Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10495
Gene name	Ecto-NOX disulfide-thiol exchanger 2
Gene symbol	ENOX2
Synonyms (NCBI Gene)	APK1COVA1tNOX
Chromosome	X
Chromosome location	Xq26.1
Summary	This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also

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Show/Hide all (186)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016542	hsa-miR-193b-3p	Microarray	20304954
MIRT550777	hsa-miR-376c-3p	PAR-CLIP	20371350
MIRT550776	hsa-miR-1265	PAR-CLIP	20371350
MIRT550775	hsa-miR-4464	PAR-CLIP	20371350
MIRT550774	hsa-miR-4748	PAR-CLIP	20371350
MIRT550773	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT550772	hsa-miR-1286	PAR-CLIP	20371350
MIRT550771	hsa-miR-4722-5p	PAR-CLIP	20371350
MIRT550770	hsa-miR-3665	PAR-CLIP	20371350
MIRT550769	hsa-miR-657	PAR-CLIP	20371350
MIRT550768	hsa-miR-4764-5p	PAR-CLIP	20371350
MIRT550767	hsa-miR-5087	PAR-CLIP	20371350
MIRT550766	hsa-miR-3944-5p	PAR-CLIP	20371350
MIRT550765	hsa-miR-143-5p	PAR-CLIP	20371350
MIRT550764	hsa-miR-8068	PAR-CLIP	20371350
MIRT550763	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT550777	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT550776	hsa-miR-1265	PAR-CLIP	21572407
MIRT550775	hsa-miR-4464	PAR-CLIP	21572407
MIRT550774	hsa-miR-4748	PAR-CLIP	21572407
MIRT550773	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT550772	hsa-miR-1286	PAR-CLIP	21572407
MIRT550771	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT550770	hsa-miR-3665	PAR-CLIP	21572407
MIRT550769	hsa-miR-657	PAR-CLIP	21572407
MIRT550768	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT550767	hsa-miR-5087	PAR-CLIP	21572407
MIRT550766	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT550765	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT550764	hsa-miR-8068	PAR-CLIP	21572407
MIRT550763	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT550777	hsa-miR-376c-3p	PAR-CLIP	20371350
MIRT550776	hsa-miR-1265	PAR-CLIP	20371350
MIRT550775	hsa-miR-4464	PAR-CLIP	20371350
MIRT550774	hsa-miR-4748	PAR-CLIP	20371350
MIRT550773	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT550772	hsa-miR-1286	PAR-CLIP	20371350
MIRT550771	hsa-miR-4722-5p	PAR-CLIP	20371350
MIRT550770	hsa-miR-3665	PAR-CLIP	20371350
MIRT550769	hsa-miR-657	PAR-CLIP	20371350
MIRT550768	hsa-miR-4764-5p	PAR-CLIP	20371350
MIRT550767	hsa-miR-5087	PAR-CLIP	20371350
MIRT550766	hsa-miR-3944-5p	PAR-CLIP	20371350
MIRT550765	hsa-miR-143-5p	PAR-CLIP	20371350
MIRT550764	hsa-miR-8068	PAR-CLIP	20371350
MIRT550763	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT550777	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT550776	hsa-miR-1265	PAR-CLIP	21572407
MIRT550775	hsa-miR-4464	PAR-CLIP	21572407
MIRT550774	hsa-miR-4748	PAR-CLIP	21572407
MIRT550773	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT550772	hsa-miR-1286	PAR-CLIP	21572407
MIRT550771	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT550770	hsa-miR-3665	PAR-CLIP	21572407
MIRT550769	hsa-miR-657	PAR-CLIP	21572407
MIRT550768	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT550767	hsa-miR-5087	PAR-CLIP	21572407
MIRT550766	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT550765	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT550764	hsa-miR-8068	PAR-CLIP	21572407
MIRT550763	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT963836	hsa-miR-3685	CLIP-seq
MIRT963837	hsa-miR-384	CLIP-seq
MIRT963838	hsa-miR-4777-5p	CLIP-seq
MIRT963839	hsa-miR-576-3p	CLIP-seq
MIRT963840	hsa-miR-586	CLIP-seq
MIRT963841	hsa-miR-1227	CLIP-seq
MIRT963842	hsa-miR-1276	CLIP-seq
MIRT963843	hsa-miR-1303	CLIP-seq
MIRT963844	hsa-miR-1321	CLIP-seq
MIRT963845	hsa-miR-138	CLIP-seq
