Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10505
Gene name	Ssemaphorin 4F
Gene symbol	SEMA4F
Synonyms (NCBI Gene)	M-SEMAPRO2353S4FSEMAMSEMAWm-Sema-M
Chromosome	2
Chromosome location	2p13.1
Summary	This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative sp

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miRTarBase ID	miRNA	Experiments	Reference
MIRT450680	hsa-miR-873-5p	HITS-CLIP	19536157
MIRT713848	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT534422	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT534421	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT534420	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT534419	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT534418	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT534417	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT534416	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT534415	hsa-miR-138-2-3p	PAR-CLIP	22012620
MIRT534414	hsa-miR-7159-3p	PAR-CLIP	22012620
MIRT534413	hsa-miR-4482-3p	PAR-CLIP	22012620
MIRT450680	hsa-miR-873-5p	PAR-CLIP	22100165
MIRT450679	hsa-miR-6165	PAR-CLIP	22100165
MIRT450678	hsa-miR-6077	PAR-CLIP	22100165
MIRT448487	hsa-miR-595	PAR-CLIP	22100165
MIRT448486	hsa-miR-603	PAR-CLIP	22100165
MIRT448485	hsa-miR-216b-3p	PAR-CLIP	22100165
MIRT448484	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT448483	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT448482	hsa-miR-4711-3p	PAR-CLIP	22100165
MIRT448481	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT448487	hsa-miR-595	PAR-CLIP	22100165
MIRT448486	hsa-miR-603	PAR-CLIP	22100165
MIRT448485	hsa-miR-216b-3p	PAR-CLIP	22100165
MIRT448484	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT448483	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT448482	hsa-miR-4711-3p	PAR-CLIP	22100165
MIRT448481	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450680	hsa-miR-873-5p	HITS-CLIP	19536157
MIRT713848	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT534422	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT534421	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT534420	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT534419	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT534418	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT534417	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT534416	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT534415	hsa-miR-138-2-3p	PAR-CLIP	22012620
MIRT534414	hsa-miR-7159-3p	PAR-CLIP	22012620
MIRT534413	hsa-miR-4482-3p	PAR-CLIP	22012620
MIRT450680	hsa-miR-873-5p	PAR-CLIP	22100165
MIRT450679	hsa-miR-6165	PAR-CLIP	22100165
MIRT450678	hsa-miR-6077	PAR-CLIP	22100165
MIRT448487	hsa-miR-595	PAR-CLIP	22100165
MIRT448486	hsa-miR-603	PAR-CLIP	22100165
MIRT448485	hsa-miR-216b-3p	PAR-CLIP	22100165
MIRT448484	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT448483	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT448482	hsa-miR-4711-3p	PAR-CLIP	22100165
MIRT448481	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT448487	hsa-miR-595	PAR-CLIP	22100165
MIRT448486	hsa-miR-603	PAR-CLIP	22100165
MIRT448485	hsa-miR-216b-3p	PAR-CLIP	22100165
MIRT448484	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT448483	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT448482	hsa-miR-4711-3p	PAR-CLIP	22100165
MIRT448481	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT1335230	hsa-miR-1245b-3p	CLIP-seq
MIRT1335231	hsa-miR-127-5p	CLIP-seq
MIRT1335232	hsa-miR-154	CLIP-seq
MIRT1335233	hsa-miR-2964a-5p	CLIP-seq
MIRT1335234	hsa-miR-3199	CLIP-seq
MIRT1335235	hsa-miR-338-3p	CLIP-seq
MIRT1335236	hsa-miR-362-5p	CLIP-seq
MIRT1335237	hsa-miR-4286	CLIP-seq
MIRT1335238	hsa-miR-4493	CLIP-seq
MIRT1335239	hsa-miR-4515	CLIP-seq
MIRT1335240	hsa-miR-4530	CLIP-seq
MIRT1335241	hsa-miR-455-3p	CLIP-seq
MIRT1335242	hsa-miR-4635	CLIP-seq
MIRT1335243	hsa-miR-4671-5p	CLIP-seq
MIRT1335244	hsa-miR-4685-5p	CLIP-seq
MIRT1335245	hsa-miR-4729	CLIP-seq
MIRT1335246	hsa-miR-500a	CLIP-seq
MIRT1335247	hsa-miR-500b	CLIP-seq
MIRT1335248	hsa-miR-548aa	CLIP-seq
MIRT1335249	hsa-miR-548g	CLIP-seq
MIRT1335250	hsa-miR-646	CLIP-seq
MIRT1335251	hsa-miR-766	CLIP-seq
MIRT2099126	hsa-miR-3158-5p	CLIP-seq
MIRT2099127	hsa-miR-3919	CLIP-seq
MIRT2099128	hsa-miR-4668-3p	CLIP-seq
MIRT1335250	hsa-miR-646	CLIP-seq
MIRT2323878	hsa-miR-4643	CLIP-seq
MIRT2323879	hsa-miR-873	CLIP-seq
MIRT2394206	hsa-miR-3184	CLIP-seq
MIRT2394207	hsa-miR-423-5p	CLIP-seq
MIRT1335239	hsa-miR-4515	CLIP-seq
MIRT2459084	hsa-miR-10a	CLIP-seq
MIRT2459085	hsa-miR-10b	CLIP-seq
MIRT2459086	hsa-miR-136	CLIP-seq
MIRT1335235	hsa-miR-338-3p	CLIP-seq
MIRT2459087	hsa-miR-3620	CLIP-seq
MIRT1335240	hsa-miR-4530	CLIP-seq
MIRT2459088	hsa-miR-545	CLIP-seq
MIRT2619759	hsa-miR-3924	CLIP-seq
MIRT2619760	hsa-miR-4699-3p	CLIP-seq
MIRT2690363	hsa-miR-3670	CLIP-seq
MIRT2690364	hsa-miR-3671	CLIP-seq
MIRT2690365	hsa-miR-376c	CLIP-seq
MIRT2323878	hsa-miR-4643	CLIP-seq
MIRT2690366	hsa-miR-466	CLIP-seq
MIRT2690367	hsa-miR-4789-3p	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001755	Process	Neural crest cell migration	IBA
GO:0005515	Function	Protein binding	IPI	35512704
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10051670
GO:0007267	Process	Cell-cell signaling	TAS	10051670
GO:0007399	Process	Nervous system development	IEA
GO:0007399	Process	Nervous system development	TAS	10051670
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IEA
GO:0007411	Process	Axon guidance	TAS	10051670
GO:0014069	Component	Postsynaptic density	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10051670
GO:0030154	Process	Cell differentiation	IEA
GO:0030215	Function	Semaphorin receptor binding	IBA
GO:0030215	Function	Semaphorin receptor binding	IEA
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0030425	Component	Dendrite	IEA
GO:0030517	Process	Negative regulation of axon extension	IEA
GO:0031290	Process	Retinal ganglion cell axon guidance	IEA
GO:0038191	Function	Neuropilin binding	IBA
GO:0042995	Component	Cell projection	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045499	Function	Chemorepellent activity	IBA
GO:0050919	Process	Negative chemotaxis	IBA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

