Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10418
Gene name	Spondin 1
Gene symbol	SPON1
Synonyms (NCBI Gene)	VSGP/F-spondinf-spondin
Chromosome	11
Chromosome location	11p15.2

237

Show/Hide all (237)

miRTarBase ID	miRNA	Experiments
MIRT1385144	hsa-miR-1207-3p	CLIP-seq
MIRT1385145	hsa-miR-1256	CLIP-seq
MIRT1385146	hsa-miR-1271	CLIP-seq
MIRT1385147	hsa-miR-182	CLIP-seq
MIRT1385148	hsa-miR-21	CLIP-seq
MIRT1385149	hsa-miR-3064-5p	CLIP-seq
MIRT1385150	hsa-miR-3135b	CLIP-seq
MIRT1385151	hsa-miR-3605-3p	CLIP-seq
MIRT1385152	hsa-miR-3616-3p	CLIP-seq
MIRT1385153	hsa-miR-3617	CLIP-seq
MIRT1385154	hsa-miR-3652	CLIP-seq
MIRT1385155	hsa-miR-3662	CLIP-seq
MIRT1385156	hsa-miR-3689d	CLIP-seq
MIRT1385157	hsa-miR-4292	CLIP-seq
MIRT1385158	hsa-miR-4308	CLIP-seq
MIRT1385159	hsa-miR-4430	CLIP-seq
MIRT1385160	hsa-miR-4435	CLIP-seq
MIRT1385161	hsa-miR-4505	CLIP-seq
MIRT1385162	hsa-miR-4539	CLIP-seq
MIRT1385163	hsa-miR-4642	CLIP-seq
MIRT1385164	hsa-miR-4698	CLIP-seq
MIRT1385165	hsa-miR-4710	CLIP-seq
MIRT1385166	hsa-miR-4721	CLIP-seq
MIRT1385167	hsa-miR-485-5p	CLIP-seq
MIRT1385168	hsa-miR-548c-3p	CLIP-seq
MIRT1385169	hsa-miR-548u	CLIP-seq
MIRT1385170	hsa-miR-590-5p	CLIP-seq
MIRT1385171	hsa-miR-641	CLIP-seq
MIRT1385172	hsa-miR-96	CLIP-seq
MIRT2115271	hsa-miR-3134	CLIP-seq
MIRT2115272	hsa-miR-3163	CLIP-seq
MIRT2115273	hsa-miR-3647-3p	CLIP-seq
MIRT1385155	hsa-miR-3662	CLIP-seq
MIRT2115274	hsa-miR-4534	CLIP-seq
MIRT2115275	hsa-miR-4802-5p	CLIP-seq
MIRT2337996	hsa-miR-136	CLIP-seq
MIRT2337997	hsa-miR-2054	CLIP-seq
MIRT2337998	hsa-miR-3152-5p	CLIP-seq
MIRT2337999	hsa-miR-380	CLIP-seq
MIRT2338000	hsa-miR-4423-5p	CLIP-seq
MIRT2338001	hsa-miR-4491	CLIP-seq
MIRT2338002	hsa-miR-4657	CLIP-seq
MIRT2338003	hsa-miR-4716-5p	CLIP-seq
MIRT2631530	hsa-miR-1178	CLIP-seq
MIRT2631531	hsa-miR-1184	CLIP-seq
MIRT2631532	hsa-miR-1205	CLIP-seq
MIRT1385144	hsa-miR-1207-3p	CLIP-seq
MIRT2631533	hsa-miR-1231	CLIP-seq
MIRT1385145	hsa-miR-1256	CLIP-seq
MIRT2631534	hsa-miR-1265	CLIP-seq
MIRT1385146	hsa-miR-1271	CLIP-seq
MIRT2631535	hsa-miR-1273e	CLIP-seq
MIRT2631536	hsa-miR-1286	CLIP-seq
MIRT2631537	hsa-miR-1297	CLIP-seq
MIRT1385147	hsa-miR-182	CLIP-seq
MIRT2631538	hsa-miR-204	CLIP-seq
MIRT2631539	hsa-miR-211	CLIP-seq
MIRT2631540	hsa-miR-216b	CLIP-seq
MIRT2631541	hsa-miR-2355-5p	CLIP-seq
MIRT2631542	hsa-miR-26a	CLIP-seq
