Gene Gene information from NCBI Gene database.
Entrez ID 1048
Gene name CEA cell adhesion molecule 5
Gene symbol CEACAM5
Synonyms (NCBI Gene)
CD66eCEA
Chromosome 19
Chromosome location 19q13.2
Summary This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development
miRNA miRNA information provided by mirtarbase database.
230
miRTarBase ID miRNA Experiments Reference
MIRT018234 hsa-miR-335-5p Microarray 18185580
MIRT677795 hsa-miR-582-3p HITS-CLIP 23824327
MIRT677794 hsa-miR-552-3p HITS-CLIP 23824327
MIRT677793 hsa-miR-764 HITS-CLIP 23824327
MIRT677792 hsa-miR-4740-3p HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
USF1 Activation 7876096
USF2 Activation 7876096
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 27489282
GO:0005576 Component Extracellular region TAS
GO:0005886 Component Plasma membrane IDA 10864933, 10931872
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS 3814146
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
114890 1817 ENSG00000105388
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P06731
Protein name Cell adhesion molecule CEACAM5 (Carcinoembryonic antigen) (CEA) (Carcinoembryonic antigen-related cell adhesion molecule 5) (CEA cell adhesion molecule 5) (Meconium antigen 100) (CD antigen CD66e)
Protein function Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antige
PDB 1E07 , 2QSQ , 2QST , 2VER , 8BW0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 38 141 Immunoglobulin V-set domain Domain
PF13927 Ig_3 146 219 Domain
PF13895 Ig_2 239 318 Immunoglobulin domain Domain
PF13927 Ig_3 324 397 Domain
PF13895 Ig_2 417 496 Immunoglobulin domain Domain
PF13927 Ig_3 502 575 Domain
PF13895 Ig_2 595 674 Immunoglobulin domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. {ECO:0000269|PubMed:10436421}.
Sequence
Sequence length 702
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Post-translational modification: synthesis of GPI-anchored proteins
Cell surface interactions at the vascular wall
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTROCYTOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Cerebrovascular Accidents Stroke BEFREE 31603298
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 31295447, 7808000
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 2789512
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 10873071, 11058588, 11092617, 11263866, 12460911, 14760382, 1484322, 15154633, 15316325, 16536871, 17540439, 17941001, 19118044, 21397974, 22252332
View all (33 more)
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 15546874, 17941001
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 10081486, 11790722, 1860736, 26053394, 26975699, 28005644, 29895542, 3670312, 61812, 6871845
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 30724779
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer BEFREE 11706527, 14592671, 28596788, 7501974
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 10022223, 17941001, 19679554, 22483782, 23099808, 23621221, 24190459, 24459065, 24487967, 24935562, 27990560, 28642881, 28705152, 28744138, 28950357
View all (15 more)
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 25409014, 30153903
★☆☆☆☆
Found in Text Mining only