-seq
MIRT798567	hsa-miR-19b	CLIP-seq
MIRT798568	hsa-miR-302f	CLIP-seq
MIRT798569	hsa-miR-3065-5p	CLIP-seq
MIRT798570	hsa-miR-3149	CLIP-seq
MIRT798571	hsa-miR-3160-3p	CLIP-seq
MIRT798572	hsa-miR-3163	CLIP-seq
MIRT798573	hsa-miR-323b-5p	CLIP-seq
MIRT798574	hsa-miR-340	CLIP-seq
MIRT798575	hsa-miR-3609	CLIP-seq
MIRT798576	hsa-miR-3613-3p	CLIP-seq
MIRT798577	hsa-miR-3662	CLIP-seq
MIRT798578	hsa-miR-3688-5p	CLIP-seq
MIRT798579	hsa-miR-369-3p	CLIP-seq
MIRT798580	hsa-miR-374c	CLIP-seq
MIRT798581	hsa-miR-378	CLIP-seq
MIRT798582	hsa-miR-378b	CLIP-seq
MIRT798583	hsa-miR-378c	CLIP-seq
MIRT798584	hsa-miR-378d	CLIP-seq
MIRT798585	hsa-miR-378e	CLIP-seq
MIRT798586	hsa-miR-378f	CLIP-seq
MIRT798587	hsa-miR-378h	CLIP-seq
MIRT798588	hsa-miR-378i	CLIP-seq
MIRT798589	hsa-miR-3910	CLIP-seq
MIRT798590	hsa-miR-3921	CLIP-seq
MIRT798591	hsa-miR-3976	CLIP-seq
MIRT798592	hsa-miR-422a	CLIP-seq
MIRT798593	hsa-miR-4262	CLIP-seq
MIRT798594	hsa-miR-4288	CLIP-seq
MIRT798595	hsa-miR-4303	CLIP-seq
MIRT798596	hsa-miR-431	CLIP-seq
MIRT798597	hsa-miR-4470	CLIP-seq
MIRT798598	hsa-miR-4483	CLIP-seq
MIRT798599	hsa-miR-4484	CLIP-seq
MIRT798600	hsa-miR-4636	CLIP-seq
MIRT798601	hsa-miR-4638-3p	CLIP-seq
MIRT798602	hsa-miR-4649-3p	CLIP-seq
MIRT798603	hsa-miR-4653-5p	CLIP-seq
MIRT798604	hsa-miR-4665-3p	CLIP-seq
MIRT798605	hsa-miR-4699-3p	CLIP-seq
MIRT798606	hsa-miR-4701-3p	CLIP-seq
MIRT798607	hsa-miR-4708-3p	CLIP-seq
MIRT798608	hsa-miR-4729	CLIP-seq
MIRT798609	hsa-miR-4762-3p	CLIP-seq
MIRT798610	hsa-miR-4766-5p	CLIP-seq
MIRT798611	hsa-miR-4768-5p	CLIP-seq
MIRT798612	hsa-miR-4769-3p	CLIP-seq
MIRT798613	hsa-miR-4772-3p	CLIP-seq
MIRT798614	hsa-miR-494	CLIP-seq
MIRT798615	hsa-miR-495	CLIP-seq
MIRT798616	hsa-miR-511	CLIP-seq
MIRT798617	hsa-miR-520g	CLIP-seq
MIRT798618	hsa-miR-520h	CLIP-seq
MIRT798619	hsa-miR-544	CLIP-seq
MIRT798620	hsa-miR-548ag	CLIP-seq
MIRT798621	hsa-miR-548ah	CLIP-seq
MIRT798622	hsa-miR-548ai	CLIP-seq
MIRT798623	hsa-miR-548an	CLIP-seq
MIRT798624	hsa-miR-552	CLIP-seq
MIRT798625	hsa-miR-577	CLIP-seq
MIRT798626	hsa-miR-579	CLIP-seq
MIRT798627	hsa-miR-584	CLIP-seq
MIRT798628	hsa-miR-607	CLIP-seq
MIRT798629	hsa-miR-632	CLIP-seq
MIRT798630	hsa-miR-633	CLIP-seq
MIRT798631	hsa-miR-640	CLIP-seq
MIRT798632	hsa-miR-655	CLIP-seq
MIRT798633	hsa-miR-664	CLIP-seq
MIRT798634	hsa-miR-891b	CLIP-seq
MIRT798635	hsa-miR-942	CLIP-seq
MIRT1935803	hsa-miR-1197	CLIP-seq
MIRT798555	hsa-miR-1262	CLIP-seq
MIRT798557	hsa-miR-1293	CLIP-seq
MIRT1935804	hsa-miR-1324	CLIP-seq
MIRT1935805	hsa-miR-145	CLIP-seq
MIRT1935806	hsa-miR-15a	CLIP-seq
MIRT1935807	hsa-miR-15b	CLIP-seq
MIRT1935808	hsa-miR-16	CLIP-seq
MIRT798564	hsa-miR-194	CLIP-seq