MIRT2631543	hsa-miR-26b	CLIP-seq
MIRT2631544	hsa-miR-2964a-3p	CLIP-seq
MIRT2631545	hsa-miR-302f	CLIP-seq
MIRT1385149	hsa-miR-3064-5p	CLIP-seq
MIRT2631546	hsa-miR-3117-5p	CLIP-seq
MIRT2631547	hsa-miR-3120-5p	CLIP-seq
MIRT2631548	hsa-miR-3128	CLIP-seq
MIRT2631549	hsa-miR-3133	CLIP-seq
MIRT1385150	hsa-miR-3135b	CLIP-seq
MIRT2631550	hsa-miR-3153	CLIP-seq
MIRT2631551	hsa-miR-3158-5p	CLIP-seq
MIRT2115272	hsa-miR-3163	CLIP-seq
MIRT2631552	hsa-miR-326	CLIP-seq
MIRT2631553	hsa-miR-330-5p	CLIP-seq
MIRT1385152	hsa-miR-3616-3p	CLIP-seq
MIRT2631554	hsa-miR-3646	CLIP-seq
MIRT1385154	hsa-miR-3652	CLIP-seq
MIRT1385155	hsa-miR-3662	CLIP-seq
MIRT2631555	hsa-miR-3679-3p	CLIP-seq
MIRT1385156	hsa-miR-3689d	CLIP-seq
MIRT2631556	hsa-miR-3691-5p	CLIP-seq
MIRT2631557	hsa-miR-3692	CLIP-seq
MIRT2631558	hsa-miR-3921	CLIP-seq
MIRT2631559	hsa-miR-4264	CLIP-seq
MIRT2631560	hsa-miR-4267	CLIP-seq
MIRT2631561	hsa-miR-4268	CLIP-seq
MIRT2631562	hsa-miR-4276	CLIP-seq
MIRT2631563	hsa-miR-4282	CLIP-seq
MIRT2631564	hsa-miR-4286	CLIP-seq
MIRT2631565	hsa-miR-4327	CLIP-seq
MIRT2631566	hsa-miR-433	CLIP-seq
MIRT2631567	hsa-miR-4425	CLIP-seq
MIRT1385159	hsa-miR-4430	CLIP-seq
MIRT2631568	hsa-miR-4446-5p	CLIP-seq
MIRT2631569	hsa-miR-4448	CLIP-seq
MIRT2631570	hsa-miR-4464	CLIP-seq
MIRT2631571	hsa-miR-4465	CLIP-seq
MIRT2631572	hsa-miR-448	CLIP-seq
MIRT2631573	hsa-miR-4486	CLIP-seq
MIRT2338001	hsa-miR-4491	CLIP-seq
MIRT2631574	hsa-miR-4495	CLIP-seq
MIRT1385161	hsa-miR-4505	CLIP-seq
MIRT2631575	hsa-miR-4535	CLIP-seq
MIRT1385162	hsa-miR-4539	CLIP-seq
MIRT1385163	hsa-miR-4642	CLIP-seq
MIRT2631576	hsa-miR-4649-5p	CLIP-seq
MIRT2631577	hsa-miR-4652-3p	CLIP-seq
MIRT2631578	hsa-miR-4653-5p	CLIP-seq
MIRT2338002	hsa-miR-4657	CLIP-seq
MIRT2631579	hsa-miR-4668-5p	CLIP-seq
MIRT1385165	hsa-miR-4710	CLIP-seq
MIRT2631580	hsa-miR-4720-5p	CLIP-seq
MIRT1385166	hsa-miR-4721	CLIP-seq
MIRT2631581	hsa-miR-4722-5p	CLIP-seq
MIRT2631582	hsa-miR-4748	CLIP-seq
MIRT2631583	hsa-miR-4752	CLIP-seq
MIRT2631584	hsa-miR-4755-5p	CLIP-seq
MIRT2631585	hsa-miR-4758-3p	CLIP-seq
MIRT2631586	hsa-miR-4760-5p	CLIP-seq
MIRT2631587	hsa-miR-4764-5p	CLIP-seq
MIRT2631588	hsa-miR-4768-5p	CLIP-seq
MIRT2631589	hsa-miR-4776-5p	CLIP-seq
MIRT2631590	hsa-miR-4797-3p	CLIP-seq
MIRT2631591	hsa-miR-4799-3p	CLIP-seq
MIRT1385167	hsa-miR-485-5p	CLIP-seq
MIRT2631592	hsa-miR-486-5p	CLIP-seq
