Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10435
Gene name	CDC42 effector protein 2
Gene symbol	CDC42EP2
Synonyms (NCBI Gene)	BORG1CEP2
Chromosome	11
Chromosome location	11q13.1
Summary	CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family prot

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Show/Hide all (245)

miRTarBase ID	miRNA	Experiments
MIRT878031	hsa-miR-103a	CLIP-seq
MIRT878032	hsa-miR-107	CLIP-seq
MIRT878033	hsa-miR-1197	CLIP-seq
MIRT878034	hsa-miR-1226	CLIP-seq
MIRT878035	hsa-miR-1252	CLIP-seq
MIRT878036	hsa-miR-125a-5p	CLIP-seq
MIRT878037	hsa-miR-125b	CLIP-seq
MIRT878038	hsa-miR-1265	CLIP-seq
MIRT878039	hsa-miR-1273g	CLIP-seq
MIRT878040	hsa-miR-1302	CLIP-seq
MIRT878041	hsa-miR-137	CLIP-seq
MIRT878042	hsa-miR-1587	CLIP-seq
MIRT878043	hsa-miR-15a	CLIP-seq
MIRT878044	hsa-miR-15b	CLIP-seq
MIRT878045	hsa-miR-16	CLIP-seq
MIRT878046	hsa-miR-1827	CLIP-seq
MIRT878047	hsa-miR-1913	CLIP-seq
MIRT878048	hsa-miR-1915	CLIP-seq
MIRT878049	hsa-miR-193a-3p	CLIP-seq
MIRT878050	hsa-miR-193b	CLIP-seq
MIRT878051	hsa-miR-195	CLIP-seq
MIRT878052	hsa-miR-2110	CLIP-seq
MIRT878053	hsa-miR-24	CLIP-seq
MIRT878054	hsa-miR-2467-3p	CLIP-seq
MIRT878055	hsa-miR-25	CLIP-seq
MIRT878056	hsa-miR-298	CLIP-seq
MIRT878057	hsa-miR-3122	CLIP-seq
MIRT878058	hsa-miR-3127-5p	CLIP-seq
MIRT878059	hsa-miR-3154	CLIP-seq
MIRT878060	hsa-miR-3185	CLIP-seq
MIRT878061	hsa-miR-32	CLIP-seq
MIRT878062	hsa-miR-3202	CLIP-seq
MIRT878063	hsa-miR-324-3p	CLIP-seq
MIRT878064	hsa-miR-331-3p	CLIP-seq
MIRT878065	hsa-miR-34b	CLIP-seq
MIRT878066	hsa-miR-361-3p	CLIP-seq
MIRT878067	hsa-miR-3614-3p	CLIP-seq
MIRT878068	hsa-miR-363	CLIP-seq
MIRT878069	hsa-miR-3649	CLIP-seq
MIRT878070	hsa-miR-3660	CLIP-seq
MIRT878071	hsa-miR-3663-5p	CLIP-seq
MIRT878072	hsa-miR-367	CLIP-seq
MIRT878073	hsa-miR-378g	CLIP-seq
MIRT878074	hsa-miR-3913-5p	CLIP-seq
MIRT878075	hsa-miR-3918	CLIP-seq
MIRT878076	hsa-miR-412	CLIP-seq
MIRT878077	hsa-miR-424	CLIP-seq
MIRT878078	hsa-miR-4271	CLIP-seq
MIRT878079	hsa-miR-4281	CLIP-seq
MIRT878080	hsa-miR-4291	CLIP-seq
MIRT878081	hsa-miR-4298	CLIP-seq
MIRT878082	hsa-miR-4307	CLIP-seq
MIRT878083	hsa-miR-4313	CLIP-seq
MIRT878084	hsa-miR-4319	CLIP-seq
MIRT878085	hsa-miR-4428	CLIP-seq
MIRT878086	hsa-miR-4435	CLIP-seq
MIRT878087	hsa-miR-4436a	CLIP-seq
MIRT878088	hsa-miR-4475	CLIP-seq
MIRT878089	hsa-miR-4492	CLIP-seq
MIRT878090	hsa-miR-4496	CLIP-seq
MIRT878091	hsa-miR-4498	CLIP-seq
MIRT878092	hsa-miR-450b-3p	CLIP-seq
MIRT878093	hsa-miR-4526	CLIP-seq
MIRT878094	hsa-miR-4530	CLIP-seq
MIRT878095	hsa-miR-4654	CLIP-seq
MIRT878096	hsa-miR-4656	CLIP-seq
MIRT878097	hsa-miR-4670-5p	CLIP-seq
MIRT878098	hsa-miR-4675	CLIP-seq
MIRT878099	hsa-miR-4700-3p	CLIP-seq
MIRT878100	hsa-miR-4707-5p	CLIP-seq
MIRT878101	hsa-miR-4713-3p	CLIP-seq
MIRT878102	hsa-miR-4725-3p	CLIP-seq
MIRT878103	hsa-miR-4732-3p	CLIP-seq
MIRT878104	hsa-miR-4741	CLIP-seq
MIRT878105	hsa-miR-4747-5p	CLIP-seq
MIRT878106	hsa-miR-4761-3p	CLIP-seq
MIRT878107	hsa-miR-4764-5p	CLIP-seq
MIRT878108	hsa-miR-4769-5p	CLIP-seq
MIRT878109	hsa-miR-486-3p	CLIP-seq
MIRT878110	hsa-miR-490-3p	CLIP-seq
MIRT878111	hsa-miR-491-5p	CLIP-seq
MIRT878112	hsa-miR-492	CLIP-seq
MIRT878113	hsa-miR-497	CLIP-seq
MIRT878114	hsa-miR-545	CLIP-seq
MIRT878115	hsa-miR-552	CLIP-seq
MIRT878116	hsa-miR-617	CLIP-seq
MIRT878117	hsa-miR-634	CLIP-seq
MIRT878118	hsa-miR-635	CLIP-seq
MIRT878119	hsa-miR-638	CLIP-seq
MIRT878120	hsa-miR-661	CLIP-seq
