Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10427
Gene name	SEC24 homolog B, COPII component
Gene symbol	SEC24B
Synonyms (NCBI Gene)	SEC24
Chromosome	4
Chromosome location	4q25
Summary	The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in

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Show/Hide all (158)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020621	hsa-miR-155-5p	Proteomics	18668040
MIRT027426	hsa-miR-98-5p	Microarray	19088304
MIRT028448	hsa-miR-30a-5p	Proteomics	18668040
MIRT051230	hsa-miR-16-5p	CLASH	23622248
MIRT050723	hsa-miR-18a-5p	CLASH	23622248
MIRT044925	hsa-miR-186-5p	CLASH	23622248
MIRT038485	hsa-miR-296-3p	CLASH	23622248
MIRT719502	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT719501	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT719500	hsa-miR-1913	HITS-CLIP	19536157
MIRT719499	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT719498	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT719497	hsa-miR-6790-3p	HITS-CLIP	19536157
MIRT719496	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT719495	hsa-miR-452-3p	HITS-CLIP	19536157
MIRT719502	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT719501	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT719500	hsa-miR-1913	HITS-CLIP	19536157
MIRT719499	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT719498	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT719497	hsa-miR-6790-3p	HITS-CLIP	19536157
MIRT719496	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT719495	hsa-miR-452-3p	HITS-CLIP	19536157
MIRT2098520	hsa-miR-1243	CLIP-seq
MIRT2098521	hsa-miR-3654	CLIP-seq
MIRT2098522	hsa-miR-4327	CLIP-seq
MIRT2098523	hsa-miR-4769-3p	CLIP-seq
MIRT2098524	hsa-miR-4775	CLIP-seq
MIRT2098525	hsa-miR-513a-3p	CLIP-seq
MIRT2098526	hsa-miR-875-3p	CLIP-seq
MIRT2323226	hsa-miR-103a	CLIP-seq
MIRT2323227	hsa-miR-107	CLIP-seq
MIRT2323228	hsa-miR-221	CLIP-seq
MIRT2323229	hsa-miR-222	CLIP-seq
MIRT2323230	hsa-miR-3143	CLIP-seq
MIRT2323231	hsa-miR-3146	CLIP-seq
MIRT2323232	hsa-miR-3692	CLIP-seq
MIRT2323233	hsa-miR-4503	CLIP-seq
MIRT2323234	hsa-miR-4760-3p	CLIP-seq
MIRT2323235	hsa-miR-543	CLIP-seq
MIRT2440071	hsa-miR-194	CLIP-seq
MIRT2323230	hsa-miR-3143	CLIP-seq
MIRT2440072	hsa-miR-3924	CLIP-seq
MIRT2440073	hsa-miR-4729	CLIP-seq
MIRT2440074	hsa-miR-520d-5p	CLIP-seq
MIRT2440075	hsa-miR-524-5p	CLIP-seq
MIRT2323235	hsa-miR-543	CLIP-seq
MIRT2323226	hsa-miR-103a	CLIP-seq
MIRT2323227	hsa-miR-107	CLIP-seq
MIRT2619004	hsa-miR-1202	CLIP-seq
MIRT2619005	hsa-miR-1271	CLIP-seq
MIRT2619006	hsa-miR-1324	CLIP-seq
MIRT2619007	hsa-miR-154	CLIP-seq
MIRT2619008	hsa-miR-182	CLIP-seq
MIRT2440071	hsa-miR-194	CLIP-seq
MIRT2619009	hsa-miR-2053	CLIP-seq
MIRT2619010	hsa-miR-210	CLIP-seq
MIRT2619011	hsa-miR-219-1-3p	CLIP-seq
MIRT2619012	hsa-miR-3127-3p	CLIP-seq
MIRT2323230	hsa-miR-3143	CLIP-seq
MIRT2323231	hsa-miR-3146	CLIP-seq
MIRT2619013	hsa-miR-3156-5p	CLIP-seq
MIRT2619014	hsa-miR-323-3p	CLIP-seq
MIRT2619015	hsa-miR-3919	CLIP-seq
MIRT2440072	hsa-miR-3924	CLIP-seq
MIRT2619016	hsa-miR-3972	CLIP-seq
MIRT2619017	hsa-miR-409-3p	CLIP-seq
MIRT2619018	hsa-miR-4452	CLIP-seq