MIRT2631593	hsa-miR-492	CLIP-seq
MIRT2631594	hsa-miR-512-5p	CLIP-seq
MIRT2631595	hsa-miR-513a-3p	CLIP-seq
MIRT2631596	hsa-miR-570	CLIP-seq
MIRT2631597	hsa-miR-593	CLIP-seq
MIRT2631598	hsa-miR-623	CLIP-seq
MIRT2631599	hsa-miR-630	CLIP-seq
MIRT2631600	hsa-miR-634	CLIP-seq
MIRT2631601	hsa-miR-654-3p	CLIP-seq
MIRT2631602	hsa-miR-660	CLIP-seq
MIRT2631603	hsa-miR-873	CLIP-seq
MIRT1385172	hsa-miR-96	CLIP-seq
MIRT2631530	hsa-miR-1178	CLIP-seq
MIRT2631531	hsa-miR-1184	CLIP-seq
MIRT2631532	hsa-miR-1205	CLIP-seq
MIRT1385144	hsa-miR-1207-3p	CLIP-seq
MIRT2631533	hsa-miR-1231	CLIP-seq
MIRT1385145	hsa-miR-1256	CLIP-seq
MIRT2631534	hsa-miR-1265	CLIP-seq
MIRT1385146	hsa-miR-1271	CLIP-seq
MIRT2631535	hsa-miR-1273e	CLIP-seq
MIRT2631536	hsa-miR-1286	CLIP-seq
MIRT2631537	hsa-miR-1297	CLIP-seq
MIRT1385147	hsa-miR-182	CLIP-seq
MIRT2631538	hsa-miR-204	CLIP-seq
MIRT2631539	hsa-miR-211	CLIP-seq
MIRT2631540	hsa-miR-216b	CLIP-seq
MIRT2631541	hsa-miR-2355-5p	CLIP-seq
MIRT2631542	hsa-miR-26a	CLIP-seq
MIRT2631543	hsa-miR-26b	CLIP-seq
MIRT2631544	hsa-miR-2964a-3p	CLIP-seq
MIRT2631545	hsa-miR-302f	CLIP-seq
MIRT1385149	hsa-miR-3064-5p	CLIP-seq
MIRT2691906	hsa-miR-3065-5p	CLIP-seq
MIRT2631546	hsa-miR-3117-5p	CLIP-seq
MIRT2631547	hsa-miR-3120-5p	CLIP-seq
MIRT2631548	hsa-miR-3128	CLIP-seq
MIRT2631549	hsa-miR-3133	CLIP-seq
MIRT1385150	hsa-miR-3135b	CLIP-seq
MIRT2631550	hsa-miR-3153	CLIP-seq
MIRT2631551	hsa-miR-3158-5p	CLIP-seq
MIRT2115272	hsa-miR-3163	CLIP-seq
MIRT2631552	hsa-miR-326	CLIP-seq
MIRT2631553	hsa-miR-330-5p	CLIP-seq
MIRT1385152	hsa-miR-3616-3p	CLIP-seq
MIRT2631554	hsa-miR-3646	CLIP-seq
MIRT1385154	hsa-miR-3652	CLIP-seq
MIRT1385155	hsa-miR-3662	CLIP-seq
MIRT2631555	hsa-miR-3679-3p	CLIP-seq
MIRT1385156	hsa-miR-3689d	CLIP-seq
MIRT2631556	hsa-miR-3691-5p	CLIP-seq
MIRT2631557	hsa-miR-3692	CLIP-seq
MIRT2631558	hsa-miR-3921	CLIP-seq
MIRT2631559	hsa-miR-4264	CLIP-seq
MIRT2631560	hsa-miR-4267	CLIP-seq
MIRT2631561	hsa-miR-4268	CLIP-seq
MIRT2631562	hsa-miR-4276	CLIP-seq
MIRT2631563	hsa-miR-4282	CLIP-seq
MIRT2631564	hsa-miR-4286	CLIP-seq
MIRT2631565	hsa-miR-4327	CLIP-seq
MIRT2631566	hsa-miR-433	CLIP-seq
MIRT2631567	hsa-miR-4425	CLIP-seq
MIRT1385159	hsa-miR-4430	CLIP-seq
MIRT2631568	hsa-miR-4446-5p	CLIP-seq
MIRT2631569	hsa-miR-4448	CLIP-seq
MIRT2631570	hsa-miR-4464	CLIP-seq
MIRT2631571	hsa-miR-4465	CLIP-seq
MIRT2631572	hsa-miR-448	CLIP-seq
