SEMA6C (semaphorin 6C)

Gene

• Entrez ID: 10500
• Gene name: Semaphorin 6C
• Gene symbol: SEMA6C
• Synonyms (NCBI Gene): SEMAY, Sema-Y, m-SemaY, m-SemaY2
• Chromosome: 1
• Chromosome location: 1q21.3
• Summary: This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration. [provided by

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1335541	hsa-miR-1245b-5p	CLIP-seq
MIRT1335542	hsa-miR-3142	CLIP-seq
MIRT1335543	hsa-miR-3653	CLIP-seq
MIRT1335544	hsa-miR-3658	CLIP-seq
MIRT1335545	hsa-miR-885-5p	CLIP-seq
MIRT1335546	hsa-miR-941	CLIP-seq
MIRT2099185	hsa-miR-1289	CLIP-seq
MIRT2099186	hsa-miR-151-5p	CLIP-seq
MIRT2099187	hsa-miR-151b	CLIP-seq
MIRT2099188	hsa-miR-3131	CLIP-seq
MIRT2099189	hsa-miR-3153	CLIP-seq
MIRT2099190	hsa-miR-3180	CLIP-seq
MIRT2099191	hsa-miR-3180-3p	CLIP-seq
MIRT2099192	hsa-miR-3196	CLIP-seq
MIRT2099193	hsa-miR-4466	CLIP-seq
MIRT2099194	hsa-miR-4481	CLIP-seq
MIRT2099195	hsa-miR-4488	CLIP-seq
MIRT2099196	hsa-miR-4649-5p	CLIP-seq
MIRT2099197	hsa-miR-4697-5p	CLIP-seq
MIRT2099198	hsa-miR-4706	CLIP-seq
MIRT2099199	hsa-miR-4716-3p	CLIP-seq
MIRT2099200	hsa-miR-4745-5p	CLIP-seq
MIRT2099201	hsa-miR-4749-5p	CLIP-seq
MIRT2099202	hsa-miR-4781-5p	CLIP-seq
MIRT2099203	hsa-miR-611	CLIP-seq
MIRT2099204	hsa-miR-625	CLIP-seq
MIRT2099205	hsa-miR-675	CLIP-seq
MIRT2099206	hsa-miR-744	CLIP-seq
MIRT2394208	hsa-miR-1291	CLIP-seq
MIRT2394209	hsa-miR-149	CLIP-seq
MIRT2394210	hsa-miR-24	CLIP-seq
MIRT2394211	hsa-miR-328	CLIP-seq
MIRT2394212	hsa-miR-331-3p	CLIP-seq
MIRT2394213	hsa-miR-4284	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001755	Process	Neural crest cell migration	IBA
GO:0005737	Component	Cytoplasm	IMP	12110693
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IEA
GO:0009986	Component	Cell surface	IMP	12110693
GO:0016020	Component	Membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030215	Function	Semaphorin receptor binding	IBA
GO:0030215	Function	Semaphorin receptor binding	IEA
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0030517	Process	Negative regulation of axon extension	IDA	12110693
GO:0045499	Function	Chemorepellent activity	IBA
GO:0050919	Process	Negative chemotaxis	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA

Other IDs

• MIM: 609294
• HGNC: 10740
• e!Ensembl: ENSG00000143434

Protein

• UniProt ID: Q9H3T2
• Protein name: Semaphorin-6C (Semaphorin-Y) (Sema Y)
• Protein function: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01403	Sema	67 → 480	Sema domain	Family

• Tissue specificity: TISSUE SPECIFICITY: In adult tissues, expressed only in skeletal muscle. {ECO:0000269|PubMed:12110693}.
• Sequence:

  MPRAPHFMPLLLLLLLLSLPHTQAAFPQDPLPLLISDLQGTSPLSWFRGLEDDAVAAELG
  LDFQRFLTLNRTLLVAARDHVFSFDLQAEEEGEGLVPNKYLTWRSQDVENCAVRGKLTDE
  CYNYIRVLVPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSNVAI
  FAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQALEHGDHVYFFF
  REVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVL
  QALTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPV
  SEDRVPSPRPGSCAGVGGAALFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTSR
  ALLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVLTPGGRSGGPEPILLEEIDAYSPARCS
  GKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLSRCARHGACQRSCLASQDPYCGWH
  SSRGCVDIRGSGGTDVDQAGNQESMEHGDCQDGATGSQSGPGDSAYGVRRDLPPASASRS
  VPIPLLLASVAAAFALGASVSGLLVSCACRRAHRRRGKDIETPGLPRPLSLRSLARLHGG
  GPEPPPPSKDGDAVQTPQLYTTFLPPPEGVPPPELACLPTPESTPELPVKHLRAAGDPWE
  WNQNRNNAKEGPGRSRGGHAAGGPAPRVLVRPPPPGCPGQAVEVTTLEELLRYLHGPQPP
  RKGAEPPAPLTSRALPPEPAPALLGGPSPRPHECASPLRLDVPPEGRCASAPARPALSAP
  APRLGVGGGRRLPFSGHRAPPALLTRVPSGGPSRYSGGPGKHLLYLGRPEGYRGRALKRV
  DVEKPQLSLKPPLVGPSSRQAVPNGGRFNF

• Sequence length: 930

Pathways

KEGG:

Axon guidance

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATOPIC ECZEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Ovarian Failure, Premature	Ovarian Failure	BEFREE	28881413, 30256425		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	35269749	Inhibit	★☆☆☆☆ Found in Text Mining only
Premature Menopause	Premature Menopause	BEFREE	28881413, 30256425		★☆☆☆☆ Found in Text Mining only