MIRT2323233	hsa-miR-4503	CLIP-seq
MIRT2619019	hsa-miR-4528	CLIP-seq
MIRT2619020	hsa-miR-4642	CLIP-seq
MIRT2619021	hsa-miR-4659a-3p	CLIP-seq
MIRT2619022	hsa-miR-4659b-3p	CLIP-seq
MIRT2440073	hsa-miR-4729	CLIP-seq
MIRT2619023	hsa-miR-4738-3p	CLIP-seq
MIRT2323234	hsa-miR-4760-3p	CLIP-seq
MIRT2098524	hsa-miR-4775	CLIP-seq
MIRT2619024	hsa-miR-4797-5p	CLIP-seq
MIRT2619025	hsa-miR-494	CLIP-seq
MIRT2619026	hsa-miR-502-5p	CLIP-seq
MIRT2619027	hsa-miR-512-3p	CLIP-seq
MIRT2440074	hsa-miR-520d-5p	CLIP-seq
MIRT2440075	hsa-miR-524-5p	CLIP-seq
MIRT2619028	hsa-miR-532-5p	CLIP-seq
MIRT2323235	hsa-miR-543	CLIP-seq
MIRT2619029	hsa-miR-548a-5p	CLIP-seq
MIRT2619030	hsa-miR-548ab	CLIP-seq
MIRT2619031	hsa-miR-548ak	CLIP-seq
MIRT2619032	hsa-miR-548b-5p	CLIP-seq
MIRT2619033	hsa-miR-548c-5p	CLIP-seq
MIRT2619034	hsa-miR-548d-5p	CLIP-seq
MIRT2619035	hsa-miR-548h	CLIP-seq
MIRT2619036	hsa-miR-548i	CLIP-seq
MIRT2619037	hsa-miR-548j	CLIP-seq
MIRT2619038	hsa-miR-548n	CLIP-seq
MIRT2619039	hsa-miR-548w	CLIP-seq
MIRT2619040	hsa-miR-548y	CLIP-seq
MIRT2619041	hsa-miR-559	CLIP-seq
MIRT2619042	hsa-miR-571	CLIP-seq
MIRT2619043	hsa-miR-579	CLIP-seq
MIRT2619044	hsa-miR-618	CLIP-seq
MIRT2619045	hsa-miR-643	CLIP-seq
MIRT2619046	hsa-miR-653	CLIP-seq
MIRT2619047	hsa-miR-664	CLIP-seq
MIRT2619048	hsa-miR-759	CLIP-seq
MIRT2619049	hsa-miR-96	CLIP-seq
MIRT2323226	hsa-miR-103a	CLIP-seq
MIRT2323227	hsa-miR-107	CLIP-seq
MIRT2619005	hsa-miR-1271	CLIP-seq
MIRT2619007	hsa-miR-154	CLIP-seq
MIRT2619008	hsa-miR-182	CLIP-seq
MIRT2440071	hsa-miR-194	CLIP-seq
MIRT2619009	hsa-miR-2053	CLIP-seq
MIRT2619011	hsa-miR-219-1-3p	CLIP-seq
MIRT2619012	hsa-miR-3127-3p	CLIP-seq
MIRT2323230	hsa-miR-3143	CLIP-seq
MIRT2323231	hsa-miR-3146	CLIP-seq
MIRT2619013	hsa-miR-3156-5p	CLIP-seq
MIRT2619014	hsa-miR-323-3p	CLIP-seq
MIRT2619015	hsa-miR-3919	CLIP-seq
MIRT2440072	hsa-miR-3924	CLIP-seq
MIRT2619017	hsa-miR-409-3p	CLIP-seq
MIRT2619018	hsa-miR-4452	CLIP-seq
MIRT2323233	hsa-miR-4503	CLIP-seq
MIRT2619019	hsa-miR-4528	CLIP-seq
MIRT2619020	hsa-miR-4642	CLIP-seq
MIRT2619021	hsa-miR-4659a-3p	CLIP-seq
MIRT2619022	hsa-miR-4659b-3p	CLIP-seq
MIRT2440073	hsa-miR-4729	CLIP-seq
MIRT2619023	hsa-miR-4738-3p	CLIP-seq
MIRT2323234	hsa-miR-4760-3p	CLIP-seq
MIRT2098524	hsa-miR-4775	CLIP-seq
MIRT2619024	hsa-miR-4797-5p	CLIP-seq
MIRT2619025	hsa-miR-494	CLIP-seq
MIRT2619026	hsa-miR-502-5p	CLIP-seq
MIRT2440074	hsa-miR-520d-5p	CLIP-seq
MIRT2440075	hsa-miR-524-5p	CLIP-seq
MIRT2619028	hsa-miR-532-5p	CLIP-seq
MIRT2323235	hsa-miR-543	CLIP-seq
MIRT2619029	hsa-miR-548a-5p	CLIP-seq
MIRT2619030	hsa-miR-548ab	CLIP-seq
MIRT2619031	hsa-miR-548ak	CLIP-seq
MIRT2619032	hsa-miR-548b-5p	CLIP-seq
MIRT2619033	hsa-miR-548c-5p	CLIP-seq
MIRT2619034	hsa-miR-548d-5p	CLIP-seq
MIRT2619035	hsa-miR-548h	CLIP-seq
MIRT2619036	hsa-miR-548i	CLIP-seq
MIRT2619037	hsa-miR-548j	CLIP-seq
MIRT2619038	hsa-miR-548n	CLIP-seq
MIRT2619039	hsa-miR-548w	CLIP-seq
MIRT2619040	hsa-miR-548y	CLIP-seq
MIRT2619041	hsa-miR-559	CLIP-seq
MIRT2619042	hsa-miR-571	CLIP-seq
MIRT2619043	hsa-miR-579	CLIP-seq
MIRT2619044	hsa-miR-618	CLIP-seq
MIRT2619046	hsa-miR-653	CLIP-seq
MIRT2619047	hsa-miR-664	CLIP-seq
MIRT2619049	hsa-miR-96	CLIP-seq