MIRT1935809	hsa-miR-195	CLIP-seq
MIRT798565	hsa-miR-198	CLIP-seq
MIRT1935810	hsa-miR-2681	CLIP-seq
MIRT798570	hsa-miR-3149	CLIP-seq
MIRT1935811	hsa-miR-323-3p	CLIP-seq
MIRT1935812	hsa-miR-323-5p	CLIP-seq
MIRT798573	hsa-miR-323b-5p	CLIP-seq
MIRT798577	hsa-miR-3662	CLIP-seq
MIRT798579	hsa-miR-369-3p	CLIP-seq
MIRT798580	hsa-miR-374c	CLIP-seq
MIRT1935813	hsa-miR-376c	CLIP-seq
MIRT798581	hsa-miR-378	CLIP-seq
MIRT798582	hsa-miR-378b	CLIP-seq
MIRT798583	hsa-miR-378c	CLIP-seq
MIRT798584	hsa-miR-378d	CLIP-seq
MIRT798585	hsa-miR-378e	CLIP-seq
MIRT798586	hsa-miR-378f	CLIP-seq
MIRT798587	hsa-miR-378h	CLIP-seq
MIRT798588	hsa-miR-378i	CLIP-seq
MIRT1935814	hsa-miR-3914	CLIP-seq
MIRT1935815	hsa-miR-3925-3p	CLIP-seq
MIRT1935816	hsa-miR-3977	CLIP-seq
MIRT798592	hsa-miR-422a	CLIP-seq
MIRT1935817	hsa-miR-424	CLIP-seq
MIRT1935818	hsa-miR-4266	CLIP-seq
MIRT1935819	hsa-miR-4317	CLIP-seq
MIRT1935820	hsa-miR-4438	CLIP-seq
MIRT1935821	hsa-miR-4450	CLIP-seq
MIRT1935822	hsa-miR-4477b	CLIP-seq
MIRT798598	hsa-miR-4483	CLIP-seq
MIRT798601	hsa-miR-4638-3p	CLIP-seq
MIRT1935823	hsa-miR-4643	CLIP-seq
MIRT1935824	hsa-miR-4695-5p	CLIP-seq
MIRT798606	hsa-miR-4701-3p	CLIP-seq
MIRT1935825	hsa-miR-4779	CLIP-seq
MIRT798614	hsa-miR-494	CLIP-seq
MIRT1935826	hsa-miR-497	CLIP-seq
MIRT1935827	hsa-miR-508-5p	CLIP-seq
MIRT1935828	hsa-miR-548c-3p	CLIP-seq
MIRT798624	hsa-miR-552	CLIP-seq
MIRT798625	hsa-miR-577	CLIP-seq
MIRT798627	hsa-miR-584	CLIP-seq
MIRT798628	hsa-miR-607	CLIP-seq
MIRT798632	hsa-miR-655	CLIP-seq
MIRT1935829	hsa-miR-876-3p	CLIP-seq
MIRT2175922	hsa-miR-1207-5p	CLIP-seq
MIRT2175923	hsa-miR-1273e	CLIP-seq
MIRT798557	hsa-miR-1293	CLIP-seq
MIRT798559	hsa-miR-142-5p	CLIP-seq
MIRT798565	hsa-miR-198	CLIP-seq
MIRT1935811	hsa-miR-323-3p	CLIP-seq
MIRT1935812	hsa-miR-323-5p	CLIP-seq
MIRT798574	hsa-miR-340	CLIP-seq
MIRT798576	hsa-miR-3613-3p	CLIP-seq
MIRT2175924	hsa-miR-3692	CLIP-seq
MIRT798579	hsa-miR-369-3p	CLIP-seq
MIRT798580	hsa-miR-374c	CLIP-seq
MIRT1935813	hsa-miR-376c	CLIP-seq
MIRT798589	hsa-miR-3910	CLIP-seq
MIRT1935814	hsa-miR-3914	CLIP-seq
MIRT2175925	hsa-miR-4282	CLIP-seq
MIRT2175926	hsa-miR-4436b-5p	CLIP-seq
MIRT1935820	hsa-miR-4438	CLIP-seq
MIRT1935821	hsa-miR-4450	CLIP-seq
MIRT798598	hsa-miR-4483	CLIP-seq
MIRT798599	hsa-miR-4484	CLIP-seq
MIRT1935823	hsa-miR-4643	CLIP-seq
MIRT2175927	hsa-miR-4659a-3p	CLIP-seq
MIRT2175928	hsa-miR-4659b-3p	CLIP-seq
MIRT2175929	hsa-miR-4736	CLIP-seq
MIRT2175930	hsa-miR-4742-5p	CLIP-seq
MIRT2175931	hsa-miR-4744	CLIP-seq
MIRT2175932	hsa-miR-4763-3p	CLIP-seq
MIRT798612	hsa-miR-4769-3p	CLIP-seq
MIRT798613	hsa-miR-4772-3p	CLIP-seq
MIRT2175933	hsa-miR-4804-3p	CLIP-seq