MIRT878121	hsa-miR-670	CLIP-seq
MIRT878122	hsa-miR-762	CLIP-seq
MIRT878123	hsa-miR-769-3p	CLIP-seq
MIRT878124	hsa-miR-92a	CLIP-seq
MIRT878125	hsa-miR-92b	CLIP-seq
MIRT1960258	hsa-miR-1255a	CLIP-seq
MIRT1960259	hsa-miR-1255b	CLIP-seq
MIRT878041	hsa-miR-137	CLIP-seq
MIRT878052	hsa-miR-2110	CLIP-seq
MIRT878055	hsa-miR-25	CLIP-seq
MIRT878061	hsa-miR-32	CLIP-seq
MIRT878062	hsa-miR-3202	CLIP-seq
MIRT878068	hsa-miR-363	CLIP-seq
MIRT878072	hsa-miR-367	CLIP-seq
MIRT878078	hsa-miR-4271	CLIP-seq
MIRT1960260	hsa-miR-4633-3p	CLIP-seq
MIRT878100	hsa-miR-4707-5p	CLIP-seq
MIRT878102	hsa-miR-4725-3p	CLIP-seq
MIRT878105	hsa-miR-4747-5p	CLIP-seq
MIRT878111	hsa-miR-491-5p	CLIP-seq
MIRT878124	hsa-miR-92a	CLIP-seq
MIRT878125	hsa-miR-92b	CLIP-seq
MIRT878035	hsa-miR-1252	CLIP-seq
MIRT1960258	hsa-miR-1255a	CLIP-seq
MIRT1960259	hsa-miR-1255b	CLIP-seq
MIRT2197053	hsa-miR-1286	CLIP-seq
MIRT2197054	hsa-miR-146b-3p	CLIP-seq
MIRT878046	hsa-miR-1827	CLIP-seq
MIRT878048	hsa-miR-1915	CLIP-seq
MIRT878053	hsa-miR-24	CLIP-seq
MIRT2197055	hsa-miR-3155	CLIP-seq
MIRT2197056	hsa-miR-3155b	CLIP-seq
MIRT2197057	hsa-miR-3173-5p	CLIP-seq
MIRT878060	hsa-miR-3185	CLIP-seq
MIRT878067	hsa-miR-3614-3p	CLIP-seq
MIRT2197058	hsa-miR-361-5p	CLIP-seq
MIRT878069	hsa-miR-3649	CLIP-seq
MIRT2197059	hsa-miR-3925-3p	CLIP-seq
MIRT878076	hsa-miR-412	CLIP-seq
MIRT878080	hsa-miR-4291	CLIP-seq
MIRT878086	hsa-miR-4435	CLIP-seq
MIRT2197060	hsa-miR-4438	CLIP-seq
MIRT1960260	hsa-miR-4633-3p	CLIP-seq
MIRT2197061	hsa-miR-484	CLIP-seq
MIRT878112	hsa-miR-492	CLIP-seq
MIRT2197062	hsa-miR-496	CLIP-seq
MIRT2197063	hsa-miR-520a-5p	CLIP-seq
MIRT2197064	hsa-miR-525-5p	CLIP-seq
MIRT878114	hsa-miR-545	CLIP-seq
MIRT2197065	hsa-miR-615-5p	CLIP-seq
MIRT2197066	hsa-miR-766	CLIP-seq
MIRT2197067	hsa-miR-874	CLIP-seq
MIRT2197068	hsa-miR-940	CLIP-seq
MIRT878048	hsa-miR-1915	CLIP-seq
MIRT878053	hsa-miR-24	CLIP-seq
MIRT2197055	hsa-miR-3155	CLIP-seq
MIRT2197056	hsa-miR-3155b	CLIP-seq
MIRT878067	hsa-miR-3614-3p	CLIP-seq
MIRT878076	hsa-miR-412	CLIP-seq
MIRT878080	hsa-miR-4291	CLIP-seq
MIRT2197060	hsa-miR-4438	CLIP-seq
MIRT1960260	hsa-miR-4633-3p	CLIP-seq
MIRT2197061	hsa-miR-484	CLIP-seq
MIRT878114	hsa-miR-545	CLIP-seq
MIRT2436211	hsa-miR-187	CLIP-seq
MIRT2436212	hsa-miR-2682	CLIP-seq
MIRT2436213	hsa-miR-3135	CLIP-seq
MIRT2436214	hsa-miR-449c	CLIP-seq
MIRT2197068	hsa-miR-940	CLIP-seq
MIRT2500287	hsa-miR-1224-3p	CLIP-seq
MIRT2500288	hsa-miR-1225-3p	CLIP-seq
MIRT2500289	hsa-miR-1233	CLIP-seq
MIRT2500290	hsa-miR-1236	CLIP-seq
MIRT2197054	hsa-miR-146b-3p	CLIP-seq
MIRT878046	hsa-miR-1827	CLIP-seq
MIRT878047	hsa-miR-1913	CLIP-seq
MIRT878054	hsa-miR-2467-3p	CLIP-seq
MIRT2436212	hsa-miR-2682	CLIP-seq
MIRT2500291	hsa-miR-296-5p	CLIP-seq
MIRT878056	hsa-miR-298	CLIP-seq
MIRT2500292	hsa-miR-3064-5p	CLIP-seq
MIRT878058	hsa-miR-3127-5p	CLIP-seq
MIRT2436213	hsa-miR-3135	CLIP-seq
MIRT878059	hsa-miR-3154	CLIP-seq
MIRT2197057	hsa-miR-3173-5p	CLIP-seq
MIRT878063	hsa-miR-324-3p	CLIP-seq
MIRT878064	hsa-miR-331-3p	CLIP-seq
MIRT2500293	hsa-miR-339-5p	CLIP-seq
MIRT878066	hsa-miR-361-3p	CLIP-seq
MIRT878067	hsa-miR-3614-3p	CLIP-seq
MIRT878069	hsa-miR-3649	CLIP-seq
MIRT2500294	hsa-miR-3652	CLIP-seq
MIRT878075	hsa-miR-3918	CLIP-seq
MIRT878076	hsa-miR-412	CLIP-seq
MIRT878080	hsa-miR-4291	CLIP-seq
MIRT878083	hsa-miR-4313	CLIP-seq
MIRT2500295	hsa-miR-4421	CLIP-seq
MIRT2500296	hsa-miR-4430	CLIP-seq
MIRT878086	hsa-miR-4435	CLIP-seq