Show/Hide all (42)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA
GO:0001843	Process	Neural tube closure	IEA
GO:0002093	Process	Auditory receptor cell morphogenesis	IEA
GO:0003151	Process	Outflow tract morphogenesis	IEA
GO:0005515	Function	Protein binding	IPI	10075675, 19706601, 24405750, 27018634, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005829	Component	Cytosol	IDA	10075675
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IEA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	20427317
GO:0008270	Function	Zinc ion binding	IBA
GO:0008270	Function	Zinc ion binding	IDA	18843296
GO:0008270	Function	Zinc ion binding	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0021747	Process	Cochlear nucleus development	IEA
GO:0030127	Component	COPII vesicle coat	IBA
GO:0030127	Component	COPII vesicle coat	IDA	10075675, 17499046
GO:0030127	Component	COPII vesicle coat	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0035909	Process	Aorta morphogenesis	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0060088	Process	Auditory receptor cell stereocilium organization	IEA
GO:0060425	Process	Lung morphogenesis	IEA
GO:0060463	Process	Lung lobe morphogenesis	IEA
GO:0060982	Process	Coronary artery morphogenesis	IEA
GO:0061156	Process	Pulmonary artery morphogenesis	IEA
GO:0070971	Component	Endoplasmic reticulum exit site	IBA
GO:0072359	Process	Circulatory system development	IEA
GO:0090110	Process	COPII-coated vesicle cargo loading	IBA
GO:0090110	Process	COPII-coated vesicle cargo loading	IDA	17499046, 18843296
GO:0090110	Process	COPII-coated vesicle cargo loading	IEA
GO:0090178	Process	Regulation of establishment of planar polarity involved in neural tube closure	IEA
GO:1901301	Process	Regulation of cargo loading into COPII-coated vesicle	IEA

MIM	HGNC	e!Ensembl
607184	10704	ENSG00000138802

O95487

Protein name

Protein transport protein Sec24B (SEC24-related protein B)

Protein function

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicle

PDB

3EH1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04810	zf-Sec23_Sec24	602 → 639	Sec23/Sec24 zinc finger	Domain
PF04811	Sec23_trunk	675 → 914	Sec23/Sec24 trunk domain	Domain
PF08033	Sec23_BS	919 → 1003	Sec23/Sec24 beta-sandwich domain	Domain
PF04815	Sec23_helical	1014 → 1115	Sec23/Sec24 helical domain	Domain
PF00626	Gelsolin	1139 → 1214	Gelsolin repeat	Domain

Sequence

MSAPAGSSHPAASARIPPKFGGAAVSGAAAPAGPGAGPAPHQQNGPAQNQMQVPSGYGLH
HQNYIAPSGHYSQGPGKMTSLPLDTQCGDYYSALYTVPTQNVTPNTVNQQPGAQQLYSRG
PPAPHIVGSTLGSFQGAASSASHLHTSASQPYSSFVNHYNSPAMYSASSSVASQGFPSTC
GHYAMSTVSNAAYPSVSYPSLPAGDTYGQMFTSQNAPTVRPVKDNSFSGQNTAISHPSPL
PPLPSQQHHQQQSLSGYSTLTWSSPGLPSTQDNLIRNHTGSLAVANNNPTITVADSLSCP
VMQNVQPPKSSPVVSTVLSGSSGSSSTRTPPTANHPVEPVTSVTQPSELLQQKGVQYGEY
VNNQASSAPTPLSSTSDDEEEEEEDEEAGVDSSSTTSSASPMPNSYDALEGGSYPDMLSS
SASSPAPDPAPEPDPASAPAPASAPAPVVPQPSKMAKPFGYGYPTLQPGYQNATAPLISG
VQPSNPVYSGFQQYPQQYPGVNQLSSSIGGLSLQSSPQPESLRPVNLTQERNILPMTPVW
APVPNLNADLKKLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSN
TIVRCRSCRTYINPFVSFIDQRRWKCNLCYRVNDVPEEFMYNPLTRSYGEPHKRPEVQNS
TVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGF
MTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLNALPNMF
TNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQH
LGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYTHNP
SQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLANINPDAGF
AVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAIC
LLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNLQHSALMAPSSLKLFPLYVLA
LLKQKAFRTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIV
PQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFIEDVLGYTNFASIPQKMTHLP
ELDTLSSERARSFITWLRDSRPLSPILHIVKDESPAKAEFFQHLIEDRTEAAFSYYEFLL
HVQQQICK

Sequence length

1268

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum Pathogenic Escherichia coli infection		COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30809968	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Craniorachischisis	Craniorachischisis	BEFREE	23592378		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neural Tube Defects	Neural Tube Defect	BEFREE	23592378		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary craniopharyngioma	Papillary Craniopharyngioma	BEFREE	20215345		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	32812852	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	36451815	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SEC24B (SEC24 homolog B, COPII component)