Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10412
Gene name	NSA2 ribosome biogenesis factor
Gene symbol	NSA2
Synonyms (NCBI Gene)	CDK105HCL-G1HCLG1HUSSY-29HUSSY29TINP1
Chromosome	5
Chromosome location	5q13.3
Summary	This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in lar

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020758	hsa-miR-155-5p	Proteomics	18668040
MIRT032355	hsa-let-7b-5p	Proteomics	18668040
MIRT695388	hsa-miR-216b-5p	HITS-CLIP	23313552
MIRT695387	hsa-miR-889-5p	HITS-CLIP	23313552
MIRT695386	hsa-miR-135a-5p	HITS-CLIP	23313552
MIRT695385	hsa-miR-135b-5p	HITS-CLIP	23313552
MIRT695384	hsa-miR-4317	HITS-CLIP	23313552
MIRT695383	hsa-miR-6515-3p	HITS-CLIP	23313552
MIRT695382	hsa-miR-1236-3p	HITS-CLIP	23313552
MIRT695381	hsa-miR-3166	HITS-CLIP	23313552
MIRT695380	hsa-miR-4771	HITS-CLIP	23313552
MIRT695379	hsa-miR-7974	HITS-CLIP	23313552
MIRT695378	hsa-miR-4687-3p	HITS-CLIP	23313552
MIRT695377	hsa-miR-6740-5p	HITS-CLIP	23313552
MIRT695376	hsa-miR-1273h-3p	HITS-CLIP	23313552
MIRT695375	hsa-miR-3678-3p	HITS-CLIP	23313552
MIRT564092	hsa-miR-371b-3p	PAR-CLIP	20371350
MIRT564091	hsa-miR-371a-3p	PAR-CLIP	20371350
MIRT564090	hsa-miR-33b-3p	PAR-CLIP	20371350
MIRT564089	hsa-miR-515-3p	PAR-CLIP	20371350
MIRT564088	hsa-miR-519e-3p	PAR-CLIP	20371350
MIRT564087	hsa-miR-5697	PAR-CLIP	20371350
MIRT564086	hsa-miR-4480	PAR-CLIP	20371350
MIRT564085	hsa-miR-1297	PAR-CLIP	20371350
MIRT564084	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT564083	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT564081	hsa-miR-4465	PAR-CLIP	20371350
MIRT564082	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT564080	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT695388	hsa-miR-216b-5p	HITS-CLIP	23313552
MIRT695387	hsa-miR-889-5p	HITS-CLIP	23313552
MIRT695386	hsa-miR-135a-5p	HITS-CLIP	23313552
MIRT695385	hsa-miR-135b-5p	HITS-CLIP	23313552
MIRT695384	hsa-miR-4317	HITS-CLIP	23313552
MIRT695383	hsa-miR-6515-3p	HITS-CLIP	23313552
MIRT695382	hsa-miR-1236-3p	HITS-CLIP	23313552
MIRT695381	hsa-miR-3166	HITS-CLIP	23313552
MIRT695380	hsa-miR-4771	HITS-CLIP	23313552
MIRT695379	hsa-miR-7974	HITS-CLIP	23313552
MIRT695378	hsa-miR-4687-3p	HITS-CLIP	23313552
MIRT695377	hsa-miR-6740-5p	HITS-CLIP	23313552
MIRT695376	hsa-miR-1273h-3p	HITS-CLIP	23313552
MIRT695375	hsa-miR-3678-3p	HITS-CLIP	23313552
MIRT564092	hsa-miR-371b-3p	PAR-CLIP	20371350
MIRT564091	hsa-miR-371a-3p	PAR-CLIP	20371350
MIRT564090	hsa-miR-33b-3p	PAR-CLIP	20371350
MIRT564089	hsa-miR-515-3p	PAR-CLIP	20371350
MIRT564088	hsa-miR-519e-3p	PAR-CLIP	20371350
MIRT564087	hsa-miR-5697	PAR-CLIP	20371350
MIRT564086	hsa-miR-4480	PAR-CLIP	20371350
MIRT564085	hsa-miR-1297	PAR-CLIP	20371350
MIRT564084	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT564083	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT564081	hsa-miR-4465	PAR-CLIP	20371350
MIRT564082	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT564080	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT1194623	hsa-miR-128	CLIP-seq
MIRT1194624	hsa-miR-135a	CLIP-seq
MIRT1194625	hsa-miR-135b	CLIP-seq
MIRT1194626	hsa-miR-27a	CLIP-seq
MIRT1194627	hsa-miR-27b	CLIP-seq
MIRT1194628	hsa-miR-34a	CLIP-seq
MIRT1194629	hsa-miR-34c-5p	CLIP-seq
MIRT1194630	hsa-miR-449a	CLIP-seq
MIRT1194631	hsa-miR-449b	CLIP-seq
MIRT1194632	hsa-miR-4659a-3p	CLIP-seq
MIRT1194633	hsa-miR-4659b-3p	CLIP-seq
MIRT1194634	hsa-miR-494	CLIP-seq
MIRT1194635	hsa-miR-499-3p	CLIP-seq
MIRT1194636	hsa-miR-499a-3p	CLIP-seq
MIRT1194623	hsa-miR-128	CLIP-seq
MIRT1194626	hsa-miR-27a	CLIP-seq
MIRT1194627	hsa-miR-27b	CLIP-seq
MIRT1194628	hsa-miR-34a	CLIP-seq
MIRT1194629	hsa-miR-34c-5p	CLIP-seq
MIRT2056547	hsa-miR-3650	CLIP-seq
MIRT1194630	hsa-miR-449a	CLIP-seq
MIRT1194631	hsa-miR-449b	CLIP-seq
MIRT2056548	hsa-miR-4540	CLIP-seq
MIRT1194632	hsa-miR-4659a-3p	CLIP-seq
MIRT1194633	hsa-miR-4659b-3p	CLIP-seq
MIRT1194634	hsa-miR-494	CLIP-seq
MIRT1194635	hsa-miR-499-3p	CLIP-seq
MIRT1194636	hsa-miR-499a-3p	CLIP-seq
MIRT2056549	hsa-miR-944	CLIP-seq
MIRT2284997	hsa-miR-1236	CLIP-seq
MIRT1194624	hsa-miR-135a	CLIP-seq
MIRT1194625	hsa-miR-135b	CLIP-seq
MIRT2284998	hsa-miR-216b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000460	Process	Maturation of 5.8S rRNA	IBA
GO:0000470	Process	Maturation of LSU-rRNA	IBA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0030684	Component	Preribosome	IEA
GO:0030687	Component	Preribosome, large subunit precursor	IBA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042273	Process	Ribosomal large subunit biogenesis	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
612497	30728	ENSG00000164346