MIRT798623	hsa-miR-548an	CLIP-seq
MIRT798624	hsa-miR-552	CLIP-seq
MIRT2175934	hsa-miR-576-5p	CLIP-seq
MIRT798625	hsa-miR-577	CLIP-seq
MIRT798628	hsa-miR-607	CLIP-seq
MIRT798630	hsa-miR-633	CLIP-seq
MIRT798632	hsa-miR-655	CLIP-seq
MIRT1935829	hsa-miR-876-3p	CLIP-seq
MIRT2175935	hsa-miR-892b	CLIP-seq
MIRT1935805	hsa-miR-145	CLIP-seq
MIRT1935815	hsa-miR-3925-3p	CLIP-seq
MIRT1935827	hsa-miR-508-5p	CLIP-seq
MIRT798554	hsa-miR-1234	CLIP-seq
MIRT798556	hsa-miR-1284	CLIP-seq
MIRT798571	hsa-miR-3160-3p	CLIP-seq
MIRT798604	hsa-miR-4665-3p	CLIP-seq
MIRT798614	hsa-miR-494	CLIP-seq
MIRT798630	hsa-miR-633	CLIP-seq
MIRT798571	hsa-miR-3160-3p	CLIP-seq
MIRT798614	hsa-miR-494	CLIP-seq
MIRT798630	hsa-miR-633	CLIP-seq
MIRT2175922	hsa-miR-1207-5p	CLIP-seq
MIRT798553	hsa-miR-1231	CLIP-seq
MIRT798554	hsa-miR-1234	CLIP-seq
MIRT798555	hsa-miR-1262	CLIP-seq
MIRT798556	hsa-miR-1284	CLIP-seq
MIRT798557	hsa-miR-1293	CLIP-seq
MIRT798558	hsa-miR-129-5p	CLIP-seq
MIRT2479183	hsa-miR-1321	CLIP-seq
MIRT2479184	hsa-miR-138	CLIP-seq
MIRT2479185	hsa-miR-186	CLIP-seq
MIRT798564	hsa-miR-194	CLIP-seq
MIRT798565	hsa-miR-198	CLIP-seq
MIRT798566	hsa-miR-19a	CLIP-seq
MIRT798567	hsa-miR-19b	CLIP-seq
MIRT2479186	hsa-miR-204	CLIP-seq
MIRT2479187	hsa-miR-211	CLIP-seq
MIRT2479188	hsa-miR-2964a-5p	CLIP-seq
MIRT798569	hsa-miR-3065-5p	CLIP-seq
MIRT2479189	hsa-miR-3121-3p	CLIP-seq
MIRT2479190	hsa-miR-3133	CLIP-seq
MIRT2479191	hsa-miR-3148	CLIP-seq
MIRT798570	hsa-miR-3149	CLIP-seq
MIRT798571	hsa-miR-3160-3p	CLIP-seq
MIRT798572	hsa-miR-3163	CLIP-seq
MIRT2479192	hsa-miR-337-3p	CLIP-seq
MIRT798574	hsa-miR-340	CLIP-seq
MIRT2479193	hsa-miR-3607-3p	CLIP-seq
MIRT798576	hsa-miR-3613-3p	CLIP-seq
MIRT2479194	hsa-miR-3685	CLIP-seq
MIRT798579	hsa-miR-369-3p	CLIP-seq
MIRT798580	hsa-miR-374c	CLIP-seq
MIRT1935813	hsa-miR-376c	CLIP-seq
MIRT798581	hsa-miR-378	CLIP-seq
MIRT798582	hsa-miR-378b	CLIP-seq
MIRT798583	hsa-miR-378c	CLIP-seq
MIRT798584	hsa-miR-378d	CLIP-seq
MIRT798585	hsa-miR-378e	CLIP-seq
MIRT798586	hsa-miR-378f	CLIP-seq
MIRT798587	hsa-miR-378h	CLIP-seq
MIRT798588	hsa-miR-378i	CLIP-seq
MIRT2479195	hsa-miR-384	CLIP-seq
MIRT2479196	hsa-miR-3938	CLIP-seq
MIRT798592	hsa-miR-422a	CLIP-seq
MIRT798594	hsa-miR-4288	CLIP-seq
MIRT2479197	hsa-miR-4299	CLIP-seq
MIRT798596	hsa-miR-431	CLIP-seq
MIRT1935822	hsa-miR-4477b	CLIP-seq
MIRT798598	hsa-miR-4483	CLIP-seq
MIRT2479198	hsa-miR-450b-5p	CLIP-seq
MIRT798600	hsa-miR-4636	CLIP-seq
MIRT798601	hsa-miR-4638-3p	CLIP-seq
MIRT1935823	hsa-miR-4643	CLIP-seq
MIRT2479199	hsa-miR-4662a-3p	CLIP-seq
MIRT798604	hsa-miR-4665-3p	CLIP-seq
MIRT798605	hsa-miR-4699-3p	CLIP-seq
MIRT798606	hsa-miR-4701-3p	CLIP-seq
