Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10486
Gene name	Cyclase associated actin cytoskeleton regulatory protein 2
Gene symbol	CAP2
Synonyms (NCBI Gene)	CMD2I
Chromosome	6
Chromosome location	6p22.3
Summary	This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein

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Show/Hide all (110)

miRTarBase ID	miRNA	Experiments	Reference
MIRT621365	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT621365	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT621365	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT621365	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT861801	hsa-miR-144	CLIP-seq
MIRT861802	hsa-miR-15a	CLIP-seq
MIRT861803	hsa-miR-15b	CLIP-seq
MIRT861804	hsa-miR-16	CLIP-seq
MIRT861805	hsa-miR-195	CLIP-seq
MIRT861806	hsa-miR-28-5p	CLIP-seq
MIRT861807	hsa-miR-3139	CLIP-seq
MIRT861808	hsa-miR-365	CLIP-seq
MIRT861809	hsa-miR-3660	CLIP-seq
MIRT861810	hsa-miR-424	CLIP-seq
MIRT861811	hsa-miR-4464	CLIP-seq
MIRT861812	hsa-miR-4526	CLIP-seq
MIRT861813	hsa-miR-4645-3p	CLIP-seq
MIRT861814	hsa-miR-4728-3p	CLIP-seq
MIRT861815	hsa-miR-4748	CLIP-seq
MIRT861816	hsa-miR-497	CLIP-seq
MIRT861817	hsa-miR-532-5p	CLIP-seq
MIRT861818	hsa-miR-628-5p	CLIP-seq
MIRT861819	hsa-miR-708	CLIP-seq
MIRT1955687	hsa-miR-1246	CLIP-seq
MIRT1955688	hsa-miR-1271	CLIP-seq
MIRT1955689	hsa-miR-182	CLIP-seq
MIRT1955690	hsa-miR-3182	CLIP-seq
MIRT1955691	hsa-miR-3184	CLIP-seq
MIRT1955692	hsa-miR-3201	CLIP-seq
MIRT1955693	hsa-miR-409-3p	CLIP-seq
MIRT1955694	hsa-miR-423-5p	CLIP-seq
MIRT1955695	hsa-miR-4307	CLIP-seq
MIRT1955696	hsa-miR-4642	CLIP-seq
MIRT1955697	hsa-miR-4652-3p	CLIP-seq
MIRT1955698	hsa-miR-4659a-3p	CLIP-seq
MIRT1955699	hsa-miR-4659b-3p	CLIP-seq
MIRT1955700	hsa-miR-4791	CLIP-seq
MIRT1955701	hsa-miR-607	CLIP-seq
MIRT1955702	hsa-miR-96	CLIP-seq
MIRT2193306	hsa-miR-1207-5p	CLIP-seq
MIRT1955687	hsa-miR-1246	CLIP-seq
MIRT2193307	hsa-miR-125a-3p	CLIP-seq
MIRT2193308	hsa-miR-1263	CLIP-seq
MIRT2193309	hsa-miR-129-5p	CLIP-seq
MIRT2193310	hsa-miR-1323	CLIP-seq
MIRT2193311	hsa-miR-3128	CLIP-seq
MIRT2193312	hsa-miR-3140-3p	CLIP-seq
MIRT1955691	hsa-miR-3184	CLIP-seq
MIRT1955692	hsa-miR-3201	CLIP-seq
MIRT2193313	hsa-miR-3665	CLIP-seq
MIRT2193314	hsa-miR-3934	CLIP-seq
MIRT1955694	hsa-miR-423-5p	CLIP-seq
MIRT2193315	hsa-miR-4450	CLIP-seq
MIRT2193316	hsa-miR-4525	CLIP-seq
MIRT2193317	hsa-miR-4710	CLIP-seq
MIRT2193318	hsa-miR-4716-3p	CLIP-seq
MIRT2193319	hsa-miR-4720-5p	CLIP-seq
MIRT2193320	hsa-miR-4736	CLIP-seq
MIRT2193321	hsa-miR-4763-3p	CLIP-seq
MIRT1955700	hsa-miR-4791	CLIP-seq
MIRT2193322	hsa-miR-4799-3p	CLIP-seq
MIRT2193323	hsa-miR-548o	CLIP-seq
MIRT2193324	hsa-miR-548p	CLIP-seq
MIRT2193325	hsa-miR-764	CLIP-seq
MIRT2193308	hsa-miR-1263	CLIP-seq
MIRT2193310	hsa-miR-1323	CLIP-seq
MIRT2193323	hsa-miR-548o	CLIP-seq
MIRT2193324	hsa-miR-548p	CLIP-seq
MIRT2496391	hsa-miR-103b	CLIP-seq
MIRT2496392	hsa-miR-1283	CLIP-seq
MIRT861801	hsa-miR-144	CLIP-seq
MIRT861802	hsa-miR-15a	CLIP-seq
MIRT861803	hsa-miR-15b	CLIP-seq
MIRT861804	hsa-miR-16	CLIP-seq
MIRT861805	hsa-miR-195	CLIP-seq
MIRT861806	hsa-miR-28-5p	CLIP-seq
MIRT2496393	hsa-miR-3127-5p	CLIP-seq
MIRT861807	hsa-miR-3139	CLIP-seq
MIRT2496394	hsa-miR-3177-5p	CLIP-seq
MIRT2496395	hsa-miR-3185	CLIP-seq
MIRT2496396	hsa-miR-3918	CLIP-seq
MIRT861810	hsa-miR-424	CLIP-seq
MIRT2496397	hsa-miR-4536	CLIP-seq
MIRT861813	hsa-miR-4645-3p	CLIP-seq
MIRT2496398	hsa-miR-487a	CLIP-seq
MIRT861816	hsa-miR-497	CLIP-seq
MIRT2496399	hsa-miR-548m	CLIP-seq
MIRT2496400	hsa-miR-577	CLIP-seq
MIRT861819	hsa-miR-708	CLIP-seq
MIRT2496391	hsa-miR-103b	CLIP-seq
MIRT2496392	hsa-miR-1283	CLIP-seq
MIRT861801	hsa-miR-144	CLIP-seq
MIRT861802	hsa-miR-15a	CLIP-seq
MIRT861803	hsa-miR-15b	CLIP-seq
MIRT861804	hsa-miR-16	CLIP-seq
MIRT861805	hsa-miR-195	CLIP-seq
MIRT861806	hsa-miR-28-5p	CLIP-seq
MIRT2496393	hsa-miR-3127-5p	CLIP-seq
MIRT861807	hsa-miR-3139	CLIP-seq
MIRT2496394	hsa-miR-3177-5p	CLIP-seq
MIRT2496395	hsa-miR-3185	CLIP-seq
MIRT2496396	hsa-miR-3918	CLIP-seq
MIRT861810	hsa-miR-424	CLIP-seq
MIRT2496397	hsa-miR-4536	CLIP-seq
MIRT861813	hsa-miR-4645-3p	CLIP-seq
MIRT2496398	hsa-miR-487a	CLIP-seq
MIRT861816	hsa-miR-497	CLIP-seq
MIRT2496399	hsa-miR-548m	CLIP-seq
MIRT2496400	hsa-miR-577	CLIP-seq
MIRT861819	hsa-miR-708	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	IBA
GO:0003779	Function	Actin binding	IBA
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 28514442, 32296183, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0007015	Process	Actin filament organization	IBA
GO:0007163	Process	Establishment or maintenance of cell polarity	IEA
GO:0007163	Process	Establishment or maintenance of cell polarity	TAS	7962207
GO:0007165	Process	Signal transduction	TAS	7962207
GO:0007190	Process	Activation of adenylate cyclase activity	TAS	7962207
GO:0008179	Function	Adenylate cyclase binding	IBA
GO:0014069	Component	Postsynaptic density	IEA
GO:0016020	Component	Membrane	IEA
GO:0019933	Process	CAMP-mediated signaling	IBA
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0099140	Process	Presynaptic actin cytoskeleton organization	IEA