MIRT878088	hsa-miR-4475	CLIP-seq
MIRT2436214	hsa-miR-449c	CLIP-seq
MIRT2500297	hsa-miR-4505	CLIP-seq
MIRT2500298	hsa-miR-4685-5p	CLIP-seq
MIRT878106	hsa-miR-4761-3p	CLIP-seq
MIRT878109	hsa-miR-486-3p	CLIP-seq
MIRT878114	hsa-miR-545	CLIP-seq
MIRT2500299	hsa-miR-593	CLIP-seq
MIRT2500300	hsa-miR-663b	CLIP-seq
MIRT2197067	hsa-miR-874	CLIP-seq
MIRT2197068	hsa-miR-940	CLIP-seq
MIRT2500287	hsa-miR-1224-3p	CLIP-seq
MIRT2500288	hsa-miR-1225-3p	CLIP-seq
MIRT2500289	hsa-miR-1233	CLIP-seq
MIRT2500290	hsa-miR-1236	CLIP-seq
MIRT2197054	hsa-miR-146b-3p	CLIP-seq
MIRT878046	hsa-miR-1827	CLIP-seq
MIRT2436211	hsa-miR-187	CLIP-seq
MIRT878047	hsa-miR-1913	CLIP-seq
MIRT878048	hsa-miR-1915	CLIP-seq
MIRT878054	hsa-miR-2467-3p	CLIP-seq
MIRT2436212	hsa-miR-2682	CLIP-seq
MIRT2500291	hsa-miR-296-5p	CLIP-seq
MIRT878056	hsa-miR-298	CLIP-seq
MIRT2500292	hsa-miR-3064-5p	CLIP-seq
MIRT878058	hsa-miR-3127-5p	CLIP-seq
MIRT2436213	hsa-miR-3135	CLIP-seq
MIRT878059	hsa-miR-3154	CLIP-seq
MIRT2197057	hsa-miR-3173-5p	CLIP-seq
MIRT878063	hsa-miR-324-3p	CLIP-seq
MIRT878064	hsa-miR-331-3p	CLIP-seq
MIRT2500293	hsa-miR-339-5p	CLIP-seq
MIRT878066	hsa-miR-361-3p	CLIP-seq
MIRT878067	hsa-miR-3614-3p	CLIP-seq
MIRT878069	hsa-miR-3649	CLIP-seq
MIRT2500294	hsa-miR-3652	CLIP-seq
MIRT878075	hsa-miR-3918	CLIP-seq
MIRT878076	hsa-miR-412	CLIP-seq
MIRT878080	hsa-miR-4291	CLIP-seq
MIRT878083	hsa-miR-4313	CLIP-seq
MIRT2500295	hsa-miR-4421	CLIP-seq
MIRT2500296	hsa-miR-4430	CLIP-seq
MIRT878086	hsa-miR-4435	CLIP-seq
MIRT878088	hsa-miR-4475	CLIP-seq
MIRT2436214	hsa-miR-449c	CLIP-seq
MIRT2500297	hsa-miR-4505	CLIP-seq
MIRT2500298	hsa-miR-4685-5p	CLIP-seq
MIRT2677858	hsa-miR-4758-3p	CLIP-seq
MIRT878106	hsa-miR-4761-3p	CLIP-seq
MIRT878109	hsa-miR-486-3p	CLIP-seq
MIRT878112	hsa-miR-492	CLIP-seq
MIRT878114	hsa-miR-545	CLIP-seq
MIRT2500299	hsa-miR-593	CLIP-seq
MIRT2500300	hsa-miR-663b	CLIP-seq
MIRT2197067	hsa-miR-874	CLIP-seq
MIRT2197068	hsa-miR-940	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001515	Function	Opioid peptide activity	IEA
GO:0005096	Function	GTPase activator activity	IMP	10430899
GO:0005515	Function	Protein binding	IPI	11584266, 20936779, 21988832, 25416956, 26871637, 31413325, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	11035016
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	10430899
GO:0007015	Process	Actin filament organization	NAS	11035016
GO:0007266	Process	Rho protein signal transduction	IBA
GO:0008360	Process	Regulation of cell shape	IBA
GO:0008360	Process	Regulation of cell shape	IDA	11035016
GO:0008360	Process	Regulation of cell shape	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016020	Component	Membrane	IDA	11035016
GO:0016020	Component	Membrane	IEA
GO:0030036	Process	Actin cytoskeleton organization	IDA	10430899
GO:0030838	Process	Positive regulation of actin filament polymerization	IBA
GO:0030838	Process	Positive regulation of actin filament polymerization	IDA	11035016
GO:0031267	Function	Small GTPase binding	IBA
GO:0031267	Function	Small GTPase binding	IPI	11035016
GO:0031274	Process	Positive regulation of pseudopodium assembly	IBA
GO:0031274	Process	Positive regulation of pseudopodium assembly	IDA	11035016
GO:0031334	Process	Positive regulation of protein-containing complex assembly	TAS	11584266
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0071346	Process	Cellular response to type II interferon	IEA