MIRT798607	hsa-miR-4708-3p	CLIP-seq
MIRT2479200	hsa-miR-4718	CLIP-seq
MIRT798608	hsa-miR-4729	CLIP-seq
MIRT2175929	hsa-miR-4736	CLIP-seq
MIRT2479201	hsa-miR-4739	CLIP-seq
MIRT2175930	hsa-miR-4742-5p	CLIP-seq
MIRT2479202	hsa-miR-4755-5p	CLIP-seq
MIRT2479203	hsa-miR-4756-5p	CLIP-seq
MIRT2175932	hsa-miR-4763-3p	CLIP-seq
MIRT798612	hsa-miR-4769-3p	CLIP-seq
MIRT798613	hsa-miR-4772-3p	CLIP-seq
MIRT2479204	hsa-miR-487a	CLIP-seq
MIRT798614	hsa-miR-494	CLIP-seq
MIRT798616	hsa-miR-511	CLIP-seq
MIRT2479205	hsa-miR-539	CLIP-seq
MIRT798619	hsa-miR-544	CLIP-seq
MIRT2479206	hsa-miR-548ac	CLIP-seq
MIRT2479207	hsa-miR-548ae	CLIP-seq
MIRT798620	hsa-miR-548ag	CLIP-seq
MIRT798622	hsa-miR-548ai	CLIP-seq
MIRT2479208	hsa-miR-548aj	CLIP-seq
MIRT2479209	hsa-miR-548am	CLIP-seq
MIRT2479210	hsa-miR-548d-3p	CLIP-seq
MIRT2479211	hsa-miR-548x	CLIP-seq
MIRT2479212	hsa-miR-548z	CLIP-seq
MIRT798624	hsa-miR-552	CLIP-seq
MIRT2479213	hsa-miR-556-3p	CLIP-seq
MIRT2479214	hsa-miR-568	CLIP-seq
MIRT2479215	hsa-miR-570	CLIP-seq
MIRT2175934	hsa-miR-576-5p	CLIP-seq
MIRT798625	hsa-miR-577	CLIP-seq
MIRT798626	hsa-miR-579	CLIP-seq
MIRT798628	hsa-miR-607	CLIP-seq
MIRT2479216	hsa-miR-623	CLIP-seq
MIRT798629	hsa-miR-632	CLIP-seq
MIRT798630	hsa-miR-633	CLIP-seq
MIRT798632	hsa-miR-655	CLIP-seq
MIRT798634	hsa-miR-891b	CLIP-seq
MIRT2175922	hsa-miR-1207-5p	CLIP-seq
MIRT798553	hsa-miR-1231	CLIP-seq
MIRT798554	hsa-miR-1234	CLIP-seq
MIRT798555	hsa-miR-1262	CLIP-seq
MIRT798556	hsa-miR-1284	CLIP-seq
MIRT798557	hsa-miR-1293	CLIP-seq
MIRT798558	hsa-miR-129-5p	CLIP-seq
MIRT2479183	hsa-miR-1321	CLIP-seq
MIRT2479184	hsa-miR-138	CLIP-seq
MIRT798564	hsa-miR-194	CLIP-seq
MIRT798565	hsa-miR-198	CLIP-seq
MIRT798566	hsa-miR-19a	CLIP-seq
MIRT798567	hsa-miR-19b	CLIP-seq
MIRT2479186	hsa-miR-204	CLIP-seq
MIRT2479187	hsa-miR-211	CLIP-seq
MIRT2479188	hsa-miR-2964a-5p	CLIP-seq
MIRT798569	hsa-miR-3065-5p	CLIP-seq
MIRT2479189	hsa-miR-3121-3p	CLIP-seq
MIRT2479191	hsa-miR-3148	CLIP-seq
MIRT798570	hsa-miR-3149	CLIP-seq
MIRT798571	hsa-miR-3160-3p	CLIP-seq
MIRT798572	hsa-miR-3163	CLIP-seq
MIRT2479192	hsa-miR-337-3p	CLIP-seq
MIRT798574	hsa-miR-340	CLIP-seq
MIRT2479193	hsa-miR-3607-3p	CLIP-seq
MIRT798576	hsa-miR-3613-3p	CLIP-seq
MIRT2479194	hsa-miR-3685	CLIP-seq
MIRT798579	hsa-miR-369-3p	CLIP-seq
MIRT798580	hsa-miR-374c	CLIP-seq
MIRT1935813	hsa-miR-376c	CLIP-seq
MIRT798581	hsa-miR-378	CLIP-seq
MIRT798582	hsa-miR-378b	CLIP-seq
MIRT798583	hsa-miR-378c	CLIP-seq
MIRT798584	hsa-miR-378d	CLIP-seq
MIRT798585	hsa-miR-378e	CLIP-seq
MIRT798586	hsa-miR-378f	CLIP-seq
MIRT798587	hsa-miR-378h	CLIP-seq
MIRT798588	hsa-miR-378i	CLIP-seq
MIRT2479195	hsa-miR-384	CLIP-seq
MIRT2479196	hsa-miR-3938	CLIP-seq
