Gene Gene information from NCBI Gene database.
Entrez ID 10447
Gene name FAM3 metabolism regulating signaling molecule C
Gene symbol FAM3C
Synonyms (NCBI Gene)
GS3786ILEI
Chromosome 7
Chromosome location 7q31.31
Summary This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]
miRNA miRNA information provided by mirtarbase database.
868
miRTarBase ID miRNA Experiments Reference
MIRT019826 hsa-miR-375 Microarray 20215506
MIRT020690 hsa-miR-155-5p Proteomics 18668040
MIRT021525 hsa-miR-145-5p Reporter assay;Microarray 21351259
MIRT025419 hsa-miR-34a-5p Proteomics 21566225
MIRT002420 hsa-miR-21-5p Microarray 18591254
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IEA
GO:0005125 Function Cytokine activity NAS 12160727
GO:0005515 Function Protein binding IPI 25416956, 31515488, 32296183
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region NAS 12160727
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608618 18664 ENSG00000196937
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92520
Protein name Protein FAM3C (Interleukin-like EMT inducer)
Protein function May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
PDB 5LC2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15711 ILEI 102 190 Interleukin-like EMT inducer Domain
Tissue specificity TISSUE SPECIFICITY: Present in most secretory epithelia (at protein level). {ECO:0000269|PubMed:16959614}.
Sequence
MRVAGAAKLVVAVAVFLLTFYVISQVFEIKMDASLGNLFARSALDTAARSTKPPRYKCGI
SKACPEKHFAFKMASGAANVVGPKICLEDNVLMSGVKNNVGRGINVALANGKTGEVLDTK
YFDMWGGDVAPFIEFLKAIQDGTIVLMGTYDDGATKLNDEARRLIADLGSTSITNLGFRD
NWVFCGGKGI
KTKSPFEQHIKNNKDTNKYEGWPEVVEMEGCIPQKQD
Sequence length 227
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Platelet degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BONE DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OSTEOPOROSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
UPPER EXTREMITY FRACTURE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 30692635, 30887707
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 30887707, 37927213 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 24072492
★☆☆☆☆
Found in Text Mining only
Coffin-Siris syndrome Coffin-Siris Syndrome BEFREE 23300646
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent Diabetes Mellitus BEFREE 28246289
★☆☆☆☆
Found in Text Mining only
Epilepsy, Temporal Lobe Epilepsy LHGDN 19109932
★☆☆☆☆
Found in Text Mining only
Esophageal Squamous Cell Carcinoma Esophageal squamous cell carcinoma Pubtator 26498278 Stimulate
★☆☆☆☆
Found in Text Mining only
Fatty Liver Fatty Liver BEFREE 28246289
★☆☆☆☆
Found in Text Mining only
Hearing Loss Sensorineural Hearing loss Pubtator 36349665 Associate
★☆☆☆☆
Found in Text Mining only
Hyperglycemia Hyperglycemia BEFREE 29285313
★☆☆☆☆
Found in Text Mining only