MIRT963846	hsa-miR-140-3p	CLIP-seq
MIRT963847	hsa-miR-190	CLIP-seq
MIRT963848	hsa-miR-190b	CLIP-seq
MIRT963849	hsa-miR-3064-3p	CLIP-seq
MIRT963850	hsa-miR-3074-5p	CLIP-seq
MIRT963851	hsa-miR-3123	CLIP-seq
MIRT963852	hsa-miR-3152-3p	CLIP-seq
MIRT963853	hsa-miR-33a	CLIP-seq
MIRT963854	hsa-miR-33b	CLIP-seq
MIRT963855	hsa-miR-3653	CLIP-seq
MIRT963856	hsa-miR-3672	CLIP-seq
MIRT963857	hsa-miR-3689a-5p	CLIP-seq
MIRT963858	hsa-miR-3689b	CLIP-seq
MIRT963859	hsa-miR-3689e	CLIP-seq
MIRT963860	hsa-miR-3689f	CLIP-seq
MIRT963861	hsa-miR-370	CLIP-seq
MIRT963862	hsa-miR-3925-5p	CLIP-seq
MIRT963863	hsa-miR-4269	CLIP-seq
MIRT963864	hsa-miR-4311	CLIP-seq
MIRT963865	hsa-miR-4327	CLIP-seq
MIRT963866	hsa-miR-4461	CLIP-seq
MIRT963867	hsa-miR-4493	CLIP-seq
MIRT963868	hsa-miR-4494	CLIP-seq
MIRT963869	hsa-miR-4495	CLIP-seq
MIRT963870	hsa-miR-4497	CLIP-seq
MIRT963871	hsa-miR-4666-5p	CLIP-seq
MIRT963872	hsa-miR-4699-3p	CLIP-seq
MIRT963873	hsa-miR-4728-5p	CLIP-seq
MIRT963874	hsa-miR-4739	CLIP-seq
MIRT963875	hsa-miR-4753-5p	CLIP-seq
MIRT963876	hsa-miR-4756-5p	CLIP-seq
MIRT963838	hsa-miR-4777-5p	CLIP-seq
MIRT963877	hsa-miR-4795-3p	CLIP-seq
MIRT963878	hsa-miR-516a-3p	CLIP-seq
MIRT963879	hsa-miR-518d-5p	CLIP-seq
MIRT963880	hsa-miR-519b-5p	CLIP-seq
MIRT963881	hsa-miR-519c-5p	CLIP-seq
MIRT963882	hsa-miR-520c-5p	CLIP-seq
MIRT963883	hsa-miR-526a	CLIP-seq
MIRT963884	hsa-miR-548q	CLIP-seq
MIRT963885	hsa-miR-583	CLIP-seq
MIRT963841	hsa-miR-1227	CLIP-seq
MIRT963845	hsa-miR-138	CLIP-seq
MIRT963849	hsa-miR-3064-3p	CLIP-seq
MIRT963850	hsa-miR-3074-5p	CLIP-seq
MIRT1985683	hsa-miR-330-3p	CLIP-seq
MIRT1985684	hsa-miR-3614-3p	CLIP-seq
MIRT963861	hsa-miR-370	CLIP-seq
MIRT1985685	hsa-miR-376c	CLIP-seq
MIRT1985686	hsa-miR-4297	CLIP-seq
MIRT1985687	hsa-miR-4436b-5p	CLIP-seq
MIRT1985688	hsa-miR-450b-5p	CLIP-seq
MIRT1985689	hsa-miR-4717-3p	CLIP-seq
MIRT1985690	hsa-miR-4769-3p	CLIP-seq
MIRT1985691	hsa-miR-4790-3p	CLIP-seq
MIRT963878	hsa-miR-516a-3p	CLIP-seq
MIRT963884	hsa-miR-548q	CLIP-seq
MIRT2220110	hsa-miR-30a	CLIP-seq
MIRT2220111	hsa-miR-30b	CLIP-seq
MIRT2220112	hsa-miR-30c	CLIP-seq
MIRT2220113	hsa-miR-30d	CLIP-seq
MIRT2220114	hsa-miR-30e	CLIP-seq
MIRT2220115	hsa-miR-3120-3p	CLIP-seq
MIRT963872	hsa-miR-4699-3p	CLIP-seq
MIRT963841	hsa-miR-1227	CLIP-seq
MIRT963845	hsa-miR-138	CLIP-seq
MIRT963849	hsa-miR-3064-3p	CLIP-seq
MIRT963850	hsa-miR-3074-5p	CLIP-seq
MIRT2220115	hsa-miR-3120-3p	CLIP-seq
MIRT963861	hsa-miR-370	CLIP-seq
MIRT963878	hsa-miR-516a-3p	CLIP-seq
MIRT963884	hsa-miR-548q	CLIP-seq
MIRT1985688	hsa-miR-450b-5p	CLIP-seq
MIRT2523996	hsa-miR-1237	CLIP-seq
MIRT2523997	hsa-miR-147b	CLIP-seq
MIRT2523998	hsa-miR-186	CLIP-seq
MIRT2523999	hsa-miR-188-5p	CLIP-seq
MIRT2524000	hsa-miR-200b	CLIP-seq
MIRT2524001	hsa-miR-200c	CLIP-seq
MIRT2524002	hsa-miR-210	CLIP-seq
MIRT2524003	hsa-miR-2113	CLIP-seq
MIRT2524004	hsa-miR-3145-5p	CLIP-seq
MIRT2524005	hsa-miR-3153	CLIP-seq
MIRT963855	hsa-miR-3653	CLIP-seq
MIRT2524006	hsa-miR-4252	CLIP-seq
MIRT2524007	hsa-miR-429	CLIP-seq
MIRT2524008	hsa-miR-4436a	CLIP-seq
MIRT2524009	hsa-miR-4475	CLIP-seq
MIRT963867	hsa-miR-4493	CLIP-seq
MIRT963868	hsa-miR-4494	CLIP-seq
MIRT2524010	hsa-miR-452	CLIP-seq
MIRT2524011	hsa-miR-4643	CLIP-seq
MIRT2524012	hsa-miR-4676-3p	CLIP-seq
MIRT2524013	hsa-miR-4711-5p	CLIP-seq
MIRT2524014	hsa-miR-4727-5p	CLIP-seq
MIRT963875	hsa-miR-4753-5p	CLIP-seq
MIRT1985690	hsa-miR-4769-3p	CLIP-seq
MIRT2524015	hsa-miR-549	CLIP-seq
MIRT2524016	hsa-miR-570	CLIP-seq
MIRT2524017	hsa-miR-605	CLIP-seq
MIRT2524018	hsa-miR-889	CLIP-seq
MIRT2524019	hsa-miR-892a	CLIP-seq
MIRT2523997	hsa-miR-147b	CLIP-seq
MIRT2524002	hsa-miR-210	CLIP-seq
MIRT2524003	hsa-miR-2113	CLIP-seq
MIRT2680061	hsa-miR-27a	CLIP-seq