MIRT798592	hsa-miR-422a	CLIP-seq
MIRT798594	hsa-miR-4288	CLIP-seq
MIRT2479197	hsa-miR-4299	CLIP-seq
MIRT798596	hsa-miR-431	CLIP-seq
MIRT798598	hsa-miR-4483	CLIP-seq
MIRT2479198	hsa-miR-450b-5p	CLIP-seq
MIRT798600	hsa-miR-4636	CLIP-seq
MIRT798601	hsa-miR-4638-3p	CLIP-seq
MIRT1935823	hsa-miR-4643	CLIP-seq
MIRT2479199	hsa-miR-4662a-3p	CLIP-seq
MIRT798604	hsa-miR-4665-3p	CLIP-seq
MIRT798605	hsa-miR-4699-3p	CLIP-seq
MIRT798606	hsa-miR-4701-3p	CLIP-seq
MIRT798607	hsa-miR-4708-3p	CLIP-seq
MIRT2479200	hsa-miR-4718	CLIP-seq
MIRT798608	hsa-miR-4729	CLIP-seq
MIRT2175929	hsa-miR-4736	CLIP-seq
MIRT2479201	hsa-miR-4739	CLIP-seq
MIRT2175930	hsa-miR-4742-5p	CLIP-seq
MIRT2479202	hsa-miR-4755-5p	CLIP-seq
MIRT2479203	hsa-miR-4756-5p	CLIP-seq
MIRT2175932	hsa-miR-4763-3p	CLIP-seq
MIRT798612	hsa-miR-4769-3p	CLIP-seq
MIRT798613	hsa-miR-4772-3p	CLIP-seq
MIRT2479204	hsa-miR-487a	CLIP-seq
MIRT798614	hsa-miR-494	CLIP-seq
MIRT798616	hsa-miR-511	CLIP-seq
MIRT2479205	hsa-miR-539	CLIP-seq
MIRT798619	hsa-miR-544	CLIP-seq
MIRT2479206	hsa-miR-548ac	CLIP-seq
MIRT2479207	hsa-miR-548ae	CLIP-seq
MIRT798620	hsa-miR-548ag	CLIP-seq
MIRT798622	hsa-miR-548ai	CLIP-seq
MIRT2479208	hsa-miR-548aj	CLIP-seq
MIRT2479209	hsa-miR-548am	CLIP-seq
MIRT2479210	hsa-miR-548d-3p	CLIP-seq
MIRT2479211	hsa-miR-548x	CLIP-seq
MIRT2479212	hsa-miR-548z	CLIP-seq
MIRT798624	hsa-miR-552	CLIP-seq
MIRT2479213	hsa-miR-556-3p	CLIP-seq
MIRT2479214	hsa-miR-568	CLIP-seq
MIRT2175934	hsa-miR-576-5p	CLIP-seq
MIRT798625	hsa-miR-577	CLIP-seq
MIRT798626	hsa-miR-579	CLIP-seq
MIRT798628	hsa-miR-607	CLIP-seq
MIRT2479216	hsa-miR-623	CLIP-seq
MIRT798629	hsa-miR-632	CLIP-seq
MIRT798630	hsa-miR-633	CLIP-seq
MIRT798632	hsa-miR-655	CLIP-seq
MIRT798634	hsa-miR-891b	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ING4	Activation	24157826

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002037	Process	Negative regulation of L-glutamate import across plasma membrane	IEA
GO:0002037	Process	Negative regulation of L-glutamate import across plasma membrane	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006749	Process	Glutathione metabolic process	IEA
GO:0007611	Process	Learning or memory	IEA
GO:0008631	Process	Intrinsic apoptotic signaling pathway in response to oxidative stress	IDA	18387645
GO:0010917	Process	Negative regulation of mitochondrial membrane potential	IMP	18387645
GO:0015031	Process	Protein transport	IDA	18167356
GO:0015813	Process	L-glutamate transmembrane transport	IEA
GO:0015813	Process	L-glutamate transmembrane transport	ISS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0032874	Process	Positive regulation of stress-activated MAPK cascade	IMP	18387645
