Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10446
Gene name	Leucine rich repeat neuronal 2
Gene symbol	LRRN2
Synonyms (NCBI Gene)	FIGLER7GAC1LRANK1LRRN5
Chromosome	1
Chromosome location	1q32.1
Summary	The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT039294	hsa-miR-671-5p	CLASH	23622248
MIRT1120942	hsa-miR-1273f	CLIP-seq
MIRT1120943	hsa-miR-1285	CLIP-seq
MIRT1120944	hsa-miR-1343	CLIP-seq
MIRT1120945	hsa-miR-143	CLIP-seq
MIRT1120946	hsa-miR-150	CLIP-seq
MIRT1120947	hsa-miR-205	CLIP-seq
MIRT1120948	hsa-miR-3187-5p	CLIP-seq
MIRT1120949	hsa-miR-3197	CLIP-seq
MIRT1120950	hsa-miR-324-5p	CLIP-seq
MIRT1120951	hsa-miR-3942-3p	CLIP-seq
MIRT1120952	hsa-miR-3945	CLIP-seq
MIRT1120953	hsa-miR-4253	CLIP-seq
MIRT1120954	hsa-miR-4663	CLIP-seq
MIRT1120955	hsa-miR-4708-5p	CLIP-seq
MIRT1120956	hsa-miR-4713-5p	CLIP-seq
MIRT1120957	hsa-miR-4770	CLIP-seq
MIRT1120958	hsa-miR-532-3p	CLIP-seq
MIRT1120959	hsa-miR-612	CLIP-seq
MIRT1120960	hsa-miR-642a	CLIP-seq
MIRT1120961	hsa-miR-3616-3p	CLIP-seq
MIRT1120962	hsa-miR-3669	CLIP-seq
MIRT1120963	hsa-miR-3689d	CLIP-seq
MIRT1120964	hsa-miR-3943	CLIP-seq
MIRT1120965	hsa-miR-4436b-3p	CLIP-seq
MIRT1120966	hsa-miR-4721	CLIP-seq
MIRT1120967	hsa-miR-515-5p	CLIP-seq
MIRT1120968	hsa-miR-548m	CLIP-seq
MIRT1120969	hsa-miR-642b	CLIP-seq
MIRT2034241	hsa-miR-4459	CLIP-seq
MIRT2264695	hsa-miR-1253	CLIP-seq
MIRT1120943	hsa-miR-1285	CLIP-seq
MIRT1120948	hsa-miR-3187-5p	CLIP-seq
MIRT2264696	hsa-miR-326	CLIP-seq
MIRT2264697	hsa-miR-330-5p	CLIP-seq
MIRT2264698	hsa-miR-378g	CLIP-seq
MIRT2264699	hsa-miR-4426	CLIP-seq
MIRT2264700	hsa-miR-4486	CLIP-seq
MIRT2264701	hsa-miR-4647	CLIP-seq
MIRT2264702	hsa-miR-4662b	CLIP-seq
MIRT1120954	hsa-miR-4663	CLIP-seq
MIRT1120959	hsa-miR-612	CLIP-seq
MIRT2264695	hsa-miR-1253	CLIP-seq
MIRT1120943	hsa-miR-1285	CLIP-seq
MIRT2453419	hsa-miR-3150a-3p	CLIP-seq
MIRT2453420	hsa-miR-3175	CLIP-seq
MIRT1120948	hsa-miR-3187-5p	CLIP-seq
MIRT2453421	hsa-miR-3612	CLIP-seq
MIRT2264698	hsa-miR-378g	CLIP-seq
MIRT2264699	hsa-miR-4426	CLIP-seq
MIRT2264700	hsa-miR-4486	CLIP-seq
MIRT2264701	hsa-miR-4647	CLIP-seq
MIRT2264702	hsa-miR-4662b	CLIP-seq
MIRT1120959	hsa-miR-612	CLIP-seq
MIRT2453422	hsa-miR-650	CLIP-seq
MIRT2453423	hsa-miR-939	CLIP-seq
MIRT2264695	hsa-miR-1253	CLIP-seq
MIRT1120943	hsa-miR-1285	CLIP-seq
MIRT2453419	hsa-miR-3150a-3p	CLIP-seq
MIRT2453420	hsa-miR-3175	CLIP-seq
MIRT1120948	hsa-miR-3187-5p	CLIP-seq
MIRT2453421	hsa-miR-3612	CLIP-seq
MIRT2264698	hsa-miR-378g	CLIP-seq
MIRT2264699	hsa-miR-4426	CLIP-seq
MIRT2264700	hsa-miR-4486	CLIP-seq
MIRT2264701	hsa-miR-4647	CLIP-seq
MIRT2264702	hsa-miR-4662b	CLIP-seq
MIRT1120959	hsa-miR-612	CLIP-seq
MIRT2453422	hsa-miR-650	CLIP-seq
MIRT2453423	hsa-miR-939	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0007155	Process	Cell adhesion	TAS	9662332
GO:0007165	Process	Signal transduction	TAS	9662332
GO:0016020	Component	Membrane	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0038023	Function	Signaling receptor activity	TAS	9662332

MIM	HGNC	e!Ensembl
605492	16914	ENSG00000170382

O75325

Protein name

Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	69 → 129	Leucine rich repeat	Repeat
PF13855	LRR_8	93 → 153	Leucine rich repeat	Repeat
PF13855	LRR_8	117 → 177	Leucine rich repeat	Repeat
PF13855	LRR_8	213 → 273	Leucine rich repeat	Repeat
PF13855	LRR_8	310 → 371	Leucine rich repeat	Repeat
PF07679	I-set	427 → 514	Immunoglobulin I-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Overamplified in malignant gliomas.

Sequence

MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL
TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL
SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI
DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE
SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS
IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN
LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC
LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG
TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH
ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA
FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG
GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS

Sequence length

713

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CUTANEOUS MELANOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMORRHOID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUMINAL A BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TRIPLE-NEGATIVE BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anaplastic astrocytoma	Anaplastic Astrocytoma	BEFREE	9662332	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	24679734	★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	16319692	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	9662332	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	9662332	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	9662332	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10626796, 11281459	★★★★★ ★☆☆☆☆ Found in Text Mining only
Respiration Disorders	Respiration Disorders	BEFREE	18753359	★★★★★ ★☆☆☆☆ Found in Text Mining only
Respiratory Tract Diseases	Respiratory Tract Diseases	BEFREE	18753359	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	31374203	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

LRRN2 (leucine rich repeat neuronal 2)