MIM	HGNC	e!Ensembl
618385	20039	ENSG00000112186

P40123

Protein name

Adenylyl cyclase-associated protein 2 (CAP 2)

Protein function

Involved in the regulation of actin polymerization.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01213	CAP_N	5 → 64	Adenylate cyclase associated (CAP) N terminal	Family
PF08603	CAP_C	321 → 475	Adenylate cyclase associated (CAP) C terminal	Family

Sequence

MANMQGLVERLERAVSRLESLSAESHRPPGNCGEVNGVIAGVAPSVEAFDKLMDSMVAEF
LKNSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPHENDVAALLKPISEKIQEIQTF
RERNRGSNMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLR
HVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTVSAFSVLSSGPGLPPPPPPLPP
PGPPPLFENEGKKEESSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPSLRAQGGQTQ
SPTKSHTPSPTSPKSYPSQKHAPVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCE
KSTIQIKGKVNSIIIDNCKKLGLVFDNVVGIVEVINSQDIQIQVMGRVPTISINKTEGCH
IYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPIPEQFKTAWDGSKLITEPAEIMA

Sequence length

477

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Cardiomyopathy, dilated, 2I	Pathogenic	rs2481027322, rs764955583, rs781025932	RCV003319297 RCV003319298 RCV003319299	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTOIMMUNE THROMBOCYTOPENIC PURPURA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CAP2-associated dilated cardiomyopathy	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, DILATED	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FAMILIAL ISOLATED DILATED CARDIOMYOPATHY	—	Disgenet, Orphanet Disgenet, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FAMILIAL OR IDIOPATHIC DILATED CARDIOMYOPATHY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMORRHOID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROBLASTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of the head and neck	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

CAP2 (cyclase associated actin cytoskeleton regulatory protein 2)