GO:0034599	Process	Cellular response to oxidative stress	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IMP	18387645
GO:0051051	Process	Negative regulation of transport	IBA
GO:0072659	Process	Protein localization to plasma membrane	IEA
GO:0098712	Process	L-glutamate import across plasma membrane	IEA
GO:0099523	Component	Presynaptic cytosol	IEA

Other IDs

• MIM: 605709
• HGNC: 16937
• e!Ensembl: ENSG00000144746

Protein

• UniProt ID: O75915
• Protein name: PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Cytoskeleton-related vitamin A-responsive protein) (Dermal papilla-derived protein 11) (GTRAP3-18) (Glutamate transporter EAAC1-int
• Protein function: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03208	PRA1	3 → 150	PRA1 family protein	Family

• Sequence:

  MDVNIAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISIVGF
  LSPFNMILGGIVVVLVFTGFVWAAHNKDVLRRMKKRYPTTFVMVVMLASYFLISMFGGVM
  VFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKRTPMGIVLDALEQQEEGINRLT
  DYISKVKE

• Sequence length: 188

Pathways

Reactome:

Glutamate Neurotransmitter Release Cycle

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE WITHDRAWAL SYNDROME	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	34654853	Associate	★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	36418457	Associate	★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	BEFREE	18291005		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	LHGDN	16331563, 17479401		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	17479401, 17479402, 17479403		★☆☆☆☆ Found in Text Mining only
Brain Ischemia	Brain ischemia	Pubtator	25583472	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	15799245, 25586271, 29658570		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	25803781	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	29658570	Inhibit	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	25925371		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	29658570	Inhibit	★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	17479401, 17479402, 17479403		★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	Pubtator	18258668	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	15016754		★☆☆☆☆ Found in Text Mining only
Eosinophilia	Eosinophilia	Pubtator	22766337	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy Idiopathic Generalized	Epilepsy	Pubtator	18554871	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	17479402		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	17479402		★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	22433565	Inhibit	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	25925371	Associate	★☆☆☆☆ Found in Text Mining only