MIM	HGNC	e!Ensembl
603706	10734	ENSG00000135622

O95754

Protein name

Semaphorin-4F (Semaphorin-M) (Sema M) (Semaphorin-W) (Sema W)

Protein function

Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity). Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal g

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01403	Sema	67 → 494	Sema domain	Family
PF01437	PSI	512 → 563	Plexin repeat	Family

Sequence

MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVP
HTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKED
ECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAA
VMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGD
EDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGP
EHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRE
LKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFP
ADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLAL
FPEPQPVENMKLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECV
AHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQ
PSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVG
AGLAGFFLGILAASLTLILIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPS
PEDERLPLALAKRGSGFGGFSPPFLLDPCPSPAHIRLTGAPLATCDETSI

Sequence length

770

Interactions

View interactions

	KEGG
	Axon guidance

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MESOTHELIOMA, MALIGNANT	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Benign Neoplasm	Benign Neoplasm	BEFREE	21925246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	21925246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	34810279	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dyslexia	Dyslexia	BEFREE	11901358		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant mesothelioma	Malignant Mesothelioma	CTD_human_DG	25756049		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21925246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	24097862		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24097862		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21925246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	24097862		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Intraepithelial Neoplasia	Prostatic intraepithelial neoplasia	Pubtator	24097862	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	24097862	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SEMA4F (ssemaphorin 4F)