MIRT2631573	hsa-miR-4486	CLIP-seq
MIRT2338001	hsa-miR-4491	CLIP-seq
MIRT2631574	hsa-miR-4495	CLIP-seq
MIRT1385161	hsa-miR-4505	CLIP-seq
MIRT2631575	hsa-miR-4535	CLIP-seq
MIRT1385162	hsa-miR-4539	CLIP-seq
MIRT1385163	hsa-miR-4642	CLIP-seq
MIRT2631576	hsa-miR-4649-5p	CLIP-seq
MIRT2631577	hsa-miR-4652-3p	CLIP-seq
MIRT2631578	hsa-miR-4653-5p	CLIP-seq
MIRT2338002	hsa-miR-4657	CLIP-seq
MIRT2631579	hsa-miR-4668-5p	CLIP-seq
MIRT1385165	hsa-miR-4710	CLIP-seq
MIRT2631580	hsa-miR-4720-5p	CLIP-seq
MIRT1385166	hsa-miR-4721	CLIP-seq
MIRT2631581	hsa-miR-4722-5p	CLIP-seq
MIRT2691907	hsa-miR-4731-3p	CLIP-seq
MIRT2631582	hsa-miR-4748	CLIP-seq
MIRT2631583	hsa-miR-4752	CLIP-seq
MIRT2631584	hsa-miR-4755-5p	CLIP-seq
MIRT2631585	hsa-miR-4758-3p	CLIP-seq
MIRT2631586	hsa-miR-4760-5p	CLIP-seq
MIRT2631587	hsa-miR-4764-5p	CLIP-seq
MIRT2631588	hsa-miR-4768-5p	CLIP-seq
MIRT2631589	hsa-miR-4776-5p	CLIP-seq
MIRT2631590	hsa-miR-4797-3p	CLIP-seq
MIRT2631591	hsa-miR-4799-3p	CLIP-seq
MIRT2691908	hsa-miR-4801	CLIP-seq
MIRT1385167	hsa-miR-485-5p	CLIP-seq
MIRT2631592	hsa-miR-486-5p	CLIP-seq
MIRT2631593	hsa-miR-492	CLIP-seq
MIRT2691909	hsa-miR-495	CLIP-seq
MIRT2631594	hsa-miR-512-5p	CLIP-seq
MIRT2631595	hsa-miR-513a-3p	CLIP-seq
MIRT2631596	hsa-miR-570	CLIP-seq
MIRT2631597	hsa-miR-593	CLIP-seq
MIRT2631598	hsa-miR-623	CLIP-seq
MIRT2631599	hsa-miR-630	CLIP-seq
MIRT2631600	hsa-miR-634	CLIP-seq
MIRT2631601	hsa-miR-654-3p	CLIP-seq
MIRT2631602	hsa-miR-660	CLIP-seq
MIRT2631603	hsa-miR-873	CLIP-seq
MIRT1385172	hsa-miR-96	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005201	Function	Extracellular matrix structural constituent	ISS
GO:0005201	Function	Extracellular matrix structural constituent	RCA	20551380
GO:0005515	Function	Protein binding	IPI	14983046, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	HDA	20551380
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0010954	Process	Positive regulation of protein processing	IEA
GO:0016485	Process	Protein processing	IEA
GO:0031012	Component	Extracellular matrix	HDA	20551380
GO:0031012	Component	Extracellular matrix	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0050693	Function	LBD domain binding	IEA
GO:1902430	Process	Negative regulation of amyloid-beta formation	IEA
GO:1902993	Process	Positive regulation of amyloid precursor protein catabolic process	IEA