Fabry Disease	Fabry disease	Pubtator	18554871	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	34207114	Associate	★☆☆☆☆ Found in Text Mining only
Hemolysis	Hemolysis	Pubtator	16637741	Associate	★☆☆☆☆ Found in Text Mining only
Hereditary Diffuse Gastric Cancer	Gastric Cancer	CTD_human_DG	22452940		★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune System Diseases	BEFREE	21708824		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	17049984, 17479403		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	LHGDN	17479403		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	22433565	Inhibit	★☆☆☆☆ Found in Text Mining only
Malabsorption Syndromes	Malabsorption syndrome	Pubtator	18258668	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	25586271, 29658570		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	17479402		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	17479402, 23347235, 24072772, 28671676, 29481911		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CTD_human_DG	22452940		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	17479401, 17479402, 17479403		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	21847655, 31703842		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	24064223, 24157826, 29658570		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	24157826	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22433565, 22452940, 23461062, 29481911, 29545876		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	28904020		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	35293383	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	28428137, 29500411		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	32753660	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	18678470		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	LHGDN	17479402		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	17479402, 22433565, 23461062, 25925371		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	17479402, 23347235, 24072772, 28671676, 29481911		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	LHGDN	17479402		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Neoplasms	Stomach Neoplasms	CTD_human_DG	22452940		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Neoplasms	Stomach neoplasms	Pubtator	23285001, 23347235, 25476899, 27167206, 27708243	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Vasospasm Intracranial	Intracranial vasospasm	Pubtator	25583472	Stimulate	★☆☆☆☆ Found in Text Mining only