O95478

Protein name

Ribosome biogenesis protein NSA2 homolog (Hairy cell leukemia protein 1) (TGF-beta-inducible nuclear protein 1)

Protein function

Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).

PDB

8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL0 , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8IDY , 8IE3 , 8INE , 8INF , 8INK , 8IPD , 8IPX , 8IPY , 8IR1 , 8IR3 , 8RL2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01201	Ribosomal_S8e	1 → 259	Ribosomal protein S8e	Family

Sequence

MPQNEYIELHRKRYGYRLDYHEKKRKKESREAHERSKKAKKMIGLKAKLYHKQRHAEKIQ
MKKTIKMHEKRNTKQKNDEKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVP
LPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFKK
AHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGK
YAQVTNNPENDGCINAVLLV

Sequence length

260

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BILIARY CIRRHOSIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, BILIARY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY BILIARY CHOLANGITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Biliary cirrhosis	Biliary cirrhosis	CTD_human_DG	18422935		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Biliary Cirrhosis, Primary, 1	Biliary cirrhosis	CTD_human_DG	18422935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36407085	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	22095236, 23220173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	22095236, 23220173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	22095236		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	22095236, 23220173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	35139491	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hairy Cell Leukemia	Hairy Cell Leukemia	BEFREE	23912275		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	22095236, 23220173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	22095236		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23912275		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary biliary cirrhosis	Biliary Cirrhosis	CTD_human_DG	18422935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Secondary Biliary Cholangitis	Biliary Cholangitis	CTD_human_DG	18422935		★★★★★ ★☆☆☆☆ Found in Text Mining only

NSA2 (NSA2 ribosome biogenesis factor)