MIRT2680062	hsa-miR-27b	CLIP-seq
MIRT2524006	hsa-miR-4252	CLIP-seq
MIRT2680063	hsa-miR-4290	CLIP-seq
MIRT2524011	hsa-miR-4643	CLIP-seq
MIRT2680064	hsa-miR-4667-3p	CLIP-seq
MIRT2680065	hsa-miR-4724-5p	CLIP-seq
MIRT2680066	hsa-miR-4760-3p	CLIP-seq
MIRT2680067	hsa-miR-513a-5p	CLIP-seq
MIRT2524019	hsa-miR-892a	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005576	Component	Extracellular region	IEA
GO:0005829	Component	Cytosol	TAS	8150545
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007624	Process	Ultradian rhythm	IDA	12356293
GO:0007624	Process	Ultradian rhythm	IEA
GO:0009897	Component	External side of plasma membrane	IDA	11488599
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0022900	Process	Electron transport chain	IDA	11888291
GO:0048511	Process	Rhythmic process	IEA

MIM	HGNC	e!Ensembl
300282	2259	ENSG00000165675

Q16206

Protein name

Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)]

Protein function

May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol i

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	130 → 189	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Tissue specificity

TISSUE SPECIFICITY: Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than canc

Sequence

MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPIL
PDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPAT
RERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALY
LSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPS
PPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHV
RRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNIS
VWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDS
LRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEA
ELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGI
ISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWK
FCGFEGLKLT

Sequence length

610

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MESOTHELIOMA, MALIGNANT	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Benign Neoplasm	Benign Neoplasm	CTD_human_DG	20518072		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	27367652		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	27367652		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	31106000		★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	21625959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	21625959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30029680	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30909652		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant mesothelioma	Malignant Mesothelioma	CTD_human_DG	26807072		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21625959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	31106000		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	26973386		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	27367652		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	18789934, 19734121, 21625959, 30029680		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	CTD_human_DG	20518072		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	21625959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	39519404	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	CTD_human_DG	20518072		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31106000		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	BEFREE	23665678		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	26973386		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	28122359	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	27367652	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ENOX2 (ecto-NOX disulfide-thiol exchanger 2)