MIM	HGNC	e!Ensembl
604989	11252	ENSG00000262655

Q9HCB6

Protein name

Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor)

Protein function

Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major fact

PDB

2ZOT , 2ZOU , 3COO , 3Q13

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02014	Reeler	44 → 172	Reeler domain	Family
PF06468	Spond_N	205 → 399	Spondin_N	Domain
PF00090	TSP_1	446 → 494	Thrombospondin type 1 domain	Domain
PF00090	TSP_1	505 → 554	Thrombospondin type 1 domain	Domain
PF00090	TSP_1	562 → 610	Thrombospondin type 1 domain	Domain
PF00090	TSP_1	618 → 665	Thrombospondin type 1 domain	Domain
PF19028	TSP1_spondin	669 → 720	Spondin-like TSP1 domain	Domain
PF00090	TSP_1	758 → 807	Thrombospondin type 1 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen. {ECO:0000269|PubMed:11368520, ECO:0000269|PubMed:9872452}.

Sequence

MRLSPAPLKLSRTPALLALALPLAAALAFSDETLDKVPKSEGYCSRILRAQGTRREGYTE
FSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALRENREGDKEEDHAGTFQIIDEE
ETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKK
LCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHS
KNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAA
PSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSG
VTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPD
NVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPC
PDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTL
PTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETS
QAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKC
MLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKC
LRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMT
VKKRFKSSQFTSCKDKKEIRACNVHPC

Sequence length

807

Interactions

View interactions

	Reactome
			Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (39)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	22232349, 23471985, 23535033, 28005991, 29573041, 33627629, 37550416, 39380021	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Alzheimer`s Disease	Alzheimer disease	GWASDB_DG	23535033		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer`s Disease	Alzheimer disease	GWASCAT_DG	23535033		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	33062700	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Atrophy	Atrophy	Pubtator	26923371	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	23471985	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain atrophy	Brain atrophy	BEFREE	26923371		★★★★★ ★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt lymphoma	Pubtator	36354023	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma in Situ	Carcinoma in situ	Pubtator	37179355	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cartilaginous exostosis	Osteochondroma	BEFREE	26032498		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral atrophy	Cerebral Atrophy	BEFREE	26923371		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	30557359		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	32322884	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24133572	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	28967680, 30557359		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	LHGDN	18780763		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	BEFREE	23471985		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	23471985	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	27796656		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	31394756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	24158112	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	24158112	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	28967680, 30557359		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	28967680, 30557359, 35595781, 38225249	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Failure Systolic	Heart failure	Pubtator	35595781	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Idiopathic pulmonary fibrosis	Pubtator	31640794, 37416778	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	23535033		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	36520032	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	31394756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	32484721	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	26032498		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	16103746, 20132413, 37179355	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	24294399	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Presenile dementia	Senile Dementia	BEFREE	23471985		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	23471985	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ST segment elevation myocardial infarction	ST Segment Elevation Myocardial Infarction	BEFREE	30115630		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36520032	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	32239176	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	36281082	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SPON1 (spondin 1)