MIM	HGNC	e!Ensembl
606132	16263	ENSG00000149798

O14613

Protein name

Cdc42 effector protein 2 (Binder of Rho GTPases 1)

Protein function

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. {ECO:0000269|

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00786	PBD	29 → 87	P21-Rho-binding domain	Domain
PF14957	BORG_CEP	103 → 154	Cdc42 effector	Family
PF14957	BORG_CEP	153 → 202	Cdc42 effector	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in the heart. Weakly expressed in the pancreas and liver. {ECO:0000269|PubMed:10490598}.

Sequence

MSTKVPIYLKRGSRKGKKEKLRDLLSSDMISPPLGDFRHTIHIGSGGGSDMFGDISFLQG
KFHLLPGTMVEGPEEDGTFDLPFQFTRTATVCGRELPDGPSPLLKNAISLPVIGGPQALT
LPTAQAPPKPPRLHLETPQPSPQEGGSVDIWRIPETGSPNSGLTPESGAEEPFLSNASSL
LSLHVDLGPSILDDVLQIMDQDLDSMQIPT

Sequence length

210

Interactions

View interactions

	Reactome
			MAPK6/MAPK4 signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HYPERURICEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Gastrointestinal Stromal Tumors	Gastrointestinal stromal tumor	Pubtator	25987131	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	35309336	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CDC42EP2 (CDC42 effector protein 2)